Avastin combined with Tarceva

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Skin Fissures 4/19/2005 85 Female 12/7/2005 Other Health Professional United States
Primary
Concomitant
Proteinuria 70 Male 12/7/2005 Physician United States
Primary
Secondary
Concomitant
Rash 68 Male 12/7/2005 Physician United States
Primary
Secondary
Concomitant
Tendon Injury Male 12/7/2005 Physician United States
Primary
Concomitant
Pain In Jaw Other Serious 6/1/2005 60 Male 2/7/2006 United States
Primary
Concomitant
Vomiting Hospitalization 10/3/2005 53 Female 143 lb 2/3/2006 Pharmacist United States
Primary
Secondary
Concomitant
Urinary Tract Infection Bacterial Other Serious 11/28/2005 51 Female 165 lb 2/14/2006 Physician Switzerland
Primary
Secondary
Hepatitis Viral Other Serious 65 Male 2/16/2006 Other Health Professional United States
Primary
Secondary
Hepatic Enzyme Increased Other Serious 47 Male 2/17/2006 United States
Primary
Secondary
Weight Decreased Male 12/7/2005 Consumer United States
Primary
Concomitant
Rash Required Intervention 11/22/2005 62 Male 157 lb 3/3/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 1/1/2006 73 Male 141 lb 3/10/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pleural Fibrosis Required Intervention 11/22/2005 62 Male 157 lb 3/7/2006 Physician United States
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Death 55 Female 3/20/2006 Physician Finland
Primary
Secondary
Concomitant
Interstitial Lung Disease Required Intervention 80 Female 3/24/2006 Physician United States
Primary
Secondary
Metastasis Required Intervention 12/2/2005 80 Female 3/31/2006 Physician United States
Primary
Secondary
Subarachnoid Haemorrhage Death 12/21/2005 61 Female 4/18/2006 Physician Finland
Primary
Secondary
Refusal Of Treatment By Patient Hospitalization 4/27/2006 Female 140 lb 5/2/2006 Other Health Professional United States
Primary
Secondary
Vaginal Ulceration Hospitalization 4/22/2006 Female 139 lb 5/10/2006 Other Health Professional United States
Primary
Secondary
Pain In Jaw Other Serious 6/1/2005 60 Male 5/17/2006 United States
Primary
Concomitant
Rash 6/1/2005 75 Female 3/1/2006 Consumer United States
Primary
Secondary
Concomitant
Rash Pruritic 65 Male 3/1/2006 Other Health Professional United States
Primary
Concomitant
Rash Pustular 66 Female 3/1/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Rash Maculo-papular 42 Female 3/1/2006 Physician United States
Primary
Secondary
Blood Uric Acid Increased 1/16/2006 55 Male 175 lb 3/1/2006 Other Health Professional United States
Primary
Concomitant
Dyspepsia Other Serious 12/15/2005 47 Female 3/1/2006 Consumer United States
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 11/28/2005 51 Female 165 lb 5/16/2006 Physician Switzerland
Primary
Secondary
Swelling Other Serious 6/1/2005 60 Male 5/24/2006 Physician United States
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 65 Male 5/23/2006 Consumer United States
Primary
Secondary
Sleep Disorder Disability 10/1/2005 63 Female 5/25/2006 Physician United States
Primary
Concomitant
Renal Failure Acute Hospitalization 4/10/2006 56 Female 6/13/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Rheumatoid Factor Increased Disability 1/1/2006 63 Female 206 lb 6/20/2006 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 6/23/2006 48 Male 192 lb 7/7/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Ulcer Other Serious 3/29/2006 Male 288 lb 7/12/2006 Other Health Professional United States
Primary
Secondary
Mucosal Inflammation Other Serious 12/16/2005 Male 388 lb 7/12/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Balance Disorder Female 5/31/2006 Physician United States
Primary
Concomitant
Rash Male 5/31/2006 Other Health Professional United States
