Bevacizumab combined with Metformin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Necrosis Hospitalization 2/20/2006 65 Female 152 lb 3/8/2006 Physician Austria
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 9/21/2006 51 Female 139 lb 10/19/2006 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/18/2007 79 Male 141 lb 3/30/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/14/2007 79 Male 130 lb 5/1/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Hospitalization 2/20/2006 65 Female 152 lb 7/12/2007 Physician Austria
Primary
Secondary
Concomitant
Anaphylactic Reaction Life Threatening 5/15/2007 Male 205 lb 8/29/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Nervous System Disorder Other Serious 6/10/2007 Male 201 lb 9/7/2007 Physician United States
Primary
Secondary
Concomitant
Sepsis Other Serious 4/7/2007 32 Female 182 lb 10/17/2007 Physician Australia
Primary
Secondary
Concomitant
Sepsis Other Serious 4/7/2007 Female 10/23/2007 Physician Australia
Primary
Secondary
Concomitant
Pulmonary Oedema Life Threatening 9/26/2007 62 Female 10/26/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Diarrhoea Death 12/31/2007 76 Male 175 lb 1/21/2008 Physician United States
Primary
Secondary
Concomitant
Nervous System Disorder Hospitalization 11/17/2007 Male 128 lb 3/13/2008 Consumer United Kingdom
Primary
Concomitant
Abdominal Discomfort Hospitalization 12/23/2006 Male 206 lb 3/27/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 12/26/2007 Male 6/19/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 9/1/2006 Female 139 lb 6/20/2008 Physician United States
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 9/21/2006 Female 139 lb 6/23/2008 Physician France
Primary
Secondary
Concomitant
Abdominal Discomfort Hospitalization 12/23/2006 Male 206 lb 7/11/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Abdominal Discomfort Hospitalization 12/23/2006 Male 206 lb 7/14/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 9/21/2006 Female 139 lb 7/16/2008 Physician France
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 9/21/2006 Female 139 lb 7/23/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious 5/21/2008 Female 120 lb 7/28/2008 Physician United States
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious 5/21/2008 Female 120 lb 9/10/2008 Physician United States
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 12/26/2007 Male 10/16/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Tympanic Membrane Perforation Hospitalization 10/25/2008 Male 180 lb 12/30/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Otitis Media Hospitalization 10/25/2008 Male 180 lb 1/9/2009 Physician United States
Primary
Secondary
Concomitant
Diarrhoea Death 12/31/2007 Male 175 lb 1/13/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 11/12/2008 Female 1/15/2009 Consumer United States
Primary
Secondary
Concomitant
Sudden Death Death Male 163 lb 3/27/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Dural Fistula Hospitalization 2/28/2009 Male 238 lb 3/27/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Tract Infection Hospitalization 3/8/2009 Male 143 lb 4/13/2009 Physician India
Primary
Concomitant
Caecitis Hospitalization 6/2/2009 Female 7/28/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 11/12/2008 Female 7/29/2009 Consumer United States
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 11/12/2008 Female 8/4/2009 Consumer United States
Primary
Secondary
Concomitant
Duodenal Ulcer Haemorrhage Death 7/11/2007 Female 176 lb 8/5/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Prurigo Hospitalization 7/22/2009 Female 194 lb 8/5/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 11/12/2008 Female 8/7/2009 Consumer United States
Primary
Secondary
Concomitant
Hyperosmolar State Hospitalization 4/23/2009 Female 8/12/2009 Physician United States
Primary
Secondary
Concomitant
