Brotizolam combined with Famotidine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Cholangitis Hospitalization 2/8/2006 86 Female 3/20/2006 Pharmacist Japan
Primary
Concomitant
Cholangitis Hospitalization 2/8/2006 86 Female 5/17/2006 Physician Japan
Primary
Concomitant
Rash Other Serious 12/4/2003 Female 108 lb 6/23/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Hyperlipidaemia Hospitalization 5/6/2002 Male 7/28/2006 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 5/6/2004 Female 8/7/2006 Physician Japan
Primary
Secondary
Concomitant
Renin Decreased Required Intervention 8/1/2003 76 Male 8/10/2006 Japan
Primary
Secondary
Concomitant
Hyperlipidaemia Hospitalization 5/6/2002 Male 8/21/2006 Physician Japan
Primary
Secondary
Concomitant
Putamen Haemorrhage Other Serious 12/12/2005 63 Male 8/17/2006 Physician Japan
Primary
Concomitant
Prothrombin Time Prolonged Other Serious 12/12/2005 63 Male 9/20/2006 Physician Japan
Primary
Concomitant
Prothrombin Time Prolonged Other Serious 12/12/2005 63 Male 10/25/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 5/6/2004 Female 12/7/2006 Physician Japan
Primary
Secondary
Concomitant
Somnolence Hospitalization 5/2/2006 Male 115 lb 1/5/2007 Japan
Primary
Concomitant
Tachycardia Other Serious 12/1/2002 18 Male 104 lb 1/10/2007 Physician Japan
Primary
Concomitant
Hallucination Other Serious 3/20/2007 77 Female 4/10/2007 Physician Japan
Primary
Secondary
Delirium Other Serious 4/13/2007 73 Male 95 lb 5/25/2007 Japan
Primary
Concomitant
Delirium Other Serious 4/13/2007 73 Male 95 lb 6/18/2007 Japan
Primary
Concomitant
Erythema Hospitalization 6/2/2007 74 Male 106 lb 7/25/2007 Physician Japan
Primary
Concomitant
Thrombocytopenia Other Serious 7/9/2007 Female 104 lb 8/2/2007 Physician Japan
Primary
Concomitant
Liver Disorder Hospitalization 9/27/2006 Male 8/22/2007 Japan
Primary
Secondary
Concomitant
Hepatic Neoplasm Malignant Hospitalization 6/1/2004 Male 9/5/2007 United Kingdom
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 10/27/2005 Male 9/7/2007 United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/9/2007 Female 104 lb 9/7/2007 Physician Japan
Primary
Concomitant
Liver Disorder 7/30/2007 79 Female 9/18/2007 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 10/27/2005 Male 10/1/2007 United Kingdom
Primary
Secondary
Concomitant
Sepsis Other Serious 5/25/2007 76 Female 11/5/2007 Physician Japan
Primary
Concomitant
Rash Pruritic Hospitalization 10/20/2007 75 Female 143 lb 11/20/2007 Pharmacist France
Primary
Secondary
Concomitant
Paranoia Other Serious 8/1/2007 57 Female 12/6/2007 Other Health Professional Japan
Primary
Concomitant
Paranoia Other Serious 8/1/2007 57 Female 12/14/2007 Other Health Professional Japan
Primary
Concomitant
Rhabdomyolysis Other Serious 11/1/2007 Male 2/8/2008 Physician Japan
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 10/27/2005 Male 146 lb 2/12/2008 United Kingdom
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 10/27/2005 Male 146 lb 2/18/2008 United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 11/1/2007 Male 3/11/2008 Physician Japan
Primary
Concomitant
Rhabdomyolysis Other Serious 11/1/2007 Male 3/18/2008 Physician Japan
Primary
Concomitant
Rash Other Serious 12/4/2003 Female 108 lb 3/21/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Pneumocystis Jiroveci Pneumonia Life Threatening 10/27/2005 Male 146 lb 4/8/2008 United Kingdom
Primary
Secondary
Concomitant
Condition Aggravated Other Serious 1/21/2008 32 Male 4/15/2008 Other Health Professional Japan
Primary
Concomitant
Condition Aggravated Other Serious 1/21/2008 32 Male 4/17/2008 Other Health Professional Japan
Primary
Concomitant
Vomiting Hospitalization 3/26/2008 70 Female 4/21/2008 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/23/2008 Female 174 lb 4/29/2008 Physician Japan
