Bevacizumab combined with Irinotecan

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Dehydration Hospitalization 2/4/2006 Male 2/16/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 12/20/2007 69 Male 148 lb 12/31/2007 Physician Canada
Primary
Secondary
Concomitant
Memory Impairment Hospitalization 11/19/2007 53 Female 157 lb 1/2/2008 Physician United States
Primary
Concomitant
Epistaxis Hospitalization 10/8/2007 Female 1/2/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Platelet Count Decreased Hospitalization 11/7/2007 Female 1/2/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 12/20/2007 Male 148 lb 1/4/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 9/10/2007 Female 119 lb 1/9/2008 Physician United States
Primary
Secondary
Pyrexia Hospitalization 11/19/2007 Male 174 lb 1/11/2008 Physician United States
Primary
Secondary
Death Death 12/26/2007 63 Male 188 lb 1/11/2008 Consumer United States
Primary
Concomitant
Disease Progression Hospitalization 9/10/2007 Female 119 lb 1/15/2008 Physician United States
Primary
Secondary
Death Death 12/26/2007 63 Male 188 lb 1/17/2008 Consumer United States
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 11/5/2007 60 Male 1/22/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 12/8/2007 40 Female 1/23/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Oesophagitis Life Threatening 1/4/2008 Male 161 lb 1/24/2008 Physician United States
Primary
Secondary
Concomitant
Peripheral Sensory Neuropathy Hospitalization 1/4/2008 Male 1/26/2008 Physician United States
Primary
Secondary
Concomitant
Facial Palsy Hospitalization 1/4/2008 Male 162 lb 1/26/2008 Physician United States
Primary
Secondary
Concomitant
Platelet Count Decreased Disability 11/7/2007 Female 1/29/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Virus Serology Test Positive Hospitalization 9/25/2007 49 Male 200 lb 1/28/2008 Other Health Professional United States
Primary
Secondary
Death Death 12/26/2007 63 Male 188 lb 2/1/2008 Consumer United States
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 12/20/2007 69 Male 148 lb 2/1/2008 Physician Canada
Primary
Secondary
Concomitant
Oesophagitis Life Threatening 1/4/2008 Male 161 lb 2/8/2008 Physician United States
Primary
Secondary
Concomitant
Peripheral Sensory Neuropathy Hospitalization 1/4/2008 Male 2/13/2008 Physician United States
Primary
Secondary
Concomitant
Oesophagitis Life Threatening 1/4/2008 Male 161 lb 2/13/2008 Physician United States
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious Male 2/9/2008 Other Health Professional Germany
Primary
Secondary
Tooth Extraction Other Serious 2/1/2006 56 Male 240 lb 2/14/2008 Physician Germany
Primary
Concomitant
Stomatitis Other Serious 12/1/2007 Male 2/14/2008 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Death 12/29/2007 Male 2/14/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Tumour Necrosis Hospitalization 11/19/2007 53 Female 157 lb 2/14/2008 Physician United States
Primary
Concomitant
Facial Palsy Hospitalization 1/4/2008 Male 162 lb 2/14/2008 Physician United States
Primary
Secondary
Concomitant
Pyrexia Life Threatening 1/5/2008 Male 2/21/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/4/2007 Female 2/22/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Platelet Count Decreased Disability 11/7/2007 Female 2/25/2008 Consumer Japan
Primary
Secondary
Concomitant
Nephrotic Syndrome Disability 2/8/2008 Male 2/26/2008 Physician United Kingdom
Primary
Concomitant
Tumour Necrosis Hospitalization 11/19/2007 53 Female 157 lb 2/27/2008 Physician United States
Primary
Secondary
Concomitant
Ileus Life Threatening 9/18/2007 Female 160 lb 3/5/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 12/21/2007 40 Female 3/7/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Haemorrhage Death 9/28/2007 Male 3/11/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 8/11/2007 Male 3/12/2008 Physician United Kingdom