Oesophagitis Other Serious 7/11/2007 Female 176 lb 8/19/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumonia Fungal Other Serious 11/28/2008 Male 311 lb 8/19/2009 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Ulcer 10/10/2007 Male 162 lb 8/19/2009 Physician United States
Primary
Secondary
Concomitant
Prurigo Hospitalization 7/22/2009 Female 194 lb 8/20/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 9/21/2006 Female 139 lb 10/1/2009 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/25/2009 Female 10/1/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 9/21/2006 Female 139 lb 10/5/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Dizziness Hospitalization 8/8/2009 Male 185 lb 10/6/2009 Physician Poland
Primary
Concomitant
Stomatitis Hospitalization 1/1/2009 Female 139 lb 10/8/2009 Physician Germany
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/25/2009 Female 10/8/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Abdominal Pain Upper Hospitalization 10/23/2009 Male 125 lb 11/4/2009 Physician Brazil
Primary
Secondary
Concomitant
Pneumothorax Hospitalization 4/11/2009 Male 11/4/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/14/2009 Male 168 lb 11/6/2009 Physician Belgium
Primary
Secondary
Concomitant
Ulcer Hospitalization 10/29/2009 Female 152 lb 11/9/2009 Physician Germany
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/25/2009 Female 11/24/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 11/12/2008 Female 11/24/2009 Consumer United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 11/21/2009 Female 172 lb 12/28/2009 Physician United States
Primary
Secondary
Concomitant
Pneumonia Aspiration Hospitalization 4/23/2009 77 Female 12/29/2009 Physician United States
Primary
Secondary
Concomitant
Pneumonia Aspiration Hospitalization 4/23/2009 77 Female 12/31/2009 Physician United States
Primary
Secondary
Concomitant
Therapeutic Agent Toxicity Hospitalization 10/18/2009 58 Male 1/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 9/21/2006 52 Female 139 lb 1/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Dementia Other Serious 11/20/2009 Male 206 lb 1/8/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 9/21/2006 Female 139 lb 1/11/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Dementia Other Serious 11/20/2009 Male 187 lb 1/13/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 9/21/2006 52 Female 139 lb 1/14/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 9/21/2006 52 Female 139 lb 1/25/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 12/5/2009 Female 142 lb 1/29/2010 Physician United States
Primary
Secondary
Concomitant
Emphysema Hospitalization 2/18/2010 Male 165 lb 3/11/2010 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/13/2009 62 Male 168 lb 4/5/2010 Physician Belgium
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 2/18/2010 66 Male 165 lb 4/23/2010 Physician United States
Primary
Secondary
Concomitant
Gastritis Hospitalization 10/23/2009 67 Male 125 lb 5/6/2010 Physician Brazil
Primary
Secondary
Concomitant
White Blood Cell Count Other Serious 4/29/2010 65 Female 7/21/2010 Consumer United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/13/2009 62 Male 168 lb 8/16/2010 Physician Belgium
Primary
Secondary
Concomitant
Lung Abscess Hospitalization 7/12/2010 50 Male 187 lb 8/24/2010 Physician Poland
Primary
Concomitant
Intestinal Dilatation Hospitalization 7/21/2010 72 Male 8/30/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Sudden Death Death Male 165 lb 8/30/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Intestinal Dilatation Hospitalization 7/21/2010 72 Male 9/2/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Anaemia Hospitalization 8/3/2010 57 Male 222 lb 8/31/2010 Physician United States
Primary
Secondary
Concomitant
Keratoconjunctivitis Sicca Other Serious 6/30/2010 63 Female 212 lb 9/3/2010 Physician United States
Primary
Secondary
Concomitant
