Carbamazepine combined with Zonisamide

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Somnolence Hospitalization 1/1/1996 10 Female 6/28/2006 Japan
Primary
Secondary
Weight Decreased Required Intervention 15 Female 9/22/2006 Physician Japan
Primary
Concomitant
Weight Decreased Required Intervention 2/27/2006 15 Female 9/28/2006 Physician Japan
Primary
Concomitant
Drug Toxicity Hospitalization 9/12/2006 Male 10/30/2006 Other Health Professional United States
Primary
Interacting
Renal Tubular Acidosis Hospitalization 35 Female 10/23/2006 Physician United States
Primary
Concomitant
Hepatic Steatosis Hospitalization 9/12/2006 Male 11/16/2006 Other Health Professional United States
Primary
Interacting
Attention Deficit/hyperactivity Disorder Required Intervention 11/1/2006 9 Male 12/4/2006 Physician Japan
Primary
Concomitant
Renal Tubular Acidosis Hospitalization 35 Female 1/3/2007 Other Health Professional United States
Primary
Concomitant
Treatment Noncompliance Hospitalization 8/8/2006 Male 8/15/2006 Pharmacist United States
Primary
Concomitant
Torticollis Hospitalization 24 Male 10/13/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Torticollis Other Serious 24 Male 11/1/2007 Japan
Primary
Secondary
Drug Rash With Eosinophilia And Systemic Symptoms Other Serious 57 Female 10/30/2007 Physician Japan
Primary
Secondary
Rash Hospitalization 10/26/2007 40 Male 11/8/2007 Physician Japan
Primary
Concomitant
Somnolence Hospitalization 24 Male 11/19/2007
Primary
Secondary
Concomitant
Torticollis Hospitalization 24 Male 11/15/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms Life Threatening 57 Female 11/16/2007 Physician Japan
Primary
Secondary
Vomiting Hospitalization 10/25/2007 40 Male 11/16/2007 Physician Japan
Primary
Secondary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms 57 Female 11/21/2007 Physician Japan
Primary
Secondary
Vomiting Hospitalization 10/25/2007 40 Male 11/28/2007 Physician Japan
Primary
Secondary
Concomitant
Intestinal Malrotation Hospitalization 8/21/2007 Female 12/16/2007 Physician Japan
Primary
Concomitant
Neuroleptic Malignant Syndrome Hospitalization 1/1/2007 24 Male 1/16/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Premature Baby Hospitalization 9/22/2006 Female 2/4/2008 Consumer United States
Primary
Secondary
Concomitant
Somnolence Hospitalization 24 Male 1/18/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Drug Effect Decreased Hospitalization 8/17/2007 41 NotSpecified 172 lb 2/4/2008 Physician China
Primary
Secondary
Concomitant
Depression Hospitalization 8/17/2007 41 Male 172 lb 1/31/2008 Physician China
Primary
Secondary
Concomitant
Status Epilepticus Life Threatening 11/2/2006 0 Male 15 lb 3/11/2008 Physician Japan
Primary
Concomitant
Respiratory Failure Life Threatening 11/2/2006 0 Male 15 lb 3/18/2008 Physician Japan
Primary
Concomitant
Premature Baby Hospitalization 9/22/2006 Female 1 lb 4/29/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Premature Baby Hospitalization 9/22/2006 Female 1 lb 5/12/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Ventricular Septal Defect Hospitalization 9/22/2006 Female 1 lb 5/14/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Ventricular Septal Defect Hospitalization 9/22/2006 Female 1 lb 5/16/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 6/3/2007 17 Male 5/22/2008 Consumer Japan
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 6/3/2007 17 Male 5/27/2008 Physician Japan
Primary
Secondary
Concomitant
Ventricular Septal Defect Hospitalization 9/22/2006 Female 1 lb 5/28/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Ventricular Septal Defect Hospitalization 9/22/2006 Female 1 lb 5/29/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Postictal State Other Serious 4/24/2008 Male 299 lb 5/30/2008 Consumer United States
Primary
Concomitant
