Bisoprolol Fumarate combined with Spironolactone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Toe Amputation Hospitalization 10/1/2005 73 Male 1/12/2006 Physician Netherlands
Primary
Concomitant
Gamma-glutamyltransferase Increased Required Intervention 11/24/2005 89 Female 129 lb 2/1/2006 Germany
Primary
Concomitant
White Blood Cell Count Decreased Death 9/5/2005 33 Male 2/13/2006 Physician Japan
Primary
Concomitant
Weight Decreased Other Serious 2/1/2006 83 Female 112 lb 6/21/2006 United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 12/1/2004 65 Male 201 lb 6/23/2006 Physician Netherlands
Primary
Secondary
Concomitant
Left Ventricular Failure Life Threatening 84 Male 7/14/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Metastases To Central Nervous System Hospitalization 11/14/2005 78 154 lb 7/18/2006 Physician Germany
Primary
Concomitant
Urinary Tract Infection Hospitalization 12/15/2004 65 Male 7/21/2006 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 10/31/2005 45 Female 7/28/2006 Physician Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 12/1/2004 65 Male 8/9/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Required Intervention 7/30/2006 76 Female 118 lb 8/6/2006 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Other Serious 4/4/2006 91 Male 8/8/2006 Denmark
Primary
Concomitant
Ventricular Tachycardia Hospitalization 11/1/2002 57 Male 8/8/2006 Other Health Professional Japan
Primary
Concomitant
Rhabdomyolysis Death 4/9/2006 69 Female 8/18/2006 Other Health Professional Denmark
Primary
Concomitant
Left Ventricular Failure Life Threatening 84 Male 8/25/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Blood Amylase Increased Other Serious 5/1/2005 78 Male 9/5/2006 United Kingdom
Primary
Concomitant
Neutropenia Hospitalization 8/10/2006 82 Male 90 lb 9/26/2006 Physician Germany
Primary
Concomitant
Neutropenia Other Serious 74 Female 175 lb 10/10/2006 Physician
Primary
Secondary
Concomitant
Respiratory Tract Infection Hospitalization 9/22/2005 65 183 lb 10/11/2006 Physician Ireland
Primary
Concomitant
Neutropenia Other Serious 74 Female 10/16/2006 Physician
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 9/16/2005 65 183 lb 10/19/2006 Physician Ireland
Primary
Concomitant
Neutropenia Other Serious 74 Female 10/23/2006 Physician
Primary
Secondary
Concomitant
Neutropenia Other Serious 74 Female 175 lb 10/18/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 5/2/2006 65 Male 11/1/2006 Other Health Professional France
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 4/26/2006 36 Female 117 lb 1/11/2007 Physician Ireland
Primary
Concomitant
Renal Failure Acute Hospitalization 12/20/2006 81 Male 1/18/2007
Primary
Secondary
Concomitant
Deep Vein Thrombosis Hospitalization 11/9/2006 73 Male 183 lb 1/19/2007 Physician Germany
Primary
Concomitant
Toe Amputation Hospitalization 10/1/2005 73 Male 1/16/2007 Netherlands
Primary
Concomitant
Renal Failure Acute Hospitalization 12/20/2006 81 Male 1/26/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Lung Neoplasm Hospitalization 1/4/2007 65 Male 1/29/2007 Physician Hungary
Primary
Concomitant
Myositis Life Threatening 6/1/2006 75 Male 139 lb 3/1/2007 United Kingdom
Primary
Concomitant
Renal Impairment Hospitalization 3/12/2007 77 Female 4/26/2007 United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 3/12/2007 77 Female 4/28/2007 United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 3/12/2007 77 Female 4/30/2007 United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 3/7/2007 72 Male 5/11/2007 Physician United Kingdom
Primary
Concomitant
White Blood Cells Urine Positive Other Serious 7/17/2006 Male 5/18/2007 Physician Belgium
Primary
Concomitant
Ventricular Fibrillation Hospitalization 12/4/2006 Female 198 lb 6/15/2007 Physician Germany
Primary
Secondary
Concomitant
