Bisoprolol Fumarate combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Eosinophilia Other Serious 7/1/2001 55 Female 3/23/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Breast Cancer Female Life Threatening Female 3/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Eosinophilia Other Serious 7/1/2001 55 Female 5/8/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Hospitalization 71 Male 5/19/2006 Physician United Kingdom
Primary
Concomitant
Pulmonary Embolism Hospitalization 3/13/2006 81 Female 5/24/2006 Physician France
Primary
Secondary
Concomitant
Shock Hospitalization 1/1/2004 53 Female 6/29/2006 Other Health Professional France
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 2/24/2006 Female 7/19/2006 Physician Belgium
Primary
Concomitant
Lung Infection Hospitalization 5/29/2006 76 Female 7/6/2006 Consumer France
Primary
Concomitant
Vomiting Hospitalization 1/1/2006 Female 161 lb 9/7/2006 Other Health Professional United Kingdom
Primary
Concomitant
Breast Cancer Female Hospitalization Female 10/6/2006 Pharmacist Germany
Primary
Concomitant
Tendon Rupture Hospitalization 6/1/2006 Female 126 lb 10/11/2006 Physician Germany
Primary
Secondary
Concomitant
Diverticular Perforation Other Serious 4/7/2004 Female 132 lb 12/1/2006 Germany
Primary
Concomitant
Urinary Tract Infection Hospitalization 8/15/2006 Male 12/4/2006 Other Health Professional Spain
Primary
Concomitant
Vomiting Hospitalization 1/27/2004 53 Female 11/28/2006 Other Health Professional France
Primary
Secondary
Concomitant
Headache Other Serious 12/20/2006 Male 1/9/2007 Other Health Professional United Kingdom
Primary
Concomitant
Convulsion Hospitalization 10/15/2006 Male 141 lb 1/9/2007 Other Health Professional United Kingdom
Primary
Concomitant
Death Other Serious 12/16/2006 Male 187 lb 1/11/2007 Physician United Kingdom
Primary
Concomitant
Myocardial Ischaemia Other Serious 8/21/2006 Male 168 lb 2/1/2007 Other Health Professional United Kingdom
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 7/5/2006 152 lb 2/8/2007 Other Health Professional United Kingdom
Primary
Concomitant
Pneumonia Hospitalization 12/22/2006 Male 198 lb 2/21/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 2/20/2007 Female 132 lb 5/18/2007 Consumer United Kingdom
Primary
Concomitant
Lower Respiratory Tract Infection Other Serious 7/5/2006 Male 152 lb 7/20/2007 Other Health Professional United Kingdom
Primary
Concomitant
Ischaemic Cerebral Infarction Other Serious 5/16/2006 66 Female 9/28/2007 Physician Germany
Primary
Concomitant
Gastric Ulcer Death 8/1/2007 Male 205 lb 10/4/2007 Physician Poland
Primary
Concomitant
Right Ventricular Failure Other Serious 3/1/2007 Male 161 lb 10/22/2007 Germany
Primary
Secondary
Concomitant
Treatment Noncompliance Other Serious 3/1/2007 Male 11/9/2007 Physician Germany
Primary
Secondary
Concomitant
Urine Analysis Abnormal Other Serious 53 Male 11/13/2007 Other Health Professional Portugal
Primary
Secondary
Concomitant
Renal Failure Hospitalization 7/9/2007 Male 11/30/2007 Australia
Primary
Concomitant
Malignant Neoplasm Of Pleura Life Threatening 11/9/2007 Male 161 lb 11/30/2007 Physician Germany
Primary
Concomitant
Superinfection Other Serious 7/20/2007 Male 190 lb 12/5/2007 Belgium
Primary
Concomitant
Renal Tubular Necrosis Other Serious 53 Male 12/6/2007 Other Health Professional Portugal
Primary
Secondary
Venous Thrombosis Other Serious 53 Male 12/7/2007 Physician Portugal
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 75 Male 1/7/2008 Germany
Primary
Concomitant
Skin Ulcer Other Serious 5/1/2006 Male 1/18/2008 Belgium
Primary
Concomitant
Transaminases Increased Hospitalization 10/3/2006 48 Female 1/23/2008 Physician Netherlands
Primary
Concomitant
Transaminases Increased Hospitalization 10/3/2006 48 Female 1/25/2008 Physician Netherlands
Primary
Concomitant