Primary
Concomitant
Dyspnoea 2/22/2006 Male 175 lb 5/31/2006 Physician United States
Primary
Secondary
Rash 3/4/2006 Male 5/31/2006 Consumer United States
Primary
Secondary
Rash Maculo-papular 42 Female 5/31/2006 Physician United States
Primary
Secondary
Proteinuria 11/3/2005 62 Male 5/31/2006 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 1/17/2006 63 Female 7/19/2006 Physician United States
Primary
Secondary
Concomitant
Iridocyclitis Required Intervention 6/19/2006 65 Female 170 lb 7/24/2006 Other Health Professional United States
Primary
Secondary
Sleep Disorder Disability 1/1/2006 63 Female 206 lb 7/20/2006 Physician United States
Primary
Concomitant
Vomiting Hospitalization 7/10/2006 Female 211 lb 7/24/2006 Other Health Professional United States
Primary
Secondary
Pneumonitis Other Serious 80 Female 5/24/2006 Physician United States
Primary
Secondary
Haemorrhage Hospitalization 2/13/2006 Female 5/24/2006 Other Health Professional United States
Primary
Concomitant
Rash Hospitalization 53 Female 5/24/2006 United States
Primary
Secondary
Concomitant
Weight Decreased 79 Male 5/24/2006 Consumer United States
Primary
Concomitant
Vomiting 6/5/2005 75 Female 5/24/2006 Consumer United States
Primary
Concomitant
Rash Male 5/24/2006 Consumer United States
Primary
Concomitant
Rash 12/1/2004 Female 5/24/2006 Consumer United States
Primary
Concomitant
Rash Male 5/24/2006 Consumer United States
Primary
Concomitant
Rash 10/5/2005 62 Male 5/24/2006 Pharmacist United States
Primary
Concomitant
Hypertension 10/24/2005 82 Male 5/24/2006 Physician United States
Primary
Concomitant
Blood Uric Acid Increased Male 5/24/2006 Other Health Professional United States
Primary
Concomitant
Respiratory Failure Hospitalization 8/8/2006 65 Male 198 lb 8/10/2006 Other Health Professional United States
Primary
Secondary
Oesophagitis Ulcerative Other Serious Male 8/29/2006 Physician Finland
Primary
Secondary
Cholecystectomy Hospitalization Female 10/13/2006 Physician United States
Primary
Concomitant
Rash Hospitalization 76 Male 11/2/2006 Physician United States
Primary
Secondary
Unevaluable Event Death 12/21/2005 61 Female 11/15/2006 Physician Finland
Primary
Secondary
Thrombosis Other Serious 5/1/2006 66 Male 11/21/2006 Physician Finland
Primary
Secondary
Concomitant
Diverticulitis Hospitalization 10/18/2006 76 Male 11/29/2006 Physician United States
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 2/1/2007 66 Male 188 lb 3/25/2007 Physician United States
Primary
Concomitant
Vomiting Hospitalization 3/24/2007 48 Female 127 lb 3/28/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Vascular Encephalopathy Other Serious 1/6/2007 Male 4/10/2007 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/13/2007 Male 220 lb 4/13/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Intestinal Perforation Hospitalization 11/26/2006 Female 171 lb 4/10/2007 Other Health Professional United States
Primary
Concomitant
Rash Male 2/28/2007 Other Health Professional United States
Primary
Concomitant
Hypertension Other Serious 53 Male 2/28/2007 Consumer United States
Primary
Secondary
Intestinal Perforation Other Serious 5/23/2006 Male 2/28/2007 Physician United States
Primary
Concomitant
Rash 53 Female 2/28/2007 Other Health Professional United States
Primary
Concomitant
Weight Decreased 73 Male 185 lb 2/28/2007 Physician United States
Primary
Secondary
Tooth Extraction Other Serious 12/11/2006 53 Female 6/8/2007 Physician United States
Primary
Concomitant
Tooth Extraction Other Serious 12/11/2006 53 Female 6/8/2007 Physician United States
Primary
Concomitant
Osteonecrosis Other Serious 4/5/2007 77 Male 178 lb 6/12/2007 United States
Primary
Concomitant
