Bevacizumab combined with Irinotecan Hydrochloride

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Intestinal Ulcer Hospitalization 10/1/2007 Female 3/6/2008 Physician United Kingdom
Primary
Concomitant
Platelet Count Decreased Life Threatening 10/2/2007 Female 3/10/2008 Physician Japan
Primary
Secondary
Concomitant
Sepsis Death 11/18/2007 Male 3/11/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Haemorrhage Death 9/28/2007 Male 3/11/2008 Physician Japan
Primary
Secondary
Concomitant
Hypersensitivity Hospitalization 1/16/2008 Male 3/13/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/25/2007 Female 79 lb 3/18/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization 2/29/2008 Male 185 lb 3/27/2008 Physician Germany
Primary
Secondary
Concomitant
Glioblastoma Multiforme Other Serious 10/1/2006 78 Male 196 lb 3/27/2008 Physician United States
Primary
Secondary
Convulsion Hospitalization 2/29/2008 Male 185 lb 3/31/2008 Consumer United States
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/8/2008 69 Male 181 lb 4/4/2008 United States
Primary
Secondary
Gastrointestinal Haemorrhage Other Serious 12/27/2007 78 Male 196 lb 4/7/2008 United States
Primary
Secondary
Weight Decreased Other Serious 1/8/2008 69 Male 181 lb 4/7/2008 Consumer United States
Primary
Secondary
Concomitant
Thrombosis Hospitalization 9/13/2007 Female 179 lb 4/9/2008 Physician Germany
Primary
Secondary
Concomitant
Weight Decreased Other Serious 1/8/2008 69 Male 181 lb 4/9/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pathological Fracture Hospitalization 11/16/2007 Male 4/11/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious 69 Male 181 lb 4/11/2008 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Other Serious 12/27/2007 78 Male 196 lb 4/16/2008 United States
Primary
Secondary
Weight Decreased Other Serious 69 Male 181 lb 4/18/2008 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 1/1/2008 4/21/2008 Consumer United States
Primary
Secondary
Glioblastoma Multiforme Other Serious 10/1/2006 78 Male 196 lb 4/24/2008 Physician United States
Primary
Secondary
Renal Failure Other Serious 1/23/2008 Male 150 lb 4/24/2008 Physician Germany
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 4/9/2008 Male 4/29/2008 Consumer United Kingdom
Primary
Concomitant
Convulsion Hospitalization 10/1/2008 Female 283 lb 10/10/2008 Consumer United States
Primary
Secondary
Keratoconjunctivitis Sicca Hospitalization 9/5/2008 68 Male 10/13/2008 Consumer Germany
Primary
Secondary
Neutrophil Count Decreased Disability 11/22/2007 Female 98 lb 10/14/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 4/2/2008 Male 134 lb 10/15/2008 Physician Japan
Primary
Secondary
Concomitant
General Physical Health Deterioration Hospitalization 8/2/2007 Male 141 lb 10/17/2008 Physician France
Primary
Secondary
Hypovolaemic Shock Life Threatening 10/5/2008 Female 10/21/2008 Physician Switzerland
Primary
Secondary
Hypovolaemic Shock Life Threatening 10/8/2008 Female 10/22/2008 Physician United Kingdom
Primary
Secondary
General Physical Health Deterioration Hospitalization 8/2/2007 Male 141 lb 10/23/2008 Physician France
Primary
Secondary
General Physical Health Deterioration Hospitalization 8/2/2007 Male 10/24/2008 Consumer United Kingdom
Primary
Secondary
Vomiting Hospitalization 10/14/2008 70 Male 10/24/2008 Consumer Germany
Primary
Secondary
Multi-organ Failure Death 10/28/2008 Consumer United Kingdom
Primary
Secondary
Stomatitis Hospitalization 9/9/2008 Male 128 lb 10/29/2008 Physician United Kingdom
Primary
Secondary
Concomitant
General Physical Health Deterioration Hospitalization 8/2/2007 Male 10/29/2008 Consumer United Kingdom
Primary
Secondary
Sinus Tachycardia Other Serious 9/1/2008 69 Male 10/31/2008 Physician Switzerland
Primary
Concomitant