Guillain-barre Syndrome Other Serious 58 Male 6/18/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sensory Loss Other Serious 58 Male 6/19/2007 United Kingdom
Primary
Secondary
Concomitant
Weight Increased Life Threatening 47 Male 143 lb 7/31/2007 Physician United Kingdom
Primary
Concomitant
Guillain-barre Syndrome Other Serious 58 Male 7/6/2007 United Kingdom
Primary
Secondary
Concomitant
Renal Failure Hospitalization 12/1/2004 79 Female 8/13/2007 Other Health Professional France
Primary
Secondary
Concomitant
Therapeutic Response Decreased Hospitalization 58 Male 9/7/2007 United Kingdom
Primary
Secondary
Concomitant
Metastases To Bone Hospitalization 8/27/2007 56 Female 128 lb 9/7/2007 Physician Japan
Primary
Concomitant
Renal Failure Other Serious 58 Male 9/13/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Breast Cancer Recurrent Hospitalization 8/27/2007 56 Female 128 lb 9/20/2007 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 9/21/2007 United Kingdom
Primary
Secondary
Concomitant
Psoriasis Other Serious 3/29/2007 Male 9/26/2007 Other Health Professional United Kingdom
Primary
Concomitant
Intra-abdominal Haematoma Other Serious 1/1/2007 58 Male 10/8/2007 Other Health Professional United Kingdom
Primary
Concomitant
Intra-abdominal Haematoma Other Serious 8/14/2007 58 Male 280 lb 10/3/2007 United Kingdom
Primary
Secondary
Concomitant
Intra-abdominal Haematoma Other Serious 1/1/2007 Male 281 lb 10/12/2007 Physician United Kingdom
Primary
Concomitant
Intra-abdominal Haematoma Other Serious 58 Male 10/15/2007 United Kingdom
Primary
Secondary
Concomitant
Vasculitis Hospitalization 6/21/2007 75 Female 10/18/2007 Consumer United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 3/9/2007 77 Female 282 lb 10/24/2007 Other Health Professional Australia
Primary
Secondary
Concomitant
Pain 1/1/2002 54 Male 10/24/2007 Consumer United States
Primary
Concomitant
Breast Cancer Recurrent Hospitalization 8/27/2007 Female 128 lb 10/25/2007 Physician Japan
Primary
Concomitant
General Physical Health Deterioration Hospitalization 7/13/2006 85 Female 11/14/2007 Physician Germany
Primary
Secondary
Concomitant
Haemorrhage Hospitalization 6/13/2006 65 Male 11/28/2007 Other Health Professional France
Primary
Secondary
Concomitant
Septic Shock Life Threatening 8/6/2007 53 Male 11/20/2007 Germany
Primary
Concomitant
Bladder Neoplasm Hospitalization 8/2/2007 71 Male 11/29/2007 Poland
Primary
Concomitant
Bladder Neoplasm Hospitalization 9/2/2007 Male 12/4/2007 Poland
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 8/4/2003 Female 1/25/2008 Physician Germany
Primary
Secondary
Concomitant
Cardiac Failure Hospitalization 9/28/2006 82 Female 1/29/2008 Physician Italy
Primary
Concomitant
Haemorrhage Hospitalization 6/13/2006 65 Male 2/4/2008 Other Health Professional France
Primary
Secondary
Concomitant
Urethritis Hospitalization 1/30/2008 63 Male 2/4/2008 Norway
Primary
Concomitant
Polymyositis Hospitalization 12/1/2006 77 Male 2/18/2008 Other Health Professional Norway
Primary
Concomitant
Polyneuropathy Hospitalization 10/1/2006 Male 2/25/2008 Other Health Professional France
Primary
Concomitant
Syncope Life Threatening 2/4/2008 63 Male 165 lb 2/27/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Death 2/4/2008 63 Male 165 lb 2/25/2008 United Kingdom
Primary
Secondary
Concomitant
Syncope Life Threatening 2/4/2008 63 Male 2/29/2008 United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 11/14/2006 48 Male 201 lb 3/11/2008 Physician Germany
Primary
Secondary
Concomitant
Nodal Rhythm Hospitalization 11/27/2007 65 Male 3/20/2008 Spain
Primary
Secondary
Weight Increased Other Serious 65 Male 163 lb 4/4/2008 Consumer Germany
Primary
Concomitant
Thrombocytopenia Hospitalization 11/14/2006 Male 201 lb 4/7/2008 Physician Germany
Primary
Secondary
Concomitant
Coronary Artery Disease Life Threatening 5/2/2007 Female 4/11/2008 United Kingdom