Stomatitis Other Serious 4/15/2007 77 Male 178 lb 7/26/2007 Physician United States
Primary
Concomitant
Osteonecrosis Other Serious 4/5/2007 77 Male 178 lb 7/28/2007 United States
Primary
Concomitant
Renal Failure Acute Other Serious 55 8/1/2007 Physician United States
Primary
Secondary
Stomatitis Other Serious 4/15/2007 77 Male 178 lb 8/2/2007 Physician United States
Primary
Concomitant
Cerebral Infarction Other Serious 9/6/2007 Male 201 lb 9/24/2007 Consumer United States
Primary
Secondary
Concomitant
Cerebral Infarction Other Serious 9/6/2007 Male 201 lb 10/1/2007 Consumer United States
Primary
Secondary
Concomitant
Liver Disorder Other Serious 6/11/2007 Male 129 lb 10/8/2007 Consumer United States
Primary
Concomitant
Ileitis Other Serious 9/1/2007 55 Female 220 lb 10/11/2007 Physician United Kingdom
Primary
Secondary
Fluid Overload Hospitalization 10/3/2007 Female 172 lb 10/19/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Ileitis Other Serious 9/1/2007 55 Female 220 lb 10/24/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Post Procedural Complication Hospitalization 10/5/2007 Female 123 lb 10/30/2007 Consumer United States
Primary
Secondary
Concomitant
Fluid Overload Hospitalization 10/3/2007 Female 172 lb 12/12/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/15/2008 69 Female 163 lb 2/18/2008 Other Health Professional United States
Primary
Secondary
Loss Of Consciousness Death 2/29/2008 81 Male 143 lb 3/14/2008 Other Health Professional United States
Primary
Secondary
Stomatitis Hospitalization 3/7/2008 Male 3/26/2008 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Disease Progression Other Serious 47 Male 2/28/2008 Other Health Professional United States
Primary
Secondary
Diarrhoea Hospitalization 4/8/2007 54 Female 96 lb 2/28/2008 Pharmacist United States
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization Female 2/28/2008 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Other Serious 1/1/2007 45 Male 5/19/2008 Consumer United States
Primary
Concomitant
Polyneuropathy Other Serious Female 132 lb 6/5/2008 Physician United Kingdom
Primary
Secondary
Renal Failure Other Serious 1/1/2007 45 Male 6/3/2008 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 6/6/2008 Female 116 lb 6/9/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Drug Eruption Other Serious 12/3/2007 50 Female 110 lb 6/16/2008 Physician United Kingdom
Primary
Concomitant
Unevaluable Event Other Serious 3/1/2008 Female 132 lb 7/3/2008 Physician United Kingdom
Primary
Secondary
Pneumonia Hospitalization 6/6/2008 Female 115 lb 7/10/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 7/10/2008 Female 102 lb 7/14/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pleural Effusion Death 7/15/2008 Female 102 lb 7/18/2008 Other Health Professional United States
Primary
Secondary
Polyneuropathy Other Serious 10/1/2007 Female 8/5/2008 Physician Germany
Primary
Secondary
Concomitant
Renal Failure Other Serious 1/1/2007 45 Male 7/31/2008 Physician United States
Primary
Concomitant
Arteriosclerosis Other Serious Male 10/15/2008 Physician United States
Primary
Secondary
Mental Status Changes Hospitalization Male 11/21/2008 Other Health Professional United States
Primary
Secondary
Tonic Convulsion Hospitalization 10/1/2008 Male 1/30/2009 Physician France
Primary
Concomitant
Mental Status Changes Hospitalization Male 186 lb 2/10/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Disease Progression Other Serious 12/16/2008 Female 3/11/2009 Physician United States
Primary
Secondary
Disease Progression Other Serious 12/16/2008 Female 3/20/2009 Physician United States
Primary
Secondary
Drug Ineffective Other Serious 3/25/2009 Consumer United States
Primary
Secondary
Disease Progression Other Serious 12/16/2008 Female 3/27/2009 Physician United States