Primary
Concomitant
Sepsis Other Serious 5/25/2007 76 Female 5/5/2008 Physician Japan
Primary
Concomitant
Sepsis Other Serious 5/25/2007 76 Female 5/19/2008 Physician Japan
Primary
Secondary
Concomitant
Communication Disorder Hospitalization 3/18/2008 80 Male 7/3/2008 Japan
Primary
Concomitant
Somnolence Other Serious 7/18/2008 76 Female 9/12/2008 Pharmacist Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 29 Female 120 lb 10/18/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Somnolence Other Serious 7/18/2008 Female 82 lb 10/27/2008 Physician Japan
Primary
Secondary
Concomitant
Pseudoaldosteronism Other Serious 8/1/2003 76 Male 134 lb 10/23/2008 Japan
Primary
Secondary
Concomitant
Weight Fluctuation Other Serious 29 Female 11/17/2008 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/17/2008 Male 104 lb 11/26/2008 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/17/2008 Male 104 lb 12/1/2008 Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/17/2008 12/22/2008 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/17/2008 1/29/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/17/2008 2/23/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Tendon Rupture Other Serious 2/24/2009 Female 110 lb 3/6/2009 Japan
Primary
Concomitant
Metabolic Encephalopathy Hospitalization 6/8/2009 66 Male 6/25/2009 Physician Japan
Primary
Concomitant
Agranulocytosis Other Serious 3/10/2009 77 6/30/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Metabolic Encephalopathy Hospitalization 6/8/2009 66 Male 7/23/2009 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Life Threatening 4/11/2009 Female 99 lb 8/21/2009 Japan
Primary
Concomitant
Interstitial Lung Disease Life Threatening 4/11/2009 Female 99 lb 9/3/2009 Japan
Primary
Concomitant
Interstitial Lung Disease Life Threatening 4/11/2009 Female 99 lb 9/15/2009 Japan
Primary
Concomitant
Tachycardia Other Serious 6/25/2009 Female 86 lb 9/22/2009 Japan
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 8/17/2009 Female 90 lb 10/29/2009 Physician Japan
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 8/20/2009 Female 157 lb 10/30/2009 Physician Japan
Primary
Concomitant
Tendon Rupture Hospitalization 2/24/2009 Female 110 lb 11/2/2009 Japan
Primary
Concomitant
Skin Ulcer Disability 8/31/2009 Female 11/4/2009 Physician Japan
Primary
Concomitant
Skin Ulcer 7/31/2009 Female 11/16/2009 Physician Japan
Primary
Concomitant
Tachycardia Other Serious 6/25/2009 Female 86 lb 11/17/2009 Japan
Primary
Secondary
Concomitant
Polymyositis Other Serious 7/27/2006 55 Male 163 lb 11/20/2009 Consumer Japan
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 8/20/2009 Female 157 lb 12/10/2009 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 11/17/2008 78 Male 104 lb 12/14/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Urine Output Decreased Life Threatening 8/17/2009 Female 90 lb 12/15/2009 Physician Japan
Primary
Concomitant
Tachycardia Other Serious 6/25/2009 Female 86 lb 2/3/2010 Japan
Primary
Secondary
Concomitant
Mania Hospitalization 3/1/2009 Male 170 lb 2/8/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 8/20/2009 Female 157 lb 2/19/2010 Physician Japan
Primary
Concomitant
Neuropathy Peripheral Other Serious 2/23/2009 67 Male 170 lb 2/23/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Systemic Lupus Erythematosus Hospitalization 5/1/2009 64 Male 154 lb 4/8/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Life Threatening 8/17/2009 58 Female 90 lb 4/14/2010 Physician Japan
Primary
Concomitant
Tachycardia Other Serious 6/25/2009 71 Female 86 lb 4/22/2010 Japan
Primary
Secondary
Concomitant
