Bisoprolol combined with Xarelto

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Gastrointestinal Haemorrhage Hospitalization 2/2/2011 79 Female 3/7/2011 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Duodenal Ulcer Hospitalization 9/11/2011 73 Male 10/7/2011 Physician Finland
Primary
Concomitant
Pruritus Hospitalization 9/15/2011 83 Male 190 lb 10/14/2011 Other Health Professional United Kingdom
Primary
Concomitant
Headache Other Serious 1/1/2012 73 Female 135 lb 2/3/2012 Consumer United States
Primary
Concomitant
Renal Impairment Other Serious 2/7/2012 84 Female 6/22/2012 Physician Belgium
Primary
Concomitant
Haemorrhage Hospitalization 5/15/2012 89 Male 176 lb 6/22/2012 Pharmacist Germany
Primary
Secondary
Concomitant
Incontinence Other Serious 6/1/2012 79 Female 8/3/2012 Physician Germany
Primary
Concomitant
Interacting
Vomiting Life Threatening 6/1/2012 79 Female 8/8/2012 Physician Germany
Primary
Concomitant
Interacting
Cerebral Ischaemia Hospitalization 6/23/2012 80 Female 187 lb 8/13/2012 Physician Germany
Primary
Concomitant
Weight Decreased Hospitalization 4/2012 Male 11/21/2012 Other Health Professional De
Primary
Concomitant
Pancreatitis Hospitalization 5/20/2012 60 Male 234 lb 9/10/2012 Physician De
Primary
Concomitant
Embolic Stroke Hospitalization 5/29/2012 82 Male 132 lb 8/30/2012 Physician De
Primary
Concomitant
Cerebral Ischaemia Hospitalization 6/23/2012 81 Female 187 lb 9/11/2012 Physician De
Primary
Concomitant
Deep Vein Thrombosis Other Serious 8/22/2012 61 Male 220 lb 11/5/2012 Physician De
Primary
Concomitant
Nausea Other Serious 5/27/2012 71 Female 172 lb 8/30/2012 Physician De
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 2012 86 Male 10/4/2012 Consumer Us
Primary
Secondary
Concomitant
Rectal Haemorrhage Other Serious Female 11/5/2012 Physician Ca
Primary
Concomitant
Dermatitis Allergic Other Serious 4/9/2012 54 Female 256 lb 9/21/2012 Other Health Professional De
Primary
Secondary
Concomitant
Death Death 2012 87 Female 9/14/2012 Pharmacist Ca
Primary
Concomitant
Renal Failure Acute Life Threatening Male 154 lb 9/26/2012 Other Health Professional De
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 9/2012 Female 10/5/2012 Physician Fr
Primary
Secondary
Concomitant
Retinal Artery Occlusion Disability 9/4/2012 67 Male 220 lb 9/28/2012 Other Health Professional Gb
Primary
Concomitant
Neuritis Disability 8/6/2011 54 Male 220 lb 2/7/2013 Physician De
Primary
Concomitant
Pain In Extremity Other Serious 9/19/2012 61 Female 243 lb 10/11/2012 Other Health Professional Gb
Primary
Concomitant
Pulmonary Embolism Other Serious 8/23/2012 83 Female 187 lb 10/30/2012 Physician De
Primary
Concomitant
Vascular Encephalopathy Hospitalization 10/5/2012 75 Female 214 lb 2/11/2013 Physician De
Primary
Concomitant
Sleep Disorder Other Serious 5/29/2012 Female 207 lb 10/30/2012 Physician De
Primary
Concomitant
Haemangioma Hospitalization 2012 Male 11/5/2012 Physician Be
Primary
Concomitant
Haemorrhage Hospitalization 6/26/2012 63 Male 11/4/2012 Other Health Professional Se