Rash Hospitalization 5/14/2008 6 Male 6/26/2008 Other Health Professional Japan
Primary
Secondary
Stevens-johnson Syndrome Hospitalization 5/15/2008 Male 48 lb 7/3/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Protein Total Increased Hospitalization 16 Female 7/1/2008 Other Health Professional Japan
Primary
Concomitant
Scleroderma Other Serious 8/1/2003 68 Female 6/25/2008 Physician Japan
Primary
Secondary
Ventricular Septal Defect Hospitalization 9/22/2006 Female 1 lb 7/15/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Protein Total Decreased Hospitalization 16 Female 7/1/2008 Japan
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Hospitalization 5/15/2008 Male 48 lb 7/22/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Hospitalization 5/14/2008 Male 48 lb 8/12/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Stillbirth Other Serious 8/13/2008 Other Health Professional United Kingdom
Primary
Secondary
Stillbirth Other Serious Female 8/15/2008 Other Health Professional United Kingdom
Primary
Secondary
Stillbirth Other Serious 8/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Premature Baby Hospitalization 8/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Drug Interaction Hospitalization 8/7/2008 25 Female 8/26/2008 Other Health Professional United Kingdom
Primary
Interacting
Convulsion Hospitalization 8/7/2008 25 Female 8/28/2008 Other Health Professional United Kingdom
Primary
Secondary
Respiratory Rate Increased Other Serious 13 Male 10/20/2008 Austria
Primary
Concomitant
Pharyngitis Hospitalization 68 Female 10/30/2008 Japan
Primary
Secondary
Upper Respiratory Tract Inflammation Life Threatening 11/2/2006 0 Male 15 lb 11/13/2008 Physician Japan
Primary
Secondary
Concomitant
Pharyngitis Other Serious 8/1/2003 69 Female 12/12/2008 Other Health Professional Japan
Primary
Secondary
Upper Respiratory Tract Inflammation Life Threatening 11/2/2008 0 Male 18 lb 1/5/2009 Physician Japan
Primary
Concomitant
Ventricular Septal Defect Hospitalization 9/22/2006 Female 1 lb 1/27/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Upper Respiratory Tract Inflammation Life Threatening 11/2/2006 0 Male 18 lb 1/22/2009 Physician Japan
Primary
Concomitant
Intra-uterine Death Other Serious 3/1/2008 40 Female 3/10/2009 Other Health Professional Netherlands
Primary
Secondary
Toxic Epidermal Necrolysis Life Threatening 17 Male 3/13/2009 Germany
Primary
Concomitant
Stevens-johnson Syndrome Life Threatening 52 Female 3/13/2009 Germany
Primary
Secondary
Ventricular Septal Defect Hospitalization 9/22/2006 Female 1 lb 3/24/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Hypercapnia Death 8/17/2008 Male 115 lb 3/25/2009 Physician Japan
Primary
Secondary
Concomitant
Status Epilepticus Other Serious 30 Male 4/21/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Speech Disorder Other Serious 12/29/2006 31 Female 4/29/2009 Physician Japan
Primary
Secondary
Speech Disorder Other Serious 12/29/2006 31 Female 5/6/2009 Physician Japan
Primary
Secondary
Neuralgia Disability 4/8/2009 Female 4/30/2009 Germany
Primary
Concomitant
Postictal State Other Serious 1/1/2005 Male 299 lb 5/21/2009 Consumer United States
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 4 6/8/2009 Physician Japan
Primary
Secondary
Vitamin B12 Deficiency Other Serious 7/1/2007 39 Male 6/10/2009 Other Health Professional Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 10/17/2008 4 6/23/2009 Physician Japan
Primary
Secondary
Concomitant
Vitamin B12 Deficiency Other Serious 7/1/2007 39 Male 181 lb 6/25/2009 Other Health Professional Japan
Primary
Concomitant
Platelet Transfusion Life Threatening 11/20/2006 13 Male 60 lb 7/2/2009 Physician Japan
Primary
Secondary
Concomitant
Paraesthesia Other Serious 1/1/2009 44 Male 137 lb 7/27/2009 Other Health Professional United Kingdom
Primary
Secondary
