Bucillamine combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Respiratory Failure Hospitalization 68 Female 10/5/2006 Physician Japan
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 10/18/2006 Female 11/28/2006 Physician Japan
Primary
Concomitant
Neck Pain Hospitalization 8/19/2006 Male 11/29/2006 Physician Japan
Primary
Concomitant
Mediastinal Abscess Hospitalization 9/27/2006 Male 12/12/2006 Physician Japan
Primary
Concomitant
Pneumonia Legionella Hospitalization 7/15/2006 58 Male 1/29/2007 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 10/18/2006 Female 154 lb 1/31/2007 Physician Japan
Primary
Secondary
Concomitant
Joint Swelling Other Serious 29 Female 2/13/2007 Japan
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 5/24/2005 Female 99 lb 3/12/2007 Japan
Primary
Secondary
Concomitant
Splenomegaly Hospitalization 7/1/2002 83 Female 4/10/2007 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/21/2007 72 Female 5/8/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Other Serious 5/29/2007 Male 157 lb 7/12/2007 Physician Japan
Primary
Concomitant
Vasculitis Hospitalization 54 Female 7/13/2007
Primary
Secondary
Pleural Effusion Hospitalization 11/28/2006 Female 10/11/2007 Physician Japan
Primary
Concomitant
Pleural Effusion Hospitalization 11/28/2006 Female 10/25/2007 Physician Japan
Primary
Concomitant
Petechiae Hospitalization 8/9/2007 Male 159 lb 1/7/2008 Physician Japan
Primary
Secondary
Concomitant
Petechiae Hospitalization 1/1/2007 Male 159 lb 2/15/2008 Physician Japan
Primary
Secondary
Concomitant
Petechiae Hospitalization 3/1/2007 Male 159 lb 3/4/2008 Physician Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 65 Male 3/6/2008
Primary
Secondary
Concomitant
Petechiae Hospitalization 8/9/2007 Male 159 lb 3/7/2008 Japan
Primary
Secondary
Concomitant
Peritonitis Hospitalization 3/1/2007 Male 159 lb 3/21/2008 Physician Japan
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 8/26/2005 Female 71 lb 5/7/2008 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/18/2006 Female 154 lb 7/2/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Aspiration Hospitalization 1/1/2005 80 Female 77 lb 1/5/2009
Primary
Secondary
Concomitant
Pneumonia Aspiration Hospitalization 1/1/2005 80 Female 77 lb 1/5/2009
Primary
Secondary
Concomitant
Nephrotic Syndrome Hospitalization 2/10/2009 78 Female 3/16/2009 Physician Japan
Primary
Secondary
Urinary Tract Infection Death 73 Female 6/12/2009 Other Health Professional Japan
Primary
Concomitant
Urinary Tract Infection Death 73 Female 6/17/2009 Other Health Professional Japan
Primary
Concomitant
Urinary Tract Infection Other Serious 73 Female 6/18/2009 Other Health Professional Japan
Primary
Concomitant
Thyroid Cancer Hospitalization 4/27/2009 55 Female 6/18/2009 Korea, Republic Of
Primary
Concomitant
Food Allergy Hospitalization 3/1/2009 47 Male 7/17/2009 Physician Japan
Primary
Secondary
Concomitant
Anaphylactic Shock Hospitalization 3/11/2009 Male 132 lb 7/27/2009 Physician Japan
Primary
Concomitant
Anaphylactic Shock Hospitalization 3/11/2009 Male 117 lb 8/13/2009 Physician Japan
Primary
Concomitant
Anaphylactic Shock Hospitalization 3/11/2009 Male 117 lb 8/20/2009 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 7/21/2009 Female 92 lb 9/4/2009 Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 7/21/2009 Female 92 lb 9/17/2009 Japan
Primary
Secondary
Concomitant
Pulmonary Tuberculosis Hospitalization 11/1/2008 Male 150 lb 9/18/2009 Japan
Primary
Secondary
Concomitant
Respiratory Arrest Life Threatening 10/14/2009 57 Female 10/23/2009 Physician Japan
Primary
Concomitant
Rib Fracture Hospitalization 4/5/2009 Male 10/29/2009 Japan
Primary
Concomitant