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 10/5/2012 52 Female 11/7/2012 Physician Fr
Primary
Concomitant
Interacting
Incision Site Haemorrhage Other Serious 6/28/2012 72 Male 168 lb 11/19/2012 Physician De
Primary
Concomitant
Interacting
Venous Occlusion Other Serious Male 1/3/2013 Physician De
Primary
Concomitant
Procedural Haemorrhage Other Serious 6/26/2012 63 Male 280 lb 12/11/2012 Physician Se
Primary
Concomitant
Drug Ineffective Other Serious 10/23/2012 65 Female 265 lb 1/21/2013 Physician De
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/2012 Male 225 lb 11/23/2012 Physician Fr
Primary
Concomitant
Pulmonary Embolism Hospitalization 10/12/2012 73 Male 154 lb 1/7/2013 Physician De
Primary
Concomitant
Malaise Other Serious 10/24/2012 79 Male 185 lb 11/26/2012 Pharmacist Gb
Primary
Concomitant
Renal Failure Other Serious 10/18/2012 Male 11/28/2012 Physician Be
Primary
Secondary
Concomitant
Pulmonary Oedema Other Serious 11/14/2012 69 Male 236 lb 11/29/2012 Physician Ch
Primary
Concomitant
Renal Impairment Other Serious 10/24/2012 Female 1/2/2013 Physician Be
Primary
Concomitant
Vomiting Life Threatening 10/2012 Male 121 lb 10/29/2012 Pharmacist Fr
Primary
Secondary
Concomitant
Peritonitis Hospitalization 10/22/2012 73 Male 3/5/2013 Physician De
Primary
Concomitant
Haemorrhage Other Serious 10/18/2012 74 Female 280 lb 12/10/2012 Physician Gb
Primary
Concomitant
Headache Disability 11/2012 Male 3/28/2013 Physician De
Primary
Concomitant
Hyponatraemia Other Serious 11/9/2012 75 Female 146 lb 12/13/2012 Physician Gb
Primary
Concomitant
Cerebrovascular Accident Disability 11/11/2012 88 Female 141 lb 12/14/2012 Pharmacist Gb
Primary
Concomitant
Upper Respiratory Tract Infection Hospitalization 11/2012 Female 137 lb 12/28/2012 Physician De
Primary
Concomitant
Haemorrhage Intracranial Hospitalization 10/22/2012 84 Male 196 lb 12/28/2012 Physician De
Primary
Secondary
Concomitant
Vomiting Other Serious 11/2012 Female 198 lb 1/15/2013 Physician Fr
Primary
Concomitant
Haemolytic Anaemia Hospitalization Male 161 lb 12/23/2012 Physician De
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Death 9/26/2012 85 Female 130 lb 12/27/2012 Physician Gb
Primary
Concomitant
Haemolytic Anaemia Life Threatening 11/6/2012 75 Male 1/24/2013 Other Health Professional Fr
Primary
Concomitant
International Normalised Ratio Increased Hospitalization Female 1/4/2013 Physician Ie
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 11/8/2012 80 Male 1/3/2013 Other Health Professional Fr
Primary
Concomitant
Gastroenteritis Hospitalization 9/10/2012 71 Male 198 lb 1/15/2013 Physician De
Primary
Secondary
Concomitant
Visual Impairment Life Threatening 12/12/2012 82 Male 154 lb 2/25/2013 Physician De
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 6/30/2012 Female 143 lb 1/21/2013 Physician De
Primary
Concomitant
Thrombocytopenia Other Serious 12/18/2012 63 Male 190 lb 2/1/2013 Physician De
Primary
Concomitant
Lacunar Infarction Life Threatening 1/11/2013 67 NotSpecified 251 lb 2/7/2013 Other Health Professional Gb
