Busulfan combined with Cyclophosphamide

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Weight Increased Required Intervention 12/15/2005 Female 117 lb 12/28/2005 United States
Primary
Secondary
Weight Increased Other Serious 10/1/2005 59 Male 198 lb 1/24/2006 Pharmacist Spain
Primary
Concomitant
Venoocclusive Liver Disease Other Serious 14 Male 3/14/2006 Japan
Primary
Secondary
White Blood Cell Count Increased Other Serious 7/1/2005 14 Male 3/21/2006 Japan
Primary
Secondary
Spinal Myelogram Abnormal Other Serious 34 Female 3/21/2006 Physician Japan
Primary
Concomitant
Stem Cell Transplant Hospitalization 53 Male 3/20/2006
Primary
Secondary
Shoulder Pain Hospitalization 53 Male 3/20/2006
Primary
Secondary
Vomiting Hospitalization 53 Male 3/20/2006
Primary
Secondary
Shoulder Pain Hospitalization 53 Male 3/20/2006
Primary
Secondary
White Blood Cell Count Decreased Other Serious 20 Male 4/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Transaminases Increased Other Serious 9 Male 41 lb 5/8/2006 Other Health Professional Italy
Primary
Secondary
Concomitant
Blood Bilirubin Increased Other Serious 1/7/2005 3 Female 5/24/2006 Spain
Primary
Concomitant
Respiratory Disorder Death 2/26/2004 6 Male 6/16/2006 Consumer Japan
Primary
Secondary
Platelet Count Decreased Hospitalization 6/28/2006 Female 160 lb 6/30/2006 United States
Primary
Secondary
Urinary Bladder Haemorrhage Other Serious 14 Male 8/24/2006 Other Health Professional France
Primary
Concomitant
Status Epilepticus Other Serious 10 Female 9/1/2006 Spain
Primary
Concomitant
Status Epilepticus Other Serious 5 Male 9/1/2006 Spain
Primary
Concomitant
Histiocytosis Haematophagic Other Serious 4 Female 10/9/2006 Japan
Primary
Concomitant
Serum Ferritin Increased Other Serious 4 Female 10/17/2006 Japan
Primary
Secondary
Concomitant
Weight Increased Death 1 Male 10/3/2006 Physician France
Primary
Concomitant
Serum Ferritin Increased Other Serious 4 Female 10/23/2006 Japan
Primary
Secondary
Concomitant
Erythema Multiforme Other Serious 10/11/2006 2 Female 31 lb 10/17/2006 Physician Argentina
Primary
Concomitant
Skin Exfoliation Other Serious 31 Female 10/31/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Erythema Multiforme Other Serious 10/11/2006 2 Female 31 lb 10/26/2006 Physician Argentina
Primary
Concomitant
Thrombophlebitis Other Serious 1/1/2003 34 Female 11/21/2006 Japan
Primary
Concomitant
Weight Increased Hospitalization 56 Female 12/9/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Myelitis Hospitalization 1/1/2004 25 Male 12/15/2006 Other Health Professional United States
Primary
Secondary
Lymphoproliferative Disorder Death Unknown 12/1/2006 Physician Japan
Primary
Concomitant
Thrombophlebitis Other Serious 1/1/2003 34 Female 1/5/2007 Japan
Primary
Secondary
Concomitant
Streptococcal Infection Other Serious 9/7/2005 5 Male 55 lb 12/29/2006 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 11/20/2006 41 Female 163 lb 12/20/2006 Physician China
Primary
Concomitant
Interstitial Lung Disease Other Serious 11/19/2006 41 Male 165 lb 12/29/2006 Physician China
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 4 Female 1/19/2007 Other Health Professional Belgium
Primary
Secondary
Tenderness Other Serious 4 Female 1/26/2007
Primary
Secondary
Pulmonary Haemorrhage Hospitalization 11/27/2006 Female 154 lb 1/22/2007 United States
Primary
Secondary
Stem Cell Transplant Death 4 Female 1/26/2007 Belgium
Primary
Secondary
Pyrexia Other Serious 12/1/2004 49 Male 2/8/2007 Japan
Primary
Concomitant
Venoocclusive Disease Hospitalization Female 2/10/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Venoocclusive Disease Hospitalization Female 2/10/2007 Other Health Professional Germany
