Biotin combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Multiple Fractures Hospitalization 2/2/2004 64 Female 2/1/2006 Physician United States
Primary
Secondary
Concomitant
Resorption Bone Increased Hospitalization 2/9/2007 Male 160 lb 6/25/2007 United States
Primary
Concomitant
Resorption Bone Increased Hospitalization 2/9/2007 Male 160 lb 7/6/2007 United States
Primary
Concomitant
Vitamin D Deficiency Other Serious 7/1/2005 Female 181 lb 12/3/2007 Physician United States
Primary
Concomitant
Vitamin D Deficiency Other Serious 7/1/2005 Female 181 lb 12/18/2007 Physician United States
Primary
Concomitant
Resorption Bone Increased Hospitalization 2/9/2007 Male 160 lb 1/4/2008 United States
Primary
Concomitant
Accidental Exposure 1/25/2008 Female 153 lb 3/15/2008 Consumer United States
Primary
Concomitant
Resorption Bone Increased Hospitalization 2/9/2007 Male 160 lb 7/9/2008 United States
Primary
Concomitant
Resorption Bone Increased Hospitalization 2/9/2007 Male 160 lb 9/11/2008 United States
Primary
Concomitant
Pneumonia Other Serious 7/1/2008 Female 170 lb 9/12/2008 Consumer United States
Primary
Concomitant
Mass Other Serious 9/1/2006 54 Female 174 lb 3/3/2008 Other Health Professional United States
Primary
Concomitant
Mass Other Serious 9/1/2006 54 Female 174 lb 9/9/2008 Physician United States
Primary
Concomitant
Tremor 4/10/2008 Female 12/9/2008 Physician United States
Primary
Concomitant
Osteolysis Hospitalization 2/9/2007 Male 160 lb 12/26/2008 United States
Primary
Concomitant
Rash 10/1/2008 Female 130 lb 6/12/2009 Consumer United States
Primary
Concomitant
Incorrect Dose Administered 1/25/2008 Female 153 lb 9/12/2009 Consumer United States
Primary
Concomitant
Gallbladder Perforation Hospitalization 9/21/2009 Female 172 lb 3/4/2010 Physician United States
Primary
Secondary
Concomitant
Dermatitis Acneiform Hospitalization 10/13/2009 Female 3/26/2010 Japan
Primary
Concomitant
Deep Vein Thrombosis Life Threatening 9/21/2009 Female 172 lb 3/29/2010 Physician United States
Primary
Secondary
Concomitant
Dermatitis Acneiform Hospitalization 10/14/2009 38 Female 4/7/2010 Japan
Primary
Concomitant
Bone Disorder Other Serious 1/1/2006 61 Female 129 lb 4/16/2010 Other Health Professional United States
Primary
Concomitant
Dermatitis Acneiform Hospitalization 10/14/2009 38 Female 4/22/2010 Japan
Primary
Concomitant
Vomiting Other Serious 11/1/2008 55 Female 208 lb 5/6/2010 United States
Primary
Concomitant
Bone Disorder Other Serious 1/1/2006 61 Female 129 lb 5/18/2010 Other Health Professional United States
Primary
Concomitant
Somnolence Other Serious 12/1/2009 62 Female 125 lb 8/2/2010 Consumer United States
Primary
Concomitant
Retching Hospitalization 4/1/2009 86 Female 8/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Septic Shock Death 12/1/2008 66 Female 176 lb 9/1/2010 Consumer United Kingdom
Primary
Concomitant
Dermatitis Acneiform Hospitalization 10/13/2009 38 Female 9/28/2010 Physician Japan
Primary
Concomitant
Thyroid Disorder Other Serious 5/1/2009 66 Female 120 lb 9/29/2010 Consumer United States
Primary
Concomitant
Oropharyngeal Pain Hospitalization 10/13/2009 38 Female 10/26/2010 Physician Japan
Primary
Concomitant
Injection Site Swelling 2/15/2010 12/19/2010 Consumer United States
Primary
Concomitant
Injection Site Warmth 7/1/2010 12/23/2010 Consumer United States
Primary
Concomitant
Rash 3/1/2010 63 Female 130 lb 1/28/2011 United States
Primary
Concomitant
Tongue Injury Hospitalization 1/1/2011 60 Female 150 lb 4/6/2011 Physician United States
Primary
Concomitant
