Avastin combined with Levoleucovorin Calcium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Anaphylactoid Reaction Other Serious 8/19/2008 Male 123 lb 9/26/2008 Physician Japan
Primary
Concomitant
Haematemesis Life Threatening 9/20/2008 Female 10/14/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Generalised Erythema Other Serious 6/20/2008 10/24/2008 Physician Japan
Primary
Concomitant
Gastric Ulcer Life Threatening 9/20/2008 Female 10/31/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 10/15/2008 Male 132 lb 11/4/2008 Consumer Japan
Primary
Concomitant
Flushing Hospitalization 10/23/2008 Male 123 lb 11/4/2008 Consumer Japan
Primary
Concomitant
Plantar Erythema Other Serious 4/23/2008 Female 11/7/2008 Consumer Japan
Primary
Secondary
Concomitant
Neuropathy Peripheral Hospitalization 10/23/2008 Male 123 lb 1/14/2009 Consumer Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 12/22/2008 Male 1/30/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 12/22/2008 Male 2/17/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death 1/1/2008 Male 2/20/2009 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Infarction Hospitalization 2/3/2009 Male 141 lb 3/6/2009 Consumer United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Death 1/1/2008 Male 3/10/2009 Physician Japan
Primary
Secondary
Concomitant
Pancreatitis Acute Hospitalization 2/9/2009 Male 3/12/2009 Physician United Kingdom
Primary
Concomitant
Interstitial Lung Disease Life Threatening 12/22/2008 Male 3/13/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Death 1/1/2008 Male 4/20/2009 Physician Japan
Primary
Secondary
Concomitant
Malignant Neoplasm Progression Other Serious 10/15/2008 Male 132 lb 5/27/2009 Consumer Japan
Primary
Concomitant
Urinary Retention Hospitalization 4/28/2009 Male 6/5/2009 Physician Japan
Primary
Secondary
Concomitant
Pancreatitis Acute Hospitalization 2/9/2009 Male 6/5/2009 Physician United Kingdom
Primary
Concomitant
Humerus Fracture Hospitalization 3/25/2009 79 Female 96 lb 6/26/2009 Consumer United Kingdom
Primary
Concomitant
Renal Failure Acute Life Threatening 3/20/2009 Female 6/26/2009 Consumer United Kingdom
Primary
Concomitant
Urinary Retention Hospitalization 4/28/2009 Male 8/11/2009 Physician Japan
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 4/28/2009 Male 8/19/2009 Physician Japan
Primary
Secondary
Concomitant
Ileus Other Serious 6/8/2009 Male 8/26/2009 Consumer United Kingdom
Primary
Concomitant
Interstitial Lung Disease Life Threatening 12/22/2008 Male 9/16/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 4/28/2009 Male 9/22/2009 Physician Japan
Primary
Secondary
Concomitant
Subdural Haematoma Death 4/7/2009 69 Male 10/28/2009 Consumer Japan
Primary
Secondary
Concomitant
Multi-organ Failure Hospitalization 62 Male 11/5/2009 Physician Japan
Primary
Concomitant
Neuropathy Peripheral Other Serious 7/13/2009 Male 11/6/2009 Physician Japan
Primary
Concomitant
Intestinal Obstruction Other Serious 62 Female 12/3/2009 Consumer United Kingdom
Primary
Concomitant
Urinary Tract Infection Hospitalization 10/23/2010 69 Female 95 lb 12/14/2010 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 6/1/2009 64 Female 3/2/2011 Physician Japan
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 8/1/2009 64 Female 3/3/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 8/1/2009 64 Female 3/15/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Other Serious 6/1/2009 64 Female 3/18/2011 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 8/1/2009 64 Female 3/29/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 8/1/2009 64 Female 7/5/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Hepatic Failure Other Serious 63 Male 10/3/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Ileus Other Serious 7/10/2010 56 Male 146 lb 10/4/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Epistaxis Hospitalization 8/1/2009 66 Female 84 lb 10/4/2011 Physician Japan
Primary
Concomitant
Diarrhoea Hospitalization 2/9/2011 71 Female 123 lb 10/11/2011 Physician Japan
Primary
Concomitant
Stomatitis Disability 1/20/2011 72 Male 152 lb 10/12/2011 Consumer Japan
Primary
Secondary
Concomitant
Hyperammonaemia Other Serious 1/13/2011 70 Male 121 lb 10/14/2011 Physician Japan
Primary
Concomitant
Haemorrhage Other Serious 75 Male 10/18/2011 Pharmacist Japan
Primary
Concomitant
Cerebral Infarction Other Serious 8/23/2011 75 Male 10/18/2011 Pharmacist Japan
Primary
Concomitant
Malaise Other Serious 86 Male 123 lb 10/19/2011 Physician Japan
Primary
Concomitant
Abscess Other Serious 1/1/2008 69 Male 10/19/2011 Physician Japan
Primary
Concomitant
Haemoptysis Hospitalization 12/1/2010 69 Male 10/19/2011 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Death 1/27/2011 74 Male 110 lb 10/20/2011 Physician Japan
Primary
Secondary
Concomitant
Hyperammonaemia Other Serious 8/26/2011 72 Female 10/21/2011 Physician Japan
Primary
Secondary
Concomitant
Blood Pressure Decreased Other Serious 6/30/2008 63 Male 10/24/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Dyspnoea Other Serious 67 Male 148 lb 10/24/2011 Physician Japan
