Calcium Folinate combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vertigo Hospitalization 5/17/2006 Female 134 lb 5/25/2006 Physician Italy
Primary
Concomitant
Bladder Cancer Other Serious 6/9/2006 Female 141 lb 7/12/2006 Italy
Primary
Concomitant
Diarrhoea Hospitalization 6/2/2006 68 Male 141 lb 8/7/2006 Consumer United States
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 6/2/2006 68 Male 141 lb 9/5/2006 Consumer United States
Primary
Secondary
Concomitant
Vertigo Hospitalization 5/17/2006 Female 134 lb 9/21/2006 Physician Italy
Primary
Concomitant
Bladder Cancer Other Serious 6/9/2006 Female 141 lb 10/4/2006 Italy
Primary
Concomitant
Stem Cell Transplant Death Unknown 9/29/2006 France
Primary
Secondary
Concomitant
Neurotoxicity Other Serious Unknown 9/29/2006 France
Primary
Secondary
Concomitant
Heart Rate Decreased Hospitalization 9/1/2006 Female 217 lb 10/18/2006 Consumer United States
Primary
Secondary
Concomitant
Heart Rate Decreased Hospitalization 9/1/2006 Female 217 lb 12/13/2006 Physician United States
Primary
Secondary
Concomitant
Vertigo Hospitalization 5/17/2006 Female 134 lb 12/30/2006 Physician Italy
Primary
Concomitant
Vertigo Hospitalization 5/17/2006 Female 134 lb 3/8/2007 Physician Italy
Primary
Concomitant
Vomiting Hospitalization 9/11/2007 Male 9/26/2007 Consumer Italy
Primary
Concomitant
Pneumonia Other Serious 76 Male 11/7/2007 Other Health Professional France
Primary
Secondary
Concomitant
Pseudomonal Sepsis Hospitalization 76 Male 11/13/2007
Primary
Secondary
Concomitant
Crohn's Disease Hospitalization 3/29/2007 Female 1/31/2008 Spain
Primary
Concomitant
Crohn's Disease Hospitalization 3/29/2007 Female 2/13/2008 Spain
Primary
Concomitant
Neutropenia Hospitalization 2/6/2008 Female 2/19/2008 Pharmacist United Kingdom
Primary
Concomitant
Crohn's Disease Hospitalization 3/29/2007 Female 2/28/2008 Spain
Primary
Concomitant
Musculoskeletal Stiffness 2/1/2006 60 Female 190 lb 6/12/2008 Other Health Professional United States
Primary
Concomitant
Paraesthesia 5/1/2008 Female 225 lb 6/13/2008 United States
Primary
Concomitant
Crohn's Disease Hospitalization 3/29/2007 Female 7/11/2008 Spain
Primary
Concomitant
Crohn's Disease Hospitalization 3/29/2007 Female 7/14/2008 Spain
Primary
Concomitant
Myocardial Infarction Hospitalization 6/25/2008 Female 8/7/2008 Other Health Professional Italy
Primary
Concomitant
Rotator Cuff Syndrome Other Serious 10/1/2007 Female 8/11/2008 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 6/25/2008 Female 231 lb 9/10/2008 Other Health Professional Italy
Primary
Concomitant
Skin Reaction 7/2/2008 Female 160 lb 9/12/2008 United States
Primary
Concomitant
Urticaria 7/17/2008 Male 80 lb 9/12/2008 United States
Primary
Concomitant
Injection Site Pain 4/1/2008 Female 200 lb 9/12/2008 Other Health Professional United States
Primary
Concomitant
Skin Laceration 8/9/2008 Female 128 lb 9/12/2008 United States
Primary
Concomitant
Tendon Rupture Other Serious 1/1/2008 Female 138 lb 10/13/2008 United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 10/25/2008 Female 2/4/2009 Other Health Professional France
Primary
Concomitant
Interacting
Neurotoxicity Other Serious 15 Male 2/5/2009
Primary
Secondary
Neurotoxicity Other Serious 13 Male 2/5/2009
Primary
Secondary
Speech Disorder Other Serious 13 Male 2/3/2009 Other Health Professional Germany
Primary
Concomitant
Pyramidal Tract Syndrome Other Serious 15 Male 2/3/2009 Other Health Professional Germany
Primary
Concomitant
Pyramidal Tract Syndrome Other Serious 15 Male 2/3/2009 Other Health Professional Germany
