Capecitabine combined with Tykerb

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting 4/12/2007 47 Female 7/6/2007 Consumer United States
Primary
Concomitant
Diarrhoea 4/10/2007 56 Female 7/6/2007 Consumer United States
Primary
Concomitant
Rash 4/16/2007 78 Female 7/6/2007 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 6/1/2007 72 Female 8/20/2007 Physician France
Primary
Secondary
Skin Inflammation Other Serious 8/29/2007 46 Female 173 lb 9/6/2007 Consumer United States
Primary
Concomitant
Transaminases Increased Hospitalization 9/19/2007 51 Female 150 lb 10/10/2007 Physician France
Primary
Secondary
Dyspepsia 53 Female 10/11/2007 Consumer United States
Primary
Concomitant
Blister Female 10/11/2007 Consumer United States
Primary
Concomitant
Somnolence 8/10/2007 36 Female 10/11/2007 Consumer United States
Primary
Concomitant
Paronychia Other Serious 56 Female 132 lb 11/5/2007 Physician France
Primary
Secondary
Transaminases Increased Hospitalization 9/19/2007 51 Female 150 lb 11/27/2007 Physician France
Primary
Secondary
Pancytopenia Hospitalization 8/1/2007 40 Female 231 lb 11/27/2007 Physician France
Primary
Secondary
Concomitant
Nausea Disability 9/1/2007 89 Female 99 lb 11/29/2007 Physician France
Primary
Concomitant
Paronychia Other Serious 56 Female 132 lb 11/30/2007 Physician France
Primary
Secondary
Thrombocytopenia Hospitalization 40 Female 3/14/2008 Physician France
Primary
Secondary
Concomitant
Pain Hospitalization 62 Female 154 lb 3/14/2008 Physician France
Primary
Secondary
Death Death 3/1/2008 50 Female 96 lb 3/25/2008 Consumer United States
Primary
Concomitant
Jaundice Hospitalization 40 Female 3/31/2008 Physician France
Primary
Secondary
Concomitant
Ejection Fraction Decreased Other Serious 10/10/2007 39 Female 4/8/2008 Pharmacist France
Primary
Concomitant
Jaundice Hospitalization 40 Female 4/8/2008 Physician France
Primary
Secondary
Concomitant
Breast Cancer Death 3/1/2008 Female 96 lb 5/1/2008 Physician United States
Primary
Concomitant
Death Death Female 217 lb 6/2/2008 Consumer United States
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 5/27/2008 Female 250 lb 6/6/2008 Consumer United States
Primary
Concomitant
Transaminases Increased Hospitalization 9/19/2007 51 Female 150 lb 7/1/2008 Physician France
Primary
Secondary
Diarrhoea Life Threatening 1/1/2007 7/3/2008 Consumer United States
Primary
Concomitant
Death Death 5/23/2008 Female 152 lb 7/10/2008 Consumer United States
Primary
Concomitant
Ejection Fraction Decreased Other Serious 6/7/2008 Female 123 lb 7/23/2008 Physician United States
Primary
Concomitant
Ejection Fraction Decreased Other Serious 6/7/2008 Female 123 lb 7/29/2008 Physician United States
Primary
Concomitant
Disease Progression Death Female 136 lb 7/29/2008 Physician United States
Primary
Concomitant
Vomiting Hospitalization 7/1/2008 57 Female 8/6/2008 Pharmacist Brazil
Primary
Concomitant
Disease Progression Other Serious 7/25/2008 Female 159 lb 8/14/2008 Consumer United States
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 7/23/2008 Female 138 lb 8/28/2008 Physician United States
Primary
Concomitant
Vomiting Hospitalization 7/1/2008 57 Female 159 lb 9/2/2008 Pharmacist Brazil
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 7/23/2008 Female 138 lb 9/30/2008 Physician United States
Primary
Concomitant
Rectal Abscess Hospitalization 9/12/2008 Female 217 lb 10/7/2008 Consumer United States
Primary
Concomitant
Ischaemic Stroke Other Serious 8/22/2008 Female 145 lb 10/14/2008 Physician United States
Primary
Concomitant
Rash Pustular Hospitalization 9/1/2008 Female 191 lb 11/17/2008 Physician United States