Anaphylactic Shock Hospitalization 3/11/2009 Male 117 lb 12/18/2009 Physician Japan
Primary
Concomitant
Tendon Rupture Hospitalization 11/5/2008 Female 103 lb 12/29/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 12/8/2009 Male 172 lb 1/14/2010 Japan
Primary
Concomitant
Renal Impairment Life Threatening 12/11/2009 Male 172 lb 1/29/2010 Japan
Primary
Concomitant
Cerebral Infarction Other Serious 9/22/2009 Female 2/8/2010 Japan
Primary
Concomitant
Renal Impairment Life Threatening 12/11/2009 Male 172 lb 2/15/2010 Japan
Primary
Concomitant
Cerebral Infarction Other Serious 9/22/2009 Female 2/15/2010 Japan
Primary
Concomitant
Tendon Rupture Hospitalization 11/5/2008 Female 103 lb 2/22/2010 Physician Japan
Primary
Secondary
Concomitant
Rash Hospitalization 3/1/2009 Female 143 lb 2/23/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/4/2008 Male 150 lb 2/25/2010 Japan
Primary
Secondary
Concomitant
Sputum Increased Other Serious 2/3/2010 Female 3/11/2010 Pharmacist Japan
Primary
Concomitant
Sputum Increased Other Serious 2/3/2010 Female 3/26/2010 Physician Japan
Primary
Concomitant
Renal Impairment Life Threatening 12/11/2009 Male 172 lb 3/26/2010 Japan
Primary
Concomitant
Cerebral Infarction Other Serious 9/22/2009 78 Female 4/12/2010 Japan
Primary
Concomitant
Cerebral Infarction Other Serious 9/22/2009 78 Female 4/22/2010 Japan
Primary
Concomitant
Bronchitis Hospitalization 4/9/2010 54 Female 4/20/2010 Other Health Professional Japan
Primary
Concomitant
Cerebral Infarction Hospitalization 9/22/2009 78 Female 4/28/2010 Japan
Primary
Concomitant
Renal Impairment Hospitalization 12/11/2009 81 Male 172 lb 5/18/2010 Japan
Primary
Concomitant
Pneumonia Bacterial Hospitalization 3/19/2010 71 Female 75 lb 5/19/2010 Japan
Primary
Concomitant
Pneumonia Bacterial Hospitalization 3/19/2010 71 Female 75 lb 5/28/2010 Japan
Primary
Concomitant
Respiratory Arrest Life Threatening 10/14/2009 57 Female 6/22/2010 Physician Japan
Primary
Concomitant
Spinal Osteoarthritis Other Serious 3/11/2010 64 Male 121 lb 6/28/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 7/17/2009 70 Female 92 lb 7/8/2010 Physician Japan
Primary
Secondary
Concomitant
Spinal Osteoarthritis Other Serious 3/11/2010 64 Male 121 lb 7/12/2010 Physician Japan
Primary
Concomitant
Spinal Osteoarthritis Other Serious 3/11/2010 64 Male 121 lb 7/26/2010 Physician Japan
Primary
Concomitant
Multi-organ Failure Death 7/1/2007 62 Male 132 lb 7/28/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Tuberculin Test Positive Hospitalization 3/23/2010 29 Female 8/6/2010 Japan
Primary
Concomitant
Spinal Osteoarthritis Other Serious 3/11/2010 64 Male 121 lb 8/18/2010 Physician Japan
Primary
Concomitant
Respiratory Failure Life Threatening 62 Male 132 lb 8/20/2010
Primary
Secondary
Spinal Compression Fracture Life Threatening 6/26/2010 64 Female 8/20/2010 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Death 3/1/2007 72 Female 8/27/2010 Physician Japan
Primary
Secondary
Concomitant
Spondylitis Other Serious 6/2/2010 64 Female 8/27/2010 Physician Japan
Primary
Concomitant
Respiratory Failure Death 3/1/2007 72 Female 9/3/2010 Physician Japan
Primary
Secondary
Concomitant
Threatened Labour Hospitalization 3/23/2010 29 Female 9/10/2010 Japan
Primary
Concomitant
Rash Hospitalization 3/1/2009 47 Female 143 lb 9/13/2010 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Death 3/16/2007 72 Female 9/13/2010 Physician Japan
Primary
Secondary
Concomitant
Spondylitis Other Serious 6/2/2010 64 Female 10/13/2010 Physician Japan
Primary
Secondary
Concomitant
Vertigo Hospitalization 2/10/2010 60 Male 10/21/2010 Physician Japan
Primary
Secondary
Concomitant
Chest X-ray Abnormal Hospitalization 4/17/2010 57 Female 122 lb 10/22/2010 Physician Japan