Primary
Concomitant
Speech Disorder Other Serious 13 Male 2/3/2009 Other Health Professional Germany
Primary
Concomitant
Renal Failure Acute Hospitalization 10/24/2008 Female 2/12/2009 Other Health Professional France
Primary
Concomitant
Interacting
Renal Failure Acute Hospitalization 10/24/2008 Female 2/27/2009 Other Health Professional France
Primary
Concomitant
Interacting
Skin Laceration 6/1/2008 Female 260 lb 3/14/2009 Consumer United States
Primary
Concomitant
Injection Site Discomfort 6/1/2006 Female 193 lb 3/14/2009 United States
Primary
Concomitant
Toxic Skin Eruption Life Threatening 10/15/2008 40 Male 3/17/2009 Consumer France
Primary
Secondary
Concomitant
Leukoencephalopathy Death 1/1/2008 64 Female 3/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 53 Female 5/13/2009 Physician Turkey
Primary
Secondary
Respiratory Arrest Hospitalization 5 Male 5/18/2009 Physician Japan
Primary
Concomitant
Septic Shock Life Threatening 4/18/2009 Male 6/8/2009 Physician Germany
Primary
Secondary
Concomitant
Septic Shock Life Threatening 4/18/2009 Male 6/9/2009 Physician Germany
Primary
Secondary
Concomitant
Renal Function Test Abnormal Hospitalization 6/9/2009 Male 150 lb 8/4/2009 Pharmacist Netherlands
Primary
Concomitant
Interacting
Somnolence Other Serious 8/14/2009 68 Female 9/8/2009 Other Health Professional Germany
Primary
Secondary
Injection Site Pain 4/1/2008 Female 200 lb 9/12/2009 Other Health Professional United States
Primary
Concomitant
Skin Laceration 8/9/2008 Female 128 lb 9/12/2009 United States
Primary
Concomitant
Injection Site Extravasation 9/29/2008 Female 126 lb 9/12/2009 Consumer United States
Primary
Concomitant
Renal Failure Acute Hospitalization 6/15/2009 Male 9/18/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Chronic Hospitalization 8/24/2009 Female 9/25/2009 Physician Japan
Primary
Concomitant
Spinal Compression Fracture Hospitalization 5/25/2009 Female 82 lb 9/30/2009 Japan
Primary
Concomitant
Septic Shock Life Threatening 4/6/2009 Male 12/3/2009 Physician Germany
Primary
Secondary
Concomitant
Spinal Compression Fracture Hospitalization 5/25/2009 Female 82 lb 12/4/2009 Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/8/2009 58 Female 106 lb 12/14/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 47 Male 1/7/2010 Other Health Professional France
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 5/27/2009 64 Female 123 lb 2/11/2010 Physician Japan
Primary
Secondary
Concomitant
Anaemia Other Serious 56 2/11/2010 Consumer Japan
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 61 Male 2/11/2010 Consumer Japan
Primary
Secondary
Concomitant
Ulcer Other Serious 48 Male 2/11/2010 Consumer Japan
Primary
Secondary
Concomitant
Penis Carcinoma Recurrent Other Serious 79 Male 2/11/2010 Consumer Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/8/2009 58 Female 106 lb 3/25/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pleurisy Hospitalization 3/1/2010 57 Female 142 lb 6/3/2010 Pharmacist Japan
Primary
Concomitant
Cardiac Disorder Death 6/3/2010 Physician France
Primary
Secondary
Concomitant
Septic Shock Death 6/3/2010 Physician France
Primary
Secondary
Concomitant
Performance Status Decreased Death 6/3/2010 France
Primary
Secondary
Concomitant
Pyothorax Hospitalization 3/1/2010 57 Female 142 lb 6/21/2010 Physician Japan
Primary
Secondary
Concomitant
Pyothorax Hospitalization 3/3/2010 57 Female 142 lb 7/2/2010 Physician Japan
Primary
Secondary
Concomitant
Pyothorax Hospitalization 3/3/2010 57 Female 142 lb 7/15/2010 Physician Japan
Primary
Secondary
Concomitant