Primary
Secondary
Skin Exfoliation Other Serious 1/1/2008 Female 191 lb 11/20/2008 Physician United States
Primary
Secondary
Vision Blurred Other Serious 9/13/2008 35 Female 12/4/2008 Physician Argentina
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 7/23/2008 Female 138 lb 12/16/2008 Physician United States
Primary
Concomitant
Skin Toxicity Other Serious Female 2/3/2009 Other Health Professional Australia
Primary
Secondary
Skin Toxicity Other Serious Female 2/5/2009 Other Health Professional Australia
Primary
Secondary
Mucosal Inflammation Other Serious Female 2/10/2009 Consumer United States
Primary
Secondary
Convulsion Other Serious Female 4/2/2009 Physician Australia
Primary
Concomitant
Respiratory Failure Hospitalization 59 Female 123 lb 4/7/2009 Physician India
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 12/8/2008 Female 232 lb 4/10/2009 Consumer United States
Primary
Secondary
Concomitant
Hydrocephalus Other Serious 3/5/2009 36 Female 5/4/2009 Physician Argentina
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Other Serious Female 126 lb 5/6/2009 Consumer United States
Primary
Concomitant
Somnolence Other Serious 3/20/2009 Female 5/22/2009 Physician Australia
Primary
Concomitant
Fatigue Other Serious 6/7/2008 Female 123 lb 6/2/2009 Physician United States
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 2/1/2009 Female 126 lb 6/9/2009 Other Health Professional United States
Primary
Secondary
Localised Infection Other Serious Female 140 lb 6/11/2009 Consumer United States
Primary
Concomitant
Hyperkalaemia Other Serious 6/22/2009 Female 128 lb 6/29/2009 Pharmacist Japan
Primary
Secondary
Concomitant
Hyperkalaemia Other Serious 6/22/2009 Female 128 lb 6/30/2009 Pharmacist Japan
Primary
Secondary
Concomitant
Therapeutic Response Unexpected Death 11/1/2008 44 Female 7/2/2009 Physician Brazil
Primary
Concomitant
Urinary Tract Disorder Other Serious 1/1/2008 64 Female 7/9/2009 Physician Brazil
Primary
Secondary
Hyperkalaemia Other Serious 6/22/2009 Female 128 lb 7/13/2009 Pharmacist Japan
Primary
Secondary
Concomitant
Drug Ineffective Other Serious Female 7/23/2009 Consumer United States
Primary
Secondary
Concomitant
Mucosal Inflammation Death 43 Female 7/24/2009 Physician Brazil
Primary
Concomitant
Somnolence Other Serious 29 Female 7/29/2009 Physician Brazil
Primary
Secondary
Concomitant
Pain Other Serious 46 Female 7/30/2009 Physician Brazil
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Death 33 Female 8/4/2009 Physician Brazil
Primary
Secondary
Malignant Neoplasm Progression Other Serious 8/7/2009 Other Health Professional United States
Primary
Secondary
Interstitial Lung Disease Other Serious 7/31/2009 72 Female 8/10/2009 Physician Japan
Primary
Concomitant
Hepatic Neoplasm Other Serious 8/13/2009 Consumer United States
Primary
Secondary
Breast Cancer Metastatic Life Threatening 7/28/2009 Female 168 lb 8/19/2009 Physician Canada
Primary
Concomitant
Neuropathy Peripheral Other Serious Female 140 lb 8/24/2009 Consumer United States
Primary
Concomitant
Interstitial Lung Disease Other Serious 7/31/2009 Female 8/27/2009 Physician Japan
Primary
Concomitant
Renal Failure Other Serious 8/3/2009 Female 149 lb 9/2/2009 Physician Canada
Primary
Secondary
Metastases To Central Nervous System Other Serious 7/1/2009 45 Female 9/2/2009 Physician Turkey
Primary
Secondary
Metastases To Central Nervous System Hospitalization 7/1/2009 Female 132 lb 9/4/2009 Physician Turkey
Primary
Concomitant
Neurological Symptom Death 10/1/2008 43 Female 9/8/2009 Physician Brazil
Primary
Secondary
