Avastin combined with Loxonin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pneumonitis Hospitalization 6/5/2007 63 Male 7/12/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/26/2007 68 Female 10/2/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 9/26/2007 61 Female 10/5/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/26/2007 68 Female 10/24/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/26/2007 68 Female 10/26/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 9/26/2007 68 Female 12/4/2007 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Impairment Life Threatening 2/11/2007 72 Male 1/16/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Neutropenia Hospitalization 9/11/2007 59 Male 2/26/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Generalised Other Serious 12/30/2007 Male 128 lb 3/21/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/31/2008 57 Male 4/8/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/31/2008 57 Male 4/15/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Cataract Hospitalization 4/25/2008 69 Female 5/2/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Purpura Hospitalization 5/10/2008 Male 155 lb 6/11/2008 Physician United Kingdom
Primary
Concomitant
Cataract Hospitalization 4/25/2008 69 Female 6/17/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Stomatitis Hospitalization 9/2/2007 Female 6/20/2008 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Life Threatening 1/1/2008 Male 132 lb 7/28/2008 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Hospitalization 10/18/2007 Male 8/6/2008 Physician Japan
Primary
Secondary
Concomitant
Tumour Haemorrhage Hospitalization 5/26/2008 28 Male 121 lb 8/25/2008 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Life Threatening 1/1/2008 Male 132 lb 9/4/2008 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 4/1/2008 Female 188 lb 9/26/2008 Consumer United Kingdom
Primary
Concomitant
Peritonitis Hospitalization 11/11/2008 Female 108 lb 11/25/2008 Physician United Kingdom
Primary
Concomitant
Varices Oesophageal Other Serious 8/20/2008 Male 12/16/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 8/20/2008 Male 110 lb 1/24/2009 Consumer Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 11/12/2007 Male 146 lb 2/11/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 4/3/2008 Male 2/12/2009 Consumer Japan
Primary
Concomitant
Pneumothorax Hospitalization 1/24/2009 Male 3/4/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Pneumothorax Hospitalization 1/24/2009 Male 117 lb 3/13/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 1/22/2009 Male 127 lb 3/17/2009 Consumer Japan
Primary
Secondary
Concomitant
Peritonitis Hospitalization 11/11/2008 Female 108 lb 3/25/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 1/22/2009 Male 127 lb 3/27/2009 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Perforation Life Threatening 8/27/2008 Female 100 lb 4/7/2009 Physician Japan
Primary
Secondary
Concomitant
Oesophageal Perforation Death 11/30/2008 Male 4/8/2009 Consumer United Kingdom
Primary
Concomitant
Gastrointestinal Perforation Life Threatening 3/23/2009 Male 123 lb 4/23/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Disease Progression Death 6/9/2008 Male 147 lb 7/10/2009 Physician Japan
Primary
Secondary
Concomitant
Nausea Hospitalization 3/24/2009 78 Male 128 lb 8/18/2009 Physician Germany
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy Other Serious 7/29/2009 Female 8/19/2009 Physician Japan
Primary
Secondary
Concomitant
Pleural Effusion Other Serious 12/15/2008 68 8/25/2009 Physician Japan
Primary
Secondary
Concomitant
Drug Exposure During Pregnancy Other Serious 7/29/2009 Female 8/28/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2009 Male 9/10/2009 Physician Japan
Primary