Primary
Concomitant
Palpitations Hospitalization 3/17/2008 76 Female 4/16/2008 Germany
Primary
Secondary
Concomitant
Septic Shock Life Threatening 8/6/2007 53 Male 4/16/2008 Germany
Primary
Concomitant
Drug Level Below Therapeutic Other Serious 1/1/2008 61 Male 4/25/2008 Physician United Kingdom
Primary
Concomitant
Renal Failure Acute Hospitalization 6/1/2007 86 Male 5/6/2008 Pharmacist United States
Primary
Secondary
Palpitations Hospitalization 3/17/2008 76 Female 5/7/2008 Physician Germany
Primary
Secondary
Concomitant
Haemoglobin Abnormal Hospitalization 2/20/2008 71 Female 5/14/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Septic Shock Life Threatening 8/6/2007 53 Male 5/9/2008 Germany
Primary
Concomitant
Syncope Life Threatening 5/22/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Haemoglobin Abnormal Hospitalization 2/20/2008 71 Female 5/22/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Bile Duct Cancer Life Threatening 70 Female 143 lb 5/22/2008 Other Health Professional United Kingdom
Primary
Concomitant
Bile Duct Cancer Life Threatening 70 Female 5/20/2008 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Life Threatening 83 Female 143 lb 5/22/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Other Serious 83 Female 143 lb 5/16/2008 United Kingdom
Primary
Secondary
Concomitant
Haemoglobin Abnormal Other Serious 2/20/2008 71 Female 5/20/2008 United Kingdom
Primary
Secondary
Concomitant
Hospitalisation Hospitalization 4/21/2008 Male 203 lb 5/30/2008 Romania
Primary
Concomitant
Syncope Life Threatening 6/2/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Syncope Other Serious 83 Female 5/30/2008 United Kingdom
Primary
Secondary
Concomitant
Ill-defined Disorder Other Serious 2/13/2008 Female 143 lb 6/4/2008 Physician Germany
Primary
Concomitant
Syncope Life Threatening 83 Female 5/29/2008 United Kingdom
Primary
Secondary
Concomitant
Syncope Life Threatening 83 Female 143 lb 6/9/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Syncope Life Threatening 83 Female 143 lb 6/9/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urethritis Hospitalization 1/30/2008 63 Male 6/5/2008 Norway
Primary
Concomitant
Syncope Other Serious 83 Female 6/6/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 6/16/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 83 Female 143 lb 6/10/2008
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 4/28/2008 Male 6/20/2008 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Life Threatening 4/15/2008 Female 6/20/2008 Other Health Professional France
Primary
Concomitant
Interacting
Thrombocytopenia Other Serious 8/22/2004 61 Female 6/20/2008 Germany
Primary
Concomitant
Renal Failure Hospitalization 1/1/2004 58 Male 6/27/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Blood Lactate Dehydrogenase Increased Other Serious 5/30/2008 38 Female 176 lb 7/2/2008 Other Health Professional Germany
Primary
Concomitant
Renal Failure Other Serious 58 Male 6/24/2008 United Kingdom
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 4/30/2008 Female 320 lb 7/11/2008 Consumer United Kingdom
Primary
Concomitant
Catheter Related Infection Life Threatening 6/30/2008 Male 236 lb 7/18/2008 Physician United States
Primary
Secondary
Concomitant
Tachyarrhythmia Life Threatening 7/2/2008 Female 284 lb 7/28/2008 Physician Germany
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 7/2/2008 50 Female 7/29/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint 6/30/2008 57 Female 119 lb 7/24/2008 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Hospitalization 11/14/2006 Male 201 lb 8/5/2008 Physician Germany
Primary
Secondary
Concomitant
Palpitations Hospitalization 3/17/2008 76 Female 8/18/2008 Germany
Primary
Secondary
Concomitant
Cardiac Failure Other Serious 61 Male 8/27/2008 United States
Primary
Concomitant