Urticaria Other Serious 43 Female 9/8/2009 Physician Indonesia
Primary
Concomitant
Pain Other Serious 46 Female 9/9/2009 Physician Brazil
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/20/2009 Female 137 lb 9/9/2009 Physician Japan
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Death 33 Female 9/10/2009 Physician Brazil
Primary
Secondary
Interstitial Lung Disease Other Serious 7/31/2009 Female 322 lb 9/10/2009 Physician Japan
Primary
Concomitant
Skin Reaction Other Serious 45 Female 9/11/2009 Physician India
Primary
Concomitant
Somnolence Other Serious 29 Female 9/16/2009 Physician Brazil
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 60 Female 9/17/2009 Physician Brazil
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 7/30/2009 Female 322 lb 9/21/2009 Physician Japan
Primary
Concomitant
Vomiting Other Serious 60 Female 9/24/2009 Physician Brazil
Primary
Secondary
Interstitial Lung Disease Death 34 Female 9/24/2009 Physician Brazil
Primary
Secondary
Urticaria Death 38 Female 9/24/2009 Physician Brazil
Primary
Secondary
Paronychia Death 1/1/2008 38 Female 9/28/2009 Physician Brazil
Primary
Secondary
Neutropenia Death 54 Female 9/28/2009 Physician Brazil
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 31 Female 9/29/2009 Physician Brazil
Primary
Secondary
Diarrhoea Life Threatening 9/2/2009 Female 71 lb 10/1/2009 Physician Japan
Primary
Secondary
Concomitant
Diarrhoea Life Threatening 9/2/2009 Female 71 lb 10/5/2009 Physician Japan
Primary
Secondary
Concomitant
Xeroderma Other Serious 49 Female 10/6/2009 Physician Brazil
Primary
Secondary
Transaminases Other Serious 7/27/2009 44 Female 10/6/2009 Physician Brazil
Primary
Secondary
Vomiting Other Serious 50 Female 10/9/2009 Physician Brazil
Primary
Secondary
Weight Decreased Hospitalization 1/1/2008 32 Female 10/9/2009 Physician Brazil
Primary
Secondary
Concomitant
Vomiting 7/11/2009 77 Female 9/24/2009 Consumer United States
Primary
Secondary
Vomiting Hospitalization 60 Female 9/24/2009 Pharmacist United States
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Death 40 Female 10/15/2009 Physician Mexico
Primary
Secondary
Vomiting Death 59 Female 10/16/2009 Physician Mexico
Primary
Secondary
Proctalgia Death 80 Female 10/16/2009 Physician Mexico
Primary
Secondary
Death Hospitalization 11/1/2008 Female 10/19/2009 Physician Brazil
Primary
Secondary
Metastases To Central Nervous System Hospitalization 7/1/2009 Female 132 lb 10/19/2009 Physician Turkey
Primary
Concomitant
Liver Injury Hospitalization 55 Female 10/20/2009 Physician Brazil
Primary
Secondary
Weight Decreased Hospitalization Female 109 lb 10/22/2009 Physician United States
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 55 Female 10/22/2009 Physician Mexico
Primary
Secondary
Pleural Effusion Other Serious 60 Female 10/23/2009 Physician Brazil
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 31 Female 11/2/2009 Physician Brazil
Primary
Secondary
Xeroderma Other Serious 49 Female 11/2/2009 Physician Brazil
Primary
Secondary
Vomiting Other Serious 50 Female 11/2/2009 Physician Brazil
Primary
Secondary
Weight Decreased Other Serious 45 Female 11/4/2009 Physician Brazil
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 3/1/2008 53 Female 11/4/2009 Physician Brazil
Primary
Secondary
Skin Laceration Other Serious 64 Female 11/4/2009 Physician Brazil
Primary
Secondary
Interstitial Lung Disease Hospitalization 7/30/2009 Female 322 lb 11/4/2009 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Death 1/1/2008 38 Female 11/5/2009 Physician Brazil
Primary
Secondary
Death Hospitalization 11/1/2008 Female 11/6/2009 Physician Brazil