Paraesthesia Other Serious 6/2/2009 44 Male 137 lb 8/12/2009 Other Health Professional United Kingdom
Primary
Secondary
Pulmonary Haemorrhage Life Threatening 11/20/2006 13 Male 60 lb 10/30/2009 Physician Japan
Primary
Secondary
Concomitant
Status Epilepticus Other Serious Female 12/16/2009 Other Health Professional Japan
Primary
Concomitant
Stillbirth Death 12/17/2009 United Kingdom
Primary
Secondary
Lethargy Other Serious 12/16/2009 27 Female 119 lb 3/4/2010 Other Health Professional United Kingdom
Primary
Secondary
Pulmonary Haemorrhage Life Threatening 11/20/2006 13 Male 60 lb 3/5/2010 Physician Japan
Primary
Secondary
Concomitant
Peritonitis Sclerosing Other Serious 14 Female 3/23/2010 United States
Primary
Secondary
White Blood Cell Count Increased Hospitalization 14 Female 3/23/2010 Physician United States
Primary
Secondary
Vomiting Hospitalization 14 Female 3/30/2010 Other Health Professional United States
Primary
Secondary
Vomiting Other Serious 14 Female 4/6/2010 Other Health Professional United States
Primary
Secondary
Peritonitis Sclerosing Hospitalization 14 Female 4/6/2010 Physician United States
Primary
Secondary
Peritonitis Sclerosing Hospitalization 14 Female 4/6/2010 Physician United States
Primary
Secondary
Peritonitis Sclerosing Hospitalization 14 Female 4/6/2010 Physician United States
Primary
Secondary
Toxic Epidermal Necrolysis Hospitalization 6/1/2007 17 Male 4/6/2010 Japan
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 14 Female 4/12/2010 France
Primary
Secondary
Concomitant
Vomiting Hospitalization 14 Female 4/9/2010 Physician United States
Primary
Secondary
Intra-uterine Death Other Serious 3/1/2008 35 Female 4/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Maternal Drugs Affecting Foetus Death 35 4/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Toxic Epidermal Necrolysis Hospitalization 17 Male 4/29/2010 Other Health Professional Japan
Primary
Secondary
Visual Impairment Other Serious 1/1/2009 35 Male 4/27/2010 Austria
Primary
Concomitant
Rash Other Serious 11/1/2006 33 Male 5/5/2010 Other Health Professional Japan
Primary
Concomitant
Rash Other Serious 11/1/2006 33 Male 5/12/2010 Other Health Professional Japan
Primary
Concomitant
Rash Hospitalization 33 Male 5/10/2010 Physician Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 17 Male 5/11/2010 Japan
Primary
Secondary
Concomitant
Psychotic Disorder Other Serious 1/1/2005 46 Male 299 lb 6/23/2010 Consumer United States
Primary
Concomitant
Psychotic Disorder Other Serious 1/1/2008 49 Male 299 lb 7/2/2010 Consumer United States
Primary
Concomitant
Infantile Spasms Other Serious Female 8/23/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Infantile Spasms Other Serious Female 8/31/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Hyperammonaemic Encephalopathy Other Serious 5 Male 9/9/2010
Primary
Secondary
Peritonitis Sclerosing Other Serious 14 Female 9/28/2010 Other Health Professional United States
Primary
Secondary
Respiratory Disorder Other Serious 14 Male 10/1/2010 Other Health Professional Japan
Primary
Secondary
Walking Aid User Hospitalization 47 Male 11/3/2010 Consumer Korea, Republic Of
Primary
Secondary
Concomitant
Walking Aid User Hospitalization 47 Male 11/8/2010 Consumer Korea, Republic Of
Primary
Secondary
Concomitant
Intestinal Malrotation Hospitalization 8/21/2007 28 Female 82 lb 11/24/2010 Physician Japan
Primary
Concomitant
Convulsion Other Serious 12/28/2010 36 Female 1/5/2011 Consumer United States
Primary
Concomitant
Sudden Death Death 12/29/2010 15 Male 64 lb 1/14/2011 Physician India
Primary
Concomitant
Sudden Death Death 12/29/2010 15 Male 64 lb 1/19/2011 India
Primary
Concomitant
Status Epilepticus Death 12/28/2010 15 Male 64 lb 1/21/2011 Physician India
Primary
Concomitant
Status Epilepticus Death 12/28/2010 15 Male 64 lb 1/21/2011 Physician India
Primary
Concomitant