Primary
Concomitant
Cerebral Infarction Hospitalization 12/14/2012 Female 134 lb 2/8/2013 Physician De
Primary
Concomitant
Withdrawal Syndrome Other Serious 1/17/2013 86 Female 132 lb 2/6/2013 Other Health Professional Gb
Primary
Concomitant
Myocardial Infarction Death 1/11/2013 83 Female 1/28/2013 Physician At
Primary
Concomitant
Transient Ischaemic Attack Other Serious Male 3/18/2013 Physician Ca
Primary
Concomitant
Chromaturia Other Serious 1/2013 62 Male 2/6/2013 Pharmacist Fr
Primary
Concomitant
Pulmonary Embolism Death 12/3/2012 Female 146 lb 3/15/2013 Physician De
Primary
Concomitant
Hypovolaemic Shock Life Threatening 11/26/2012 76 Male 146 lb 2/20/2013 Physician De
Primary
Concomitant
Syncope Death 1/25/2013 78 Male 196 lb 2/20/2013 Physician Gb
Primary
Concomitant
Atrial Thrombosis Other Serious 2/4/2013 83 Male 198 lb 3/13/2013 Physician De
Primary
Concomitant
Pleural Effusion Hospitalization 12/2012 Female 2/21/2013 Physician Es
Primary
Concomitant
Off Label Use Other Serious 12/22/2012 64 Male 159 lb 1/21/2013 Other Health Professional De
Primary
Concomitant
Interacting
Non-cardiac Chest Pain Disability 1/26/2013 74 Male 234 lb 2/22/2013 Physician Gb
Primary
Concomitant
Hemiparesis Hospitalization 10/12/2012 73 Male 190 lb 3/14/2013 Physician De
Primary
Concomitant
Post Procedural Swelling Hospitalization 2/2/2013 68 Male 4/3/2013 Physician Se
Primary
Concomitant
Ischaemic Stroke Hospitalization 1/11/2013 63 Male 3/11/2013 Physician Hu
Primary
Concomitant
Renal Failure Acute Other Serious 68 Male 209 lb 2/27/2013 Physician Gb
Primary
Concomitant
Haemoglobin Decreased Life Threatening 2/17/2013 69 Male 225 lb 4/7/2013 Physician De
Primary
Concomitant
Renal Impairment Other Serious 76 Female 143 lb 5/6/2013 Pharmacist Gb
Primary
Concomitant
Vascular Purpura Hospitalization 12/22/2012 79 Male 3/1/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Hemiparesis Life Threatening 11/2012 Male 306 lb 3/4/2013 Physician De
Primary
Concomitant
General Physical Health Deterioration Hospitalization 1/11/2013 82 Male 3/7/2013 Other Health Professional Fr
Primary
Concomitant
Neuroleptic Malignant Syndrome Hospitalization 2/16/2013 72 Male 198 lb 3/20/2013 Physician De
Primary
Secondary
Concomitant
Syncope Other Serious 1/21/2013 Male 3/6/2013 Consumer De
Primary
Concomitant
Subdural Haematoma Hospitalization 12/25/2012 68 Female 3/11/2013 Consumer Fr
Primary
Concomitant
Subdural Haematoma Death 2/13/2013 73 Male 176 lb 3/22/2013 Physician De
Primary
Concomitant
Subcutaneous Haematoma Hospitalization 1/24/2012 74 Female 150 lb 5/6/2013 Physician De
Primary
Concomitant
Intestinal Ulcer Hospitalization 2/15/2013 81 Female 161 lb 4/1/2013 Pharmacist Gb
Primary
Concomitant
Cerebral Haemorrhage Other Serious 3/4/2013 90 Female 4/3/2013 Physician Ch
Primary
Concomitant
Rectal Haemorrhage Hospitalization 1/2013 55 Female 101 lb 6/13/2013 Physician De
Primary
Concomitant
Renal Impairment Hospitalization 4/2013 93 Female 4/15/2013 Physician Fr
