Carboplatin combined with Topotecan

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Tumour Lysis Syndrome Hospitalization 62 Female 3/3/2006 Consumer United States
Primary
Secondary
Tumour Lysis Syndrome Hospitalization 62 Female 3/13/2006 Consumer United States
Primary
Secondary
Treatment Noncompliance Required Intervention 3/3/2005 69 Male 253 lb 2/15/2006 Other Health Professional United States
Primary
Secondary
Drug Hypersensitivity Other Serious 60 Female 6/18/2006 United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/4/2006 50 Female 8/2/2006 Physician Italy
Primary
Secondary
Concomitant
Shock Haemorrhagic Hospitalization 11/3/2006 53 Female 117 lb 11/14/2006 Physician Germany
Primary
Secondary
Concomitant
Shock Haemorrhagic Hospitalization 11/3/2006 53 Female 117 lb 11/27/2006 Physician Germany
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 2/12/2007 67 Female 114 lb 2/21/2007 Physician United States
Primary
Secondary
Sepsis Death 10/8/2003 67 Female 298 lb 2/5/2007 Other Health Professional United States
Primary
Secondary
Paraesthesia Other Serious 11/11/2002 65 Female 170 lb 2/8/2007 Other Health Professional United States
Primary
Secondary
Waist Circumference Increased Required Intervention 6/12/2003 46 Female 122 lb 2/5/2007 Other Health Professional United States
Primary
Secondary
Malignant Neoplasm Progression Other Serious Female 2/28/2007 Consumer United States
Primary
Secondary
Subdural Haematoma Hospitalization 2/12/2007 67 Female 114 lb 3/8/2007 Physician United States
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 2/12/2007 67 Female 114 lb 3/9/2007 Physician United States
Primary
Secondary
Concomitant
Rash Vesicular 1/1/2005 Female 222 lb 3/28/2007 Other Health Professional United States
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 62 Female 4/25/2007 Physician United States
Primary
Secondary
Concomitant
Unevaluable Event Other Serious 1/1/2007 Male 184 lb 6/13/2007 Consumer United States
Primary
Concomitant
Coma Life Threatening 4/11/2007 71 Female 6/16/2007 Portugal
Primary
Concomitant
Vomiting Other Serious 7/1/2007 70 Female 7/9/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 7/1/2007 70 Female 7/13/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/1/2007 70 Female 7/18/2007 Physician United States
Primary
Secondary
Concomitant
Leukaemia Other Serious 7/11/2007 64 Female 8/1/2007 Physician Japan
Primary
Concomitant
Acute Myeloid Leukaemia Other Serious 7/11/2007 64 Female 8/16/2007 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Hospitalization 8/14/2007 78 Female 140 lb 8/21/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/11/2007 83 Male 188 lb 8/22/2007 Physician United States
Primary
Secondary
Tachycardia Hospitalization 8/26/2007 72 Female 92 lb 9/6/2007 Physician United States
Primary
Secondary
Tachycardia Hospitalization 8/26/2007 72 Female 92 lb 9/17/2007 Physician United States
Primary
Secondary
Vomiting Hospitalization 8/11/2007 83 Male 188 lb 9/26/2007 Physician United States
Primary
Secondary
Muscular Weakness Hospitalization 8/14/2007 78 Female 140 lb 10/1/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/13/2007 72 Female 101 lb 10/2/2007 Physician United States
Primary
Secondary
Tachycardia Hospitalization 8/26/2007 72 Female 92 lb 10/3/2007 Physician United States
Primary
Secondary
Tachycardia Hospitalization 8/26/2007 72 Female 92 lb 11/5/2007 Physician United States
Primary
Secondary
Pain Hospitalization 11/5/2007 Female 110 lb 11/5/2007 Other Health Professional United States
Primary
Concomitant
Pyrexia Hospitalization 12/16/2007 79 Male 119 lb 1/10/2008 Physician United States
Primary
Secondary
Thrombocytopenia Hospitalization 1/11/2008 79 Male 118 lb 2/7/2008 Physician United States
Primary
Secondary
Venoocclusive Liver Disease Other Serious 11 Male 3/1/2008 Consumer Hong Kong
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 2/28/2008 53 Female 193 lb 3/13/2008 Physician Germany