Systemic Lupus Erythematosus Hospitalization 3/31/2009 64 Male 154 lb 4/30/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Life Threatening 4/8/2010 67 Male 152 lb 5/20/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Life Threatening 4/8/2010 67 Male 152 lb 6/1/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 4/11/2009 67 Female 99 lb 6/15/2010 Other Health Professional Japan
Primary
Concomitant
Water Intoxication Hospitalization 4/22/2010 63 Male 7/30/2010 Physician Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 6/25/2009 71 Female 86 lb 8/2/2010 Physician Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 6/25/2009 71 Female 86 lb 8/17/2010 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 4/11/2009 67 Female 99 lb 12/1/2010 Other Health Professional Japan
Primary
Concomitant
Acute Myeloid Leukaemia Recurrent Death 8/6/2010 67 Female 110 lb 1/7/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 9/17/2010 69 Male 154 lb 2/2/2011 Physician Japan
Primary
Concomitant
Large Intestine Perforation Other Serious 11/25/2010 28 Female 104 lb 2/21/2011 Physician Japan
Primary
Concomitant
Pneumonia Death 9/17/2010 69 Male 154 lb 3/1/2011 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 9/17/2010 69 Male 154 lb 3/3/2011 Other Health Professional Japan
Primary
Concomitant
Intestinal Fistula Infection Hospitalization 11/25/2010 28 Female 104 lb 3/4/2011 Physician Japan
Primary
Concomitant
Intestinal Fistula Infection Hospitalization 11/25/2010 28 Female 104 lb 4/5/2011 Physician Japan
Primary
Concomitant
Aspartate Aminotransferase Increased Hospitalization 12/21/2010 69 Male 121 lb 4/14/2011 Physician Japan
Primary
Concomitant
Fungal Infection Other Serious 10/13/2009 36 Male 143 lb 4/27/2011 Physician Japan
Primary
Concomitant
Blood Creatinine Increased Hospitalization 12/20/2010 69 Male 121 lb 6/21/2011 Physician Japan
Primary
Concomitant
Amnesia Other Serious 6/3/2011 87 Male 99 lb 7/22/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Enterococcal Sepsis Hospitalization 11/4/2010 77 Male 110 lb 7/22/2011 Physician Japan
Primary
Concomitant
Cytomegalovirus Infection Hospitalization 6/26/2011 71 Male 7/27/2011 Physician Japan
Primary
Secondary
Concomitant
Insomnia Hospitalization 5/10/2011 79 Male 8/2/2011 Physician Japan
Primary
Concomitant
Amnesia Other Serious 5/20/2011 87 Male 99 lb 8/4/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Neuropathy Peripheral Other Serious 8/3/2010 76 Male 152 lb 8/10/2011 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/7/2011 Male 99 lb 8/16/2011 Physician Japan
Primary
Concomitant
Thrombotic Microangiopathy Other Serious 2/7/2011 20 Male 196 lb 8/22/2011 Physician Japan
Primary
Concomitant
Pneumonia Cytomegaloviral Hospitalization 7/19/2011 54 Male 136 lb 8/22/2011 Physician Japan
Primary
Secondary
Concomitant
Alanine Aminotransferase Increased Death 12/28/2010 83 Female 99 lb 8/26/2011 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/7/2011 Male 99 lb 9/8/2011 Physician Japan
Primary
Concomitant
Cytomegalovirus Infection Hospitalization 7/19/2011 54 Male 136 lb 9/14/2011 Physician Japan
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 12/28/2010 83 Female 99 lb 10/21/2011 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/11/2011 71 Male 99 lb 10/25/2011 Physician Japan
Primary
Concomitant
Neutrophil Count Decreased Other Serious 7/17/2011 76 Male 139 lb 10/27/2011 Physician Japan
Primary
Concomitant
Staphylococcal Sepsis Life Threatening 10/13/2009 36 Male 143 lb 11/7/2011 Physician Japan
Primary
Concomitant
Dry Skin Death 8/3/2010 76 Male 152 lb 11/30/2011 Physician Japan
Primary
Secondary
Concomitant
Bacteraemia Other Serious 7/16/2011 76 Male 139 lb 12/1/2011 Physician Japan
Primary
Concomitant
Neutrophil Count Decreased Other Serious 1/11/2011 71 Male 99 lb 12/7/2011 Physician Japan
