Bisoprolol Fumarate combined with Isosorbide Mononitrate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Somnolence Hospitalization 9/4/2005 89 Male 170 lb 1/10/2006 United States
Primary
Concomitant
Shock Life Threatening 67 Female 1/9/2006 United Kingdom
Primary
Secondary
Sinoatrial Block Other Serious 67 Female 2/1/2006 Other Health Professional United Kingdom
Primary
Secondary
Shock Hospitalization 67 Female 2/7/2006 Other Health Professional United Kingdom
Primary
Secondary
Shock Life Threatening 67 Female 2/3/2006 Other Health Professional United Kingdom
Primary
Secondary
Subcutaneous Haematoma Hospitalization 6/15/2005 66 Male 198 lb 2/9/2006 Poland
Primary
Concomitant
Interacting
Gravitational Oedema Hospitalization 11/26/2005 80 Female 132 lb 3/9/2006 Other Health Professional Poland
Primary
Secondary
Concomitant
Sinoatrial Block Hospitalization 67 Female 3/14/2006 United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 3/1/2006 68 Male 154 lb 4/12/2006 Other Health Professional United Kingdom
Primary
Concomitant
Non-cardiac Chest Pain Hospitalization 2/23/2006 77 Female 6/23/2006 Physician United Kingdom
Primary
Concomitant
Non-cardiac Chest Pain Other Serious 2/23/2006 77 Female 6/27/2006 Physician United Kingdom
Primary
Concomitant
Wheezing Hospitalization 5/17/2006 Male 6/30/2006 United Kingdom
Primary
Concomitant
Renal Impairment Disability 4/7/2006 77 Male 128 lb 7/21/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious Female 8/9/2006 Canada
Primary
Concomitant
Ischaemic Stroke Life Threatening 5/29/2006 86 Female 8/25/2006 United Kingdom
Primary
Secondary
Concomitant
Epistaxis Other Serious 2/8/2006 45 Male 8/28/2006 United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 8/10/2006 60 Male 284 lb 9/1/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 8/10/2006 60 Male 271 lb 9/6/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Blood Amylase Increased Other Serious 5/1/2005 78 Male 9/5/2006 United Kingdom
Primary
Concomitant
Syncope Vasovagal Hospitalization 7/10/2005 63 Female 234 lb 9/15/2006 Other Health Professional United Kingdom
Primary
Concomitant
Rhinorrhoea Hospitalization 8/8/2006 60 Male 234 lb 9/12/2006 Other Health Professional Poland
Primary
Secondary
Concomitant
Syncope Vasovagal Hospitalization 7/9/2005 63 Female 234 lb 10/9/2006 Other Health Professional United Kingdom
Primary
Concomitant
Panic Attack Hospitalization 9/3/2006 63 Male 258 lb 10/5/2006 Germany
Primary
Concomitant
Panic Attack Hospitalization 8/15/2006 63 Male 258 lb 10/5/2006 Other Health Professional Germany
Primary
Concomitant
Po2 Decreased Life Threatening 7/21/2006 70 Female 10/12/2006 United Kingdom
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 1/1/2005 65 Female 180 lb 11/1/2006 United States
Primary
Concomitant
Vomiting Other Serious 11/2/2006 48 Female 11/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Renal Impairment Disability 4/7/2006 77 Male 128 lb 11/20/2006 Physician Japan
Primary
Concomitant
Vomiting Other Serious 10/21/2006 85 Female 12/6/2006 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting Other Serious 10/21/2006 85 Female 12/11/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tremor Other Serious 1/1/1998 Female 12/12/2006 Consumer Canada
Primary
Concomitant
Otorrhoea Hospitalization 7/9/2005 Female 234 lb 12/29/2006 Physician United Kingdom
Primary
Concomitant
Ventricular Fibrillation Life Threatening 3/4/2004 62 Male 10/6/2006 United States
Primary
Secondary
Concomitant
Haematuria Hospitalization 9/2/2006 86 Male 1/9/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Shock Hospitalization 67 Female 1/23/2007 Consumer United Kingdom
Primary
Secondary
Haematuria Hospitalization 9/2/2006 86 Male 1/16/2007 United Kingdom
Primary
Secondary
Concomitant
Endometrial Hypertrophy Hospitalization 5/17/2004 Female 203 lb 1/25/2007 Germany
Primary
Concomitant
Femur Fracture Other Serious 10/15/2005 Female 3/2/2007 Other Health Professional Sweden
Primary
Concomitant
International Normalised Ratio Increased Other Serious 9/1/2006 46 Male 344 lb 3/27/2007 Physician United Kingdom
Primary
Concomitant
Linear Iga Disease Life Threatening 1/23/2007 79 Female 110 lb 4/28/2007 United Kingdom
Primary
Concomitant
Angina Pectoris Hospitalization 4/28/2007 62 Female 174 lb 5/11/2007 Consumer United Kingdom
Primary
Concomitant
Pulmonary Embolism Other Serious 3/7/2007 72 Male 5/11/2007 Physician United Kingdom
Primary
Concomitant
Dyspnoea Hospitalization 4/24/2007 72 Male 152 lb 5/11/2007 Consumer United States
Primary
Secondary
Concomitant
Retinopathy Other Serious 3/1/2006 Female 5/14/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Diabetic Retinopathy Other Serious 3/1/2006 Female 5/4/2007 Other Health Professional United Kingdom
Primary
Concomitant
Angina Pectoris Hospitalization 4/28/2007 62 Female 174 lb 6/4/2007 Consumer United Kingdom
Primary
Concomitant
Syncope Life Threatening 64 Male 207 lb 6/5/2007 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Life Threatening 1/1/2006 64 Male 5/31/2007 United Kingdom