Primary
Secondary
Concomitant
Weight Decreased Other Serious 12/1/2004 49 Male 2/10/2007 Japan
Primary
Concomitant
Stem Cell Transplant Death 4 Female 2/7/2007 Belgium
Primary
Secondary
Malignant Neoplasm Progression Death 4 Female 2/14/2007 Belgium
Primary
Secondary
Lymphoproliferative Disorder Other Serious 10/11/2006 2 Female 31 lb 2/6/2007 Physician Argentina
Primary
Concomitant
Pyrexia Other Serious 22 Male 2/22/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Vomiting Other Serious 55 Male 2/23/2007
Primary
Secondary
Malignant Neoplasm Progression Death 4 Female 2/26/2007 Belgium
Primary
Secondary
Chronic Graft Versus Host Disease Other Serious 48 Male 3/3/2007 Japan
Primary
Concomitant
Malignant Neoplasm Progression Death 4 Female 3/9/2007 Belgium
Primary
Secondary
Weight Decreased Other Serious 48 Male 3/10/2007 Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 44 Male 3/14/2007 Japan
Primary
Concomitant
Ureteric Stenosis Other Serious 35 Male 3/14/2007 Japan
Primary
Secondary
Concomitant
Cerebral Toxoplasmosis Death 22 Male 3/15/2007 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Other Serious 32 Female 3/17/2007 Japan
Primary
Secondary
Ureteric Stenosis Other Serious 35 Male 3/28/2007 Japan
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 52 Male 4/4/2007 Other Health Professional United States
Primary
Secondary
Pneumonia Other Serious 32 Female 4/10/2007 Japan
Primary
Secondary
Platelet Count Decreased Other Serious 10/11/2006 2 Female 31 lb 4/3/2007 Physician Argentina
Primary
Secondary
Concomitant
Thrombocytopenia Death 13 Female 4/16/2007 Other Health Professional India
Primary
Secondary
Concomitant
Reticulocyte Count Increased Hospitalization 0 Female 4/28/2007 Other Health Professional United States
Primary
Concomitant
Viral Pharyngitis Other Serious 8/26/2005 19 Male 5/11/2007 Poland
Primary
Secondary
Concomitant
No Adverse Effect 4 Female 5/25/2007 Belgium
Primary
Secondary
Neurotoxicity Other Serious 4 6/15/2007 Other Health Professional Italy
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 46 Male 6/24/2007 Japan
Primary
Concomitant
Pneumoperitoneum Other Serious 4 Male 6/29/2007 Belgium
Primary
Secondary
Pleural Effusion Other Serious 46 Male 7/6/2007 Japan
Primary
Concomitant
Lymphoproliferative Disorder Other Serious 10/11/2006 2 Female 31 lb 2/8/2007 Physician Argentina
Primary
Secondary
Concomitant
Erythema Multiforme Other Serious 10/11/2006 2 Female 31 lb 10/20/2006 Physician Argentina
Primary
Secondary
Concomitant
Secondary Immunodeficiency Life Threatening 5/4/2007 10 Male 93 lb 7/2/2007 Denmark
Primary
Concomitant
Weight Increased Life Threatening 4/5/2007 51 Female 7/16/2007 Other Health Professional Japan
Primary
Concomitant
Septic Shock Hospitalization 6/10/2007 Male 146 lb 7/17/2007 United States
Primary
Secondary
Septic Shock Hospitalization 6/10/2007 Male 146 lb 7/16/2007 United States
Primary
Secondary
Somnolence Hospitalization 8/1/2007 8 Male 88 lb 9/11/2007 Pharmacist Canada
Primary
Secondary
Concomitant
Paralysis Life Threatening 5/4/2007 10 Male 93 lb 8/29/2007 Denmark
Primary
Concomitant
Somnolence Other Serious 8/1/2007 8 Male 88 lb 10/12/2007 Pharmacist Canada
Primary
Secondary
Concomitant
Somnolence Other Serious 8/1/2007 8 Male 88 lb 11/8/2007 Physician Canada
Primary
Secondary
Concomitant
Subdural Haematoma Other Serious 7 Female 11/23/2007 Other Health Professional Turkey
Primary
Concomitant
Vaginal Disorder Other Serious 28 Female 12/13/2007 Other Health Professional Greece
Primary
Secondary