Secondary
Concomitant
Nausea Hospitalization 3/24/2009 78 Male 128 lb 9/22/2009 Consumer United States
Primary
Secondary
Concomitant
Nausea Hospitalization 3/24/2009 78 Male 128 lb 9/24/2009 Consumer United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2009 Male 10/6/2009 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 8/21/2009 68 10/23/2009 Physician Japan
Primary
Secondary
Concomitant
Nausea Hospitalization 3/24/2009 78 Male 128 lb 11/13/2009 Consumer United States
Primary
Secondary
Concomitant
Retroperitoneal Abscess Life Threatening 7/14/2009 Male 137 lb 1/21/2010 Physician Japan
Primary
Concomitant
Shock Life Threatening 12/2/2009 Male 130 lb 2/8/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 10/8/2008 Male 128 lb 2/16/2010 Physician Japan
Primary
Secondary
Concomitant
Peritonitis Life Threatening 1/18/2010 Male 139 lb 2/22/2010 Physician Japan
Primary
Concomitant
Peritonitis Life Threatening 1/18/2010 Male 139 lb 2/22/2010 Physician Japan
Primary
Concomitant
Septic Shock Other Serious 9/1/2009 Female 84 lb 3/18/2010 Physician Japan
Primary
Concomitant
Vomiting Other Serious 8/21/2009 68 Male 170 lb 3/23/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 12/12/2009 Male 121 lb 3/25/2010 Physician Japan
Primary
Concomitant
Septic Shock Other Serious 9/1/2009 66 Female 84 lb 4/2/2010 Physician Japan
Primary
Concomitant
Pneumothorax Life Threatening 3/16/2010 67 Male 130 lb 4/16/2010 Physician Japan
Primary
Secondary
Concomitant
Peritonitis Hospitalization 1/1/2009 66 Male 128 lb 5/3/2010 Physician Japan
Primary
Concomitant
Gastrointestinal Necrosis Life Threatening 4/27/2010 61 Female 117 lb 5/19/2010 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 5/4/2010 64 Male 115 lb 6/1/2010 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Necrosis Death 4/27/2010 61 Female 117 lb 6/2/2010 Physician Japan
Primary
Secondary
Concomitant
Tubulointerstitial Nephritis Other Serious 12/28/2009 57 Male 165 lb 6/4/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Death 5/4/2010 64 Male 115 lb 6/7/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Death 5/4/2010 64 Male 115 lb 6/15/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Life Threatening 4/30/2010 64 Male 115 lb 6/16/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Death 5/4/2010 64 Male 115 lb 6/22/2010 Physician Japan
Primary
Secondary
Concomitant
Wound Dehiscence Other Serious 6/1/2009 67 Male 104 lb 6/24/2010 Physician Japan
Primary
Concomitant
Subcutaneous Haematoma Other Serious 5/25/2010 63 Female 104 lb 6/30/2010 Pharmacist Japan
Primary
Concomitant
Pyrexia Hospitalization 8/28/2009 74 Male 93 lb 7/6/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/28/2009 75 Male 7/8/2010 Physician Japan
Primary
Secondary
Concomitant
Vertigo Other Serious 5/1/2010 63 Female 104 lb 7/28/2010 Pharmacist Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Hospitalization 6/8/2010 58 Female 130 lb 7/28/2010 Physician Japan
Primary
Secondary
Concomitant
Vertigo Other Serious 5/20/2010 63 Female 104 lb 7/29/2010 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 5/11/2010 70 Female 84 lb 8/2/2010 Physician Japan
Primary
Concomitant
Pneumothorax Life Threatening 1/1/2010 66 Male 130 lb 8/13/2010 Physician Japan
Primary
Secondary
Concomitant
Vertigo Other Serious 5/20/2010 63 Female 104 lb 8/13/2010 Physician Japan
Primary
Secondary
Concomitant
Vertigo Other Serious 5/1/2010 63 Female 104 lb 8/13/2010 Pharmacist Japan
Primary
Secondary
Concomitant
Disease Progression Disability 2/1/2010 73 Female 104 lb 8/16/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/1/2010 53 Male 106 lb 8/26/2010 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/21/2009 65 Female 8/27/2010 Physician Japan
Primary
Secondary
Concomitant
Rectal Perforation Hospitalization 2/5/2010 60 Male 97 lb 9/4/2010 Physician Japan