Primary
Concomitant
Convulsion Hospitalization 5/22/2007 78 Male 6/14/2007 Other Health Professional United Kingdom
Primary
Concomitant
Hyperthyroidism Other Serious 1/1/2007 83 Female 6/20/2007 Other Health Professional France
Primary
Concomitant
Angina Pectoris Hospitalization 4/28/2007 62 Female 174 lb 6/22/2007 Consumer United Kingdom
Primary
Concomitant
Swelling Face Other Serious 6/1/2007 57 Male 7/30/2007 Pharmacist Canada
Primary
Concomitant
Unresponsive To Stimuli Life Threatening 67 Female 7/27/2007 Physician United Kingdom
Primary
Concomitant
Swelling Face Other Serious 6/1/2007 57 Male 8/3/2007 Pharmacist Canada
Primary
Concomitant
Somnolence Life Threatening 4/18/2007 56 Male 8/3/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Somnolence Life Threatening 4/18/2007 56 Male 8/1/2007 United Kingdom
Primary
Secondary
Concomitant
Somnolence Life Threatening 4/18/2007 56 Male 8/1/2007 United Kingdom
Primary
Secondary
Concomitant
Postinfarction Angina Death Male 158 lb 8/30/2007 Physician Canada
Primary
Concomitant
Unresponsive To Stimuli Other Serious 67 Female 9/14/2007 Other Health Professional United Kingdom
Primary
Secondary
Unresponsive To Stimuli Life Threatening 67 Female 9/11/2007 United Kingdom
Primary
Secondary
Unresponsive To Stimuli Other Serious 67 Female 9/19/2007 Other Health Professional United Kingdom
Primary
Secondary
Shock Life Threatening 67 Female 9/11/2007 Other Health Professional United Kingdom
Primary
Secondary
Unresponsive To Stimuli Life Threatening 67 Female 8/24/2007 United Kingdom
Primary
Secondary
Rhabdomyolysis Hospitalization 8/6/2007 50 Male 10/19/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Unresponsive To Stimuli Life Threatening 1/1/2003 67 Female 10/16/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 8/6/2007 50 Male 10/23/2007 Other Health Professional Sweden
Primary
Secondary
Concomitant
Pain In Extremity Other Serious 5/1/2007 68 Male 198 lb 10/22/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Sinoatrial Block Life Threatening 1/1/2003 67 Female 10/31/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 10/20/2007 55 Male 181 lb 11/28/2007 Other Health Professional United Kingdom
Primary
Concomitant
Dyspnoea Hospitalization 4/24/2007 72 Male 152 lb 12/13/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Anaemia Haemolytic Autoimmune Other Serious 3/28/2007 70 Male 1/23/2008 Consumer Finland
Primary
Concomitant
Thinking Abnormal Other Serious 1/1/2007 Male 1/25/2008 Other Health Professional United Kingdom
Primary
Concomitant
Death Death 78 Male 165 lb 1/28/2008 Pharmacist United Kingdom
Primary
Concomitant
Urethritis Hospitalization 1/30/2008 63 Male 2/4/2008 Norway
Primary
Concomitant
Haemoglobin Decreased Other Serious 10/30/2007 Male 2/14/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Polymyositis Hospitalization 12/1/2006 77 Male 2/18/2008 Other Health Professional Norway
Primary
Concomitant
Pruritus Other Serious 12/8/2004 Male 2/18/2008 Other Health Professional Germany
Primary
Concomitant
Epistaxis Life Threatening 1/1/2007 76 Male 186 lb 2/20/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Hospitalization 1/1/2007 79 Male 2/13/2008 Other Health Professional Israel
Primary
Concomitant
Pancreatitis Hospitalization 4/30/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 82 Female 5/1/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 82 Female 5/2/2008 United Kingdom
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 82 Female 5/2/2008 United Kingdom
Primary
Secondary
Concomitant
Bradycardia Hospitalization 11/29/2007 Female 196 lb 5/8/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Pancreatitis Other Serious 82 Female 5/6/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Bradycardia Hospitalization 11/29/2007 Female 196 lb 6/4/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Urethritis Hospitalization 1/30/2008 63 Male 6/5/2008 Norway
Primary
Concomitant
Therapeutic Response Unexpected With Drug Substitution Required Intervention Male 5/28/2008 United Kingdom
Primary
Concomitant
Therapeutic Response Unexpected With Drug Substitution Other Serious 71 Male 6/6/2008 Pharmacist United Kingdom
Primary
Concomitant
Multiple Myeloma Other Serious Male 304 lb 8/4/2008 Consumer United Kingdom
Primary
Concomitant
Lung Neoplasm Malignant Other Serious 6/16/2008 75 Male 8/6/2008 Other Health Professional Croatia (Local Name: Hrvatska)
Primary
Secondary
Concomitant
Vomiting Other Serious 10/21/2006 85 Female 8/9/2008 United Kingdom
Primary
Concomitant
Blood Pressure Decreased Other Serious 7/30/2008 68 Male 190 lb 8/25/2008 Other Health Professional United Kingdom
Primary
Concomitant
Multiple Myeloma Other Serious Male 304 lb 9/5/2008 Consumer United Kingdom
Primary
Concomitant
Blood Pressure Decreased Other Serious 7/30/2008 68 Male 190 lb 9/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Blood Pressure Decreased Other Serious 7/30/2008 68 Male 190 lb 9/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Hypokinesia Hospitalization 5/7/2008 Female 9/11/2008 Other Health Professional Portugal
