Caspofungin combined with Voriconazole

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
International Normalised Ratio Increased 6/30/2004 53 9/12/2005 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased 7/22/2004 9/12/2005 Physician United States
Primary
Concomitant
Tracheostomy Life Threatening 7/10/2005 42 Female 1/23/2006 United Kingdom
Primary
Secondary
Concomitant
Transplant Failure Life Threatening 7/1/2005 42 Female 1/24/2006 Consumer Germany
Primary
Secondary
Concomitant
Thrombocytopenia Required Intervention 1/6/2006 41 Female 152 lb 1/20/2006 Other Health Professional United States
Primary
Concomitant
Cardiac Failure Congestive Hospitalization 2/8/2005 18 Female 128 lb 1/10/2006 Physician United States
Primary
Concomitant
Therapy Non-responder Death 2/1/2006 47 Female 123 lb 3/10/2006 Physician United States
Primary
Concomitant
Thrombocytopenia Death 3/26/2006 73 Male 4/24/2006 Physician United States
Primary
Secondary
Concomitant
Syncope Other Serious 6/2/2006 48 Male 7/21/2006 Physician United States
Primary
Secondary
Concomitant
Syncope Other Serious 6/2/2006 48 Male 9/19/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Required Intervention 1/1/2006 37 Female 9/28/2006 Physician United States
Primary
Concomitant
Tumour Lysis Syndrome Required Intervention 8/30/2006 37 Female 10/13/2006 Physician United States
Primary
Secondary
Concomitant
Transplant Rejection Hospitalization 8/1/2004 10 Female 10/19/2006 Germany
Primary
Concomitant
Vomiting 2/8/2006 36 Male Physician United States
Primary
Concomitant
Tumour Lysis Syndrome Required Intervention 8/30/2006 37 Female 11/7/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Required Intervention 8/30/2006 37 Female 11/21/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 11/25/2006 19 Male 1/24/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 19 Male 2/23/2007 Physician Germany
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 11/25/2006 19 Male 3/13/2007 Physician Germany
Primary
Secondary
Concomitant
Zygomycosis Hospitalization 2/27/2007 Male 132 lb 3/29/2007 Physician Canada
Primary
Concomitant
Drug Ineffective Hospitalization 12/11/2006 Male 4/30/2007 Physician United States
Primary
Concomitant
Anaemia Haemolytic Autoimmune Other Serious 5/17/2007 Physician United States
Primary
Secondary
Concomitant
Swelling Face Other Serious 8/2/2006 11 Male 110 lb 3/27/2007 Pharmacist United States
Primary
Concomitant
Torsade De Pointes Life Threatening 14 Female 6/4/2007 Other Health Professional France
Primary
Concomitant
Interacting
Zygomycosis Other Serious 54 Male 7/26/2007 United States
Primary
Concomitant
Pyrexia Other Serious 5/12/2007 Male 8/17/2007 Pharmacist United States
Primary
Secondary
Concomitant
Intubation Other Serious 5/31/2007 29 Female 117 lb 8/23/2007 Pharmacist United States
Primary
Concomitant
Pancytopenia Hospitalization 1/1/2007 57 Male 9/13/2007 Consumer France
Primary
Secondary
Concomitant
Pyrexia Other Serious 2/1/2007 Male 9/14/2007 Other Health Professional France
Primary
Concomitant
Ventricular Dysfunction Other Serious 8/13/2007 10 Female 75 lb 9/11/2007 Pharmacist United States
Primary
Concomitant
Pancytopenia Hospitalization Male 9/19/2007 Consumer France
Primary
Secondary
Concomitant
Pruritus 5/24/2007 16 Male 99 lb 8/15/2007 Physician United States
Primary
Concomitant
Hypersensitivity 5/25/2007 16 Male 8/15/2007 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/1/2007 57 Male 9/18/2007 Other Health Professional France
Primary
Concomitant
Varicose Vein Life Threatening 6/15/2007 67 Male 190 lb 10/1/2007 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 2/1/2007 Male 10/19/2007 Other Health Professional France