Memory Impairment Other Serious Female 101 lb 7/29/2010 Physician Japan
Primary
Concomitant
Pyothorax Hospitalization 3/3/2010 57 Female 142 lb 8/18/2010 Physician Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/20/2007 74 152 lb 8/30/2010 Physician France
Primary
Secondary
Concomitant
Vomiting Hospitalization 6/1/2010 36 Female 86 lb 9/10/2010 Consumer France
Primary
Secondary
Concomitant
Amnesia Other Serious 2/5/2010 61 Female 101 lb 9/16/2010 Physician Japan
Primary
Concomitant
Deep Vein Thrombosis Other Serious 10/12/2010 59 Male 10/26/2010 Other Health Professional Australia
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/8/2009 58 Female 106 lb 10/28/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/8/2009 58 Female 106 lb 11/2/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 10/1/2008 53 Female 11/5/2010 Other Health Professional France
Primary
Concomitant
Interacting
Weight Increased Other Serious 1/17/2010 Male 168 lb 11/22/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/29/2010 49 Male 110 lb 12/13/2010 Physician Japan
Primary
Concomitant
Injection Site Urticaria 3/12/2010 12/19/2010 Physician United States
Primary
Concomitant
Pain In Jaw 4/15/2010 12/22/2010 Consumer United States
Primary
Concomitant
Abdominal Pain 12/22/2010 Consumer United States
Primary
Concomitant
Upper Respiratory Tract Infection 1/1/2010 12/22/2010 Physician United States
Primary
Concomitant
Injection Site Erythema 8/4/2010 12/23/2010 Consumer United States
Primary
Concomitant
Injection Site Warmth 7/12/2010 12/23/2010 Consumer United States
Primary
Concomitant
Neuralgia 9/9/2010 12/23/2010 Consumer United States
Primary
Concomitant
Staphylococcal Bacteraemia Other Serious 11/28/2009 73 Male 112 lb 12/29/2010 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Infection Death 10/10/2009 72 Male 112 lb 12/30/2010 Physician Japan
Primary
Concomitant
Pyrexia Death 11/28/2009 73 Male 112 lb 1/3/2011 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 1/6/2012 12 Female 89 lb 3/19/2012 France
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Death 2/12/2012 16 Male 3/21/2012 Physician France
Primary
Secondary
Concomitant
Thrombosis Hospitalization 2/27/2011 39 Male 137 lb 3/22/2012 Physician Japan
Primary
Concomitant
Rhinitis Allergic Other Serious 11/14/2010 12 Female 106 lb 3/23/2012 Physician Japan
Primary
Secondary
Concomitant
Memory Impairment Hospitalization 2/14/2012 51 Female 95 lb 3/23/2012 Physician Japan
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 2/12/2012 16 Male 4/30/2012 France
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 4/8/2009 58 Female 105 lb 4/17/2013 Consumer Jp
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 5/28/2009 64 Female 123 lb 4/11/2013 Consumer Jp
Primary
Secondary
Concomitant
Stomatitis Life Threatening 9/27/2010 60 Male 151 lb 9/12/2012 Physician Jp
Primary
Concomitant
Uterine Leiomyoma Other Serious Female 11/1/2012 Physician Country Not Specified
Primary
Concomitant
Pulmonary Mass Other Serious 2011 Female 160 lb 2/26/2013 Consumer Ca
Primary
Concomitant
Toxicity To Various Agents Other Serious 1/6/2012 12 Female 89 lb 11/1/2012 Physician Fr
Primary
Secondary
Concomitant
Sepsis Death Female 8/27/2012 Physician Be
Primary
Secondary
Concomitant
Neutropenia Other Serious 8/28/2012 Physician Country Not Specified
Primary
Secondary
Concomitant
Sepsis Death 3/26/2012 14 Male 115 lb 3/15/2013 Physician Jp
Primary
Secondary
Concomitant
Rash Disability 1/15/2013 53 Female 148 lb 2/4/2013 Other Health Professional Pt
Primary
Concomitant
