Bevacizumab combined with Isovorin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pyrexia Hospitalization 7/3/2007 63 Female 108 lb 7/26/2007 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/3/2007 62 Female 108 lb 8/2/2007 Physician Japan
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 6/14/2007 Male 8/7/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Pupils Unequal Hospitalization 7/21/2007 Male 8/15/2007 Consumer United Kingdom
Primary
Secondary
Pyrexia Hospitalization 8/2/2007 Female 8/15/2007 Consumer United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 8/2/2007 Female 101 lb 8/23/2007 Consumer United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 7/3/2007 62 Female 108 lb 8/30/2007 Physician Japan
Primary
Secondary
Concomitant
Somnolence Hospitalization 8/18/2007 Male 9/4/2007 Physician United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 7/3/2007 62 Female 108 lb 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Visual Field Defect Hospitalization 8/20/2007 Male 9/7/2007 Consumer United Kingdom
Primary
Secondary
Muscular Weakness Life Threatening 8/24/2007 Female 9/12/2007 Physician United Kingdom
Primary
Secondary
Appendicitis Perforated Hospitalization 8/5/2007 Male 9/13/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Transient Ischaemic Attack Hospitalization 7/21/2007 Male 9/14/2007 Consumer United Kingdom
Primary
Secondary
Platelet Count Decreased Hospitalization 8/20/2007 Male 9/14/2007 Physician Japan
Primary
Secondary
Bone Marrow Failure Hospitalization 8/16/2007 Female 9/20/2007 Physician United Kingdom
Primary
Secondary
Hypoaesthesia Life Threatening 8/24/2007 Female 9/21/2007 Physician United Kingdom
Primary
Secondary
Acute Pulmonary Oedema Death 9/15/2007 Female 10/3/2007 Consumer United Kingdom
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 8/22/2007 Male 10/3/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Hypersensitivity Other Serious 7/23/2007 Male 10/3/2007 Physician United Kingdom
Primary
Secondary
Fall Hospitalization 8/20/2007 Male 10/5/2007 Consumer United Kingdom
Primary
Secondary
Thrombocytopenia Death 9/15/2007 Female 10/5/2007 Consumer United Kingdom
Primary
Concomitant
Liver Disorder Hospitalization 9/19/2007 55 Male 10/5/2007 Physician United Kingdom
Primary
Concomitant
Pulmonary Embolism Other Serious 9/3/2007 32 Male 205 lb 10/9/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Intestinal Fistula Life Threatening 9/5/2007 Female 10/10/2007 Physician Japan
Primary
Secondary
Concomitant
Fall Hospitalization 8/20/2007 Male 10/10/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 8/11/2007 Male 10/11/2007 Physician United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 8/2/2007 Female 101 lb 10/11/2007 Consumer United Kingdom
Primary
Secondary
White Blood Cell Count Abnormal Death 9/26/2007 Male 10/11/2007 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Abnormal Other Serious 8/27/2007 Male 10/11/2007 Physician United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal Hospitalization 9/17/2007 Male 10/11/2007 Consumer United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/25/2007 Female 79 lb 10/12/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/12/2007 Male 10/12/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Rash Other Serious 9/4/2007 Female 10/16/2007 Physician United Kingdom
Primary
Concomitant
Nausea Hospitalization 8/16/2007 Female 10/16/2007 Physician United Kingdom
Primary
Secondary
Pyrexia Death Male 10/23/2007 Physician Japan
Primary
Secondary
Concomitant
Intestinal Obstruction Death 9/5/2007 Female 10/24/2007 Consumer United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 9/4/2007 Female 10/25/2007 Physician United Kingdom
Primary
Concomitant
Liver Disorder Hospitalization 9/19/2007 55 Male 10/26/2007 Physician United Kingdom
Primary
Concomitant
Liver Disorder Hospitalization 9/19/2007 55 Male 10/30/2007 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Hospitalization 9/15/2007 Female 10/31/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Intestinal Ulcer Hospitalization 9/28/2007 Female 10/31/2007 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Death 9/15/2007 Female 11/2/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 9/19/2007 55 Male 11/7/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 9/16/2007 Male 11/10/2007 Physician United Kingdom
Primary
Concomitant
Wound Dehiscence Death 9/5/2007 Female 11/13/2007 Consumer United Kingdom
Primary
Concomitant
Pneumonia Aspiration Death 9/26/2007 Male 11/13/2007 Physician United Kingdom
Primary
Concomitant
Interstitial Lung Disease Death Female 11/15/2007 Physician United Kingdom
Primary
Secondary