Primary
Concomitant
Intracardiac Thrombus Other Serious 11/17/2010 60 Male 110 lb 12/19/2011 Physician Japan
Primary
Concomitant
Bradycardia Hospitalization 11/30/2010 69 Male 119 lb 12/20/2011 Physician Japan
Primary
Concomitant
Epstein-barr Virus Associated Lymphoproliferative Disorder Death 9/23/2011 66 Female 139 lb 12/21/2011 Physician Japan
Primary
Concomitant
Liver Disorder Other Serious 2/7/2011 Male 99 lb 12/28/2011 Physician Japan
Primary
Concomitant
Diarrhoea Other Serious 12/16/2011 68 Female 123 lb 2/6/2012 Physician Japan
Primary
Concomitant
Multi-organ Failure Death 2/7/2011 20 Male 196 lb 2/7/2012 Physician Japan
Primary
Concomitant
Peritoneal Tuberculosis Hospitalization 4/9/2011 79 Female 131 lb 2/8/2012 Physician Japan
Primary
Secondary
Concomitant
Tuberculous Pleurisy Hospitalization 4/9/2011 79 Female 131 lb 2/14/2012 Physician Japan
Primary
Secondary
Concomitant
Drug Effect Decreased Death 12/16/2009 42 Male 154 lb 2/17/2012 Physician Japan
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 5/24/2011 58 Female 126 lb 2/17/2012 Physician Japan
Primary
Concomitant
Catheter Removal Other Serious 12/16/2009 42 Male 154 lb 2/21/2012 Physician Japan
Primary
Secondary
Concomitant
Diarrhoea Other Serious 10/1/2011 68 Female 123 lb 2/23/2012 Physician Japan
Primary
Secondary
Concomitant
Herpes Zoster Hospitalization 11/4/2010 77 Male 110 lb 2/28/2012 Physician Japan
Primary
Concomitant
Renal Impairment Other Serious 4/28/2011 22 Female 106 lb 3/12/2012 Physician Japan
Primary
Secondary
Concomitant
Rash 6/1/2011 22 Female 106 lb 3/16/2012 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Hospitalization 1/1/2012 70 Male 3/9/2012 Japan
Primary
Concomitant
Loss Of Consciousness Other Serious 5/24/2011 58 Female 126 lb 3/26/2012 Physician Japan
Primary
Concomitant
Peritoneal Tuberculosis Hospitalization 4/9/2011 79 Female 131 lb 4/9/2012 Physician Japan
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 5/24/2011 58 Female 126 lb 4/11/2012 Physician Japan
Primary
Concomitant
Rash 6/30/2011 22 Female 106 lb 4/23/2012 Physician Japan
Primary
Secondary
Concomitant
Neuroleptic Malignant Syndrome Hospitalization 4/1/2012 47 Male 174 lb 5/7/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 9/29/2010 59 Male 155 lb 5/16/2012 Physician Japan
Primary
Concomitant
Alopecia 6/30/2011 22 Female 106 lb 5/29/2012 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Other Serious 1/1/2009 59 Male 112 lb 6/1/2012 Consumer Japan
Primary
Secondary
Concomitant
Delirium Other Serious 4/27/2012 70 Male 6/17/2012 Japan
Primary
Concomitant
Subarachnoid Haemorrhage Hospitalization 8/10/2010 57 Female 146 lb 6/27/2012 Physician Japan
Primary
Concomitant
Subarachnoid Haemorrhage Hospitalization 8/10/2010 57 Female 146 lb 7/11/2012 Physician Japan
Primary
Concomitant
Respiratory Arrest Other Serious 5/12/2012 78 Male 6/29/2012 Other Health Professional Japan
Primary
Concomitant
Liver Disorder Hospitalization 9/29/2010 59 Male 155 lb 7/17/2012 Physician Japan
Primary
Concomitant
Delirium Other Serious 4/27/2012 70 Male 7/25/2012 Other Health Professional Japan
Primary
Concomitant
Blood Bilirubin Increased Other Serious 61 Male 8/6/2012 Physician United States
Primary
Secondary
Concomitant
Coronary Artery Disease Hospitalization 7/2/2012 70 Female 118 lb 8/14/2012 Physician Japan
Primary
Secondary
Concomitant
Fatigue Hospitalization 9/2/2011 8/22/2012 United States
Primary
Secondary
Concomitant
Coronary Artery Disease Hospitalization 7/2/2012 70 Female 118 lb 8/27/2012 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 9/23/2011 67 Female 139 lb 12/21/2012 Physician Jp
Primary
Concomitant
Renal Failure Hospitalization 1/27/2012 70 Male 12/31/2012 Consumer Jp
Primary
Concomitant

Drug Data