Primary
Concomitant
Pneumonia Bacterial Hospitalization 8/24/2010 65 Female 11/4/2010 Physician Japan
Primary
Concomitant
Respiratory Failure Death 3/15/2007 72 Female 11/8/2010 Physician Japan
Primary
Secondary
Concomitant
Vertigo Hospitalization 2/10/2010 60 Male 11/15/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Bacterial Hospitalization 3/19/2010 71 Female 75 lb 11/22/2010 Physician Japan
Primary
Concomitant
Respiratory Failure Death 3/15/2007 72 Female 137 lb 11/29/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 6/1/2010 12/9/2010 Physician Japan
Primary
Secondary
Concomitant
Skin Infection Hospitalization 6/7/2010 67 Female 95 lb 12/10/2010 Physician Japan
Primary
Concomitant
Vertigo Hospitalization 2/10/2010 60 Male 12/20/2010 Physician Japan
Primary
Secondary
Concomitant
Bronchopneumonia Hospitalization 4/17/2010 57 Female 122 lb 12/21/2010 Physician Japan
Primary
Concomitant
Pneumonia Bacterial Hospitalization 3/19/2010 71 Female 75 lb 12/22/2010 Physician Japan
Primary
Concomitant
Organising Pneumonia Other Serious 1/21/2011 Other Health Professional Japan
Primary
Concomitant
Organising Pneumonia Other Serious 62 Female 1/28/2011 Other Health Professional Japan
Primary
Concomitant
Organising Pneumonia Other Serious 62 Female 1/31/2011 Other Health Professional Japan
Primary
Concomitant
Eye Pruritus Life Threatening 8/1/2010 79 Female 2/10/2011 Physician Japan
Primary
Concomitant
Terminal State Hospitalization 8/1/2010 79 Female 2/21/2011 Physician Japan
Primary
Concomitant
Pneumonia Bacterial Hospitalization 3/19/2010 71 Female 75 lb 3/3/2011 Physician Japan
Primary
Concomitant
Ulcer Haemorrhage Hospitalization 72 Male 3/9/2011 Other Health Professional Japan
Primary
Secondary
Pleural Effusion Life Threatening 11/12/2008 73 Female 112 lb 3/11/2011 Physician Japan
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 3/14/2011 85 Female 4/15/2011 Physician Japan
Primary
Concomitant
Pleural Effusion Life Threatening 11/8/2008 73 Female 112 lb 4/19/2011 Physician Japan
Primary
Secondary
Concomitant
Jaundice Cholestatic Hospitalization 8/1/2010 79 Female 4/27/2011 Physician Japan
Primary
Concomitant
Gastric Ulcer Haemorrhage Hospitalization 5/12/2011 Pharmacist Japan
Primary
Concomitant
Eosinophilic Pneumonia Other Serious 70 Male 5/17/2011 Physician Japan
Primary
Concomitant
Gastric Ulcer Haemorrhage Hospitalization 5/24/2011 Pharmacist Japan
Primary
Concomitant
Liver Disorder Hospitalization 2/5/2011 86 Female 6/17/2011 Physician Japan
Primary
Secondary
Concomitant
Fall Other Serious 10/1/2010 62 Female 142 lb 6/21/2011 Physician Japan
Primary
Concomitant
Vasoconstriction Other Serious 5/1/2011 80 Female 6/23/2011 Physician Japan
Primary
Concomitant
Oedema Peripheral Other Serious 5/1/2011 80 Female 7/1/2011 Physician Japan
Primary
Concomitant
Bronchopneumonia Hospitalization 4/17/2010 57 Female 122 lb 7/2/2011 Physician Japan
Primary
Concomitant
Hepatitis Fulminant Death 2/1/2008 72 Female 7/8/2011 Physician Japan
Primary
Concomitant
Arthralgia Hospitalization 10/1/2010 62 Female 142 lb 7/13/2011 Physician Japan
Primary
Concomitant
Cellulitis Other Serious 5/1/2011 80 Female 7/15/2011 Physician Japan
Primary
Secondary
Concomitant
Pain Death 5/1/2011 80 Female 7/26/2011 Physician Japan
Primary
Secondary
Concomitant
Atrial Fibrillation Life Threatening 10/14/2009 57 Female 8/2/2011 Physician Japan
Primary
Concomitant
Vasoconstriction Death 5/1/2011 80 Female 8/5/2011 Physician Japan
Primary
Secondary
Concomitant
Feeling Hot Death 5/1/2011 80 Female 8/8/2011 Physician Japan
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 1/1/2011 72 Female 8/12/2011 Consumer Japan
Primary
Concomitant