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 2/28/2008 53 Female 193 lb 3/20/2008 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Hospitalization 12/16/2007 79 Male 119 lb 4/9/2008 Physician United States
Primary
Secondary
Nausea Hospitalization 2/28/2008 45 Female 150 lb 4/10/2008 Physician Germany
Primary
Secondary
Nausea Hospitalization 2/28/2008 45 Female 150 lb 4/11/2008 Physician Germany
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 12/16/2007 79 Male 119 lb 4/22/2008 Physician United States
Primary
Secondary
Ovarian Cancer Other Serious 59 Female 4/24/2008 Physician United States
Primary
Secondary
Concomitant
Thrombosis Hospitalization 4/22/2008 65 Female 150 lb 4/28/2008 Physician Germany
Primary
Secondary
Ileus Hospitalization 4/29/2008 77 Female 5/2/2008 Physician Germany
Primary
Secondary
Ileus Life Threatening 4/29/2008 77 Female 5/22/2008 Physician Germany
Primary
Secondary
Upper Respiratory Tract Infection Hospitalization 5/14/2008 Female 157 lb 5/22/2008 Physician Germany
Primary
Secondary
Upper Respiratory Tract Infection Hospitalization 5/14/2008 38 Female 157 lb 6/5/2008 Physician Germany
Primary
Secondary
Muscle Spasms Other Serious 5/28/2008 Female 153 lb 6/5/2008 Physician Germany
Primary
Secondary
Concomitant
Thrombosis Hospitalization 4/22/2008 65 Female 150 lb 6/19/2008 Physician Germany
Primary
Secondary
Muscle Spasms Other Serious 5/28/2008 Female 153 lb 6/25/2008 Physician Germany
Primary
Secondary
Concomitant
Rash Hospitalization 6/1/2008 Female 131 lb 6/25/2008 Physician Germany
Primary
Secondary
Ileus Life Threatening 4/29/2008 77 Female 7/1/2008 Physician Germany
Primary
Secondary
Therapeutic Response Delayed Other Serious 1/1/1999 Female 145 lb 7/3/2008 Consumer United States
Primary
Concomitant
Nausea Hospitalization 2/28/2008 45 Female 150 lb 7/7/2008 Physician Germany
Primary
Secondary
Muscle Spasms Other Serious 5/28/2008 Female 153 lb 7/8/2008 Physician Germany
Primary
Secondary
Concomitant
Rash Hospitalization 6/1/2008 Female 131 lb 7/18/2008 Physician Germany
Primary
Secondary
Tachyarrhythmia Life Threatening 7/2/2008 Female 284 lb 7/28/2008 Physician Germany
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 7/28/2008 Female 132 lb 8/7/2008 Physician Germany
Primary
Secondary
Thrombocytopenia Hospitalization 7/28/2008 Female 132 lb 8/19/2008 Physician Germany
Primary
Secondary
Thrombocytopenia Hospitalization 7/28/2008 Female 132 lb 8/28/2008 Physician Germany
Primary
Secondary
Cerebrovascular Accident Hospitalization 2/28/2008 53 Female 193 lb 9/23/2008 Physician Germany
Primary
Secondary
Concomitant
Therapeutic Response Delayed Other Serious 1/1/1999 Female 155 lb 9/24/2008 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 10/8/2008 77 Male 182 lb 10/17/2008 Physician United States
Primary
Secondary
Concomitant
Flushing Hospitalization 10/22/2008 Female 203 lb 10/28/2008 Physician Germany
Primary
Secondary
Dyspnoea Hospitalization 10/21/2008 67 Female 161 lb 10/29/2008 Physician Germany
Primary
Secondary
Flushing Hospitalization 10/22/2008 Female 203 lb 10/31/2008 Physician Germany
Primary
Secondary
Pyrexia Hospitalization 10/8/2008 77 Male 182 lb 11/12/2008 Physician United States
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 10/21/2008 67 Female 161 lb 11/13/2008 Physician Germany
Primary
Secondary
Haemoglobin Life Threatening 10/21/2008 67 Female 165 lb 11/17/2008 Physician Germany
Primary
Secondary
Haemoglobin Life Threatening 10/21/2008 67 Female 165 lb 11/26/2008 Physician Germany
Primary
Secondary
Thrombosis Hospitalization 11/25/2008 69 Female 148 lb 12/3/2008 Physician Germany
Primary
Secondary
Thrombocytopenia Hospitalization 7/28/2008 Female 132 lb 12/4/2008 Physician Germany
Primary
Secondary
Viral Infection Hospitalization 11/25/2008 Female 147 lb 12/4/2008 Physician Germany
Primary
Secondary