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 2/1/2007 57 Male 10/22/2007 Other Health Professional France
Primary
Concomitant
Pancytopenia Hospitalization 1/1/2007 57 Male 10/31/2007 Consumer France
Primary
Secondary
Concomitant
Pancytopenia Hospitalization Male 11/2/2007 Consumer France
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 9/19/2007 Female 137 lb 11/2/2007 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Venoocclusive Disease Life Threatening 9/19/2007 19 Female 11/19/2007 Consumer United Kingdom
Primary
Secondary
Dilatation Intrahepatic Duct Acquired Life Threatening 9/19/2007 19 Female 11/21/2007 United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 9/19/2007 19 Female 11/26/2007 Other Health Professional United Kingdom
Primary
Secondary
Dilatation Intrahepatic Duct Acquired Life Threatening 9/19/2007 19 Female 11/26/2007 United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 9/19/2007 12/1/2007 Other Health Professional United Kingdom
Primary
Secondary
Hypersensitivity 5/25/2007 16 Male 11/12/2007 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 19 Female 11/30/2007 Pharmacist United Kingdom
Primary
Concomitant
Lymphoproliferative Disorder Hospitalization 15 Female 12/7/2007
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 9/19/2007 Female 137 lb 12/26/2007 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Ventricular Fibrillation Other Serious 10/5/2007 36 Male 1/16/2008 Netherlands
Primary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 Female 143 lb 2/15/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 Female 143 lb 2/23/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious Male 2/27/2008 Netherlands
Primary
Concomitant
Respiratory Failure Other Serious 15 Male 3/6/2008 Other Health Professional United Kingdom
Primary
Secondary
Respiratory Failure Other Serious 15 Male 3/12/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Virus Urine Test Positive Hospitalization 17 Male 6/5/2008
Primary
Secondary
Concomitant
Drug Ineffective Death 35 Male 6/27/2008 Czech Republic
Primary
Secondary
Drug Ineffective Death 35 Male 7/16/2008 Czech Republic
Primary
Secondary
Drug Ineffective Other Serious 30 Male 7/16/2008 Czech Republic
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 15 Male 7/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Metabolic Acidosis Hospitalization 10/28/2007 Female 143 lb 9/2/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 2/1/2007 57 Male 8/29/2008 Other Health Professional France
Primary
Concomitant
Pancytopenia Death 9/7/2008 55 Female 9/10/2008 Pharmacist Israel
Primary
Concomitant
Metabolic Acidosis Life Threatening 10/28/2007 Female 143 lb 9/17/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 7 Female 9/25/2008 Other Health Professional Austria
Primary
Secondary
Concomitant
Neutropenia Other Serious 7 Female 10/6/2008 Other Health Professional Austria
Primary
Secondary
Concomitant
Renal Failure Hospitalization 9/19/2008 Male 150 lb 11/5/2008 Spain
Primary
Concomitant
Potentiating Drug Interaction Other Serious 14 Male 141 lb 11/10/2008 Germany
Primary
Concomitant
Interacting
Systemic Candida Other Serious 32 Male 12/1/2008
Primary
Secondary
Concomitant
Endocarditis Death 53 Male 12/8/2008
Primary
Concomitant
Arrhythmia Death 11/29/2008 12/11/2008 Physician Italy
Primary
Secondary
Concomitant
Arrhythmia Death 11/29/2008 12/16/2008 Physician Italy
Primary
Secondary
Concomitant
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/16/2008 Physician Spain
Primary
Secondary
Concomitant
Pericardial Effusion Death 53 Male 12/17/2008 France
Primary
Concomitant
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/19/2008 Physician Spain
Primary
Secondary
Concomitant
