Bevacizumab combined with Irinotecan Hcl

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Oral Intake Reduced Hospitalization 2/14/2006 55 Male 145 lb 2/23/2006 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Perforation Hospitalization 2/6/2006 70 Female 95 lb 3/8/2006 Physician Italy
Primary
Secondary
Febrile Neutropenia Hospitalization 10/1/2005 80 Male 210 lb 2/24/2006 United States
Primary
Secondary
Concomitant
Prothrombin Time Abnormal Required Intervention 10/9/2006 Male 211 lb 10/12/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Hemiparesis Hospitalization 9/20/2006 Male 162 lb 10/18/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 9/27/2006 61 Male 192 lb 10/25/2006 Physician Italy
Primary
Secondary
Concomitant
Sepsis Hospitalization 6/7/2005 Female 10/26/2006 Other Health Professional Spain
Primary
Secondary
Concomitant
Oral Intake Reduced Hospitalization 10/19/2006 80 Female 121 lb 10/27/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/21/2006 63 Female 88 lb 10/31/2006 Physician France
Primary
Secondary
Vomiting Hospitalization 9/21/2006 63 Female 88 lb 11/2/2006 Physician France
Primary
Secondary
Thrombosis Hospitalization 8/2/2006 55 Male 150 lb 11/3/2006 Physician Germany
Primary
Secondary
Vomiting Hospitalization 9/27/2006 61 Male 192 lb 11/10/2006 Physician Italy
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 10/19/2006 80 Female 121 lb 11/16/2006 Physician United States
Primary
Secondary
Concomitant
Proctalgia Hospitalization 8/15/2006 47 Male 157 lb 11/27/2006 Physician Germany
Primary
Secondary
Respiratory Failure Hospitalization 10/19/2006 80 Female 121 lb 11/23/2006 Physician United States
Primary
Secondary
Concomitant
Peritonitis Bacterial Hospitalization 20 Male 11/30/2006
Primary
Secondary
Toe Amputation Other Serious 57 Male 12/28/2006 Switzerland
Primary
Secondary
Necrosis Ischaemic Other Serious 57 Male 1/15/2007
Primary
Secondary
Intestinal Perforation Life Threatening 10/18/2006 61 Male 172 lb 1/16/2007 Other Health Professional France
Primary
Secondary
Toe Amputation Other Serious 57 Male 1/29/2007 Switzerland
Primary
Secondary
Platelet Count Decreased Other Serious Male 2/15/2007 France
Primary
Concomitant
Dehydration Hospitalization 2/4/2006 Male 3/14/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
Sepsis Hospitalization 3/19/2007 63 Female 4/2/2007 Physician United Kingdom
Primary
Secondary
Platelet Count Decreased Other Serious 1/24/2007 Male 154 lb 4/6/2007 France
Primary
Concomitant
Oesophagitis Hospitalization 11/7/2006 Female 207 lb 4/10/2007 United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 52 Male 4/17/2007 Other Health Professional United States
Primary
Secondary
Hypotension Hospitalization 4/18/2007 73 Male 163 lb 4/23/2007 Other Health Professional United States
Primary
Concomitant
Cerebral Haemorrhage Life Threatening 10/16/2006 Female 220 lb 5/1/2007 United States
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 4/17/2007 Male 5/2/2007 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/13/2007 Female 121 lb 5/3/2007 Other Health Professional France
Primary
Secondary
Vomiting Hospitalization 5/3/2007 Male 161 lb 5/14/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 4/17/2007 Male 5/16/2007 Physician United States
Primary
Secondary
Concomitant
Local Swelling Hospitalization Female 124 lb 5/16/2007 Consumer United Kingdom
Primary
Secondary
Vomiting Hospitalization 5/3/2007 Male 161 lb 5/18/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Hypomagnesaemia Hospitalization 4/29/2007 Male 5/25/2007 Consumer United States
Primary
Secondary
Death Death Female 5/30/2007 Other Health Professional United Kingdom
Primary
Secondary
Vena Cava Thrombosis Hospitalization Female 124 lb 5/30/2007 Consumer United Kingdom
Primary
Secondary