White Blood Cell Count Decreased Other Serious 10/1/2005 26 Female 12/14/2007 Other Health Professional Spain
Primary
Concomitant
Oesophagitis Other Serious 26 Female 1/23/2008 Other Health Professional Spain
Primary
Secondary
Chronic Graft Versus Host Disease Other Serious 39 Female 1/23/2008 Other Health Professional United States
Primary
Secondary
Oesophagitis Other Serious 26 Female 1/29/2008 Other Health Professional Spain
Primary
Secondary
Sepsis Other Serious 1 Male 2/7/2008 Japan
Primary
Concomitant
Vulvovaginal Dryness Other Serious 2/1/2001 28 Female 2/12/2008
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 4 Male 2/15/2008 Japan
Primary
Secondary
Concomitant
Subarachnoid Haemorrhage Disability 6/10/2006 52 Female 132 lb 2/19/2008 Physician Slovakia (Slovak Republic)
Primary
Secondary
Concomitant
Complications Of Bone Marrow Transplant Death 2/22/2008 Germany
Primary
Secondary
Concomitant
Complications Of Bone Marrow Transplant Death 2/22/2008 Germany
Primary
Secondary
Concomitant
Venoocclusive Disease Death 2/22/2008 Other Health Professional Germany
Primary
Concomitant
Subarachnoid Haemorrhage Disability 6/10/2006 52 Female 2/26/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 42 Male 2/26/2008 Other Health Professional Spain
Primary
Concomitant
Complications Of Bone Marrow Transplant Death 2/26/2008 Germany
Primary
Secondary
Concomitant
Complications Of Bone Marrow Transplant Death 2/26/2008 Germany
Primary
Secondary
Concomitant
Rash Papular Hospitalization 10/1/2005 26 Female 2/27/2008
Primary
Secondary
Concomitant
Venoocclusive Disease Death 2/29/2008 Other Health Professional Germany
Primary
Concomitant
Graft Versus Host Disease Other Serious 39 Female 3/3/2008
Primary
Secondary
Swelling Other Serious 22 Male 3/21/2008 Other Health Professional Pakistan
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious Male 3/27/2008 Other Health Professional Germany
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Other Serious Male 3/31/2008 Other Health Professional Germany
Primary
Secondary
Therapeutic Agent Toxicity Death 4/2/2008 Germany
Primary
Secondary
Progressive Multifocal Leukoencephalopathy Death Male 4/2/2008 Germany
Primary
Secondary
Subcutaneous Nodule Other Serious 4 Female 4/3/2008 Japan
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 13 Male 4/10/2008 Other Health Professional Germany
Primary
Secondary
Parkinson's Disease Other Serious 12 Female 4/10/2008 Other Health Professional Germany
Primary
Secondary
Parkinson's Disease Other Serious 12 Female 4/14/2008 Other Health Professional Germany
Primary
Secondary
Graft Versus Host Disease Other Serious 13 Female 4/14/2008 Other Health Professional Germany
Primary
Secondary
Graft Versus Host Disease Other Serious 14 Male 4/14/2008 Other Health Professional Germany
Primary
Secondary
Neutropenia Other Serious 4 Female 4/14/2008 Other Health Professional Germany
Primary
Secondary
Convulsion Other Serious 4/15/2008 Other Health Professional Germany
Primary
Concomitant
Graft Versus Host Disease Other Serious 4/15/2008 Other Health Professional Germany
Primary
Concomitant
Venoocclusive Liver Disease Other Serious Male 5/13/2008 Other Health Professional United States
Primary
Secondary
Vertigo Death Male 5/2/2008 Germany
Primary
Concomitant
Progressive Multifocal Leukoencephalopathy Hospitalization 1/1/2004 Male 5/15/2008 Other Health Professional Germany
Primary
Secondary
Venoocclusive Liver Disease Other Serious 34 Female 5/19/2008 Other Health Professional United States
Primary
Secondary
Venoocclusive Liver Disease Other Serious 39 Female 5/19/2008 Other Health Professional United States
Primary
Secondary