Urinary Tract Infection Other Serious 10/2/2007 Female 199 lb 8/29/2008 Physician United Kingdom
Primary
Concomitant
Rhabdomyolysis Other Serious 74 Male 9/4/2008 United Kingdom
Primary
Secondary
Concomitant
Interacting
Catheter Related Infection Life Threatening 6/30/2008 Male 236 lb 9/5/2008 Physician United States
Primary
Secondary
Concomitant
Palpitations Hospitalization 3/17/2008 76 Female 9/5/2008 Germany
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 6/8/2007 Female 9/17/2008 Other Health Professional United Kingdom
Primary
Concomitant
Atrial Fibrillation Hospitalization 6/27/2008 69 Female 9/12/2008 Physician Poland
Primary
Concomitant
Infarction Life Threatening 3/16/2008 Female 320 lb 10/1/2008 Consumer United Kingdom
Primary
Concomitant
Cardio-respiratory Arrest Death 9/21/2008 Male 176 lb 10/16/2008 Other Health Professional France
Primary
Concomitant
Renal Failure Acute Other Serious 4/4/2006 91 Male 10/22/2008 Denmark
Primary
Concomitant
Rhabdomyolysis Death 4/9/2006 69 Female 10/22/2008 Denmark
Primary
Concomitant
Vomiting Hospitalization 5/13/2008 Female 132 lb 10/29/2008 Physician Germany
Primary
Secondary
Concomitant
Ventricular Tachycardia Life Threatening 73 NotSpecified 212 lb 10/24/2008 Physician United Kingdom
Primary
Concomitant
Nodal Rhythm Hospitalization 11/27/2007 65 Male 10/30/2008 Spain
Primary
Secondary
International Normalised Ratio Increased Hospitalization 9/25/2008 77 Male 11/10/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 2/5/2007 71 Female 11/10/2008 Other Health Professional United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Life Threatening 10/21/2008 86 Female 11/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ventricular Dysfunction Other Serious 61 Male 11/21/2008 Italy
Primary
Concomitant
Renal Failure Acute Hospitalization 2/5/2007 71 Female 11/24/2008 Other Health Professional United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Life Threatening 10/21/2008 86 Female 11/18/2008 United Kingdom
Primary
Secondary
Concomitant
Death Death 11/22/2007 Male 185 lb 12/1/2008 Physician United Kingdom
Primary
Concomitant
Haemoglobin Decreased Life Threatening 10/21/2008 86 Female 11/25/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Cytolytic Hepatitis Hospitalization 9/10/2008 Female 12/8/2008 Consumer Germany
Primary
Secondary
Concomitant
Pneumonia Life Threatening 10/1/2008 65 Female 12/9/2008 Physician Austria
Primary
Secondary
Concomitant
Ventricular Tachycardia Life Threatening 73 Male 212 lb 11/26/2008 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Hospitalization 11/14/2006 Male 201 lb 12/12/2008 Physician Germany
Primary
Secondary
Concomitant
Pulmonary Hypertension Life Threatening 11/27/2008 Female 12/12/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Septic Shock Life Threatening 1/10/2008 63 Male 12/4/2008 Australia
Primary
Secondary
Concomitant
Pulmonary Hypertension Life Threatening 11/27/2008 Female 12/17/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Hepatic Encephalopathy Hospitalization 3/20/2007 69 Male 258 lb 12/19/2008 Other Health Professional Canada
Primary
Concomitant
Renal Failure Acute Life Threatening 10/22/2008 51 Male 12/22/2008 Other Health Professional France
Primary
Secondary
Concomitant
Product Quality Issue Death 4/7/2007 72 Male 170 lb 12/19/2008 Consumer United States
Primary
Concomitant
Myocardial Infarction Death 3/14/2008 Female 148 lb 12/17/2008 Physician Canada
Primary
Concomitant
Pleural Effusion Death 9/4/2008 85 Female 12/26/2008 Physician Germany
Primary
Concomitant
Thrombocytopenia Hospitalization 11/14/2006 Male 201 lb 12/29/2008 Physician Germany
Primary
Secondary
Concomitant
Ventricular Dysfunction Life Threatening 11/27/2008 Female 12/31/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Life Threatening 1/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Interacting

Drug Data