Carboplatin combined with Melphalan Hydrochloride

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Thrombotic Microangiopathy Hospitalization 5/28/2009 Male 27 lb 6/5/2009 United States
Primary
Secondary
Transplant Failure Other Serious 69 Male 8/17/2009 United States
Primary
Secondary
Transaminases Increased Other Serious 0 Female 8/27/2009 Other Health Professional Italy
Primary
Secondary
Venoocclusive Liver Disease Other Serious Unknown 10/2/2009 Korea, Republic Of
Primary
Secondary
Capillary Leak Syndrome Death Unknown 12/14/2009 Italy
Primary
Secondary
Weight Increased Hospitalization 12/23/2009 Male 30 lb 1/11/2010 United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 5/25/2009 Male 22 lb 2/25/2010 United States
Primary
Secondary
Respiratory Distress Hospitalization 12/11/2009 Male 40 lb 3/3/2010 United States
Primary
Secondary
Weight Increased Hospitalization 7/21/2009 Male 48 lb 2/24/2010 United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization Male 26 lb 3/4/2010 United States
Primary
Secondary
Use Of Accessory Respiratory Muscles Hospitalization 2/12/2010 Male 26 lb 3/9/2010 United States
Primary
Secondary
Venoocclusive Liver Disease Required Intervention 4 Male 3/10/2010 Physician United States
Primary
Secondary
Concomitant
Viral Test Positive Hospitalization 12/11/2009 Male 40 lb 3/17/2010 United States
Primary
Secondary
Concomitant
Stem Cell Transplant Death 6 Female 3/25/2010 Germany
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 5 Male 3/25/2010 Germany
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 2/12/2010 2 Male 26 lb 4/8/2010 United States
Primary
Secondary
Respiratory Failure Life Threatening 6 Male 4/13/2010 Japan
Primary
Concomitant
Pyrexia Other Serious 9 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 5 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 9 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 11 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Other Serious 11 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 13 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 1 Unknown 5/4/2010 United States
Primary
Secondary
Concomitant
Sepsis Death 7 5/4/2010 United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 2 5/4/2010 Physician United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Other Serious 5/19/2010 Physician United States
Primary
Secondary
Concomitant
Sepsis Other Serious 5/19/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Death Unknown 5/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Roseolovirus Test Positive Hospitalization 4/20/2010 1 Female 20 lb 5/20/2010 United States
Primary
Secondary
Stem Cell Transplant Hospitalization 6 Male 5/25/2010 Japan
Primary
Secondary
Renal Failure Hospitalization 4/20/2010 1 Female 20 lb 5/28/2010 United States
Primary
Secondary
Urinary Tract Infection Other Serious 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Herpes Zoster Other Serious 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Death 7/1/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Death 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Other Serious 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Venoocclusive Disease Death 7/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 7 Male 8/24/2010 India
Primary
Secondary
Renal Impairment 7 Male 9/13/2010 Physician India
Primary
Secondary
Pyrexia Other Serious 49 Female 9/23/2010 Other Health Professional Switzerland
Primary
Concomitant
Pleural Effusion Other Serious 31 Female 11/30/2010 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 7 Male 12/24/2010 Other Health Professional United States
Primary
Secondary
Intestinal Obstruction Other Serious 22 Male 1/28/2011 Greece
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 22 Male 2/28/2011 Other Health Professional Greece
Primary
Secondary
Concomitant
Engraftment Syndrome Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Engraftment Syndrome Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 4/1/2011 Physician Spain
Primary
Secondary
Concomitant
Device Breakage Hospitalization 3/23/2011 6 Male 66 lb 4/21/2011 Physician United States
Primary
Secondary
Syncope Hospitalization 5/3/2011 70 Female 5/20/2011 Physician United States
Primary
Secondary
Concomitant
Vitreous Haemorrhage Other Serious 1 5/18/2011 Physician United States
Primary
Concomitant
Vitreous Haemorrhage Other Serious 2 5/18/2011 Other Health Professional United States
Primary
Concomitant