Ventricular Fibrillation Death 36 Male 2/2/2009 Other Health Professional Netherlands
Primary
Concomitant
Ventricular Fibrillation Other Serious 10/5/2007 36 Male 2/13/2009 Netherlands
Primary
Concomitant
Arrhythmia Death 11/29/2008 2/24/2009 Physician Italy
Primary
Secondary
Concomitant
Cerebral Aspergillosis Other Serious 42 Male 3/4/2009
Primary
Secondary
Sepsis Other Serious 64 Male 3/13/2009 Other Health Professional Austria
Primary
Concomitant
Septic Shock Death 3/4/2009 4/3/2009 Physician Italy
Primary
Secondary
Concomitant
Surgery Other Serious 74 Male 4/8/2009 Other Health Professional United States
Primary
Concomitant
Encephalopathy Hospitalization 11/1/2008 4/22/2009 Other Health Professional Belgium
Primary
Secondary
Concomitant
Encephalopathy Hospitalization 11/1/2008 4/23/2009 Other Health Professional Belgium
Primary
Secondary
Concomitant
Rectal Haemorrhage Required Intervention 12/15/2008 73 Male 174 lb 1/6/2009 Pharmacist United States
Primary
Concomitant
Encephalopathy Hospitalization 11/1/2008 5/5/2009 Other Health Professional Belgium
Primary
Secondary
Concomitant
Encephalopathy Hospitalization 11/1/2008 52 6/16/2009 Other Health Professional Belgium
Primary
Secondary
Concomitant
Blood Creatine Phosphokinase Increased Other Serious 6/8/2009 Male 161 lb 6/18/2009 Pharmacist United States
Primary
Concomitant
Septic Shock Death 3/4/2009 64 6/30/2009 Other Health Professional Italy
Primary
Secondary
Concomitant
Sinusitis Aspergillus Other Serious 3 Female 7/2/2009
Primary
Secondary
Multi-organ Failure Other Serious 18 Female 93 lb 7/20/2009 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Death Death 16 10/28/2009 Physician Korea, Republic Of
Primary
Concomitant
Acute Myeloid Leukaemia Death 16 Female 82 lb 11/9/2009 Physician Korea, Republic Of
Primary
Concomitant
Multi-organ Failure Other Serious 75 Male 11/11/2009 Physician Belgium
Primary
Secondary
Concomitant
Drug Resistance Other Serious 13 Male 12/29/2009 Physician Netherlands
Primary
Concomitant
Bronchopulmonary Aspergillosis Other Serious 64 Male 1/15/2010
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Death 7/11/2007 16 Female 82 lb 1/25/2010 Physician Korea, Republic Of
Primary
Concomitant
Nephropathy Toxic Other Serious 4/1/2010 United States
Primary
Secondary
Concomitant
Arrhythmia Death 11/29/2008 66 Male 198 lb 3/30/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Nephropathy Toxic Other Serious 4/6/2010 United States
Primary
Secondary
Concomitant
Drug Resistance Death 9 Female 4/30/2010 Other Health Professional France
Primary
Secondary
Concomitant
Drug Resistance Death Female 5/6/2010 Other Health Professional France
Primary
Secondary
Concomitant
Multiple-drug Resistance Death 9 Female 5/6/2010 France
Primary
Secondary
Concomitant
Pathogen Resistance Death 11 Female 7/22/2010 Physician Italy
Primary
Secondary
Concomitant
Organising Pneumonia Other Serious 53 Male 7/30/2010 Physician Italy
Primary
Secondary
Organising Pneumonia Other Serious 53 Male 8/5/2010 Physician Italy
Primary
Secondary
Drug Ineffective 15 Female 8/6/2010 Consumer United States
Primary
Concomitant
Zygomycosis Death 23 Female 8/23/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Life Threatening Female 8/30/2010 Pharmacist United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 9/19/2007 19 Female 9/9/2010 Consumer United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening Female 9/9/2010 Pharmacist United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 9/19/2007 19 Female 9/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 19 Female 9/10/2010 Pharmacist United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 19 Female 9/10/2010 Consumer United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 9/19/2007 19 Female 9/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 9/19/2007 19 Female 9/10/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Life Threatening 19 Female 9/15/2010 Other Health Professional United Kingdom