Liver Disorder Hospitalization 9/19/2007 55 Male 11/16/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Hypoaesthesia Life Threatening 8/24/2007 Female 11/16/2007 Physician United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 9/12/2007 Male 11/19/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Cardiac Failure Death 9/26/2007 Male 11/21/2007 Physician United Kingdom
Primary
Concomitant
Leukopenia Other Serious 9/12/2007 Female 11/21/2007 Physician Japan
Primary
Secondary
Concomitant
Somnolence Hospitalization 8/18/2007 Male 11/21/2007 Physician United Kingdom
Primary
Concomitant
Platelet Count Abnormal Death Female 11/26/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Hypertension Other Serious 7/23/2007 Male 11/29/2007 Physician United Kingdom
Primary
Secondary
Renal Failure Acute Hospitalization 9/19/2007 Female 12/4/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 9/16/2007 Male 12/5/2007 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 10/4/2007 Female 12/5/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Death Death 10/11/2007 Female 12/6/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Sepsis Death 11/20/2007 Male 12/7/2007 Consumer United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/25/2007 Female 79 lb 12/12/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 10/17/2007 Female 12/12/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 8/22/2007 Male 12/12/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Death Death 10/11/2007 Female 12/12/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Epistaxis Hospitalization 9/17/2007 Male 12/14/2007 Consumer United Kingdom
Primary
Concomitant
Sepsis Death 11/6/2007 Male 12/14/2007 Consumer United Kingdom
Primary
Concomitant
Shock Haemorrhagic Other Serious 10/8/2007 Male 12/14/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 9/19/2007 Female 12/14/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Sepsis Death 11/20/2007 Male 12/14/2007 Consumer United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 9/4/2007 Female 12/17/2007 Physician United Kingdom
Primary
Concomitant
Interstitial Lung Disease Other Serious 11/15/2007 Male 12/18/2007 Physician United Kingdom
Primary
Secondary
Hypertension Other Serious 10/29/2007 Male 12/18/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 11/19/2007 Male 12/18/2007 Consumer United Kingdom
Primary
Concomitant
Cardiac Failure Death 9/26/2007 Male 12/18/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Anaphylactic Shock Life Threatening 10/15/2007 Male 12/19/2007 Consumer United Kingdom
Primary
Concomitant
Anaphylactic Shock Life Threatening 10/9/2007 Male 12/19/2007 Consumer United Kingdom
Primary
Secondary
Hepatic Failure Death 11/15/2007 Male 12/21/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/28/2007 Female 12/21/2007 Consumer United Kingdom
Primary
Secondary
Sepsis Death 11/20/2007 Male 12/21/2007 Consumer United Kingdom
Primary
Concomitant
Platelet Count Decreased Hospitalization 11/7/2007 Female 12/21/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Sepsis Death 11/6/2007 Male 12/21/2007 Consumer United Kingdom
Primary
Concomitant
Hypersensitivity Hospitalization 11/26/2007 Male 12/21/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 12/3/2007 40 Female 12/27/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Platelet Count Decreased Hospitalization 11/7/2007 Female 1/2/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Hepatic Failure Death 11/15/2007 Male 1/2/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Death Death 10/11/2007 Female 1/2/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Shock Haemorrhagic Other Serious 10/8/2007 Male 1/3/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 10/22/2007 Male 1/3/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 11/19/2007 Male 1/4/2008 Consumer United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 10/17/2007 Female 1/4/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 11/27/2007 73 Female 128 lb 1/9/2008 Consumer United Kingdom
Primary
Secondary
Hypertension Hospitalization 12/23/2007 Male 1/9/2008 Consumer United Kingdom
Primary
Secondary
Interstitial Lung Disease Hospitalization 9/7/2007 Female 1/9/2008 Consumer United Kingdom
Primary
Secondary
Disseminated Intravascular Coagulation Hospitalization 12/27/2007 74 Male 1/10/2008 Consumer United Kingdom
Primary
Concomitant
Hypersensitivity Hospitalization 11/26/2007 Male 1/10/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypertension Other Serious 10/29/2007 Male 1/10/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 12/18/2007 Male 1/10/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 1/5/2008 Male 1/19/2008 Physician United Kingdom
Primary
Concomitant
Intestinal Obstruction Hospitalization 12/8/2007 40 Female 1/23/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Death Female 1/24/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Anaphylactic Shock Life Threatening 10/23/2007 Male 1/26/2008 Consumer United Kingdom
Primary
Secondary