Primary
Secondary
Dry Mouth Life Threatening 11/27/2008 Female 11/6/2009 Physician Venezuela
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 6/28/2009 Female 11/6/2009 Physician Venezuela
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 4/22/2008 Female 11/6/2009 Physician Venezuela
Primary
Secondary
Metastatic Neoplasm Other Serious 60 Female 11/6/2009 Physician Brazil
Primary
Secondary
Metastatic Neoplasm Other Serious 11/1/2008 65 Female 11/6/2009 Physician Brazil
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2008 32 Female 11/9/2009 Physician Brazil
Primary
Secondary
Concomitant
Disease Progression Other Serious 3/1/2009 44 Female 11/9/2009 Physician Brazil
Primary
Secondary
Skin Exfoliation Other Serious 5/22/2008 41 Female 11/9/2009 Other Health Professional Colombia
Primary
Secondary
Vomiting Other Serious 3/1/2008 35 Female 11/11/2009 Physician Argentina
Primary
Concomitant
Metastases To Liver Other Serious 35 Female 11/11/2009 Physician Malaysia
Primary
Concomitant
Swelling Life Threatening 11/28/2008 63 Female 11/12/2009 Consumer United States
Primary
Secondary
Concomitant
Hepatic Function Abnormal Life Threatening 8/27/2009 Female 99 lb 11/17/2009 Physician Japan
Primary
Secondary
Vomiting Other Serious 11/28/2008 Female 12/1/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Urticaria Life Threatening 12/4/2008 63 Female 12/2/2009 Consumer United States
Primary
Secondary
Concomitant
Pancreatic Mass Hospitalization 11/19/2009 36 Female 12/9/2009 Physician Argentina
Primary
Secondary
Paronychia Disability 10/15/2009 Female 130 lb 12/14/2009 Pharmacist Japan
Primary
Secondary
Skin Disorder Other Serious Female 140 lb 12/21/2009 Consumer United States
Primary
Concomitant
Fall Hospitalization 6/1/2009 Female 118 lb 12/23/2009 Physician Ecuador
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 8/25/2009 40 Female 12/23/2009 Consumer United States
Primary
Concomitant
Malignant Neoplasm Progression Other Serious Female 194 lb 12/30/2009 Consumer United States
Primary
Concomitant
Skin Exfoliation Other Serious Female 140 lb 1/14/2010 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 12/3/2009 Female 150 lb 1/22/2010 Consumer United States
Primary
Secondary
Pyrexia Hospitalization 59 Female 2/11/2010 Physician Japan
Primary
Secondary
Ureteric Obstruction Hospitalization Female 145 lb 2/12/2010 Consumer United States
Primary
Secondary
Swelling Hospitalization 10/3/2009 Female 152 lb 2/24/2010 Physician Japan
Primary
Secondary
Concomitant
Swelling Hospitalization 10/1/2009 Female 152 lb 3/12/2010 Physician Japan
Primary
Secondary
Concomitant
Skin Lesion Other Serious Female 3/17/2010 Physician Argentina
Primary
Concomitant
Palpitations Hospitalization Female 3/19/2010 Consumer United States
Primary
Secondary
Jaundice Other Serious 3/23/2010 Physician Japan
Primary
Concomitant
Rash Other Serious Female 4/8/2010 Physician Japan
Primary
Secondary
Pericardial Effusion Other Serious Female 4/8/2010 Physician Japan
Primary
Secondary
General Physical Health Deterioration Other Serious Female 4/8/2010 Physician Japan
Primary
Secondary
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 4/8/2010 Physician Japan
Primary
Secondary
Visual Impairment 78 Female 4/9/2010 Consumer United States
Primary
Concomitant
Malignant Neoplasm Progression Other Serious Female 134 lb 4/26/2010 Consumer United States
Primary
Concomitant
Swelling Hospitalization 10/1/2009 62 Female 152 lb 4/27/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 2/1/2010 80 Female 140 lb 5/7/2010 Physician United States
Primary
Secondary
Concomitant

Drug Data