Tubulointerstitial Nephritis Other Serious Male 3/21/2013 Country Not Specified
Primary
Concomitant
Thrombocytopenia Hospitalization 12/18/2009 66 Female 2/24/2013 Other Health Professional Gb
Primary
Concomitant
Stomatitis Hospitalization 12/18/2009 66 Female 2/26/2013 Physician Gb
Primary
Concomitant
Transplant Rejection Other Serious 29 Male 3/28/2013 Other Health Professional Us
Primary
Secondary
Transplant Rejection Hospitalization 29 Male 3/26/2013 Other Health Professional Us
Primary
Secondary
Obliterative Bronchiolitis Other Serious 4/6/2012 29 Male 128 lb 7/10/2013 Physician Jp
Primary
Secondary
Concomitant
Posterior Reversible Encephalopathy Syndrome Life Threatening 11/10/2011 37 Female 5/25/2013 Physician Jp
Primary
Secondary
Concomitant
Varicella Virus Test Positive Life Threatening 11/10/2011 37 Female 5/22/2013 Jp
Primary
Secondary
Concomitant
Sepsis Hospitalization 4/2013 69 Female 8/15/2013 Physician Es
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 6/20/2013 15 Male 93 lb 7/18/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 6/20/2013 15 Male 93 lb 7/25/2013 Pharmacist Gb
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 6/20/2013 15 Male 93 lb 7/29/2013 Pharmacist Gb
Primary
Secondary
Concomitant
Vomiting Other Serious 7/30/2013 27 Male 8/28/2013 Pharmacist Ch
Primary
Secondary
Concomitant
Melaena Death 7/2013 64 Male 10/8/2013 Physician Fr
Primary
Secondary
Concomitant
Melaena Death 7/2013 64 Male 10/16/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
White Blood Cell Count Increased Life Threatening 6/20/2013 NotSpecified 11/11/2013 Pharmacist Gb
Primary
Secondary
Concomitant
Second Primary Malignancy Death NotSpecified 11/22/2013 Physician No
Primary
Secondary
Nervous System Disorder Other Serious NotSpecified 11/22/2013 Physician No
Primary
Secondary
Completed Suicide Death NotSpecified 11/22/2013 Physician No
Primary
Secondary
Death Death NotSpecified 11/22/2013 Physician No
Primary
Secondary
Pulmonary Embolism Death NotSpecified 11/22/2013 Physician No
Primary
Secondary
Disease Progression Death NotSpecified 11/22/2013 Physician No
Primary
Secondary
Disease Progression Other Serious NotSpecified 11/25/2013 Physician No
Primary
Secondary
Nervous System Disorder Other Serious NotSpecified 11/25/2013 Physician No
Primary
Secondary
Nervous System Disorder Other Serious NotSpecified 11/25/2013 Physician No
Primary
Secondary
Disease Progression Other Serious NotSpecified 11/25/2013 Physician No
Primary
Secondary
Disease Progression Other Serious NotSpecified 11/25/2013 Physician No
Primary
Secondary
Disease Progression Other Serious NotSpecified 11/25/2013 Physician No
Primary
Secondary
Nervous System Disorder Other Serious NotSpecified 11/25/2013 Physician No
Primary
Secondary
Nervous System Disorder Other Serious NotSpecified 11/25/2013 Physician No
Primary
Secondary
Disease Progression Death NotSpecified 11/25/2013 Physician No
Primary
Secondary
Second Primary Malignancy Death NotSpecified 11/25/2013 Physician No
Primary
Secondary
Nervous System Disorder Other Serious NotSpecified 11/25/2013 Physician No
Primary
Secondary
Completed Suicide Death NotSpecified 11/25/2013 Physician No
Primary
Secondary
Disease Progression Death NotSpecified 11/25/2013 Physician No
Primary
Secondary
Disease Progression Death NotSpecified 11/25/2013 Physician No
Primary
Secondary
Disease Progression Death NotSpecified 11/25/2013 Physician No
Primary
Secondary
Death Death NotSpecified 11/25/2013 Physician No
Primary
Secondary
Disease Progression Death NotSpecified 11/25/2013 Physician No
Primary
Secondary

Drug Data