Campath combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
White Blood Cell Count Decreased Other Serious 20 Male 4/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Granulocytopenia Required Intervention 59 Male 5/11/2006 Other Health Professional United States
Primary
Concomitant
Weight Increased Hospitalization 56 Female 12/9/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Tremor Other Serious 58 Male 6/11/2007 Physician Japan
Primary
Concomitant
Reticulocyte Count Decreased Other Serious 54 Male 10/25/2007 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 2/5/2007 46 Female 10/27/2007 Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 2/5/2007 46 Female 10/27/2007 Japan
Primary
Secondary
Concomitant
Systemic Candida Other Serious 26 Male 11/8/2007 Other Health Professional Germany
Primary
Secondary
Reticulocyte Count Decreased Hospitalization 2/16/2004 54 Male 11/21/2007 Physician Japan
Primary
Secondary
Concomitant
Reticulocyte Count Decreased Hospitalization 2/16/2004 54 Male 12/18/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Systemic Candida Hospitalization 26 Male 12/19/2007 Germany
Primary
Secondary
Hypertension Other Serious 12/12/2007 1 Female 12/27/2007 United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 12/24/2007 39 Male 176 lb 1/7/2008 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 1/17/2008 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/10/2008 20 Male 234 lb 1/25/2008 Physician United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 1/25/2008 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/10/2008 20 Male 234 lb 1/30/2008 Physician United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 2/12/2008 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 2/14/2008 Physician United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 2/22/2008 Other Health Professional United States
Primary
Secondary
Renal Disorder Other Serious 2/29/2008 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 4/1/2008 28 Male 123 lb 5/6/2008 Physician United States
Primary
Secondary
Concomitant
Intestinal Haemorrhage Hospitalization 3/14/2008 5/6/2008 Physician Italy
Primary
Secondary
Mesenteric Vein Thrombosis Other Serious 4/10/2008 5/16/2008 Physician Italy
Primary
Secondary
Concomitant
Viral Haemorrhagic Cystitis Other Serious 4/25/2007 Physician United States
Primary
Secondary
Concomitant
Neutropenic Sepsis Other Serious 4/16/2008 52 Male 157 lb 5/21/2008 Physician Malaysia
Primary
Concomitant
Hypertension Other Serious 12/12/2007 1 Male 5/29/2008 United States
Primary
Concomitant
Stomatitis Hospitalization 6/3/2008 27 Male 88 lb 6/12/2008 Physician United States
Primary
Secondary
Hypertension Other Serious 12/12/2007 1 Male 6/23/2008 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 6/25/2008 Physician United States
Primary
Secondary
Concomitant
Stomatitis Hospitalization 6/3/2008 27 Male 88 lb 6/30/2008 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/1/2008 28 Male 123 lb 7/18/2008 Physician United States
Primary
Secondary
Concomitant
Musculoskeletal Disorder Hospitalization 6/16/2008 7/28/2008 Physician Italy
Primary
Secondary
Musculoskeletal Disorder Hospitalization 6/16/2008 8/4/2008 Physician Italy
Primary
Secondary
Peripheral Sensory Neuropathy Hospitalization 6/1/2008 61 Female 8/8/2008 Physician Italy
Primary
Secondary
Cytomegalovirus Colitis Other Serious 42 Male 9/2/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Peripheral Sensory Neuropathy Hospitalization 6/16/2008 61 Female 9/8/2008 Physician Italy
Primary
Secondary
Renal Failure Other Serious 12 Male 9/27/2008 Physician United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 29 Female 9/27/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 8 Male 9/26/2008 United States
Primary
Secondary
Concomitant
Staphylococcal Bacteraemia Other Serious 10 Male 9/26/2008 United States
Primary
Secondary
Concomitant
Viral Diarrhoea Other Serious 29 Female 9/26/2008 United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 12 Male 9/26/2008 United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Life Threatening 10/6/2008 55 Male 10/24/2008 Physician Italy
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Life Threatening 10/6/2008 55 Male 11/3/2008 Physician Italy
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Life Threatening 10/6/2008 55 Male 12/8/2008 Physician Italy
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 12/10/2008 Physician United States
Primary
Secondary
Concomitant
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/16/2008 Physician Spain
Primary
Secondary
Concomitant
Sinusitis Hospitalization 1/1/2007 60 Male 143 lb 12/19/2008 Physician Spain
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 3/26/2009 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/1/2008 75 Female 4/3/2009 Physician Italy
