Bortezomib combined with Melphalan

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Osteonecrosis Other Serious 11/9/2005 65 Female 95 lb 4/7/2006 Physician Germany
Primary
Concomitant
Renal Failure Acute Hospitalization 6/29/2006 62 Male 146 lb 11/7/2006 France
Primary
Concomitant
Renal Failure Acute Hospitalization 6/29/2006 62 Male 146 lb 11/14/2006 Physician France
Primary
Concomitant
Osteonecrosis Other Serious 10/1/2006 Male 5/14/2007 Physician Germany
Primary
Concomitant
Osteonecrosis Other Serious 10/1/2006 Male 5/14/2007 Physician Germany
Primary
Concomitant
Urine Amylase Increased Death 7/1/2006 71 Female 7/3/2007 Physician Spain
Primary
Concomitant
Urine Amylase Increased Death 7/1/2006 71 Female 7/13/2007 Physician Spain
Primary
Concomitant
Rash Pustular Other Serious 65 Female 7/26/2007
Primary
Secondary
Sensory Disturbance Hospitalization 10/7/2007 Female 10/26/2007 Physician Italy
Primary
Secondary
Concomitant
Sensory Disturbance Hospitalization 10/7/2007 Female 10/31/2007 Physician Italy
Primary
Secondary
Concomitant
Sensory Disturbance Hospitalization 10/7/2007 Female 11/7/2007 Physician Italy
Primary
Secondary
Concomitant
Sensory Disturbance Hospitalization 10/7/2007 Female 12/7/2007 Physician Italy
Primary
Secondary
Concomitant
Supraventricular Tachycardia Life Threatening 2/8/2008 Male 181 lb 2/22/2008 Consumer United States
Primary
Concomitant
Haemorrhage Other Serious 4/7/2008 Other Health Professional Italy
Primary
Secondary
Pneumonia Other Serious 1/1/2004 Male 8/11/2008 Germany
Primary
Concomitant
Tooth Extraction Other Serious 10/1/2004 Female 8/12/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Somnolence Death 3/22/2007 Female 12/24/2008 Canada
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 54 Male 1/15/2009 Physician Japan
Primary
Secondary
Thrombotic Microangiopathy Other Serious 11/1/2007 54 Male 1/20/2009 Physician Japan
Primary
Secondary
Thrombotic Microangiopathy Other Serious 11/17/2007 54 Male 2/2/2009 Physician Japan
Primary
Secondary
Concomitant
Somnolence Death 3/22/2007 Female 3/2/2009 Canada
Primary
Secondary
Concomitant
Nervous System Disorder Death 54 Male 3/9/2009 Consumer United States
Primary
Secondary
Concomitant
Right Ventricular Dysfunction Other Serious 7/1/2008 77 Male 3/19/2009 Other Health Professional Canada
Primary
Secondary
Concomitant
Somnolence Death 3/22/2007 Female 4/7/2009 Canada
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 4/14/2009 Consumer United Kingdom
Primary
Secondary
Febrile Neutropenia Other Serious 4/27/2009 Consumer United Kingdom
Primary
Secondary
Renal Failure Other Serious 5/1/2009 Physician United States
Primary
Secondary
Concomitant
Respiratory Distress Other Serious 5/28/2007 65 Female 5/12/2009 Physician United States
Primary
Secondary
Pyrexia Hospitalization 11/1/2007 Male 5/12/2009 Physician United States
Primary
Secondary
Drug Rash With Eosinophilia And Systemic Symptoms Other Serious 1/1/2008 60 Female 5/13/2009 Other Health Professional Japan
Primary
Secondary
Pyrexia Hospitalization 6/26/2009 81 Male 193 lb 7/15/2009 Physician United States
Primary
Secondary
Concomitant
Presyncope Hospitalization 8/1/2007 62 Female 140 lb 8/5/2009 Physician United States
Primary
Secondary
Rash Other Serious 41 Female 10/23/2009 Other Health Professional Italy
Primary
Concomitant
Pancytopenia Other Serious 39 Female 12/3/2009 Physician United States
Primary
Secondary