Blood Creatinine Increased Other Serious 4/19/2011 69 Female 128 lb 6/7/2011 Physician United States
Primary
Concomitant
Diarrhoea Hospitalization 4/19/2011 69 Female 128 lb 7/18/2011 Physician United States
Primary
Concomitant
Convulsion Other Serious 58 Female 10/21/2011 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Injection Site Pruritus 6/1/2011 54 Female 177 lb 11/2/2011 Consumer United States
Primary
Concomitant
Underdose Other Serious 3/1/2011 64 Female 130 lb 1/11/2012 Consumer United States
Primary
Concomitant
Sinusitis 11/1/2011 63 Female 1/11/2012 Consumer United States
Primary
Concomitant
Sinusitis 11/1/2011 63 Female 1/11/2012 Consumer United States
Primary
Concomitant
Back Pain 81 Female 1/24/2012 Physician United States
Primary
Concomitant
Device Malfunction 1/22/2011 66 Female 140 lb 1/27/2012 Consumer United States
Primary
Concomitant
Alopecia 1/1/2009 48 Female 238 lb 1/28/2012 Consumer United States
Primary
Secondary
Concomitant
Sinus Disorder 1/1/2011 75 Female 1/29/2012 Consumer United States
Primary
Concomitant
Injection Site Pain 12/27/2011 46 Female 1/29/2012 Consumer United States
Primary
Concomitant
Hypersensitivity 12/19/2011 25 Female 1/29/2012 Consumer United States
Primary
Secondary
Concomitant
Diarrhoea 11/7/2011 63 Female 1/29/2012 Consumer United States
Primary
Concomitant
Cough 11/22/2011 59 Female 1/29/2012 Consumer United States
Primary
Concomitant
Injection Site Thrombosis 9/7/2011 67 Female 1/28/2012 Consumer United States
Primary
Concomitant
Injection Site Haemorrhage Other Serious 11/1/2011 57 Female 2/2/2012 Physician United States
Primary
Secondary
Concomitant
Impaired Healing Other Serious 11/1/2011 57 Female 124 lb 3/2/2012 Physician United States
Primary
Secondary
Concomitant
Meningitis Noninfective Hospitalization 58 Female 3/19/2012 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Meningitis Hospitalization 58 Female 3/21/2012 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Meningitis Hospitalization 58 Female 3/21/2012 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Meningitis Life Threatening 58 Female 4/19/2012 Other Health Professional Switzerland
Primary
Secondary
Pyoderma Gangrenosum Hospitalization 2/4/2012 60 Female 131 lb 5/8/2012 Physician Japan
Primary
Concomitant
Adverse Drug Reaction Other Serious 10/1/2011 59 Female 219 lb 5/11/2012 Other Health Professional United States
Primary
Concomitant
Adverse Drug Reaction Other Serious 10/1/2011 59 Female 219 lb 5/24/2012 Other Health Professional United States
Primary
Concomitant
Adverse Drug Reaction Hospitalization 1/1/2011 61 Female 220 lb 5/24/2012 Physician United States
Primary
Concomitant
Surgery Other Serious 10/1/2011 59 Female 219 lb 5/29/2012 Other Health Professional United States
Primary
Concomitant
Drug Ineffective Other Serious 1/1/2011 61 Female 220 lb 6/1/2012 Physician United States
Primary
Concomitant
Injection Site Haematoma 5/1/2012 61 Female 6/5/2012 Physician United States
Primary
Concomitant
Herpes Zoster 4/20/2012 58 Female 6/11/2012 Other Health Professional Canada
Primary
Concomitant
Lymphadenopathy Mediastinal Hospitalization 1/1/2011 41 Female 340 lb 6/22/2012 Physician United States
Primary
Secondary
Concomitant
Depression Other Serious 1/1/2002 60 Female 200 lb 7/9/2012 Consumer United States
Primary
Secondary
Concomitant
Injection Site Erythema Female 7/9/2012 Consumer United States
Primary
Concomitant
Vulvovaginal Mycotic Infection Other Serious 10/1/2011 73 Female 123 lb 7/31/2012 Consumer United States
Primary
Concomitant
Cataract Other Serious 10/1/2011 73 Female 123 lb 8/2/2012 Consumer United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 7/29/2012 61 Female 8/2/2012 Physician United States