Gastroenteritis Hospitalization 4/4/2007 Male 154 lb 6/11/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Hepatic Failure Hospitalization 5/29/2007 Male 232 lb 6/13/2007 Physician United States
Primary
Secondary
Concomitant
Fanconi Syndrome Other Serious 77 Female 6/15/2007 United States
Primary
Concomitant
Ventricular Fibrillation Death 1/19/2005 Male 6/21/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 8/20/2006 74 Female 121 lb 6/25/2007 Physician Germany
Primary
Secondary
Drug Interaction Other Serious 7/3/2007 Physician Israel
Primary
Concomitant
Interacting
Pyrexia Hospitalization 3/19/2007 Male 136 lb 7/9/2007 Physician United States
Primary
Secondary
Concomitant
Wound Infection Life Threatening 6/4/2007 72 Male 7/11/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 7/4/2007 Female 95 lb 7/13/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Neutropenia Life Threatening 7/4/2007 Female 95 lb 7/16/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 7/4/2007 Female 95 lb 7/19/2007 Consumer United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 7/10/2007 Male 223 lb 7/19/2007 Other Health Professional United States
Primary
Secondary
Pyrexia Hospitalization 7/10/2007 Male 223 lb 7/26/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/17/2005 74 Male 170 lb 7/26/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/26/2007 Male 116 lb 8/2/2007 Other Health Professional United States
Primary
Secondary
Ventricular Fibrillation Death 1/19/2005 Male 8/7/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 4/28/2007 Female 8/8/2007 Other Health Professional United Kingdom
Primary
Secondary
Bone Marrow Failure Life Threatening 8/1/2007 Female 117 lb 8/15/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Pupils Unequal Hospitalization 7/21/2007 Male 8/15/2007 Consumer United Kingdom
Primary
Secondary
Anaemia Hospitalization 8/9/2007 Female 154 lb 8/24/2007 Consumer Germany
Primary
Concomitant
Weight Decreased Death 7/30/2007 71 Male 168 lb 8/27/2007 Physician France
Primary
Secondary
Concomitant
Bone Marrow Failure Life Threatening 8/1/2007 Female 117 lb 8/29/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Death 7/30/2007 Male 8/30/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Oesophagitis Hospitalization 7/16/2007 59 Male 159 lb 9/5/2007 United States
Primary
Secondary
Neuropathy Other Serious 39 Male 9/6/2007 Physician France
Primary
Concomitant
Pyrexia Life Threatening 8/1/2007 Female 117 lb 9/7/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Nervous System Disorder Other Serious 6/10/2007 Male 201 lb 9/7/2007 Physician United States
Primary
Secondary
Concomitant
Febrile Neutropenia Hospitalization 8/18/2007 75 Male 114 lb 9/5/2007 Other Health Professional United States
Primary
Secondary
Haemorrhage Hospitalization 7/29/2007 Male 204 lb 9/11/2007 Physician United States
Primary
Secondary
Concomitant
Haemorrhage Other Serious 1/18/2007 Male 9/11/2007 Physician United States
Primary
Secondary
Concomitant
Sudden Death Death 9/4/2007 Female 172 lb 9/12/2007 Physician United States
Primary
Secondary
Transient Ischaemic Attack Hospitalization 7/21/2007 Male 9/14/2007 Consumer United Kingdom
Primary
Secondary
Haemorrhage Hospitalization 7/29/2007 Male 204 lb 9/19/2007 Physician United States
Primary
Secondary
Concomitant
Neutropenia Life Threatening 7/4/2007 Female 95 lb 9/24/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Haemorrhage Other Serious 1/18/2007 Male 9/25/2007 Physician United States
Primary
Secondary
Concomitant
Disease Progression Death 8/23/2007 49 Male 231 lb 9/27/2007 Consumer United States
Primary
Secondary
Concomitant
Bone Marrow Failure Life Threatening 8/1/2007 Female 117 lb 10/2/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 9/19/2007 55 Male 10/5/2007 Physician United Kingdom