Primary
Secondary
Concomitant
Neutrophil Count Decreased Life Threatening 8/7/2010 62 Male 108 lb 9/7/2010 Physician Japan
Primary
Concomitant
Septic Shock Life Threatening 4/23/2010 52 Female 75 lb 9/8/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Other Serious 8/7/2010 62 Male 108 lb 9/9/2010 Physician Japan
Primary
Concomitant
Neutrophil Count Decreased Life Threatening 8/7/2010 62 Male 108 lb 9/13/2010 Physician Japan
Primary
Concomitant
Rectal Perforation Hospitalization 2/5/2010 60 Male 9/17/2010 Physician Japan
Primary
Secondary
Concomitant
Vesical Fistula Other Serious 8/7/2010 60 Female 9/20/2010 Pharmacist Japan
Primary
Secondary
Concomitant
Peripheral Coldness Death 8/20/2010 66 Female 66 lb 9/21/2010 Physician Japan
Primary
Concomitant
Tumour Necrosis Life Threatening 4/23/2010 52 Female 75 lb 9/23/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 6/26/2010 81 Female 9/27/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pneumonia Other Serious 8/7/2010 62 Male 108 lb 9/27/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 6/23/2010 54 Male 106 lb 9/30/2010 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2009 54 Male 165 lb 10/6/2010 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 5/7/2010 70 Female 84 lb 10/12/2010 Physician Japan
Primary
Concomitant
Haemoglobin Decreased Other Serious 8/4/2010 61 Male 126 lb 10/13/2010 Physician Japan
Primary
Secondary
Concomitant
Peptic Ulcer Other Serious 7/31/2010 60 Female 88 lb 10/13/2010 Physician Japan
Primary
Secondary
Concomitant
Pneumothorax Other Serious 1/1/2010 66 Male 130 lb 10/15/2010 Physician Japan
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 4/13/2010 45 Female 139 lb 10/20/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 6/17/2010 81 Female 10/22/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyothorax Other Serious 6/18/2010 74 Female 121 lb 10/28/2010 Physician Japan
Primary
Concomitant
Myocardial Infarction Hospitalization 4/13/2010 45 Female 139 lb 11/1/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombosis Other Serious 4/27/2010 61 Female 117 lb 11/3/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Death 6/17/2010 81 Female 11/10/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Vertigo Other Serious 5/1/2010 63 Female 104 lb 11/12/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Death 1/1/2008 77 Female 79 lb 12/3/2010 Physician Japan
Primary
Concomitant
Sepsis Hospitalization 6/17/2010 81 Female 12/7/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombosis Other Serious 1/1/2010 60 Female 117 lb 12/14/2010 Physician Japan
Primary
Secondary
Concomitant
Sepsis Death 1/1/2008 77 Female 79 lb 12/16/2010 Physician Japan
Primary
Concomitant
Pneumothorax Life Threatening 3/16/2010 67 Male 130 lb 12/16/2010 Physician Japan
Primary
Secondary
Concomitant
Tachycardia Death 8/1/2009 52 Male 150 lb 12/17/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 1/1/2010 55 Male 157 lb 12/23/2010 Physician Japan
Primary
Concomitant
Pneumonia Hospitalization 12/3/2010 66 Female 101 lb 12/23/2010 Physician Japan
Primary
Secondary
Concomitant
Constipation Death 8/1/2009 52 Male 1/3/2011 Consumer Japan
Primary
Secondary
Concomitant
Pyothorax Hospitalization 6/18/2010 74 Female 121 lb 1/3/2011 Other Health Professional Japan
Primary
Concomitant
Decreased Appetite Other Serious 2/22/2010 72 Male 123 lb 1/18/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Haematochezia Hospitalization 1/1/2010 55 Male 157 lb 1/25/2011 Physician Japan
Primary
Concomitant
Cerebral Haemorrhage Hospitalization 8/9/2010 70 Male 99 lb 2/3/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 11/22/2010 61 Male 132 lb 2/10/2011 Physician Japan