Neoplasm Progression Other Serious 3 5/18/2011 Other Health Professional United States
Primary
Concomitant
Stem Cell Transplant Death 46 Female 5/20/2011 Greece
Primary
Secondary
Concomitant
Vitreous Haemorrhage Other Serious 5 5/27/2011 Physician United States
Primary
Concomitant
Vitreous Haemorrhage Disability 2 5/27/2011 Physician United States
Primary
Concomitant
Vitreous Haemorrhage Other Serious 3 5/27/2011 Physician United States
Primary
Concomitant
Vitreous Haemorrhage Disability 2 5/27/2011 Physician United States
Primary
Concomitant
Retinal Exudates Other Serious Female 5/31/2011 Physician United States
Primary
Concomitant
Acute Graft Versus Host Disease Death 5 6/23/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Neoplasm Malignant Death 5 6/25/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Acute Graft Versus Host Disease Death 3 6/25/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Pancreatitis Other Serious 2/10/2010 23 Male 117 lb 6/30/2011 Physician Japan
Primary
Secondary
Concomitant
Memory Impairment Hospitalization 2/10/2010 23 Male 117 lb 7/6/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Blood Pressure Decreased Hospitalization 1/26/2011 2 Male 27 lb 7/26/2011 Physician France
Primary
Secondary
Concomitant
Enterococcal Infection Hospitalization 2/10/2010 23 Male 117 lb 10/3/2011 Physician Japan
Primary
Secondary
Concomitant
Orbital Oedema Hospitalization 11/7/2011 3 Male 28 lb 11/7/2011 United States
Primary
Secondary
Stomatitis Hospitalization 11/3/2011 3 Male 33 lb 11/8/2011 Physician United States
Primary
Secondary
Visual Acuity Reduced Other Serious 74 Male 11/17/2011 Physician United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 50 Female 11/17/2011 Physician United States
Primary
Concomitant
Vitreous Haemorrhage Other Serious 12/6/2011 Physician United States
Primary
Secondary
Concomitant
Retinal Pigment Epitheliopathy Other Serious 12/6/2011 Physician United States
Primary
Secondary
Concomitant
Retinal Pigment Epitheliopathy Other Serious 12/6/2011 Physician United States
Primary
Secondary
Concomitant
Arterial Stenosis Other Serious 12/6/2011 Physician United States
Primary
Secondary
Concomitant
Retinal Pigment Epitheliopathy Other Serious 12/6/2011 Physician United States
Primary
Secondary
Concomitant
Retinal Detachment Other Serious 12/6/2011 Physician United States
Primary
Secondary
Concomitant
Enterococcal Infection Hospitalization 2/10/2010 23 Male 117 lb 12/8/2011 Physician Japan
Primary
Secondary
Concomitant
Focal Nodular Hyperplasia Other Serious 7/28/2004 18 Female 66 lb 12/13/2011 Physician Japan
Primary
Secondary
Subileus Hospitalization 12/1/2011 2 Male 28 lb 12/12/2011 Switzerland
Primary
Secondary
Concomitant
Candidiasis Hospitalization 1/1/2010 23 Male 117 lb 12/28/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Choroidal Dystrophy Other Serious 12/28/2011 Physician United States
Primary
Concomitant
Eyelid Oedema Other Serious 12/28/2011 Physician United States
Primary
Secondary
Concomitant
Eyelid Oedema Other Serious 12/28/2011 Physician United States
Primary
Secondary
Concomitant
Extraocular Muscle Disorder Other Serious 12/28/2011 Physician United States
Primary
Secondary
Concomitant
Eyelid Oedema Other Serious 12/28/2011 Physician United States
Primary
Secondary
Concomitant
Eyelid Oedema Other Serious 12/28/2011 Physician United States
Primary
Secondary
Concomitant
Eye Excision Other Serious 1/3/2012 Physician United States
Primary
Secondary
Eye Excision Other Serious 1/3/2012 Physician United States
Primary
Secondary
Ocular Vascular Disorder Other Serious 1/3/2012 Physician United States
Primary
Secondary
Chorioretinal Atrophy Other Serious 1/3/2012 Physician United States
Primary
Secondary
Retinal Artery Occlusion Other Serious 1/3/2012 Physician United States
Primary
Secondary
Retinal Artery Occlusion Other Serious 1/3/2012 Physician United States
Primary
Secondary
Metastases To Central Nervous System Life Threatening 2 Male 1/3/2012 Other Health Professional Japan
Primary
Secondary
Metastases To Bone Life Threatening 2 Male 1/3/2012 Other Health Professional Japan
Primary
Secondary
Metastases To Liver Life Threatening 2 Male 1/3/2012 Other Health Professional Japan
Primary
Secondary
No Therapeutic Response Life Threatening 2 Male 1/3/2012 Other Health Professional Japan
Primary
Secondary
Retinal Artery Stenosis Other Serious 1/3/2012 Physician United States
Primary
Secondary
Retinal Artery Occlusion Other Serious 1/3/2012 Physician United States
Primary