Septic Shock Other Serious 12/10/2009 Israel
Primary
Concomitant
Septic Shock Death 2/19/2010 Physician Italy
Primary
Secondary
Concomitant
Cardiac Disorder Other Serious 2/22/2010 Korea, Republic Of
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 9/1/2009 Female 3/4/2010 Greece
Primary
Secondary
Concomitant
Pneumonia Death 3/8/2010 Consumer United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 57 Female 3/8/2010 Other Health Professional Poland
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 71 7/14/2010 Italy
Primary
Secondary
Renal Failure Acute Other Serious 1/1/2009 55 Male 186 lb 8/6/2010 Physician United States
Primary
Secondary
Concomitant
Red Blood Cell Count Decreased Other Serious 8/23/2010 Japan
Primary
Secondary
Concomitant
Multiple Myeloma Other Serious 11/3/2010 Other Health Professional United States
Primary
Concomitant
Multiple Myeloma Other Serious Male 11/5/2010 Other Health Professional United States
Primary
Concomitant
Refractory Cytopenia With Multilineage Dysplasia Other Serious 77 Female 12/22/2010 Other Health Professional Spain
Primary
Secondary
Concomitant
Disease Progression Other Serious 1/7/2011 Italy
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/12/2011 Other Health Professional Italy
Primary
Secondary
Concomitant
Death Death 68 1/24/2011 Other Health Professional United States
Primary
Secondary
Breast Cancer Other Serious 61 Male 1/26/2011 Other Health Professional United States
Primary
Secondary
Malignant Melanoma Other Serious 59 1/28/2011 Other Health Professional United States
Primary
Secondary
Myelodysplastic Syndrome Other Serious 54 1/31/2011 Other Health Professional United States
Primary
Secondary
Swelling Other Serious 86 Female 2/10/2011 Pharmacist Germany
Primary
Concomitant
Haemochromatosis Other Serious 67 Male 132 lb 2/24/2011 Physician Japan
Primary
Secondary
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Cytomegaloviral Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/25/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/25/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Other Serious 3/25/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Rash Papular Other Serious 86 Female 5/12/2011 Pharmacist Germany
Primary
Concomitant
Acute Graft Versus Host Disease In Intestine Other Serious 66 Male 5/12/2011 Physician United States
Primary
Secondary
Concomitant
Diverticulitis Hospitalization 6/2/2010 80 Male 165 lb 8/24/2011 Physician Germany
Primary
Secondary
Stress Fracture Other Serious 1/24/2012 Physician United States
Primary
Secondary
Concomitant
No Therapeutic Response Other Serious 2/23/2012 Physician United States
Primary
Secondary
Concomitant
Nausea Hospitalization 4/25/2012 66 Female 71 lb 5/22/2012 Physician United States
Primary
Secondary
Concomitant
Pain Death 11/11/2011 91 Female 142 lb 5/23/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Retching Hospitalization 5/4/2012 57 Female 123 lb 5/24/2012 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Death 2009 72 Male 10/9/2012 Sk
Primary
Concomitant
Squamous Cell Carcinoma Of Skin Death 4/5/2010 69 Female 3/22/2013 Other Health Professional Us
Primary
Secondary
Thrombocytopenia Other Serious NotSpecified 2/19/2013 It
Primary
Secondary
Concomitant
Thrombosis Death 10/10/2012 Other Health Professional Sk
Primary
Concomitant
Renal Failure Other Serious 5/10/2011 80 Female 168 lb 11/3/2012 Physician De
Primary
Concomitant