Intestinal Obstruction Life Threatening 9/17/2008 Female 10/31/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Neutrophil Count Decreased Other Serious 1/11/2008 Male 106 lb 10/31/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypomagnesaemia Other Serious 5/13/2008 Male 185 lb 10/31/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/14/2008 70 Male 11/4/2008 Consumer Germany
Primary
Secondary
Intracranial Hypotension Death 1/1/2007 Female 11/4/2008 United States
Primary
Secondary
Concomitant
Intracranial Hypotension Death 1/1/2007 Male 11/4/2008 United States
Primary
Secondary
Concomitant
Death Death 1/25/2008 Male 11/4/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Ileus Other Serious 9/17/2008 Male 207 lb 11/5/2008 Physician Germany
Primary
Secondary
Dyspnoea Hospitalization 10/5/2008 Male 11/7/2008 Physician Germany
Primary
Secondary
Diarrhoea Hospitalization 9/29/2008 68 Male 11/7/2008 Consumer Germany
Primary
Secondary
Neoplasm Progression Death 9/1/2008 Female 11/7/2008 Physician United Kingdom
Primary
Concomitant
Hypovolaemic Shock Life Threatening 10/5/2008 65 Female 11/3/2008 Physician Switzerland
Primary
Secondary
Grand Mal Convulsion Hospitalization 9/10/2008 Female 11/10/2008 Physician United Kingdom
Primary
Concomitant
Peptic Ulcer Disability 1/1/2008 Male 119 lb 11/10/2008 Consumer Japan
Primary
Secondary
Concomitant
Aortic Valve Incompetence Other Serious Male 11/10/2008 Consumer United Kingdom
Primary
Secondary
Interstitial Lung Disease Other Serious 4/2/2008 Male 115 lb 11/11/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Hypomagnesaemia Other Serious 5/13/2008 Male 185 lb 11/11/2008 Physician United States
Primary
Secondary
Concomitant
Keratoconjunctivitis Sicca Hospitalization 9/5/2008 68 Male 11/11/2008 Consumer United States
Primary
Secondary
Hypovolaemic Shock Life Threatening 10/8/2008 Female 11/11/2008 Physician United Kingdom
Primary
Secondary
Herpes Zoster Hospitalization 11/29/2007 Female 105 lb 11/12/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Skin Discolouration Other Serious 10/14/2008 Female 11/12/2008 Physician United Kingdom
Primary
Concomitant
Keratoconjunctivitis Sicca Hospitalization 9/10/2008 Male 11/12/2008 Physician Switzerland
Primary
Secondary
Nephrotic Syndrome Other Serious 1/10/2008 Male 11/14/2008 Physician Japan
Primary
Concomitant
Ileus Other Serious 9/19/2008 Male 11/14/2008 Physician Germany
Primary
Secondary
Cardiomyopathy Hospitalization 4/1/2008 68 Female 11/17/2008 Physician Switzerland
Primary
Secondary
Concomitant
Cerebral Infarction Hospitalization 8/23/2008 11/18/2008 Consumer United Kingdom
Primary
Secondary
Ileus Hospitalization 9/17/2008 Male 207 lb 11/19/2008 Physician Germany
Primary
Secondary
Anaemia Other Serious 11/19/2008 Physician United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Other Serious 8/11/2007 Male 11/19/2008 Physician United Kingdom
Primary
Secondary
Vomiting Other Serious 10/11/2008 70 Male 11/20/2008 Consumer Germany
Primary
Secondary
Grand Mal Convulsion Hospitalization 9/10/2008 Female 11/20/2008 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 8/11/2007 Male 11/20/2008 Physician United Kingdom
Primary
Secondary
Renal Failure Acute Other Serious 10/5/2008 Female 11/24/2008 Physician Switzerland
Primary
Secondary
Pulmonary Embolism Life Threatening 10/8/2008 Female 11/25/2008 Physician United Kingdom
Primary
Secondary
Cardiomyopathy Hospitalization 4/1/2008 68 Female 11/25/2008 Physician Switzerland
Primary
Secondary
Concomitant
Epistaxis Hospitalization 9/18/2007 Male 11/25/2008 Consumer Japan
Primary
Secondary
Concomitant
Renal Failure Other Serious 10/14/2008 Male 11/25/2008 Physician United Kingdom
Primary
Secondary
Anaemia Death 9/16/2008 Female 11/25/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Other Serious 12/27/2007 78 Male 196 lb 11/26/2008 United States