Venoocclusive Liver Disease Other Serious 49 Male 5/19/2008 Other Health Professional United States
Primary
Secondary
Venoocclusive Liver Disease Other Serious 47 Male 5/19/2008 Other Health Professional United States
Primary
Secondary
Venoocclusive Liver Disease Other Serious 38 Male 5/19/2008 Other Health Professional United States
Primary
Secondary
Venoocclusive Liver Disease Other Serious 34 Female 5/19/2008 Other Health Professional United States
Primary
Secondary
Venoocclusive Liver Disease Other Serious 31 Female 5/20/2008 Other Health Professional United States
Primary
Secondary
Venoocclusive Liver Disease Other Serious 25 Male 5/20/2008 Other Health Professional United States
Primary
Secondary
Venoocclusive Liver Disease Other Serious 1 Male 5/20/2008 Other Health Professional United States
Primary
Secondary
Venoocclusive Liver Disease Other Serious 33 Male 5/20/2008 Other Health Professional United States
Primary
Secondary
Venoocclusive Liver Disease Other Serious 23 Male 5/20/2008 Other Health Professional United States
Primary
Secondary
Venoocclusive Disease Other Serious 42 Male 6/4/2008 Other Health Professional Spain
Primary
Secondary
Venoocclusive Disease Other Serious 42 Male 6/9/2008 Other Health Professional Spain
Primary
Secondary
Metabolic Encephalopathy Other Serious 23 Female 6/10/2008 Other Health Professional United States
Primary
Concomitant
Renal Failure Chronic Other Serious 5/1/2006 43 Male 6/18/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Other Serious 47 Male 6/19/2008 United States
Primary
Secondary
Venoocclusive Liver Disease Other Serious 48 Male 6/20/2008 Other Health Professional Spain
Primary
Secondary
Concomitant
Viraemia Other Serious 6/20/2008 South Africa
Primary
Secondary
Concomitant
Psychotic Disorder Hospitalization 37 Male 6/20/2008 Korea, Republic Of
Primary
Concomitant
Viraemia Other Serious 6/23/2008 South Africa
Primary
Secondary
Concomitant
Hallucination Life Threatening 6/18/2008 Female 129 lb 6/23/2008 Consumer United States
Primary
Secondary
Myelodysplastic Syndrome Other Serious 47 Male 6/24/2008 United States
Primary
Secondary
Vomiting Hospitalization 23 Male 7/3/2008
Primary
Secondary
Concomitant
Tuberculosis Other Serious 31 Female 7/22/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hypoxia Life Threatening 7/22/2008 Female 129 lb 7/23/2008 Consumer United States
Primary
Secondary
Haematemesis Hospitalization 7/25/2008 Male 156 lb 7/28/2008 Consumer United States
Primary
Secondary
Vomiting Other Serious 25 Male 8/4/2008 Consumer United States
Primary
Secondary
Guillain-barre Syndrome Other Serious 57 Male 8/5/2008 Other Health Professional United States
Primary
Secondary
Guillain-barre Syndrome Other Serious 34 Female 8/5/2008 Other Health Professional United States
Primary
Secondary
Guillain-barre Syndrome Other Serious 42 Male 8/5/2008 Other Health Professional United States
Primary
Secondary
Therapeutic Agent Toxicity Death 8/7/2008 Germany
Primary
Secondary
Concomitant
Vomiting Other Serious 31 Female 8/7/2008 United Kingdom
Primary
Secondary
Vomiting Other Serious 31 Female 8/11/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Hospitalization 31 Female 8/13/2008 Consumer United States
Primary
Secondary
Concomitant
Transplant Rejection Hospitalization 8/13/2008 Other Health Professional Denmark
Primary
Concomitant
Vomiting Other Serious 31 Female 8/13/2008 United Kingdom
Primary
Secondary
Concomitant
Pneumonia Klebsiella Hospitalization 8/7/2008 Male 155 lb 8/12/2008 Consumer United States
Primary
Secondary
Weight Increased Other Serious 5/16/2008 Female 8/15/2008 Other Health Professional Brazil
Primary
Concomitant

Drug Data