Haemorrhoids Hospitalization 3/4/2011 76 Female 129 lb 11/1/2012 Consumer Us
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 9/30/2011 57 Male 9/4/2012 Physician Fr
Primary
Secondary
Concomitant
Renal Failure Death 2/21/2012 94 Female 12/20/2012 Other Health Professional Us
Primary
Secondary
Ventricular Tachyarrhythmia Other Serious NotSpecified 3/29/2013 Other Health Professional De
Primary
Concomitant
Osteonecrosis Of Jaw Other Serious 59 Female 9/11/2012 Other Health Professional Fi
Primary
Secondary
Concomitant
Endometrial Cancer Life Threatening 10/17/2011 80 Female 143 lb 8/29/2012 Physician Gr
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 8/3/2012 56 Female 141 lb 9/20/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 59 Female 10/23/2012 Other Health Professional Country Not Specified
Primary
Secondary
Respiratory Failure Life Threatening 10/26/2012 68 Male 173 lb 10/30/2012 Consumer Us
Primary
Secondary
Renal Failure Hospitalization 7/24/2012 84 Male 6/21/2013 Physician De
Primary
Secondary
Concomitant
Wound Infection Staphylococcal Hospitalization 10/7/2012 59 Male 145 lb 6/21/2013 Physician Tw
Primary
Concomitant
Multi-organ Failure Death 11/10/2012 68 Male 173 lb 11/12/2012 Consumer Us
Primary
Secondary
Respiratory Failure Life Threatening 10/26/2012 68 Male 173 lb 10/30/2012 Consumer Us
Primary
Secondary
Zygomycosis Death 54 Male 12/19/2012 De
Primary
Secondary
Thrombocytopenia Other Serious NotSpecified 1/7/2013 Physician Ir
Primary
Concomitant
Thrombocytopenia Other Serious NotSpecified 1/14/2014 Other Health Professional It
Primary
Concomitant
Nausea Hospitalization 1/16/2012 59 Male 301 lb 1/28/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Viral Haemorrhagic Cystitis Other Serious 67 Male 6/6/2013 Consumer Jp
Primary
Secondary
Concomitant
Electrocardiogram Qt Prolonged Hospitalization 1/14/2013 67 Male 2/28/2013 Jp
Primary
Concomitant
Neuropathy Peripheral Other Serious 69 Male 3/19/2013 Physician Si
Primary
Secondary
Concomitant
Thrombocytopenia Required Intervention 56 Female 3/15/2013 Us
Primary
Concomitant
Thrombocytopenia Other Serious NotSpecified 3/22/2013 Physician Us
Primary
Secondary
Septic Shock Other Serious 6/21/2012 52 Female 3/25/2013 Other Health Professional Kr
Primary
Secondary
Platelet Count Decreased Death 62 Male 3/21/2013 In
Primary
Concomitant
Thrombocytopenia Death NotSpecified 4/19/2013 Other Health Professional It
Primary
Secondary
Graft Versus Host Disease Death 54 Female 5/2/2013 Other Health Professional Mx
Primary
Concomitant
Vomiting Death NotSpecified 5/6/2013 Other Health Professional Cn
Primary
Secondary
Concomitant
Death Death NotSpecified 5/17/2013 Other Health Professional Cn
Primary
Secondary
Concomitant
Dysphagia Death 5/1/2013 78 Female 139 lb 5/29/2013 Physician Us
Primary
Concomitant
Vomiting Other Serious 3/5/2013 70 Female 124 lb 6/4/2013 Physician Tw
Primary
Concomitant
Febrile Neutropenia Hospitalization 4/11/2013 57 Male 189 lb 6/6/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Peripheral Sensory Neuropathy Other Serious 57 Female 6/10/2013 Physician Pl
Primary
Secondary
Pancytopenia Hospitalization 5/23/2013 51 Female 112 lb 6/14/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Syncope Hospitalization 5/28/2013 55 Female 97 lb 6/19/2013 Physician Us
Primary
Secondary
Concomitant
Cardiovascular Disorder Hospitalization 2/8/2013 83 Female 6/24/2013 Physician De
Primary
Secondary
Concomitant

Drug Data