Primary
Secondary
Hypoaesthesia Disability 11/22/2007 Female 98 lb 7/22/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization 6/14/2008 Female 200 lb 12/5/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 6/8/2009 Female 99 lb 8/20/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/10/2009 Female 12/30/2009 Physician United States
Primary
Secondary
Concomitant
Septic Shock Hospitalization 8/12/2009 Male 298 lb 1/4/2010 Physician Germany
Primary
Concomitant
Disease Progression Hospitalization 11/21/2009 Female 1/4/2010 Physician Denmark
Primary
Secondary
Concomitant
Small Intestinal Obstruction Death 7/26/2008 Male 137 lb 1/15/2010 Physician China
Primary
Secondary
Tumour Haemorrhage Other Serious 11/14/2009 Female 132 lb 3/10/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 3/14/2010 75 Female 163 lb 5/10/2010 Physician Belgium
Primary
Secondary
Sepsis Death 1/15/2010 51 Male 5/10/2010 Physician United States
Primary
Secondary
Diarrhoea Hospitalization 5/5/2010 62 Male 142 lb 5/6/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Autoimmune Thrombocytopenia Other Serious 3/9/2010 68 Male 212 lb 5/18/2010 Physician Germany
Primary
Secondary
Sepsis Death 1/15/2010 51 Male 5/18/2010 Physician United States
Primary
Secondary
Malignant Neoplasm Progression Other Serious Female 224 lb 5/18/2010 United States
Primary
Secondary
Concomitant
Gliomatosis Cerebri Other Serious 28 Male 5/25/2010 Other Health Professional United States
Primary
Concomitant
Perineal Infection Death 9/24/2009 53 Male 163 lb 5/25/2010 Physician France
Primary
Secondary
Acute Myeloid Leukaemia Death 11/9/2009 48 Male 154 lb 5/26/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 1/6/2010 67 Male 5/26/2010 Consumer United States
Primary
Secondary
Concomitant
Thrombosis Hospitalization 4/5/2010 Male 5/28/2010 Physician United States
Primary
Secondary
Oesophagitis Hospitalization 2/15/2010 Female 6/1/2010 Physician United States
Primary
Secondary
Perineal Infection Death 9/24/2009 53 Male 6/1/2010 Physician France
Primary
Secondary
Thrombosis Other Serious 5/22/2010 67 Male 134 lb 6/2/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Perineal Infection Death 9/24/2009 53 Male 163 lb 6/4/2010 Physician France
Primary
Secondary
Oesophagitis Hospitalization 2/17/2010 Male 6/4/2010 Physician United States
Primary
Secondary
Upper Gastrointestinal Haemorrhage Death 5/30/2010 66 Male 187 lb 6/7/2010 Physician Switzerland
Primary
Secondary
Tooth Disorder Hospitalization 5/31/2010 63 Male 134 lb 6/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/9/2010 64 Male 252 lb 6/11/2010 Physician United States
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Death 5/30/2010 66 Male 187 lb 6/12/2010 Physician Switzerland
Primary
Secondary
Thrombosis Other Serious 5/22/2010 67 Male 134 lb 6/15/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Neutropenia Hospitalization 1/15/2010 78 Female 122 lb 6/16/2010 Physician Spain
Primary
Secondary
Weight Decreased Hospitalization 2/23/2009 57 Female 120 lb 6/17/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Intracranial Pressure Increased Death 12/4/2009 55 Female 137 lb 6/17/2010 Physician France
Primary
Secondary
Meningitis Bacterial Hospitalization 6/2/2010 57 Male 232 lb 6/17/2010 Physician United States
Primary
Secondary
Concomitant
Thrombosis Hospitalization 4/5/2010 Male 6/23/2010 Physician United States
Primary
Secondary
Thrombosis Hospitalization 4/5/2010 Male 6/24/2010 Physician United States
Primary
Secondary
Tubulointerstitial Nephritis Hospitalization 5/25/2010 57 Male 159 lb 6/24/2010 Physician Germany
Primary
Secondary
Concomitant
Tubulointerstitial Nephritis Hospitalization 5/25/2010 57 Male 159 lb 6/29/2010 Physician Germany
Primary
Secondary
Concomitant