Primary
Concomitant
Injection Site Pain Other Serious 8/8/2012 28 Female 8/17/2012 Physician United States
Primary
Concomitant
Liver Function Test Abnormal 8/3/2012 79 Female 142 lb 8/20/2012 Consumer United States
Primary
Concomitant
Cellulitis Other Serious 7/10/2012 15 Female 98 lb 8/27/2012 Other Health Professional United States
Primary
Concomitant
Weight Increased Hospitalization 2011 43 Female 340 lb 7/24/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Cellulitis Other Serious 7/10/2012 15 Female 98 lb 8/31/2012 Other Health Professional Us
Primary
Concomitant
Trismus Other Serious Female 10/17/2012 Physician Us
Primary
Concomitant
Psoriasis 7/19/2012 41 Female 240 lb 10/23/2012 Physician Us
Primary
Concomitant
Increased Tendency To Bruise Female 165 lb 10/23/2012 Physician Us
Primary
Concomitant
Injection Site Pain Female 10/25/2012 Physician Us
Primary
Concomitant
Injection Site Bruising 6/29/2012 61 Female 170 lb 10/26/2012 Consumer Us
Primary
Concomitant
Pneumonia Bacterial Hospitalization 7/10/2012 72 Female 12/31/2012 Consumer Us
Primary
Concomitant
Rhinorrhoea 7/29/2012 65 Female 170 lb 10/26/2012 Consumer Us
Primary
Concomitant
Drug Ineffective Female 185 lb 10/26/2012 Physician Us
Primary
Concomitant
Pruritus 8/29/2012 54 Female 152 lb 10/23/2012 Physician Us
Primary
Concomitant
Headache 9/24/2007 57 Female 419 lb 11/7/2012 Physician Us
Primary
Concomitant
Sinusitis Female 11/7/2012 Physician Us
Primary
Concomitant
Sinusitis 11/12/2013 67 Female 12/2/2013 Physician Us
Primary
Concomitant
Localised Infection 4/14/2012 64 Female 170 lb 11/8/2012 Other Health Professional Us
Primary
Concomitant
Herpes Zoster Female 11/8/2012 Physician Us
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 5/2012 Female 210 lb 11/21/2012 Consumer Us
Primary
Concomitant
Rash 12/2012 47 Female 180 lb 2/4/2013 Consumer Us
Primary
Concomitant
Weight Bearing Difficulty Hospitalization 9/2004 72 Female 1/7/2013 Physician Country Not Specified
Primary
Concomitant
Drug Ineffective Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Bruising 2/15/2012 63 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Bacterial Infection 2/2011 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Upper Respiratory Tract Infection 11/2011 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Drug Ineffective 2/27/2012 63 Female 1/28/2013 Consumer Country Not Specified
Primary
Concomitant
Gastrooesophageal Reflux Disease Other Serious 2005 Female 142 lb 1/30/2013 Consumer Pr
Primary
Concomitant
Injection Site Pain 8/15/2012 62 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Pain 7/8/2012 47 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Restless Legs Syndrome 2012 Female 270 lb 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Reaction 3/26/2012 63 Female 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Sinusitis 8/2012 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Fatigue 7/9/2012 50 Female 1/30/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Haemorrhage 10/8/2012 66 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Injection Site Pain 10/2012 76 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Sinus Congestion 10/2012 28 Female 2/1/2013 Consumer Country Not Specified
Primary
Concomitant
Rheumatoid Arthritis 2012 Female 117 lb 1/31/2013 Consumer Country Not Specified
Primary
Secondary
Concomitant
Sinusitis 5/2012 51 Female 1/31/2013 Consumer Country Not Specified
Primary
Concomitant
Poor Quality Drug Administered Female 100 lb 1/29/2013 Consumer Country Not Specified