Pneumonia Legionella Hospitalization 1/8/2008 69 Male 181 lb 1/29/2008 Physician Italy
Primary
Secondary
Concomitant
Ischaemic Cerebral Infarction Other Serious 5/16/2006 66 Female 2/8/2008 Physician Germany
Primary
Concomitant
Pelvic Fracture Hospitalization 2/5/2007 Female 130 lb 2/18/2008 Canada
Primary
Concomitant
Right Ventricular Failure Other Serious 3/1/2007 Male 161 lb 2/20/2008 Germany
Primary
Secondary
Concomitant
Pelvic Fracture Hospitalization 2/5/2007 Female 130 lb 3/3/2008 Canada
Primary
Concomitant
Restlessness Hospitalization Female 3/5/2008 Germany
Primary
Concomitant
Accidental Exposure 12/25/2007 Female 210 lb 3/14/2008 Consumer United States
Primary
Concomitant
Urinary Tract Infection Other Serious 3/1/2007 Male 161 lb 3/18/2008 Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 3/1/2007 Male 161 lb 3/24/2008 Germany
Primary
Secondary
Concomitant
Haematochezia Other Serious 1/1/2008 70 Female 141 lb 3/28/2008 Other Health Professional Canada
Primary
Concomitant
Cardiomyopathy Other Serious 30 Female 4/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Myocardial Infarction Death 3/28/2008 Female 4/17/2008 Germany
Primary
Concomitant
Anaphylactic Reaction Other Serious 3/31/2008 64 Male 5/13/2008 Physician
Primary
Concomitant
Vomiting Hospitalization 1/12/2007 71 Female 130 lb 5/16/2008 Physician Germany
Primary
Secondary
Concomitant
Bronchopneumonia Death 4/6/2008 Male 220 lb 5/16/2008 Czech Republic
Primary
Secondary
Concomitant
Weight Increased Hospitalization 7/1/2007 Male 5/21/2008 Germany
Primary
Secondary
Concomitant
Bronchopneumonia Death 4/6/2008 Male 220 lb 5/23/2008 Czech Republic
Primary
Secondary
Concomitant
Bronchopneumonia Hospitalization 4/6/2008 Male 220 lb 6/2/2008 Czech Republic
Primary
Secondary
Concomitant
Palpitations Other Serious 3/1/2008 Female 180 lb 6/4/2008 Physician Canada
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 Male 6/6/2008 Germany
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious 11/1/2007 Female 167 lb 6/12/2008 Consumer United Kingdom
Primary
Concomitant
Right Ventricular Failure Hospitalization 4/6/2008 Male 220 lb 6/16/2008 Czech Republic
Primary
Secondary
Concomitant
Hip Fracture Hospitalization 3/27/2008 Female 6/17/2008 Consumer United Kingdom
Primary
Concomitant
Non-small Cell Lung Cancer Stage Iv Life Threatening 4/10/2008 Male 150 lb 6/18/2008 Physician Netherlands
Primary
Secondary
Concomitant
Infarction Hospitalization 2/21/2008 Male 6/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Hyperplasia Hospitalization 8/21/2007 58 Female 6/30/2008 Germany
Primary
Secondary
Concomitant
Pneumonia Other Serious 12/1/2007 72 Female 7/9/2008 Physician Australia
Primary
Concomitant
Heart Rate Irregular Hospitalization 5/1/2008 Female 7/10/2008 Belgium
Primary
Concomitant
Hyperplasia Hospitalization 8/21/2007 58 Female 7/11/2008 Germany
Primary
Secondary
Concomitant
Cutaneous Lupus Erythematosus Other Serious 2/1/2006 71 Male 196 lb 7/11/2008 Physician France
Primary
Concomitant
Cerebrovascular Accident Hospitalization 2/21/2008 Male 7/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombosis Other Serious 53 Male 7/16/2008 Other Health Professional Portugal
Primary
Secondary
Concomitant
Stevens-johnson Syndrome Life Threatening 4/11/2008 7/21/2008 Physician United States
Primary
Secondary
Concomitant
Sepsis Life Threatening 1/1/2008 Male 7/23/2008 Other Health Professional France
Primary
Secondary
Concomitant
Sepsis Life Threatening 4/11/2008 Male 7/30/2008 Other Health Professional France
Primary
Secondary
Concomitant
Vomiting Other Serious 7/22/2008 58 Female 117 lb 7/30/2008 Pharmacist United Kingdom
Primary
Concomitant
Myocardial Infarction Hospitalization 3/28/2008 Female 8/6/2008 Germany
Primary
Secondary
Concomitant
Goitre Hospitalization Female 8/7/2008 Belgium