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 10/21/2008 72 Female 11/11/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 10/21/2008 72 Female 11/14/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 10/21/2008 72 Female 11/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Hospitalization Male 12/9/2008 Physician United Kingdom
Primary
Concomitant
Product Quality Issue Death 4/7/2007 72 Male 170 lb 12/19/2008 Consumer United States
Primary
Concomitant
Rash Pruritic Other Serious 11/29/2008 Male 12/18/2008 Physician United Kingdom
Primary
Concomitant
Troponin Increased Other Serious 10/1/2008 Female 154 lb 12/29/2008 Consumer Ireland
Primary
Concomitant
Rib Fracture Other Serious 2/13/2009 Physician South Africa
Primary
Concomitant
Weight Increased Hospitalization 1/1/2008 44 Male 2/19/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 3/13/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 3/20/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 3/25/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 3/26/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Bacterial Infection Hospitalization 3/6/2009 Female 4/27/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 3/16/2009 69 Male 165 lb 5/5/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Septic Shock Hospitalization 3/6/2009 Female 5/7/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 3/16/2009 69 Male 165 lb 5/11/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 3/16/2009 69 Male 165 lb 5/19/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 3/16/2009 69 Male 5/14/2009 United Kingdom
Primary
Secondary
Concomitant
Syncope Death 1/6/2009 79 Female 5/18/2009 United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Life Threatening 3/16/2009 69 Male 165 lb 5/20/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Reflux Oesophagitis Hospitalization 2/1/2009 93 Female 6/18/2009 Other Health Professional Sweden
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/1/2008 43 Female 362 lb 6/29/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 7/2/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 360 lb 7/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 360 lb 7/13/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 10/10/2008 43 Female 360 lb 7/16/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 360 lb 7/17/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 362 lb 7/23/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Haemoglobin Decreased Other Serious 1/1/2009 80 Female 8/10/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Impairment Other Serious 6/9/2009 62 Male 8/28/2009 Physician Japan
Primary
Concomitant
Tuberculous Pleurisy Life Threatening 9/9/2007 Male 143 lb 9/22/2009 Physician Thailand
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 362 lb 10/28/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Tuberculous Pleurisy Life Threatening 9/9/2007 Male 143 lb 11/3/2009 Physician Thailand
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2007 43 Female 360 lb 10/29/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 362 lb 11/19/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Amnesia Other Serious Female 12/22/2009 Other Health Professional United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2008 43 Female 359 lb 12/23/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Presyncope Hospitalization 2/7/2010 70 Male 3/19/2010 Physician Italy
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 98 Female 3/15/2010 United Kingdom
Primary
Concomitant
Presyncope Hospitalization 2/7/2010 70 Male 3/29/2010 Physician Italy
Primary
Secondary
Concomitant
Cardiac Failure Hospitalization 4/5/2010 83 Male 4/26/2010 Pharmacist Italy
Primary
Secondary
Concomitant
Dermatitis Exfoliative Other Serious 3/11/2010 5/12/2010 Consumer United Kingdom
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 5/7/2010 75 Male 6/2/2010 Other Health Professional United Kingdom
Primary
Concomitant
Ventricular Fibrillation Hospitalization 55 Female 6/28/2010 Consumer United Kingdom
Primary
Concomitant
Syncope Other Serious 57 Female 7/20/2010 United Kingdom
Primary
Secondary
Concomitant
Death Death 2/10/2010 76 Female 203 lb 7/30/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Multiple Drug Overdose Hospitalization 76 Female 203 lb 8/3/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Drug Administration Error Death 2/10/2010 76 Female 203 lb 8/5/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Intentional Drug Misuse Death 2/10/2010 76 Female 8/5/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Intentional Drug Misuse Death 2/10/2010 76 Female 8/5/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Intentional Drug Misuse Death 2/10/2010 76 Female 203 lb 8/3/2010 Other Health Professional
Primary
Secondary
Concomitant
Flushing Male 8/16/2010 Consumer United States
Primary
Concomitant

Drug Data