Primary
Secondary
Venoocclusive Disease Other Serious 9/19/2007 19 Female 137 lb 9/17/2010 Pharmacist United Kingdom
Primary
Secondary
Venoocclusive Liver Disease Other Serious 9/20/2010 Other Health Professional United Kingdom
Primary
Secondary
Enterococcal Sepsis Death 11 Female 12/17/2010 Physician Italy
Primary
Secondary
Concomitant
Pancytopenia Death 11 Female 12/21/2010 United States
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Life Threatening 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Life Threatening 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Heat Illness Hospitalization 26 Male 1/14/2011 Other Health Professional Australia
Primary
Secondary
Concomitant
Movement Disorder Other Serious 26 Male 1/31/2011 Other Health Professional Australia
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Death 54 Male 2/15/2011 China
Primary
Concomitant
Drug Interaction Other Serious 54 Male 2/17/2011 Other Health Professional Canada
Primary
Secondary
Concomitant
Interacting
Venoocclusive Liver Disease Life Threatening 9/19/2007 19 Female 137 lb 2/18/2011 Pharmacist United Kingdom
Primary
Secondary
Drug Ineffective Other Serious 56 Male 2/23/2011 China
Primary
Concomitant
Drug Interaction Other Serious 54 Male 2/24/2011 Physician Canada
Primary
Concomitant
Interacting
Venoocclusive Liver Disease Life Threatening 9/19/2007 19 Female 137 lb 2/24/2011 Other Health Professional United Kingdom
Primary
Secondary
Blood Bilirubin Increased Life Threatening 22 Female 2/23/2011 Other Health Professional United Kingdom
Primary
Secondary
Hepatosplenic Candidiasis Other Serious Female 2/17/2011 Physician Philippines
Primary
Concomitant
Blood Alkaline Phosphatase Increased Other Serious 19 Female 3/2/2011 Other Health Professional
Primary
Secondary
Hypophosphataemia Other Serious 9 Female 3/7/2011 Other Health Professional France
Primary
Secondary
Concomitant
Lung Transplant Rejection Other Serious 9 Male 4/12/2011 Other Health Professional Canada
Primary
Secondary
Concomitant
Sopor Hospitalization 12/6/2010 Male 4/26/2011 Physician Slovakia (Slovak Republic)
Primary
Concomitant
Death Death 7/27/2009 60 Female 4/27/2011 Consumer Turkey
Primary
Secondary
Acute Myeloid Leukaemia Death 7/27/2009 60 Female 5/2/2011 Physician Turkey
Primary
Secondary
Encephalopathy Hospitalization 11/1/2008 52 Female 132 lb 5/23/2011 Other Health Professional Belgium
Primary
Secondary
Concomitant
Liver Disorder Other Serious 53 Female 5/23/2011 Physician France
Primary
Concomitant
Encephalopathy Hospitalization 11/1/2008 52 Female 132 lb 7/15/2011 Other Health Professional Belgium
Primary
Secondary
Concomitant
Retinoic Acid Syndrome Other Serious 1/1/2011 24 Male 9/6/2011 Physician Switzerland
Primary
Secondary
Concomitant
Candidiasis Death 11/1/2011 45 Female 2/24/2012 Physician France
Primary
Concomitant
Rosacea Other Serious 1/1/2008 59 Male 4/3/2012 Other Health Professional Sweden
Primary
Concomitant
Liver Function Test Abnormal Other Serious 7/15/2012 56 Male 8/6/2012 Pharmacist United Kingdom
Primary
Concomitant
Renal Failure Acute Life Threatening 4/25/2012 33 Male 205 lb 8/29/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Skin Lesion Life Threatening 7/23/2012 12 Male 181 lb 11/5/2012 Physician Us
Primary
Secondary
Concomitant
Multi-organ Failure Death 2012 Female 171 lb 11/12/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Transplant Rejection Hospitalization 31 Female 11/16/2012 Other Health Professional Hr
Primary
Secondary
Concomitant

Drug Data