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 Male 8/8/2008 Germany
Primary
Secondary
Concomitant
Restlessness Hospitalization 11/11/2006 Female 8/8/2008 Germany
Primary
Concomitant
Urinary Tract Infection Other Serious 3/1/2007 Male 161 lb 8/8/2008 Germany
Primary
Secondary
Concomitant
Hepatic Steatosis Other Serious 1/1/2008 Male 181 lb 8/15/2008 Germany
Primary
Concomitant
Weight Increased Hospitalization 7/1/2007 Male 8/19/2008 Germany
Primary
Secondary
Concomitant
Troponin Increased Hospitalization 9/12/2005 Male 8/26/2008 Physician France
Primary
Secondary
Concomitant
Retinal Vein Thrombosis Hospitalization 8/8/2008 Female 172 lb 8/29/2008 Physician Germany
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 5/24/2006 Female 9/4/2008 Germany
Primary
Concomitant
Pericardial Effusion Hospitalization 9/12/2005 Male 9/12/2008 Other Health Professional France
Primary
Secondary
Concomitant
Headache 6/1/2008 Female 9/12/2008 United States
Primary
Concomitant
Shock Death 4/8/2008 17 Male 9/12/2008 Other Health Professional France
Primary
Secondary
Concomitant
Cardiac Failure Congestive Other Serious 9/7/2007 Female 106 lb 9/22/2008 Other Health Professional United Kingdom
Primary
Concomitant
Haematuria Hospitalization 11/18/2007 53 Male 206 lb 9/30/2008 Other Health Professional United Kingdom
Primary
Concomitant
Vasculitis Disability Male 168 lb 9/30/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 5/24/2006 Female 10/15/2008 Germany
Primary
Concomitant
Coronary Artery Disease Hospitalization 9/26/2008 Female 11/5/2008 Belgium
Primary
Concomitant
Retinal Vein Thrombosis Hospitalization 8/8/2008 Female 172 lb 11/7/2008 Physician Germany
Primary
Secondary
Concomitant
Coronary Artery Disease Hospitalization 9/26/2008 Female 11/12/2008 Belgium
Primary
Concomitant
Hepatic Steatosis Other Serious 1/1/2008 Male 181 lb 11/17/2008 Germany
Primary
Concomitant
Acute Coronary Syndrome Hospitalization Female 11/24/2008 Belgium
Primary
Concomitant
Renal Failure Life Threatening 7/5/2007 Male 11/25/2008 Australia
Primary
Concomitant
Encephalopathy Other Serious 5/24/2006 Female 12/2/2008 Germany
Primary
Concomitant
Hyperthyroidism Hospitalization 12/3/2007 Female 12/2/2008 Belgium
Primary
Concomitant
Pulmonary Embolism Hospitalization 4/12/2006 Male 12/3/2008 Physician France
Primary
Concomitant
Osteolysis Hospitalization 3/14/2008 82 Female 12/8/2008 Other Health Professional Italy
Primary
Concomitant
Osteolysis Hospitalization 3/14/2008 82 Female 12/26/2008 Other Health Professional Italy
Primary
Concomitant
Pneumonia Legionella Hospitalization 1/8/2008 69 Male 181 lb 12/30/2008 Physician Italy
Primary
Secondary
Concomitant
Foot Operation Hospitalization 11/27/2008 Female 12/31/2008 Consumer Germany
Primary
Concomitant
White Blood Cell Disorder Life Threatening 9/1/2008 65 Female 180 lb 1/5/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Wound Haemorrhage Other Serious 5/1/2006 Male 1/9/2009 Belgium
Primary
Concomitant
Skin Ulcer Hospitalization 5/1/2007 Female 1/26/2009 Physician Germany
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 11/25/2008 62 Female 163 lb 1/28/2009 Other Health Professional France
Primary
Concomitant
Toxic Epidermal Necrolysis Other Serious 11/28/2008 Female 163 lb 2/6/2009 Germany
Primary
Secondary
Concomitant
Diverticular Perforation Other Serious 4/7/2004 Female 132 lb 3/27/2009 Germany
Primary
Concomitant
Haematuria Life Threatening 11/18/2007 Male 206 lb 4/9/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 11/30/2008 Male 4/10/2009 Physician Germany
Primary
Secondary
Concomitant
Haematuria Other Serious 9/15/2008 Male 176 lb 4/15/2009 United Kingdom
Primary
Secondary
Concomitant
Haematuria Life Threatening 11/18/2007 53 Male 206 lb 4/22/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Haematuria Other Serious 9/15/2008 Male 206 lb 4/27/2009 United Kingdom