Primary
Secondary
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 4/6/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/3/2007 49 Female 207 lb 4/16/2009 Physician United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 4/16/2009 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 4/16/2009 Physician United States
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 1/1/2008 20 Male 240 lb 4/16/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/1/2008 27 Male 123 lb 4/17/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/1/2008 27 Male 123 lb 4/21/2009 Physician United States
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 1/18/2008 39 Male 176 lb 5/1/2009 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/24/2007 39 Male 176 lb 5/4/2009 Physician United States
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 50 Male 5/12/2009 Other Health Professional United States
Primary
Concomitant
Tubulointerstitial Nephritis Hospitalization 50 Male 6/18/2009 Greece
Primary
Secondary
Concomitant
Renal Impairment Other Serious 2 Female 9/2/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 2 Female 9/3/2009 Physician United Kingdom
Primary
Secondary
Sudden Death Death 59 9/28/2009 Other Health Professional United Kingdom
Primary
Secondary
Respiratory Failure Death 7 Male 9/28/2009 Other Health Professional United Kingdom
Primary
Secondary
Respiratory Failure Death 7 Male 10/1/2009 Consumer United Kingdom
Primary
Secondary
Sepsis Other Serious 10/5/2009 Consumer United Kingdom
Primary
Secondary
Renal Impairment Other Serious 1 Female 11/3/2009 Other Health Professional United Kingdom
Primary
Secondary
Respiratory Failure Death 12/8/2009 29 Female 1/13/2010 Physician Italy
Primary
Secondary
Klebsiella Sepsis Death 22 Male 3/17/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Intracranial Hypotension Hospitalization 2/23/2010 51 Male 3/17/2010 Physician Italy
Primary
Secondary
Concomitant
Klebsiella Sepsis Death 22 Male 3/19/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Intracranial Hypotension Hospitalization 2/23/2010 51 Male 3/19/2010 Physician Italy
Primary
Secondary
Concomitant
Klebsiella Sepsis Death 22 Male 3/29/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Quality Of Life Decreased Death 22 Male 3/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Klebsiella Sepsis Death 22 Male 4/6/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypertension Hospitalization 10/4/2008 67 Female 4/13/2010 Physician United States
Primary
Secondary
Wernicke's Encephalopathy Disability 5/9/2008 4/13/2010 Physician United States
Primary
Secondary
Mesenteric Vein Thrombosis Other Serious 4/10/2008 4/13/2010 Physician United States
Primary
Secondary
Concomitant
Peripheral Sensory Neuropathy Hospitalization 6/16/2008 61 Female 4/13/2010 Physician United States
Primary
Secondary
Intestinal Haemorrhage Hospitalization 3/14/2008 4/13/2010 Physician United States
Primary
Secondary
T-cell Lymphoma Hospitalization 11/30/2008 70 Male 4/13/2010 Physician United States
Primary
Secondary
Concomitant
Wernicke's Encephalopathy Disability 5/9/2008 4/20/2010 Physician United States
Primary
Secondary
Intestinal Haemorrhage Hospitalization 3/14/2008 4/20/2010 Physician United States
Primary
Secondary
T-cell Lymphoma Hospitalization 11/30/2008 70 Male 4/20/2010 Physician United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Life Threatening 10/6/2008 55 Male 4/27/2010 Physician United States
Primary
Secondary
Concomitant
T-cell Lymphoma Hospitalization 5/9/2008 4/30/2010 Physician United States
Primary
Secondary
Intracranial Hypotension Hospitalization 2/23/2010 51 Male 5/12/2010 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 5/10/2010 34 Female 6/4/2010 Physician United Kingdom
Primary
Secondary
Pyrexia Hospitalization 5/10/2010 34 Female 6/8/2010 Physician United Kingdom
Primary
Secondary
Pyrexia Hospitalization 5/10/2010 34 Female 6/15/2010 Physician Italy
Primary
Secondary
Concomitant
Zygomycosis Death 29 Female 7/9/2010 Other Health Professional Germany
Primary
Concomitant
Urinary Bladder Haemorrhage Hospitalization 4/30/2009 55 Male 8/6/2010 Physician Italy
Primary
Secondary
Concomitant
Urinary Bladder Haemorrhage Hospitalization 4/30/2009 55 Male 8/18/2010 Physician Italy
Primary
Secondary
Concomitant
Aspiration Other Serious 1 Male 9/29/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 9/20/2010 32 Female 187 lb 10/5/2010 Physician United States
Primary
Secondary
Pneumonia Life Threatening 9/20/2010 32 Female 188 lb 10/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Somnolence Hospitalization 6/16/2010 61 Male 10/21/2010 Physician Germany
Primary
Secondary
Concomitant
Pneumonia Life Threatening 9/20/2010 32 Female 188 lb 11/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 1 Male 11/3/2010 Physician United States