Primary
Secondary
Diarrhoea Hospitalization 9/29/2008 Male 11/26/2008 Physician Switzerland
Primary
Secondary
Disorientation Hospitalization 2/13/2008 Male 119 lb 11/26/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Mood Altered Hospitalization 11/13/2008 11/26/2008 Physician United Kingdom
Primary
Secondary
C-reactive Protein Increased Hospitalization 9/29/2008 Male 11/26/2008 Consumer United States
Primary
Secondary
Keratoconjunctivitis Sicca Hospitalization 9/10/2008 Male 12/2/2008 Physician Switzerland
Primary
Secondary
Renal Failure Acute Other Serious 10/5/2008 Female 12/2/2008 Physician Switzerland
Primary
Secondary
Pyrexia Hospitalization 11/13/2008 Male 109 lb 12/3/2008 Physician United Kingdom
Primary
Secondary
Death Death Male 12/5/2008 Physician United Kingdom
Primary
Concomitant
Death Death Female 12/5/2008 Consumer United Kingdom
Primary
Concomitant
Somnolence Hospitalization 10/10/2007 61 Male 181 lb 12/9/2008 Physician
Primary
Secondary
Rectal Haemorrhage Hospitalization 11/13/2008 12/10/2008 Physician United Kingdom
Primary
Secondary
Platelet Count Decreased Hospitalization 11/25/2008 Male 146 lb 12/10/2008 Physician Japan
Primary
Secondary
Concomitant
Keratoconjunctivitis Sicca Hospitalization 9/5/2008 68 Male 12/12/2008 Consumer United States
Primary
Secondary
Iliac Artery Thrombosis Other Serious 63 Female 12/19/2008 Physician Greece
Primary
Secondary
Concomitant
Vomiting Hospitalization 73 Male 12/19/2008 Physician Greece
Primary
Secondary
Concomitant
Pyrexia Hospitalization 11/13/2008 Male 109 lb 1/16/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Neutrophil Count Decreased Hospitalization 10/18/2007 Male 143 lb 1/21/2009 Physician Japan
Primary
Secondary
Concomitant
Hypertension Life Threatening 11/25/2008 Male 146 lb 2/4/2009 Physician Japan
Primary
Secondary
Concomitant
Subileus Hospitalization 1/23/2009 Female 136 lb 2/12/2009 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/14/2007 Female 2/17/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Anal Abscess Hospitalization 5/13/2008 3/6/2009 Physician France
Primary
Secondary
Hypertension Life Threatening 11/25/2008 Male 146 lb 3/17/2009 Physician Japan
Primary
Secondary
Concomitant
Hepatic Steatosis Hospitalization 1/1/2009 55 Male 4/8/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Acute Myeloid Leukaemia Other Serious 56 Female 4/30/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Life Threatening 12/28/2007 Male 165 lb 5/4/2009 Physician Japan
Primary
Secondary
Concomitant
Dyspnoea Hospitalization 10/5/2008 Male 6/22/2009 Physician Germany
Primary
Secondary
Fanconi Syndrome Acquired Hospitalization 1/1/2006 77 Female 10/9/2009 Other Health Professional United States
Primary
Secondary
Small Intestinal Perforation Hospitalization 9/13/2007 Male 190 lb 10/19/2009 Physician France
Primary
Secondary
Colitis Hospitalization 10/11/2007 Male 11/18/2009 Physician France
Primary
Secondary
Concomitant
Anal Abscess Hospitalization 5/13/2008 11/19/2009 Physician France
Primary
Secondary
Febrile Bone Marrow Aplasia Hospitalization 6/12/2007 Male 11/23/2009 Physician United States
Primary
Secondary
Concomitant
Ataxia Hospitalization 10/6/2009 Female 159 lb 2/16/2010 Physician United States
Primary
Secondary
Myelodysplastic Syndrome Other Serious 16 Male 3/10/2010 Physician United States
Primary
Secondary
Urinary Tract Infection Other Serious 6/1/2009 Female 104 lb 3/24/2010 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Hospitalization 11/27/2009 4/8/2010 Physician Sweden
Primary
Secondary
Disseminated Intravascular Coagulation Death 2/13/2006 38 Male 161 lb 4/9/2010 Physician Italy
Primary
Secondary
Blood Calcium Decreased Other Serious 12/30/2009 5 Male 4/12/2010 Physician United States
Primary
Secondary
Lung Abscess Hospitalization 1/1/2009 71 Female 4/12/2010 Physician Germany