Primary
Secondary
Sepsis Death 3/1/2009 Female 4/14/2009 Consumer United Kingdom
Primary
Secondary
Rash Hospitalization 1/1/2008 Male 5/14/2009 Physician France
Primary
Concomitant
Vomiting Hospitalization 5/22/2009 52 Female 161 lb 6/2/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Skin Laceration Other Serious Female 7/2/2009 Consumer United States
Primary
Secondary
Tooth Extraction Other Serious 12/11/2006 Female 9/1/2009 Physician United States
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 12/11/2006 Female 9/8/2009 Physician United States
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 6/30/2009 Male 10/1/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 6/30/2009 Male 11/3/2009 Other Health Professional Italy
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 6/30/2009 Male 11/10/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 6/30/2009 Male 12/2/2009 Other Health Professional Italy
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 6/30/2009 Male 12/3/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Decreased Appetite Other Serious 1/1/2009 64 Female 12/9/2009 Physician United Kingdom
Primary
Secondary
Tremor Other Serious 11/8/2009 58 Female 12/1/2009 Physician Jordan
Primary
Secondary
Treatment Failure 12/15/2009 Consumer
Primary
Concomitant
Decreased Appetite Other Serious 1/1/2009 64 Female 12/11/2009 Physician Switzerland
Primary
Secondary
Metastases To Central Nervous System Other Serious 1/1/2008 Female 12/22/2009 Physician Netherlands
Primary
Secondary
Hypokinesia Other Serious 8/6/2009 60 Male 12/24/2009 Other Health Professional France
Primary
Secondary
Concomitant
Left Ventricular Hypertrophy Other Serious 8/6/2009 Male 12/29/2009 Other Health Professional France
Primary
Concomitant
Weight Decreased Other Serious 63 Male 1/13/2010 Consumer United States
Primary
Concomitant
Non-small Cell Lung Cancer Other Serious 1/1/2008 Female 12/24/2009 Physician Netherlands
Primary
Secondary
Urinary Retention Other Serious 1/11/2007 Male 1/22/2010 Physician United States
Primary
Concomitant
Hypokinesia Other Serious 8/6/2009 60 Female 1/15/2010 Physician France
Primary
Secondary
Concomitant
Metastatic Gastric Cancer Death 1/1/2009 1/27/2010 Physician Netherlands
Primary
Secondary
Rash Other Serious 6/27/2008 41 Female 126 lb 2/5/2010 Physician Portugal
Primary
Secondary
Concomitant
Ejection Fraction Decreased Other Serious 8/6/2009 Male 2/8/2010 Other Health Professional France
Primary
Concomitant
Pneumocystis Jiroveci Pneumonia Other Serious 12/28/2009 Male 159 lb 2/25/2010 Physician Japan
Primary
Secondary
Pneumocystis Jiroveci Pneumonia Other Serious 12/28/2009 Male 159 lb 3/2/2010 Physician Japan
Primary
Secondary
Rash Other Serious 6/27/2008 41 Female 2/16/2010 Portugal
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 12/28/2009 Male 159 lb 3/3/2010 Physician Japan
Primary
Secondary
Urinary Retention Other Serious 1/11/2007 Male 3/15/2010 Physician United States
Primary
Concomitant
Respiratory Failure Other Serious 12/28/2009 46 Male 3/9/2010 Other Health Professional Japan
Primary
Secondary
Urinary Retention Other Serious 1/11/2007 Male 3/18/2010 Physician United States
Primary
Concomitant
Respiratory Failure Other Serious 12/28/2009 46 Male 3/12/2010 Physician Japan
Primary
Secondary
Thrombocytopenia Other Serious 12/28/2009 Male 159 lb 3/26/2010 Physician Japan
Primary
Secondary
Thrombocytopenia Other Serious 12/28/2009 Male 159 lb 3/29/2010 Physician Japan
Primary
Secondary
Disease Progression Death 1/1/2008 Female 3/31/2010 Physician Netherlands
Primary
Secondary
White Blood Cell Count Decreased 54 Male 154 lb 3/25/2010 Physician United States
Primary
Concomitant

Drug Data