Microangiopathic Haemolytic Anaemia Hospitalization 8/3/2010 57 Male 223 lb 9/6/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Anaemia Hospitalization Male 222 lb 9/7/2010 Physician United States
Primary
Secondary
Concomitant
Eyelid Function Disorder Other Serious 6/30/2010 63 Female 212 lb 9/14/2010 Physician United States
Primary
Secondary
Concomitant
Dyspnoea Other Serious 9/4/2010 66 Male 334 lb 9/14/2010 Physician United States
Primary
Secondary
Concomitant
Convulsion Hospitalization 9/6/2010 42 Female 165 lb 9/17/2010 Physician Netherlands
Primary
Secondary
Concomitant
Intestinal Dilatation Hospitalization 7/21/2010 72 Male 9/21/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Hospitalization 9/13/2010 59 Male 186 lb 9/17/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 4/2/2009 55 Female 244 lb 10/7/2010 Physician United States
Primary
Secondary
Concomitant
Convulsion Hospitalization 9/6/2010 42 Female 165 lb 10/11/2010 Physician Netherlands
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 10/11/2010 54 Female 176 lb 10/18/2010 Physician Germany
Primary
Secondary
Concomitant
Dyspnoea Other Serious 8/30/2010 66 Male 334 lb 10/25/2010 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 10/11/2010 54 Female 176 lb 11/2/2010 Physician Germany
Primary
Secondary
Concomitant
Confusional State Hospitalization 11/5/2010 69 Female 170 lb 11/29/2010 Physician Germany
Primary
Secondary
Concomitant
Vertigo Other Serious 10/1/2010 45 Female 212 lb 11/30/2010 Physician Germany
Primary
Concomitant
Malignant Neoplasm Progression Hospitalization 10/7/2010 66 Male 12/6/2010 Physician Germany
Primary
Secondary
Concomitant
Thoracic Vertebral Fracture Other Serious 9/1/2010 62 Female 190 lb 12/14/2010 Consumer Canada
Primary
Concomitant
Hypokalaemia Hospitalization 12/9/2008 71 Female 117 lb 12/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Bundle Branch Block Right Hospitalization 12/4/2008 78 Male 153 lb 12/30/2010 Physician United States
Primary
Secondary
Concomitant
Arthralgia Other Serious 3/24/2010 48 Male 209 lb 1/4/2011 Physician Japan
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 11/13/2010 73 1/28/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Congestive Hospitalization 1/2/2011 67 Female 155 lb 2/7/2011 Consumer United States
Primary
Secondary
Concomitant
Cardiac Failure Congestive Hospitalization 1/2/2011 67 Female 155 lb 2/7/2011 Consumer United States
Primary
Secondary
Concomitant
Death Death 12/1/2010 64 Male 553 lb 2/22/2011 Other Health Professional Canada
Primary
Concomitant
General Physical Health Deterioration Hospitalization 2/17/2011 70 Male 179 lb 2/28/2011 Physician Germany
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 11/13/2010 73 3/11/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Neutropenia Other Serious 2/11/2011 66 Male 338 lb 3/11/2011 Physician United States
Primary
Secondary
Concomitant
Catheter Site Infection Hospitalization 2/16/2011 67 Male 251 lb 3/16/2011 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/9/2010 65 Female 159 lb 3/21/2011 Consumer United States
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Death 5/30/2010 66 Male 187 lb 3/23/2011 Physician Switzerland
Primary
Secondary
Concomitant
Orthostatic Hypotension Hospitalization 2/16/2011 66 Male 338 lb 3/25/2011 Physician United States
Primary
Secondary
Concomitant
Malaise Death 11/5/2010 73 Male 4/8/2011 Physician Netherlands
Primary
Secondary
Concomitant
Malaise Death 11/5/2010 73 Male 4/15/2011 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Malaise Hospitalization 11/5/2010 73 Male 4/18/2011 Physician Netherlands
Primary
Secondary
Concomitant
Colon Cancer Metastatic Hospitalization 11/5/2010 73 Male 4/26/2011 Other Health Professional Netherlands
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 1/18/2007 66 Male 235 lb 5/23/2011 Physician Canada
Primary
Secondary
Concomitant
Confusional State Hospitalization 7/9/2010 65 Female 159 lb 5/23/2011 Physician United States
Primary
Secondary
Concomitant