Peritonitis Hospitalization 50 Female 12/4/2008 Physician Germany
Primary
Concomitant
Intestinal Obstruction Hospitalization 11/26/2008 Female 149 lb 12/5/2008 Physician Germany
Primary
Secondary
White Blood Cell Count Decreased Other Serious 4/1/2008 Female 12/12/2008 Consumer United States
Primary
Concomitant
Dehydration Hospitalization 12/9/2008 68 Female 108 lb 12/22/2008 Physician Germany
Primary
Secondary
Concomitant
Dehydration Hospitalization 12/9/2008 68 Female 108 lb 12/29/2008 Physician Germany
Primary
Secondary
Concomitant
Stem Cell Transplant Other Serious 12 Female 1/6/2009 Physician United States
Primary
Secondary
Viral Infection Hospitalization 11/25/2008 Female 147 lb 1/12/2009 Physician Germany
Primary
Secondary
Pancreatic Pseudocyst Other Serious 49 Female 1/26/2009
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 12 Female 1/28/2009 United States
Primary
Secondary
Viral Infection Hospitalization 11/25/2008 Female 147 lb 2/20/2009 Physician Germany
Primary
Secondary
Intestinal Obstruction Hospitalization 11/26/2008 Female 149 lb 2/20/2009 Physician Germany
Primary
Secondary
Dehydration Hospitalization 12/9/2008 68 Female 108 lb 3/4/2009 Physician Germany
Primary
Secondary
Concomitant
Tachyarrhythmia Life Threatening 6/24/2008 Female 284 lb 3/13/2009 Physician Germany
Primary
Secondary
Concomitant
Tachyarrhythmia Life Threatening 6/24/2008 Female 284 lb 3/26/2009 Physician Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 4/2/2009 67 Female 185 lb 4/2/2009 Other Health Professional United States
Primary
Secondary
Pleural Effusion Hospitalization 4/6/2009 Female 143 lb 4/16/2009 Physician Germany
Primary
Secondary
Pulmonary Oedema Hospitalization 4/6/2009 Female 143 lb 4/21/2009 Physician Germany
Primary
Secondary
Thrombosis Hospitalization 11/25/2008 Female 148 lb 6/5/2009 Physician Germany
Primary
Secondary
White Blood Cell Disorder Hospitalization 4/4/2009 Female 137 lb 6/24/2009 Physician Germany
Primary
Secondary
Ileus Life Threatening 4/29/2008 Female 6/29/2009 Physician Germany
Primary
Secondary
White Blood Cell Disorder Hospitalization 4/4/2009 Female 137 lb 7/1/2009 Physician Germany
Primary
Secondary
Concomitant
Oral Fungal Infection Hospitalization 1/1/2009 Female 150 lb 7/23/2009 Physician France
Primary
Secondary
Diarrhoea Hospitalization 8/12/2009 Female 181 lb 8/20/2009 Physician Germany
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 8/12/2009 Female 181 lb 9/3/2009 Physician Germany
Primary
Secondary
Concomitant
General Physical Health Deterioration Hospitalization 8/14/2009 Female 165 lb 9/3/2009 Physician Germany
Primary
Secondary
Diarrhoea Hospitalization 8/12/2009 Female 181 lb 9/10/2009 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/14/2009 Female 9/22/2009 Physician Germany
Primary
Secondary
Pyrexia Hospitalization 9/14/2009 Female 151 lb 9/28/2009 Physician Germany
Primary
Secondary
General Physical Health Deterioration Hospitalization 8/14/2009 Female 165 lb 9/28/2009 Physician Germany
Primary
Secondary
Venoocclusive Disease Hospitalization 8/25/2009 Male 33 lb 9/23/2009 United States
Primary
Secondary
Weight Increased Hospitalization 8/25/2009 Male 33 lb 10/5/2009 United States
Primary
Secondary
Cardiac Failure Congestive Hospitalization 10/21/2009 Male 254 lb 11/2/2009 United States
Primary
Secondary
Ventricular Tachycardia Hospitalization 66 Female 11/11/2009 Germany
Primary
Concomitant
Platelet Disorder Hospitalization 11/3/2009 Female 11/13/2009 Physician Germany
Primary
Secondary
Platelet Disorder Hospitalization 11/3/2009 Female 134 lb 11/24/2009 Physician Germany
Primary
Secondary
Platelet Disorder Hospitalization 11/3/2009 Female 134 lb 12/7/2009 Physician Germany
Primary
Secondary
Thrombosis Hospitalization 11/12/2008 57 Female 132 lb 12/22/2009 Physician Germany
Primary
Concomitant
Vomiting Hospitalization 11/24/2009 Female 220 lb 12/15/2009 United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/24/2009 Female 220 lb 12/3/2009 United States