Secondary
Ocular Vascular Disorder Other Serious 1/3/2012 Physician United States
Primary
Secondary
Lung Disorder Hospitalization 1/14/2012 2 Female 35 lb 1/18/2012 Physician United States
Primary
Secondary
Foreign Body Reaction Other Serious 1 Male 1/19/2012 Physician United States
Primary
Secondary
Concomitant
Glaucoma Other Serious 1 Female 1/19/2012 Physician United States
Primary
Secondary
Concomitant
Eyelid Oedema Other Serious 6 Male 1/19/2012 Physician United States
Primary
Secondary
Concomitant
Extraocular Muscle Disorder Other Serious 3 Male 1/19/2012 Physician United States
Primary
Secondary
Concomitant
Chorioretinal Atrophy Other Serious 2 Male 1/19/2012 Physician United States
Primary
Secondary
Concomitant
Optic Atrophy Other Serious 1 Male 1/19/2012 Physician United States
Primary
Secondary
Concomitant
Extraocular Muscle Disorder Other Serious 1 Male 2/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Eyelid Oedema Other Serious 1 Male 2/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Eye Excision Disability 1 Female 2/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Extraocular Muscle Disorder Disability 1 Female 2/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Extraocular Muscle Disorder Other Serious 3 Male 2/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Retinal Pigment Epitheliopathy Other Serious 3 Male 2/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Extraocular Muscle Disorder Other Serious 2 Male 2/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Choroidal Dystrophy Other Serious 2 Male 2/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Retinal Artery Occlusion Other Serious 1 Male 2/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Optic Atrophy Other Serious 1 Male 2/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Eyelid Ptosis Disability 6 Male 2/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Extraocular Muscle Disorder Disability 6 Male 2/7/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Vitreous Haemorrhage Other Serious 1 Female 2/2/2012 Other Health Professional United Kingdom
Primary
Concomitant
Eye Excision Disability 30 Male 2/2/2012 Other Health Professional United Kingdom
Primary
Concomitant
Vitreous Haemorrhage Other Serious 2 Male 2/2/2012 Other Health Professional United Kingdom
Primary
Concomitant
Epistaxis Other Serious 1 Female 2/2/2012 Other Health Professional United Kingdom
Primary
Concomitant
Retinal Detachment Other Serious 1 Male 2/2/2012 Other Health Professional United Kingdom
Primary
Concomitant
Eye Excision Disability 12 Female 2/2/2012 Other Health Professional United Kingdom
Primary
Concomitant
Arterial Disorder Other Serious 1 Male 2/2/2012 Physician United States
Primary
Secondary
Concomitant
Glaucoma Disability 1 Female 2/2/2012 Physician United States
Primary
Secondary
Concomitant
Extraocular Muscle Disorder Disability 6 Male 2/2/2012 Physician United States
Primary
Secondary
Concomitant
Extraocular Muscle Disorder Other Serious 3 Male 2/2/2012 Physician United States
Primary
Secondary
Concomitant
Extraocular Muscle Disorder Other Serious 2 Male 2/2/2012 Physician United States
Primary
Secondary
Concomitant
Retinal Pigment Epitheliopathy Other Serious 1 Male 2/2/2012 Physician United States
Primary
Secondary
Concomitant
Extraocular Muscle Disorder Other Serious 1 Male 2/2/2012 Physician United States
Primary
Concomitant
Retinoblastoma Disability 1 Female 2/2/2012 Physician United States
Primary
Concomitant
Renal Failure Acute Death 2/21/2012 Other Health Professional United States
Primary
Secondary
Pneumonia Death 2/10/2010 23 Male 117 lb 3/20/2012 Physician Japan
Primary
Secondary
Concomitant
Melaena Hospitalization 2/10/2010 23 Male 117 lb 3/20/2012 Physician Japan
Primary
Secondary
Concomitant
Memory Impairment Hospitalization 1/1/2010 23 Male 117 lb 3/28/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Mucosal Inflammation Death 1 Female 4/10/2012 Other Health Professional Turkey
Primary
Secondary
Concomitant
Hypertension Death 8 Female 4/10/2012 Other Health Professional Turkey
Primary
Secondary
Concomitant
Renal Failure Required Intervention 4/13/2012 Other Health Professional United States
Primary
Secondary
Ascites Hospitalization 5/1/2012 2 Male 35 lb 5/1/2012 United States
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 5/1/2012 2 Male 35 lb 5/4/2012 Physician United States
Primary
Secondary
Concomitant
Diarrhoea 5/8/2012 2 Male 20 lb 5/11/2012 United States
Primary
Secondary

Drug Data