Hepatic Function Abnormal Other Serious 11/1/2006 33 Male 1/28/2011 Physician Japan
Primary
Concomitant
Speech Disorder Other Serious 21 Female 2/2/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 21 Female 2/4/2011 United Kingdom
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 17 Male 2/24/2011 Other Health Professional Japan
Primary
Secondary
Drug Rash With Eosinophilia And Systemic Symptoms Hospitalization 17 Male 3/7/2011 Other Health Professional Japan
Primary
Concomitant
Status Epilepticus Death 12/28/2010 15 Male 64 lb 3/21/2011 Physician India
Primary
Concomitant
Balance Disorder Other Serious 37 Female 3/21/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Status Epilepticus Death 12/28/2010 15 Male 64 lb 4/7/2011 India
Primary
Concomitant
Diplopia Other Serious 37 Female 3/28/2011 United Kingdom
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 27 Female 5/4/2011 Other Health Professional United Kingdom
Primary
Secondary
Brain Herniation Other Serious 27 Female 4/20/2011 Other Health Professional United Kingdom
Primary
Secondary
Encephalocele Other Serious 27 Female 4/28/2011 Other Health Professional United Kingdom
Primary
Secondary
Drug Ineffective Other Serious 27 Female 4/27/2011 Other Health Professional United Kingdom
Primary
Secondary
Encephalocele Other Serious 27 Female 5/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 27 Female 5/11/2011 Other Health Professional United Kingdom
Primary
Concomitant
Drug Ineffective 27 Female 5/3/2011 Other Health Professional United Kingdom
Primary
Secondary
Ovarian Granulosa-theca Cell Tumour Hospitalization 14 Female 5/13/2011 Other Health Professional United States
Primary
Concomitant
Respiratory Disorder Hospitalization 17 Male 5/18/2011 Other Health Professional Japan
Primary
Concomitant
Rash Other Serious 1/1/2007 33 Male 5/24/2011 Other Health Professional Japan
Primary
Concomitant
Drug Rash With Eosinophilia And Systemic Symptoms Hospitalization 17 Male 6/8/2011 Japan
Primary
Concomitant
Hypotension Other Serious 1/1/1988 26 Female 6/21/2011 Other Health Professional United States
Primary
Secondary
Drug Ineffective Other Serious 21 Male 6/27/2011 Other Health Professional United States
Primary
Secondary
Drug Ineffective 21 Male 6/29/2011 Other Health Professional United States
Primary
Secondary
Toxic Epidermal Necrolysis Hospitalization 17 Male 3/7/2011 Other Health Professional Japan
Primary
Concomitant
Respiratory Distress Hospitalization 14 Female 7/8/2011 Other Health Professional United States
Primary
Secondary
Abdominal Pain Hospitalization 4/7/2008 48 Male 7/26/2011 Other Health Professional Korea, Republic Of
Primary
Concomitant
Malaise Other Serious 5/1/2011 44 Male 8/1/2011 Consumer United Kingdom
Primary
Concomitant
Headache Other Serious 5/1/2011 45 Male 8/2/2011 Other Health Professional United Kingdom
Primary
Concomitant
Grand Mal Convulsion Hospitalization 12 Male 8/8/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Anencephaly Other Serious Female 8/10/2011 Other Health Professional Japan
Primary
Concomitant
Fatigue Hospitalization 12 Male 8/12/2011 Physician United States
Primary
Secondary
Concomitant
Convulsion Other Serious 67 Male 8/15/2011 Other Health Professional Japan
Primary
Concomitant
Rib Fracture Other Serious 5/1/2011 45 Male 8/22/2011 Other Health Professional United Kingdom
Primary
Concomitant
Convulsion Other Serious 67 Male 8/24/2011 Other Health Professional Japan
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 8/1/2011 Male 8/29/2011 Physician United States
Primary
Concomitant
Hypotension Hospitalization 8/19/2011 45 Male 8/26/2011 United States
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 7/15/2011 85 Male 9/23/2011 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/14/2011 36 Female 229 lb 9/23/2011 Consumer United States
Primary
Secondary
Concomitant

Drug Data