Pneumonia Bacterial Hospitalization 8/24/2010 65 Female 9/1/2011 Physician Japan
Primary
Concomitant
Herpes Zoster 7/10/2011 59 Female 9/16/2011 Physician Japan
Primary
Concomitant
Incorrect Dose Administered Other Serious 5/1/2011 80 Female 9/16/2011 Physician Japan
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 3/14/2011 85 Female 90 lb 9/29/2011 Physician Japan
Primary
Concomitant
Cerebral Infarction Hospitalization 3/14/2011 85 Female 90 lb 10/3/2011 Physician Japan
Primary
Concomitant
Disseminated Tuberculosis Hospitalization 11/4/2008 66 Male 150 lb 10/14/2011 Physician Japan
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 3/14/2011 85 Female 90 lb 10/21/2011 Physician Japan
Primary
Concomitant
Herpes Zoster Hospitalization 3/14/2011 85 Female 90 lb 11/4/2011 Physician Japan
Primary
Concomitant
Skin Disorder Other Serious 42 Female 11/7/2011 Other Health Professional Japan
Primary
Concomitant
Pneumonia Hospitalization 7/29/2011 67 Female 106 lb 11/11/2011 Physician Japan
Primary
Secondary
Concomitant
Therapeutic Response Decreased Hospitalization 61 Female 12/2/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Rheumatoid Vasculitis Hospitalization 61 Female 12/2/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Polyneuropathy Hospitalization 61 Female 12/12/2011 Other Health Professional Japan
Primary
Concomitant
Polyneuropathy Hospitalization 61 Female 12/12/2011 Other Health Professional Japan
Primary
Concomitant
Pyrexia Other Serious 6/10/2011 61 Female 12/13/2011 Other Health Professional Japan
Primary
Concomitant
Therapeutic Response Decreased Hospitalization 6/10/2011 61 Female 12/13/2011 Other Health Professional Japan
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 2/5/2011 86 Female 12/19/2011 Consumer Japan
Primary
Secondary
Concomitant
Ileus Other Serious 11/25/2011 79 Female 12/21/2011 Physician Japan
Primary
Concomitant
Pneumonia Bacterial Hospitalization 8/24/2010 66 Female 1/20/2012 Physician Japan
Primary
Concomitant
Hepatic Cancer Metastatic Life Threatening 11/25/2011 79 Female 1/23/2012 Physician Japan
Primary
Concomitant
Large Intestine Carcinoma Hospitalization 9/14/2011 68 Female 97 lb 2/2/2012 Japan
Primary
Secondary
Concomitant
Ileus Life Threatening 11/25/2011 79 Female 2/14/2012 Physician Japan
Primary
Concomitant
Large Intestine Carcinoma Hospitalization 9/14/2011 68 Female 97 lb 3/15/2012 Physician Japan
Primary
Secondary
Concomitant
Haemorrhage Subcutaneous Hospitalization 4/28/2009 75 Female 4/27/2012 Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/29/2011 67 Female 106 lb 5/4/2012 Physician Japan
Primary
Secondary
Concomitant
Lung Disorder Other Serious 69 Male 5/15/2012 Physician Japan
Primary
Concomitant
Renal Disorder Other Serious 3/28/2012 63 Female 86 lb 5/22/2012 Physician Japan
Primary
Concomitant
Diarrhoea Other Serious 65 Male 5/28/2012 Consumer Japan
Primary
Concomitant
Haemorrhage Subcutaneous Hospitalization 4/28/2009 75 Female 6/6/2012 Japan
Primary
Secondary
Concomitant
Asthma Other Serious 5/8/2012 64 Female 77 lb 6/14/2012 Physician Japan
Primary
Concomitant
Pain In Extremity Hospitalization 4/27/2012 73 Female 109 lb 6/18/2012 Physician Japan
Primary
Secondary
Concomitant
Cellulitis Hospitalization 8/25/2010 67 Female 121 lb 6/18/2012 Physician Japan
Primary
Concomitant
Grip Strength Decreased Other Serious 4/27/2012 73 Female 109 lb 7/3/2012 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Other Serious 3/28/2012 63 Female 86 lb 7/5/2012 Physician Japan
Primary
Concomitant
Lupus-like Syndrome Hospitalization 8/25/2010 67 Female 121 lb 7/5/2012 Physician Japan
Primary
Concomitant
Herpes Zoster Hospitalization 4/27/2012 73 Female 109 lb 7/12/2012 Physician Japan
Primary
Secondary
Concomitant

Drug Data