Cerebral Haemorrhage Hospitalization 7/12/2010 47 Female 119 lb 10/12/2010 Physician United States
Primary
Secondary
Concomitant
Gastric Cancer Hospitalization 10/15/2010 52 Male 140 lb 11/24/2010 Physician United States
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 11/5/2010 67 Male 185 lb 12/1/2010 Physician Spain
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 12/7/2010 61 Male 231 lb 12/16/2010 Physician United States
Primary
Secondary
Concomitant
Intracranial Tumour Haemorrhage Hospitalization 12/8/2010 59 Male 143 lb 1/4/2011 Physician United States
Primary
Secondary
Concomitant
Partial Seizures Hospitalization 12/30/2010 63 Female 157 lb 1/10/2011 Other Health Professional France
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 1/15/2010 78 Female 122 lb 1/14/2011 Physician Spain
Primary
Secondary
Hypertension Other Serious 65 Female 1/19/2011 Physician Canada
Primary
Secondary
Concomitant
Neutropenia Death 1/14/2010 58 Male 141 lb 1/25/2011 Physician Spain
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 12/7/2010 61 Male 247 lb 2/9/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Obstruction Hospitalization 10/5/2010 68 Male 154 lb 2/11/2011 Physician Spain
Primary
Secondary
Concomitant
Chest Pain Hospitalization 1/1/2010 72 Male 2/15/2011 Physician Austria
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Death 5/30/2010 66 Male 187 lb 2/16/2011 Physician Switzerland
Primary
Secondary
Concomitant
Dyspepsia Hospitalization 7/20/2010 76 Female 2/16/2011 Physician Germany
Primary
Concomitant
Mental Status Changes Hospitalization Female 285 lb 2/21/2011 Consumer United States
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 3/11/2010 73 Female 115 lb 2/25/2011 Physician Italy
Primary
Secondary
Concomitant
Glioblastoma Multiforme Other Serious 38 Male 2/25/2011 Other Health Professional United States
Primary
Secondary
Cerebral Haemorrhage Death 2/18/2011 37 Male 2/28/2011 Physician Italy
Primary
Secondary
Concomitant
Mucosal Inflammation Hospitalization 1/14/2010 58 Male 141 lb 3/2/2011 Physician Spain
Primary
Secondary
Concomitant
Death Death 2/9/2011 64 Female 143 lb 3/2/2011 Physician Italy
Primary
Secondary
Myopathy Other Serious 38 Male 3/3/2011 Physician United States
Primary
Secondary
Concomitant
Acne Death 38 Male 3/4/2011 United States
Primary
Secondary
Pulmonary Embolism Hospitalization 2/25/2011 55 Male 146 lb 3/4/2011 Physician United States
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 2/25/2011 3/8/2011 Physician Sweden
Primary
Secondary
Cholecystitis Hospitalization 12/31/2010 52 Male 183 lb 3/8/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Enterocutaneous Fistula Death 12/27/2010 47 Male 3/8/2011 Physician Italy
Primary
Secondary
Moyamoya Disease Death 9 Male 3/9/2011 Physician United States
Primary
Concomitant
Cerebrovascular Accident Disability 8/29/2010 56 Female 108 lb 3/10/2011 Physician France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 1/14/2010 58 Male 141 lb 3/11/2011 Physician Spain
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 3/14/2011 Physician Austria
Primary
Secondary
Dysuria Hospitalization 12/9/2010 55 Male 179 lb 3/14/2011 Physician Germany
Primary
Secondary
Enterocutaneous Fistula Death 12/27/2010 47 Male 3/14/2011 Physician Italy
Primary
Secondary
Intestinal Obstruction Death 3/15/2011 71 Female 129 lb 3/25/2011 Physician Spain
Primary
Secondary
Concomitant
Cerebral Ischaemia Hospitalization 3/13/2011 67 Male 176 lb 3/29/2011 Physician Italy
Primary
Secondary
Concomitant
Portal Vein Thrombosis Other Serious 3/29/2011 Physician United States
Primary
Secondary
Intestinal Obstruction Death 3/15/2011 71 Female 129 lb 3/29/2011 Physician Spain
Primary
Secondary
Concomitant
Meningitis Bacterial Death 2/16/2011 73 Male 225 lb 3/30/2011 Physician Spain
Primary
Secondary
Concomitant