Primary
Secondary
Concomitant
Mucosal Inflammation Other Serious 1 Male 11/3/2010 Physician Germany
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal Other Serious 9/20/2010 32 Female 188 lb 11/9/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Erysipelas Hospitalization 9/30/2010 39 Female 103 lb 11/11/2010 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal Other Serious 9/20/2010 32 Female 188 lb 11/19/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 17 Male 11/23/2010 Physician United States
Primary
Concomitant
Venoocclusive Disease Other Serious 12/15/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Other Serious 11/29/2010 Female 181 lb 12/17/2010 Physician United States
Primary
Secondary
Weight Decreased Other Serious 17 Male 12/7/2010 Physician United States
Primary
Concomitant
Immunosuppression Other Serious 44 Male 1/25/2011 Physician Greece
Primary
Secondary
Concomitant
Epstein-barr Virus Infection Other Serious 19 Male 1/25/2011 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Other Serious 42 Male 1/27/2011 Physician Germany
Primary
Secondary
Concomitant
Adenovirus Infection Other Serious 19 Male 1/27/2011 Physician Germany
Primary
Secondary
Concomitant
Renal Impairment Other Serious 12 Female 2/25/2011 Physician United States
Primary
Secondary
Concomitant
Cytomegalovirus Infection Hospitalization 4/30/2009 55 Male 3/1/2011 Physician Germany
Primary
Secondary
Concomitant
Cerebral Haemorrhage Life Threatening 9/20/2010 32 Female 188 lb 3/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Opportunistic Infection Other Serious 10/17/2010 28 Female 249 lb 3/11/2011 Consumer United States
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 42 Female 3/23/2011 Physician Sweden
Primary
Secondary
Concomitant
Lower Respiratory Tract Infection Fungal Death 1/9/2011 28 Female 249 lb 3/31/2011 Physician United States
Primary
Secondary
Concomitant
Pneumonia Fungal Other Serious 34 Female 3/31/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Cytomegalovirus Test Positive Other Serious 42 Female 3/31/2011 Physician Sweden
Primary
Secondary
Concomitant
Death Death 4/7/2011 Physician Portugal
Primary
Concomitant
Disease Recurrence Death 4/7/2011 Physician Portugal
Primary
Concomitant
Disease Recurrence Death 4/7/2011 Physician Portugal
Primary
Concomitant
Disease Recurrence Death 4/7/2011 Physician Portugal
Primary
Concomitant
Aspartate Aminotransferase Increased Other Serious 11/29/2010 21 Female 171 lb 4/13/2011 Physician United States
Primary
Secondary
Aplasia Other Serious 34 Female 4/21/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Neutropenic Sepsis Death 34 Female 4/25/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lymphadenitis Hospitalization 1/1/2008 52 Female 152 lb 5/11/2011 Physician United States
Primary
Concomitant
Status Epilepticus Other Serious 1/1/2008 52 Female 152 lb 5/19/2011 Physician United States
Primary
Concomitant
Cytomegalovirus Infection Death Female 151 lb 6/3/2011 Physician Portugal
Primary
Concomitant
Disease Recurrence Death 6/3/2011 Physician Portugal
Primary
Concomitant
Disease Recurrence Other Serious 6/3/2011 Physician Portugal
Primary
Concomitant
Death Death 6/3/2011 Physician Portugal
Primary
Concomitant
Acute Graft Versus Host Disease Other Serious Male 119 lb 6/3/2011 Physician Portugal
Primary
Concomitant
Diarrhoea Other Serious 11/29/2010 21 Female 185 lb 6/7/2011 Physician Germany
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease Other Serious Male 6/8/2011 Physician Portugal
Primary
Concomitant
Thrombocytopenia Other Serious 1/1/1991 16 Female 6/14/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Cytomegalovirus Infection Life Threatening Female 6/15/2011 Pharmacist United Kingdom
Primary
Concomitant
Mucosal Inflammation Hospitalization 8 Female 6/21/2011 Pharmacist United Kingdom
Primary
Concomitant
Venoocclusive Disease Hospitalization 6/21/2011 Pharmacist United Kingdom
Primary
Concomitant
Multi-organ Failure Death Female 151 lb 7/27/2011 Physician Portugal
Primary
Concomitant
Chronic Graft Versus Host Disease Death Male 119 lb 7/27/2011 Physician Portugal
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Death 9/2/2011 Physician United Kingdom
Primary
Secondary
Thrombotic Thrombocytopenic Purpura Death 9/12/2011 Physician United Kingdom
Primary
Secondary
Herpes Simplex Death 42 10/14/2011 Physician Germany
Primary
Concomitant
Sepsis Other Serious 42 11/1/2011 Physician Germany
Primary
Concomitant
Liver Injury Other Serious 59 Male 3/22/2012 Other Health Professional France
Primary
Concomitant
Renal Failure Acute Hospitalization 5/31/2012 51 Female 2/22/2013 Other Health Professional Us
Primary
Secondary
Renal Failure Acute Other Serious 2012 51 Female 2/20/2013 Consumer Us
Primary
Secondary
Concomitant

Drug Data