Primary
Secondary
Vomiting Hospitalization 1/3/2010 50 Female 136 lb 4/15/2010 Physician United States
Primary
Secondary
Concomitant
Paraesthesia Hospitalization 12/1/2009 61 Male 4/14/2010 Other Health Professional France
Primary
Secondary
Concomitant
Hepatitis Cholestatic Hospitalization 8/21/2009 60 Male 4/16/2010 Other Health Professional France
Primary
Secondary
Concomitant
Oedema Peripheral Hospitalization 8/5/2009 67 Male 152 lb 4/22/2010 Physician Spain
Primary
Secondary
Concomitant
Paraesthesia Hospitalization 7/12/2008 32 Male 165 lb 4/27/2010 Physician United States
Primary
Secondary
Concomitant
Multi-organ Failure Death 4/20/2010 79 Male 146 lb 4/28/2010 Physician Spain
Primary
Secondary
Hepatitis Cholestatic Hospitalization 8/21/2009 60 Male 4/27/2010 Other Health Professional France
Primary
Secondary
Concomitant
Sepsis Death 1/15/2010 51 Male 5/4/2010 Physician United States
Primary
Secondary
Paraesthesia Hospitalization 1/1/2009 60 Male 5/4/2010 Other Health Professional France
Primary
Secondary
Concomitant
Gastrointestinal Fistula Death 9/24/2009 53 Male 163 lb 5/4/2010 Physician France
Primary
Secondary
Multi-organ Failure Death 4/18/2010 79 Male 146 lb 5/5/2010 Physician Spain
Primary
Secondary
Vomiting Hospitalization 4/9/2010 64 Male 252 lb 5/5/2010 Consumer United States
Primary
Secondary
Concomitant
Enteritis Hospitalization 12/21/2009 78 Male 137 lb 5/6/2010 Physician Germany
Primary
Secondary
Concomitant
Ileus Hospitalization 11/10/2006 58 Male 164 lb 6/17/2010 Physician Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 6/1/2009 71 Female 6/22/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 11/27/2009 67 Female 7/14/2010 Physician Italy
Primary
Secondary
Mucosal Inflammation Hospitalization 5/7/2010 68 Male 168 lb 8/3/2010 Physician Germany
Primary
Secondary
Concomitant
Malaise Hospitalization 6/25/2010 65 Female 8/4/2010 Physician Japan
Primary
Secondary
Concomitant
Malaise Hospitalization 6/4/2010 65 Female 8/19/2010 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Inflammation Hospitalization 8/12/2010 46 Male 8/24/2010 Physician Japan
Primary
Secondary
Concomitant
Malaise Hospitalization 6/4/2010 65 Female 9/21/2010 Physician Japan
Primary
Secondary
Concomitant
Constipation Hospitalization 3/4/2010 74 Male 190 lb 11/18/2010 Physician Germany
Primary
Secondary
Concomitant
Malignant Hypertension Hospitalization 4/11/2009 69 Female 12/16/2010 Consumer United States
Primary
Secondary
Urinary Tract Infection Other Serious 1/1/2010 69 Female 12/17/2010 Physician Japan
Primary
Secondary
Concomitant
Dystonia Other Serious 8/18/2010 66 Female 12/21/2010 Spain
Primary
Secondary
Arthralgia Other Serious 3/24/2010 48 Male 209 lb 1/4/2011 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/2010 69 Female 1/4/2011 Physician Japan
Primary
Secondary
Concomitant
Coma Death 64 Female 1/4/2011 Physician United States
Primary
Secondary
Diarrhoea Hospitalization 1/1/2010 69 Female 1/13/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Abdominal Infection Other Serious 1/1/2010 69 Female 1/20/2011 Physician Japan
Primary
Secondary
Concomitant
Epilepsy Other Serious 1/1/2011 2/21/2011 Physician France
Primary
Secondary
Epilepsy Other Serious 1/1/2011 2/21/2011 Physician France
Primary
Secondary
Hypertension Other Serious 3/15/2011 Physician Finland
Primary
Secondary
Lymphocyte Count Decreased Hospitalization 10/21/2010 20 Female 3/16/2011 Consumer United States
Primary
Secondary
Optic Neuropathy Other Serious 24 Female 3/22/2011 Other Health Professional United States
Primary
Concomitant
Ileus Death 3/12/2011 69 Female 3/22/2011 Physician Czech Republic
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Death 5/30/2010 66 Male 187 lb 3/23/2011 Physician Switzerland
Primary
Secondary
Concomitant

Drug Data