Gastritis Hospitalization 7/28/2011 59 Female 247 lb 9/9/2011 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Death 5/25/2010 72 Male 9/9/2011 Physician Netherlands
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 3/21/2011 67 Female 200 lb 9/22/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Microangiopathic Haemolytic Anaemia Hospitalization 8/3/2010 57 Male 222 lb 11/11/2011 Physician United States
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization Male 12/23/2013 Physician Ca
Primary
Secondary
Weight Decreased Death 2006 Female 9/11/2012 Consumer Us
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 11/21/2009 67 Female 172 lb 7/12/2013 Physician Us
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 10/11/2010 55 Female 176 lb 12/11/2013 Physician De
Primary
Secondary
Concomitant
Vertigo Other Serious 10/23/2010 45 Female 212 lb 2/1/2013 Physician De
Primary
Concomitant
Renal Failure Acute Other Serious 7/25/2011 70 Male 278 lb 9/5/2012 Other Health Professional Us
Primary
Secondary
Transient Ischaemic Attack Hospitalization 10/30/2011 78 Male 8/7/2013 Physician Gb
Primary
Secondary
Concomitant
Metastases To Central Nervous System Death 11/26/2011 Female 173 lb 1/16/2013 Physician De
Primary
Concomitant
Gastrointestinal Perforation Other Serious 2/10/2012 63 Female 107 lb 12/7/2012 Physician Kr
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 7/11/2011 70 Male 278 lb 9/24/2012 Other Health Professional Us
Primary
Secondary
Concomitant
Sepsis Hospitalization 8/2/2012 44 Female 235 lb 5/21/2013 Physician Us
Primary
Secondary
Concomitant
Constipation Hospitalization 10/9/2012 58 Male 10/31/2012 Physician Dk
Primary
Secondary
Concomitant
Hemiparesis Hospitalization 10/15/2012 47 Male 201 lb 10/26/2012 Physician De
Primary
Concomitant
Neoplasm Progression Other Serious 5/18/2010 64 Female 150 lb 11/7/2012 Other Health Professional De
Primary
Concomitant
Neoplasm Malignant Other Serious 11/6/2012 Female 137 lb 11/19/2012 Physician De
Primary
Concomitant
Pneumonia Hospitalization 9/30/2012 65 Male 154 lb 3/6/2013 Physician De
Primary
Concomitant
Thrombocytopenia Hospitalization 6/17/2010 60 Female 250 lb 4/16/2013 Consumer Gb
Primary
Secondary
Concomitant
Intestinal Perforation Death 10/27/2011 67 Male 152 lb 1/10/2013 Consumer Gb
Primary
Secondary
Concomitant
Death Death Male 226 lb 1/2/2013 Pharmacist Ca
Primary
Concomitant
Gastric Perforation Hospitalization 4/12/2009 71 Male 138 lb 2/13/2013 Physician Gb
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/16/2012 71 Male 170 lb 3/8/2013 Physician Gb
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 5/31/2012 62 Female 149 lb 4/9/2013 Physician Be
Primary
Secondary
Concomitant
Stress Cardiomyopathy Life Threatening 2/28/2013 57 Female 178 lb 4/10/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 12/20/2012 45 Male 3/25/2013 Physician Us
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Life Threatening 2/19/2013 72 Male 172 lb 4/11/2013 Physician Gb
Primary
Secondary
Concomitant
Infection Other Serious 3/4/2013 69 Male 164 lb 6/7/2013 Physician De
Primary
Secondary
Concomitant
Cheilitis Other Serious 3/11/2013 69 Male 164 lb 5/22/2013 Physician De
Primary
Secondary
Concomitant
Malabsorption Other Serious 63 Female 4/19/2013 Other Health Professional Us
Primary
Secondary
Confusional State Hospitalization 5/14/2013 56 Male 175 lb 6/27/2013 Physician Us
Primary
Secondary
Concomitant
Aphasia Hospitalization 5/30/2013 74 Male 207 lb 7/17/2013 Other Health Professional De
Primary
Secondary
Concomitant
Embolism Death 7/17/2013 53 Male 8/2/2013 Other Health Professional Us
Primary
Secondary
Concomitant
Tumour Associated Fever Hospitalization 4/2/2013 59 Male 165 lb 11/21/2013 Physician Es
Primary
Secondary
Concomitant
Dysphagia Hospitalization 7/5/2013 70 Male 205 lb 8/28/2013 Physician Gb
Primary
Secondary
Concomitant
Treatment Noncompliance Other Serious 4/12/2008 62 Male 11/13/2013 Consumer Us
Primary
Secondary
Concomitant

Drug Data