Primary
Concomitant
Subarachnoid Haemorrhage Hospitalization 7/29/2007 Male 204 lb 10/11/2007 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 8/11/2007 Male 10/11/2007 Physician United Kingdom
Primary
Secondary
White Blood Cell Count Abnormal Hospitalization 9/17/2007 Male 10/11/2007 Consumer United Kingdom
Primary
Concomitant
West Nile Viral Infection Hospitalization 9/25/2007 49 Male 200 lb 10/5/2007 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 9/25/2007 Female 79 lb 10/12/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Rash Other Serious 9/4/2007 Female 10/16/2007 Physician United Kingdom
Primary
Concomitant
General Physical Health Deterioration Death 9/4/2007 Female 172 lb 10/18/2007 Physician United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/26/2007 Male 10/19/2007 Physician United Kingdom
Primary
Secondary
Small Intestinal Obstruction Hospitalization 9/22/2007 Male 165 lb 10/22/2007 Physician United States
Primary
Secondary
Disease Progression Death 8/23/2007 49 Male 231 lb 10/22/2007 Consumer United States
Primary
Secondary
Concomitant
Polycythaemia Other Serious 9/17/2007 Male 399 lb 10/24/2007 Consumer France
Primary
Secondary
Mental Status Changes Hospitalization 3/12/2007 10/25/2007 Physician United States
Primary
Secondary
Rash Generalised Other Serious 9/4/2007 Female 10/25/2007 Physician United Kingdom
Primary
Concomitant
Liver Disorder Hospitalization 9/19/2007 55 Male 10/26/2007 Physician United Kingdom
Primary
Concomitant
Intracranial Hypotension Hospitalization 10/10/2007 Male 180 lb 10/29/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 9/19/2007 55 Male 10/30/2007 Physician United Kingdom
Primary
Concomitant
Intestinal Ulcer Hospitalization 9/28/2007 Female 10/31/2007 Physician United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 9/26/2007 Male 10/31/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 9/10/2007 Female 119 lb 11/2/2007 Physician United States
Primary
Secondary
Small Intestinal Obstruction Hospitalization 9/22/2007 Male 165 lb 11/2/2007 Physician United States
Primary
Secondary
Death Death 10/5/2007 72 Male 219 lb 11/5/2007 Physician United States
Primary
Concomitant
Hemiparesis Hospitalization 7/18/2007 Male 11/7/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 9/19/2007 55 Male 11/7/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Diarrhoea Haemorrhagic Life Threatening 9/25/2007 Female 11/8/2007 Physician United Kingdom
Primary
Secondary
Somnolence Hospitalization 10/10/2007 Male 180 lb 11/9/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 9/10/2007 Female 119 lb 11/9/2007 Physician United States
Primary
Secondary
Convulsion Hospitalization 7/6/2007 Male 11/9/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 9/16/2007 Male 11/10/2007 Physician United Kingdom
Primary
Concomitant
Rectal Haemorrhage Hospitalization 4/14/2005 Male 143 lb 11/13/2007 United Kingdom
Primary
Secondary
Concomitant
General Physical Health Deterioration Death 9/4/2007 Female 172 lb 11/15/2007 Physician United States
Primary
Secondary
Concomitant
Liver Disorder Hospitalization 9/19/2007 55 Male 11/16/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Somnolence Hospitalization 10/10/2007 Male 180 lb 11/19/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Life Threatening 10/1/2007 11/21/2007 Physician Germany
Primary
Secondary
Leukopenia Other Serious 9/12/2007 Female 11/21/2007 Physician Japan
Primary
Secondary
Concomitant
Convulsion Hospitalization 7/6/2007 Male 11/26/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/10/2004 64 Male 156 lb 11/27/2007 United States
Primary
Secondary
Glioblastoma Death 8/23/2007 49 Male 231 lb 11/27/2007 Consumer United States
Primary
Secondary
Concomitant