Primary
Concomitant
Pulmonary Haemorrhage Hospitalization 2/24/2013 62 Female 4/29/2013 Physician Be
Primary
Concomitant
Thrombocytopenia Hospitalization 2/1/2013 77 Male 181 lb 8/28/2013 Physician De
Primary
Concomitant
Loss Of Consciousness Hospitalization 2/4/2013 78 Female 4/11/2013 Physician De
Primary
Concomitant
Pneumonia Death 10/12/2012 81 Male 6/21/2013 Pharmacist De
Primary
Secondary
Concomitant
Haematochezia Other Serious 1/1/2013 87 Female 234 lb 4/18/2013 Physician De
Primary
Secondary
Gastrointestinal Haemorrhage Hospitalization 1/30/2013 75 Female 5/29/2013 Physician Be
Primary
Concomitant
Dehydration Hospitalization 11/16/2012 88 Female 5/3/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 3/13/2013 72 Female 165 lb 6/19/2013 Physician De
Primary
Secondary
Concomitant
Renal Failure Hospitalization 11/16/2012 88 Female 5/7/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Tenotomy Other Serious 4/2013 79 Male 159 lb 5/8/2013 Physician De
Primary
Secondary
Concomitant
Vertigo Other Serious Female 6/21/2013 Pharmacist Ca
Primary
Concomitant
Jaundice Hospitalization 12/10/2012 74 Male 154 lb 7/18/2013 Physician De
Primary
Concomitant
Shock Hospitalization 4/22/2013 55 Female 139 lb 5/15/2013 Physician Fr
Primary
Concomitant
Swelling Face Other Serious 3/4/2013 70 Male 192 lb 6/12/2013 Consumer De
Primary
Concomitant
Visual Impairment Hospitalization 4/19/2013 82 Male 163 lb 6/13/2013 Physician De
Primary
Concomitant
Hypersensitivity Vasculitis Other Serious 4/6/2013 82 Male 397 lb 8/14/2013 Physician De
Primary
Concomitant
Subclavian Artery Thrombosis Other Serious 4/20/2013 79 Male 5/7/2013 Physician Pl
Primary
Concomitant
Cerebral Haemorrhage Hospitalization 4/24/2013 80 Female 7/15/2013 Physician Il
Primary
Concomitant
Ischaemic Stroke Death 4/4/2013 89 Female 5/14/2013 Other Health Professional Fr
Primary
Concomitant
Nausea Hospitalization Female 192 lb 5/20/2013 Physician De
Primary
Concomitant
Rectal Haemorrhage Other Serious 1/18/2013 77 Male 115 lb 5/20/2013 Pharmacist Gb
Primary
Concomitant
Tremor Other Serious 2/26/2013 56 Male 231 lb 5/20/2013 Pharmacist Gb
Primary
Concomitant
Malaise Other Serious 79 Male 260 lb 5/22/2013 Other Health Professional Gb
Primary
Concomitant
Pulmonary Embolism Hospitalization 5/8/2013 73 Male 115 lb 6/14/2013 Physician De
Primary
Concomitant
Pain In Extremity Other Serious 4/19/2013 81 Male 5/24/2013 Other Health Professional Gb
Primary
Concomitant
Thrombocytopenia Other Serious 4/17/2013 78 Female 172 lb 7/22/2013 Physician De
Primary
Concomitant
Suicidal Ideation Hospitalization 66 Male 196 lb 7/12/2013 Physician Gb
Primary
Concomitant
Ischaemic Stroke Disability 10/14/2012 72 Male 187 lb 7/9/2013 Physician De
Primary
Secondary
Concomitant
Cerebrovascular Accident Other Serious 5/17/2013 89 Male 5/30/2013 Physician Us
Primary
Concomitant
Sensory Disturbance Life Threatening Male 209 lb 6/3/2013 Physician De
Primary
Concomitant
Renal Impairment Hospitalization 5/10/2013 83 Male 8/28/2013 Physician Fr
Primary