Primary
Secondary
Concomitant
Thrombosis Hospitalization 11/12/2008 57 Female 132 lb 12/23/2009 Physician Germany
Primary
Concomitant
Thrombosis Hospitalization 11/12/2008 57 Female 132 lb 1/22/2010 Physician Germany
Primary
Concomitant
Small Cell Lung Cancer Stage Unspecified Other Serious 9/1/2009 Male 1/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 1/20/2010 Female 1/29/2010 Physician France
Primary
Secondary
Thrombocytopenia Life Threatening 6/24/2008 Female 284 lb 2/25/2010 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/28/2010 Female 181 lb 3/3/2010 United States
Primary
Secondary
Venoocclusive Liver Disease Required Intervention 4 Male 3/10/2010 Physician United States
Primary
Secondary
Concomitant
Myeloid Leukaemia Other Serious 1 Male 3/10/2010 Physician United States
Primary
Secondary
Thrombosis Hospitalization 11/25/2008 Female 148 lb 3/16/2010 Physician Germany
Primary
Secondary
Thrombosis Hospitalization 11/25/2008 Female 148 lb 3/24/2010 Physician Germany
Primary
Secondary
Thrombocytopenia Other Serious 1/16/2010 51 Female 4/16/2010 Physician France
Primary
Secondary
Ureteric Obstruction Other Serious 1/1/2008 56 Female 5/10/2010 Pharmacist United States
Primary
Concomitant
Sepsis Other Serious 3/23/2010 65 Male 226 lb 5/17/2010 Physician United States
Primary
Secondary
Concomitant
Sepsis Other Serious 3/23/2010 65 Male 5/17/2010 Other Health Professional United States
Primary
Secondary
Hyponatraemia Hospitalization 6/26/2010 40 Male 313 lb 8/9/2010 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/8/2009 55 Female 148 lb 8/12/2010 Physician Germany
Primary
Secondary
Urge Incontinence Other Serious 7/9/2002 57 Female 8/20/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 3/29/2010 65 Male 8/23/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Other Serious 3/29/2010 65 Male 8/25/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Blood Creatinine Increased Hospitalization 9/6/2010 30 Female 185 lb 9/17/2010 Physician Germany
Primary
Secondary
Concomitant
Blood Creatinine Increased Hospitalization 9/6/2010 30 Female 185 lb 9/29/2010 Physician Germany
Primary
Secondary
Concomitant
Urge Incontinence Other Serious 7/9/2002 57 Female 9/29/2010 United States
Primary
Secondary
Concomitant
Urge Incontinence Other Serious 7/9/2002 57 Female 10/7/2010 United States
Primary
Secondary
Concomitant
Urge Incontinence Other Serious 7/9/2002 57 Female 10/7/2010 United States
Primary
Secondary
Concomitant
Urge Incontinence Other Serious 7/9/2002 57 Female 10/8/2010 United States
Primary
Secondary
Concomitant
Thrombocytopenia 8/11/2010 55 Female 123 lb 11/1/2010 United States
Primary
Secondary
Urge Incontinence Other Serious 7/9/2002 57 Female 11/11/2010 United States
Primary
Secondary
Concomitant
Renal Failure Chronic Other Serious Female 160 lb 12/10/2010 Physician United States
Primary
Secondary
Concomitant
Mucosal Inflammation 8/11/2010 67 Female 130 lb 12/1/2010 United States
Primary
Secondary
Central Venous Pressure Increased Hospitalization 7/9/2002 57 Female 2/9/2011 Lawyer United States
Primary
Secondary
Concomitant
Diarrhoea Other Serious 59 Female 2/28/2011 Physician United States
Primary
Secondary
Febrile Neutropenia Other Serious 22 Male 2/28/2011 Other Health Professional Greece
Primary
Secondary
Concomitant
Hepatic Steatosis Hospitalization 7/9/2002 57 Female 3/7/2011 Lawyer United States
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 10/21/2009 63 Male 254 lb 3/14/2011 Physician United States
Primary
Secondary
Concomitant
Cardiac Failure Congestive Hospitalization 10/21/2009 63 Male 254 lb 3/16/2011 United States
Primary
Secondary
Lymphadenopathy Other Serious 24 Female 3/15/2011 Other Health Professional Poland
Primary
Secondary
Concomitant
Neutropenia Other Serious 4/1/2011 Other Health Professional Italy
Primary
Secondary
Concomitant

Drug Data