Primary
Concomitant
Palpitations Hospitalization 62 Female 226 lb 7/19/2012 Us
Primary
Secondary
Concomitant
Therapeutic Response Decreased 10/2012 63 Female 178 lb 5/6/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Weight Increased 5/10/2013 65 Female 178 lb 11/27/2013 Other Health Professional Us
Primary
Concomitant
Urinary Tract Infection Hospitalization 6/9/2013 68 Female 207 lb 7/12/2013 Consumer Us
Primary
Concomitant
Mycobacterium Avium Complex Infection Other Serious 2/2012 72 Female 133 lb 9/18/2013 Physician Us
Primary
Concomitant
White Blood Cell Count Decreased 7/25/2013 63 Female 8/5/2013 Other Health Professional Us
Primary
Concomitant
Extra Dose Administered 6/16/2013 44 Female 185 lb 8/7/2013 Other Health Professional Us
Primary
Concomitant
Visual Impairment Other Serious 2012 65 Female 8/9/2013 Consumer Country Not Specified
Primary
Concomitant
Stress Fracture Other Serious 2/2013 70 Female 126 lb 9/1/2013 Consumer Ca
Primary
Secondary
Concomitant
Diverticulitis Other Serious 6/2013 64 Female 120 lb 10/3/2013 Physician Us
Primary
Concomitant
Pain 7/31/2013 53 Female 127 lb 9/30/2013 Physician Us
Primary
Concomitant
Rheumatoid Nodule 4/9/2013 53 Female 127 lb 9/30/2013 Physician Us
Primary
Concomitant
Urinary Tract Infection Other Serious 8/2012 59 Female 266 lb 9/30/2013 Other Health Professional Us
Primary
Concomitant
Injection Site Pain Female 10/1/2013 Physician Us
Primary
Concomitant
Bronchitis 12/13/2012 63 Female 110 lb 10/1/2013 Physician Us
Primary
Concomitant
Injection Site Bruising Female 126 lb 10/1/2013 Physician Us
Primary
Concomitant
Vomiting Female 10/1/2013 Physician Us
Primary
Concomitant
Erythema 3/4/2013 71 Female 185 lb 10/1/2013 Physician Us
Primary
Concomitant
Drug Ineffective 2/28/2013 49 Female 185 lb 10/1/2013 Physician Us
Primary
Concomitant
Dizziness 5/27/2013 60 Female 154 lb 10/2/2013 Physician Us
Primary
Concomitant
Iritis 58 Female 145 lb 10/2/2013 Physician Us
Primary
Concomitant
Injection Site Pain 54 Female 10/2/2013 Physician Us
Primary
Concomitant
Musculoskeletal Pain 57 Female 190 lb 10/2/2013 Physician Us
Primary
Concomitant
Hypersensitivity 1/9/2013 39 Female 200 lb 10/2/2013 Physician Us
Primary
Concomitant
Pruritus 6/15/2013 64 Male 270 lb 10/2/2013 Physician Us
Primary
Concomitant
Injection Site Swelling 6/20/2013 60 Female 155 lb 10/2/2013 Physician Us
Primary
Concomitant
Headache 5/19/2013 53 Female 125 lb 10/2/2013 Physician Us
Primary
Concomitant
Injection Site Swelling 22 Female 122 lb 10/2/2013 Physician Us
Primary
Concomitant
Tendonitis 2013 51 Female 175 lb 10/2/2013 Physician Us
Primary
Secondary
Concomitant
Sensitivity Of Teeth 6/12/2013 59 Female 135 lb 10/2/2013 Physician Us
Primary
Concomitant
Injection Site Swelling 7/17/2013 47 Female 130 lb 10/2/2013 Physician Us
Primary
Concomitant
Reaction To Preservatives 56 Female 126 lb 10/2/2013 Consumer Us
Primary
Concomitant
Therapeutic Response Decreased 8/1/2012 84 Female 10/3/2013 Physician Us
Primary
Concomitant
Therapeutic Response Decreased Female 220 lb 10/3/2013 Physician Us
Primary
Concomitant
Urticaria 11/16/2012 79 Female 10/3/2013 Physician Us
Primary
Concomitant
Upper Respiratory Tract Infection 4/1/2012 53 Female 10/3/2013 Consumer Us
Primary
Concomitant
Injection Site Erythema 1/1/2013 65 Female 116 lb 10/4/2013 Physician Us
Primary
Concomitant
Injection Site Haemorrhage 3/13/2013 64 Female 159 lb 10/4/2013 Physician Us
Primary
Concomitant
Sinusitis 30 Female 10/4/2013 Consumer Us
Primary
Concomitant
Drug Ineffective 59 Female 10/4/2013 Physician Us
Primary
Concomitant

Drug Data