Concomitant
Memory Impairment 11/2012 77 Male 125 lb 6/4/2013 Consumer Us
Primary
Concomitant
Pulmonary Embolism Other Serious 12/31/2012 79 Female 130 lb 6/5/2013 Pharmacist Gb
Primary
Concomitant
Deep Vein Thrombosis Hospitalization 4/13/2013 83 Male 176 lb 7/26/2013 Physician Es
Primary
Concomitant
Urinary Retention Hospitalization 5/26/2013 Male 6/21/2013 Physician De
Primary
Concomitant
Skin Necrosis Other Serious 4/21/2013 77 Male 6/11/2013 Other Health Professional Fr
Primary
Concomitant
Gingival Bleeding Hospitalization 1/1/2013 76 Female 154 lb 6/17/2013 Physician De
Primary
Concomitant
Renal Failure Chronic Hospitalization 4/2013 63 Female 121 lb 6/20/2013 Pharmacist Ch
Primary
Secondary
Concomitant
Iron Deficiency Anaemia Life Threatening 11/29/2012 81 Female 165 lb 6/21/2013 Physician De
Primary
Concomitant
Headache Hospitalization 1/10/2013 54 Male 187 lb 6/24/2013 Other Health Professional Gb
Primary
Concomitant
Subdural Haematoma Death 6/6/2013 78 Female 6/26/2013 Other Health Professional Fr
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 6/10/2013 80 Male 194 lb 7/1/2013 Physician Es
Primary
Concomitant
Gastrointestinal Haemorrhage Other Serious 5/1/2013 94 Female 139 lb 6/27/2013 Physician Gb
Primary
Concomitant
Osteoarthritis Hospitalization Male 366 lb 6/28/2013 Consumer Ca
Primary
Concomitant
Dyspnoea Hospitalization 5/13/2013 74 Female 7/15/2013 Physician De
Primary
Concomitant
Cardiac Disorder Hospitalization 6/18/2013 65 Male 7/1/2013 Pharmacist Fr
Primary
Concomitant
Ischaemic Stroke Hospitalization 10/14/2012 72 Male 187 lb 7/1/2013 Physician De
Primary
Secondary
Concomitant
Thrombosis Death 6/6/2013 62 Female 7/4/2013 Other Health Professional Fr
Primary
Concomitant
Sepsis Hospitalization 6/7/2013 77 Female 139 lb 8/14/2013 Physician De
Primary
Concomitant
Polyarthritis Other Serious 4/29/2013 92 Female 126 lb 7/15/2013 Physician De
Primary
Concomitant
Nausea Hospitalization 6/17/2013 81 Female 167 lb 7/15/2013 Physician Gb
Primary
Concomitant
Syncope Other Serious 5/16/2013 75 Female 183 lb 7/15/2013 Physician De
Primary
Concomitant
Tachycardia Other Serious 2013 75 Female 185 lb 7/15/2013 Physician Country Not Specified
Primary
Concomitant
Viith Nerve Paralysis Hospitalization 5/30/2013 83 Female 7/17/2013 Physician Gb
Primary
Concomitant
Weight Increased Hospitalization 3/25/2013 58 Male 7/25/2013 Other Health Professional Fr
Primary
Concomitant
Renal Function Test Abnormal Other Serious 5/27/2013 78 Male 163 lb 7/22/2013 Physician De
Primary
Concomitant
Thrombocytopenia Hospitalization 6/6/2013 63 Male 7/22/2013 Other Health Professional Fr
Primary
Concomitant
Weight Increased Hospitalization 3/25/2013 58 Male 7/25/2013 Other Health Professional Fr
Primary
Concomitant
Off Label Use Other Serious 5/3/2013 58 Female 135 lb 7/23/2013 Consumer De
Primary
Concomitant
Renal Failure Other Serious 2013 85 Female 8/27/2013 Consumer Ca
Primary
Concomitant
Sedation Disability 6/15/2013 69 Female 112 lb 7/26/2013 Physician Gb
Primary
Concomitant

Drug Data