Neutropenia Hospitalization 3/18/2011 66 Female 161 lb 3/30/2011 Consumer United States
Primary
Secondary
Device Related Infection Hospitalization 8/4/2010 75 Male 4/7/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 3/11/2011 76 Male 227 lb 4/7/2011 Physician Germany
Primary
Secondary
Concomitant
Obstruction Gastric Hospitalization 3/18/2011 65 Male 147 lb 4/7/2011 Consumer United States
Primary
Secondary
Concomitant
Toxicity To Various Agents Other Serious 4/8/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Incision Site Infection Other Serious 7/26/2010 48 Male 187 lb 4/11/2011 Physician United States
Primary
Secondary
Concomitant
Convulsion Other Serious 6/3/2010 62 Female 141 lb 4/12/2011 Consumer United States
Primary
Secondary
Concomitant
Fall Hospitalization 3/12/2011 71 Male 159 lb 4/12/2011 Physician Canada
Primary
Secondary
Concomitant
Enterocutaneous Fistula Death 12/27/2010 47 Male 4/13/2011 Physician Italy
Primary
Secondary
Abdominal Abscess Hospitalization 10/12/2010 59 Female 4/13/2011 Physician Italy
Primary
Secondary
Device Related Infection Hospitalization 8/4/2010 75 Male 4/13/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Neutropenia Hospitalization 3/17/2011 71 Male 159 lb 4/14/2011 Physician Canada
Primary
Secondary
Concomitant
Acute Myocardial Infarction Other Serious 4/15/2011 Other Health Professional Italy
Primary
Secondary
Pyrexia Hospitalization 8/4/2010 75 Male 4/15/2011 Physician United States
Primary
Secondary
Concomitant
Death Death 9/1/2010 68 Male 4/18/2011 Physician China
Primary
Concomitant
Grand Mal Convulsion Death 50 Female 4/18/2011 Physician Turkey
Primary
Secondary
Pneumonitis Hospitalization 8/4/2010 75 Male 4/19/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Atrial Fibrillation Other Serious 2/23/2009 55 Male 4/20/2011 Consumer Croatia (Local Name: Hrvatska)
Primary
Concomitant
Atrial Fibrillation 2/23/2009 55 Male 4/20/2011 Consumer Croatia (Local Name: Hrvatska)
Primary
Concomitant
Constipation Death 12/9/2010 77 Female 126 lb 4/26/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Grand Mal Convulsion Death 50 Female 4/26/2011 Physician Turkey
Primary
Secondary
Grand Mal Convulsion Death 9/3/2010 50 Female 165 lb 4/28/2011 Consumer Turkey
Primary
Concomitant
Musculoskeletal Stiffness Other Serious 6/3/2010 62 Female 135 lb 4/28/2011 Consumer United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death 65 Female 203 lb 5/3/2011 Physician Germany
Primary
Concomitant
Neoplasm Malignant Death Male 174 lb 5/3/2011 Consumer Germany
Primary
Concomitant
Neoplasm Malignant Death Male 165 lb 5/3/2011 Consumer Germany
Primary
Concomitant
No Therapeutic Response Death Female 172 lb 5/3/2011 Consumer Germany
Primary
Concomitant
No Therapeutic Response Death Female 110 lb 5/3/2011 Physician Germany
Primary
Concomitant
Neoplasm Malignant Death Female 154 lb 5/3/2011 Physician Germany
Primary
Concomitant
General Physical Health Deterioration Hospitalization 4/16/2011 76 Female 110 lb 5/4/2011 Physician Spain
Primary
Secondary
Concomitant
Neoplasm Malignant Death Male 172 lb 5/4/2011 Consumer Germany
Primary
Concomitant
Stomatitis Death 12/10/2010 78 Female 126 lb 12/18/2012 Physician Country Not Specified
Primary
Secondary
Concomitant
Acute Lymphocytic Leukaemia Life Threatening 8/31/2011 57 Male 10/17/2012 Physician Fr
Primary
Secondary
Drug Effect Decreased Death Male 192 lb 12/3/2012 Physician Us
Primary
Secondary
Concomitant
Pulmonary Embolism Death 8/20/2010 76 Female 157 lb 11/23/2012 Physician De
Primary
Secondary
Concomitant
Cholelithiasis Hospitalization 7/20/2012 69 Female 123 lb 10/19/2012 Physician De
Primary
Concomitant
Muscular Weakness Hospitalization 9/3/2012 82 Male 149 lb 11/1/2012 Physician Us
Primary
Secondary
Wound Dehiscence Hospitalization 14 Male 9/19/2012 Au
Primary
Secondary
Concomitant

Drug Data