Epistaxis Hospitalization 10/8/2007 Female 11/27/2007 Consumer United Kingdom
Primary
Secondary
Leukoencephalopathy Hospitalization 9/10/2007 Female 119 lb 11/27/2007 Physician United States
Primary
Secondary
Leukopenia Other Serious 10/28/2007 Female 11/28/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Somnolence Hospitalization 10/10/2007 61 Male 180 lb 11/28/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 11/19/2007 Male 11/28/2007 Physician United States
Primary
Secondary
Diarrhoea Haemorrhagic Life Threatening 9/25/2007 Female 11/29/2007 Physician United Kingdom
Primary
Secondary
Renal Failure Life Threatening 10/1/2007 Male 150 lb 11/29/2007 Consumer United States
Primary
Secondary
Tachycardia Hospitalization 10/26/2007 Male 181 lb 11/29/2007 Physician United Kingdom
Primary
Secondary
Ventricular Fibrillation Death 1/19/2005 Male 11/30/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Gastritis Hospitalization 9/11/2005 Female 180 lb 11/30/2007 Physician United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 59 Female 12/3/2007 United States
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 9/19/2004 52 Female 150 lb 11/19/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Intestinal Obstruction Hospitalization 9/16/2007 Male 12/5/2007 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 10/4/2007 Female 12/5/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Paraesthesia Hospitalization 11/21/2007 Male 209 lb 12/5/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Rhinorrhoea Life Threatening 11/27/2007 Male 174 lb 12/6/2007 Physician United States
Primary
Secondary
Concomitant
Sepsis Death 11/20/2007 Male 12/7/2007 Consumer United Kingdom
Primary
Concomitant
Interstitial Lung Disease Hospitalization 11/6/2007 Female 12/11/2007 Consumer United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 9/25/2007 Female 79 lb 12/12/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 10/17/2007 Female 12/12/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Lymphangiosis Carcinomatosa Hospitalization 11/6/2007 Female 12/14/2007 Consumer United Kingdom
Primary
Secondary
Epistaxis Hospitalization 9/17/2007 Male 12/14/2007 Consumer United Kingdom
Primary
Concomitant
Sepsis Death 11/20/2007 Male 12/14/2007 Consumer United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 9/4/2007 Female 12/17/2007 Physician United Kingdom
Primary
Concomitant
Somnolence Hospitalization 10/10/2007 61 Male 180 lb 12/17/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Brain Abscess Hospitalization 11/19/2007 53 Female 157 lb 12/21/2007 Physician United States
Primary
Concomitant
Paraesthesia Hospitalization 11/21/2007 Male 209 lb 12/21/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Hepatic Failure Death 11/15/2007 Male 12/21/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Sepsis Death 11/20/2007 Male 12/21/2007 Consumer United Kingdom
Primary
Concomitant
Platelet Count Decreased Hospitalization 11/7/2007 Female 12/21/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Rhinorrhoea Life Threatening 11/27/2007 Male 174 lb 12/26/2007 Physician United States
Primary
Concomitant
Leukoencephalopathy Hospitalization 9/10/2007 Female 119 lb 12/27/2007 Physician United States
Primary
Secondary
Intestinal Obstruction Hospitalization 12/3/2007 40 Female 12/27/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Hepatic Failure Death 11/15/2007 Male 1/2/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 10/17/2007 Female 1/4/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Other Serious 1/1/2003 62 Male 1/8/2008 Germany
Primary
Secondary
Hypertension Hospitalization 12/23/2007 Male 1/9/2008 Consumer United Kingdom
Primary
Secondary
Leukopenia Other Serious 9/12/2007 Female 1/31/2008 Physician Japan
Primary
Secondary
Concomitant

Drug Data