Muscle Contractions Involuntary Hospitalization 12/17/2007 Male 1/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Platelet Count Decreased Disability 11/7/2007 Female 1/29/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Disability 9/9/2007 Female 1/29/2008 Physician Japan
Primary
Secondary
Concomitant
Anaphylactic Shock Life Threatening 10/15/2007 Male 1/29/2008 Consumer United Kingdom
Primary
Concomitant
Leukopenia Other Serious 9/12/2007 Female 1/31/2008 Physician Japan
Primary
Secondary
Concomitant
Anaphylactic Shock Life Threatening 1/18/2008 Male 2/6/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Pathological Fracture Hospitalization 11/16/2007 Male 2/7/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Hypoaesthesia Life Threatening 8/24/2007 Female 2/11/2008 Physician United Kingdom
Primary
Secondary
Neuropathy Peripheral Hospitalization 6/14/2007 Male 2/13/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Small Intestinal Perforation Other Serious 12/31/2007 Male 95 lb 2/20/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumothorax Hospitalization 9/28/2007 Male 2/20/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Disseminated Intravascular Coagulation Hospitalization 12/27/2007 74 Male 2/21/2008 Consumer United Kingdom
Primary
Concomitant
Pyrexia Life Threatening 1/5/2008 Male 2/21/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Disseminated Intravascular Coagulation Other Serious 1/22/2008 Male 2/22/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/4/2007 Female 2/22/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 11/27/2007 73 Female 128 lb 2/25/2008 Consumer United Kingdom
Primary
Secondary
Platelet Count Decreased Disability 11/7/2007 Female 2/25/2008 Consumer Japan
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 8/22/2007 Male 2/25/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Nephrotic Syndrome Disability 2/8/2008 Male 2/26/2008 Physician United Kingdom
Primary
Concomitant
Disease Progression Hospitalization 10/17/2007 Male 2/27/2008 Physician United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 9/12/2007 Male 3/3/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Disseminated Intravascular Coagulation Other Serious 1/22/2008 Male 3/6/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Intestinal Ulcer Hospitalization 10/1/2007 Female 3/6/2008 Physician United Kingdom
Primary
Concomitant
Pelvic Abscess Other Serious 9/25/2007 Male 3/7/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 11/22/2007 Female 3/7/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 12/21/2007 40 Female 3/7/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Sepsis Death 11/18/2007 Male 3/11/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Haemorrhage Death 9/28/2007 Male 3/11/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 8/11/2007 Male 3/12/2008 Physician United Kingdom
Primary
Secondary
Death Death 2/24/2008 Male 3/12/2008 Physician United Kingdom
Primary
Secondary
Hypoaesthesia Hospitalization 8/1/2007 Male 3/12/2008 Consumer United Kingdom
Primary
Secondary
Ventricular Tachycardia Other Serious 12/11/2007 Male 3/12/2008 Consumer United Kingdom
Primary
Concomitant
Platelet Count Decreased Hospitalization 11/7/2007 Female 3/13/2008 Consumer Japan
Primary
Secondary
Concomitant
Hypersensitivity Hospitalization 1/16/2008 Male 3/13/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Small Intestinal Perforation Other Serious 12/31/2007 Male 95 lb 3/13/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 11/27/2007 73 Female 128 lb 3/13/2008 Consumer United Kingdom
Primary
Secondary
Fall Other Serious 8/20/2007 Male 3/14/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Fall Other Serious 8/20/2007 Male 3/15/2008 Physician Japan
Primary
Secondary
Concomitant
Skin Disorder Other Serious 1/24/2008 Male 3/17/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/25/2007 Female 79 lb 3/18/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Death Death 2/24/2008 Male 3/19/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Anaphylactoid Shock Life Threatening 1/18/2008 Male 3/20/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Atrial Flutter Hospitalization 11/28/2007 Female 3/20/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 3/6/2008 Male 3/21/2008 Consumer United Kingdom
Primary
Concomitant
Neutrophil Count Decreased Life Threatening 2/26/2008 54 Male 3/24/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Epistaxis Hospitalization 9/25/2007 Female 3/26/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/2/2007 Female 101 lb 3/26/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypertension Other Serious 7/23/2007 Male 3/27/2008 Consumer United Kingdom
Primary
Secondary
Anaphylactic Shock Life Threatening 1/18/2008 Male 3/27/2008 Consumer United Kingdom
Primary
Secondary
Concomitant

Drug Data