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 1/25/2011 74 Male 132 lb 2/18/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Intestinal Obstruction Other Serious 10/18/2007 38 Male 2/18/2011 Physician Japan
Primary
Secondary
Concomitant
Delirium Other Serious 8/1/2009 52 Male 150 lb 2/22/2011 Physician Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Other Serious 8/25/2010 47 Male 2/23/2011 Physician Japan
Primary
Concomitant
Anaphylactic Reaction Other Serious 1/25/2011 62 Female 143 lb 2/25/2011 Physician Japan
Primary
Secondary
Concomitant
Sudden Death Death 1/19/2011 67 Female 88 lb 3/4/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumothorax Hospitalization 10/29/2010 47 Female 93 lb 3/4/2011 Physician Japan
Primary
Concomitant
Tachycardia Death 8/1/2009 52 Male 3/10/2011 Consumer Japan
Primary
Secondary
Concomitant
Hypocalcaemia Other Serious 1/25/2011 62 Female 143 lb 3/11/2011 Physician Japan
Primary
Secondary
Concomitant
Cerebral Haemorrhage Hospitalization 1/19/2011 62 Female 3/11/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Intestinal Perforation Other Serious 2/10/2011 62 Female 108 lb 3/16/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Life Threatening 8/25/2010 47 Male 183 lb 3/21/2011 Physician Japan
Primary
Secondary
Concomitant
Haemorrhoidal Haemorrhage Disability 10/19/2010 66 Female 101 lb 3/22/2011 Physician Japan
Primary
Secondary
Concomitant
Hypertension Hospitalization 6/8/2010 58 Female 130 lb 3/25/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Haemolytic Anaemia Disability 8/25/2010 47 Male 183 lb 4/11/2011 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Life Threatening 7/14/2009 47 Male 187 lb 4/12/2011 Physician Japan
Primary
Secondary
Concomitant
Intestinal Perforation Hospitalization 2/4/2011 62 Female 108 lb 4/14/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombosis Hospitalization 1/24/2011 63 Female 110 lb 4/14/2011 Other Health Professional Japan
Primary
Concomitant
Thrombosis Other Serious 7/14/2009 47 Male 183 lb 4/22/2011 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 11/22/2010 61 Male 132 lb 4/25/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumothorax Other Serious 1/13/2011 59 Male 110 lb 4/26/2011 Other Health Professional Japan
Primary
Concomitant
Pneumonia Hospitalization 6/11/2010 65 Female 101 lb 5/20/2011 Physician Japan
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 1/1/2009 66 Male 5/24/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Dehydration Other Serious 1/1/2010 55 Male 157 lb 5/24/2011 Other Health Professional Japan
Primary
Concomitant
Renal Impairment Hospitalization 6/5/2010 55 Male 157 lb 6/1/2011 Other Health Professional Japan
Primary
Concomitant
Anal Abscess Other Serious 8/11/2010 55 Male 157 lb 6/2/2011 Other Health Professional Japan
Primary
Concomitant
Decreased Appetite Other Serious 9/17/2007 61 Male 134 lb 6/13/2011 Physician Japan
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Other Serious 3/31/2011 68 Male 88 lb 6/15/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Disseminated Intravascular Coagulation Life Threatening 7/14/2009 47 Male 187 lb 6/30/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Urticaria Hospitalization 7/14/2009 47 Male 183 lb 7/8/2011 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Haemorrhage Other Serious 1/1/2011 68 Male 88 lb 7/21/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Cardiac Failure Death 6/19/2011 71 Male 123 lb 7/22/2011 Other Health Professional Japan
Primary
Concomitant
Infectious Peritonitis Hospitalization 6/1/2011 Male 143 lb 8/2/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Diarrhoea Death 1/27/2011 74 Male 110 lb 9/14/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death 6/23/2011 62 Female 77 lb 9/20/2011 Physician Japan
Primary
Secondary
Concomitant

Drug Data