Primary
Secondary
Concomitant
Bacterial Infection Hospitalization 3/6/2009 Female 4/27/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Haematuria Life Threatening 11/18/2007 53 Male 206 lb 4/28/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 1/1/2008 61 Male 5/5/2009 Other Health Professional United Kingdom
Primary
Concomitant
Septic Shock Hospitalization 3/6/2009 Female 5/7/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Myocardial Ischaemia Hospitalization 10/28/2008 70 Male 183 lb 6/4/2009 Physician Israel
Primary
Concomitant
Weight Decreased Other Serious 3/1/2004 75 Female 7/2/2009
Primary
Secondary
Concomitant
Right Ventricular Failure Hospitalization 4/6/2008 Male 220 lb 7/15/2009 Czech Republic
Primary
Secondary
Concomitant
Pneumonia Hospitalization 7/16/2009 Female 110 lb 9/1/2009 Japan
Primary
Concomitant
Pneumonia Hospitalization 7/16/2009 Female 110 lb 9/3/2009 Japan
Primary
Concomitant
Musculoskeletal Stiffness Other Serious 70 Male 12/17/2009 Other Health Professional United Kingdom
Primary
Concomitant
Nausea Hospitalization 5/21/2009 62 Female 181 lb 12/28/2009 Poland
Primary
Concomitant
Benign Prostatic Hyperplasia Hospitalization 11/1/2008 Male 198 lb 1/22/2010 Germany
Primary
Concomitant
Non-cardiac Chest Pain Hospitalization 8/1/2009 66 Female 115 lb 1/25/2010 Physician United Kingdom
Primary
Concomitant
Musculoskeletal Stiffness Other Serious 6/20/2009 Male 1/25/2010 Physician United Kingdom
Primary
Concomitant
Renal Transplant Other Serious 3/6/2009 29 Female 79 lb 1/29/2010 Germany
Primary
Concomitant
Palpitations 10/10/2009 Male 1/30/2010 Pharmacist United States
Primary
Concomitant
Musculoskeletal Stiffness Other Serious 70 Male 3/8/2010 Other Health Professional United Kingdom
Primary
Concomitant
Pulmonary Embolism Life Threatening 4/6/2010 58 Female 141 lb 4/20/2010 Other Health Professional Germany
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 4/7/2010 61 Female 5/28/2010 Japan
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 4/7/2010 61 Female 6/9/2010 Japan
Primary
Secondary
Concomitant
Renal Failure Hospitalization 62 Male 7/2/2010 Physician United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 4/7/2010 61 Female 7/1/2010 Japan
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 4/7/2010 61 Female 7/1/2010 Japan
Primary
Secondary
Concomitant
Rheumatoid Arthritis Hospitalization 4/7/2010 61 Female 7/13/2010 Japan
Primary
Concomitant
Sensorimotor Disorder Hospitalization 62 Female 7/29/2010 Physician France
Primary
Secondary
Concomitant
Sensorimotor Disorder Hospitalization 1/1/2007 62 Female 8/2/2010 Physician France
Primary
Secondary
Concomitant
Pneumonitis Life Threatening 5/1/2010 Female 125 lb 8/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Systemic Lupus Erythematosus Other Serious 12/1/2008 64 Female 8/31/2010 Physician Switzerland
Primary
Secondary
Concomitant
Cerebrovascular Accident Hospitalization 9/24/2010 62 Female 196 lb 11/18/2010 Physician Germany
Primary
Secondary
Concomitant
Oedema Peripheral 12/15/2010 Consumer United States
Primary
Concomitant
Hypotension Hospitalization 9/8/2008 74 Female 150 lb 12/22/2010 Other Health Professional Germany
Primary
Concomitant
Interacting
Tuberculin Test Positive 12/22/2010 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection 8/30/2010 12/23/2010 Consumer United States
Primary
Concomitant
Vasculitis Hospitalization 4/7/2010 61 Female 12/28/2010 Physician Japan
Primary
Concomitant
Condition Aggravated Hospitalization 4/7/2010 61 Female 1/24/2011 Physician Japan
Primary
Concomitant
Malaise Hospitalization 12/30/2010 64 Male 2/8/2011 Consumer United Kingdom
Primary
Concomitant
Interstitial Lung Disease Hospitalization 10/26/2010 73 Female 163 lb 2/17/2011 Physician Poland
Primary
Secondary
Concomitant

Drug Data