Primary
Concomitant
Neutrophil Count Decreased Other Serious 76 Male 10/25/2011 Japan
Primary
Concomitant
Dyschezia Other Serious 11/1/2010 71 Female 10/27/2011 Japan
Primary
Concomitant
Lower Gastrointestinal Haemorrhage Death 59 Male 101 lb 10/27/2011 Japan
Primary
Concomitant
Disease Progression Death 10/25/2009 61 Female 10/27/2011 Physician Japan
Primary
Concomitant
Hyperammonaemia Other Serious 78 Male 10/31/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Cardiac Failure Other Serious 9/16/2011 58 Male 11/1/2011 Physician Japan
Primary
Concomitant
Congestive Cardiomyopathy Hospitalization 5/24/2010 68 Male 11/2/2011 Physician Japan
Primary
Secondary
Concomitant
Peptic Ulcer Other Serious 7/31/2010 60 Female 88 lb 11/2/2011 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Anastomotic Leak Hospitalization 1/1/2009 64 Male 84 lb 11/3/2011 Physician Japan
Primary
Secondary
Concomitant
Aortic Dissection Rupture Other Serious 1/1/2011 63 Male 119 lb 11/3/2011 Physician Japan
Primary
Concomitant
Disease Progression Death 9/26/2008 46 Male 108 lb 11/4/2011 Consumer Japan
Primary
Concomitant
Cardiac Failure Other Serious 74 Male 110 lb 11/14/2011 Physician Japan
Primary
Concomitant
Haemolytic Uraemic Syndrome Hospitalization 11/1/2011 60 Male 11/16/2011 Physician Japan
Primary
Secondary
Gastrointestinal Perforation Life Threatening 1/2/2011 76 Female 77 lb 11/16/2011 Physician Japan
Primary
Concomitant
Hyponatraemia Other Serious 10/31/2011 89 Female 108 lb 11/16/2011 Physician Japan
Primary
Secondary
Concomitant
Altered State Of Consciousness Hospitalization 5/1/2010 70 Male 11/17/2011 Japan
Primary
Concomitant
Haemoglobin Decreased Other Serious 57 Male 128 lb 11/21/2011 Physician Japan
Primary
Concomitant
Hyperthermia Other Serious 60 Female 11/21/2011 Pharmacist Japan
Primary
Concomitant
Mesenteric Vein Thrombosis Hospitalization 9/26/2008 46 Male 108 lb 11/23/2011 Physician Japan
Primary
Concomitant
Haemorrhage Other Serious 75 Male 11/23/2011 Pharmacist Japan
Primary
Concomitant
Neutrophil Count Decreased Other Serious 76 Male 11/24/2011 Physician Japan
Primary
Concomitant
Retroperitoneal Fibrosis Other Serious 59 Female 11/24/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Atrial Fibrillation Hospitalization 7/26/2011 66 Male 174 lb 11/24/2011 Physician France
Primary
Concomitant
Gastrointestinal Perforation Other Serious 1/1/2008 69 Male 11/25/2011 Japan
Primary
Concomitant
Haemolytic Uraemic Syndrome Hospitalization 10/13/2011 66 Male 11/25/2011 Consumer Japan
Primary
Secondary
Concomitant
Venous Thrombosis Hospitalization 3/24/2009 34 Female 123 lb 11/25/2011 Consumer Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 9/1/2011 78 Male 11/28/2011 Physician Japan
Primary
Secondary
Mechanical Ileus Death 1/1/2008 59 Male 11/29/2011 Other Health Professional Japan
Primary
Concomitant
Palpitations Death 12/1/2010 69 Male 11/30/2011 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Aspiration Other Serious 10/1/2011 82 Male 115 lb 11/30/2011 Physician Japan
Primary
Secondary
Concomitant
Hyponatraemia Life Threatening 6/14/2011 77 Female 146 lb 12/1/2011 Physician Japan
Primary
Concomitant
Pulmonary Embolism Death 9/20/2011 80 Male 12/5/2011 Physician France
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 11/1/2011 68 Male 12/6/2011 Pharmacist Japan
Primary
Secondary
Concomitant
Shock Haemorrhagic Death Male 106 lb 12/12/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 11/18/2011 76 Female 12/12/2011 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 11/18/2011 76 Female 12/12/2011 Physician Japan
Primary
Secondary
Concomitant
Disease Progression Life Threatening 10/25/2009 61 Female 12/13/2011 Physician Japan
Primary
Concomitant
Colitis Ischaemic Hospitalization 5/27/2010 81 Male 12/13/2011 Physician France
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 8/2/2010 58 Female 136 lb 12/13/2011 Belgium
Primary
Secondary
Concomitant
Pneumonia Aspiration Life Threatening 6/14/2011 82 Male 115 lb 12/14/2011 Physician Japan
Primary
Secondary
Concomitant
Microangiopathy Other Serious 65 Female 12/15/2011 Physician Japan
Primary
Concomitant
Microangiopathy Other Serious 65 Female 12/16/2011 Physician Japan
Primary
Concomitant
Pulmonary Oedema Other Serious 68 Female 12/19/2011 Physician Japan
Primary
Concomitant
Hepatic Failure Other Serious 55 Male 165 lb 12/20/2011 Physician Japan
Primary
Secondary
Concomitant
Epistaxis Hospitalization 5/24/2010 68 Male 97 lb 12/21/2011 Physician Japan
Primary
Concomitant
Femoral Neck Fracture Disability 8/23/2011 65 Female 12/22/2011 Consumer Japan
Primary
Concomitant
Contusion Death 5/31/2011 71 Male 123 lb 12/27/2011 Physician Japan
Primary
Concomitant
Dyschezia Other Serious 11/14/2011 52 Male 132 lb 12/27/2011 Physician Japan
Primary
Secondary
Concomitant
Abscess Other Serious 1/2/2011 76 Female 77 lb 12/27/2011 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Death 3/7/2011 62 Male 112 lb 12/27/2011 Physician Japan
Primary
Secondary
Concomitant
Hypomagnesaemia Hospitalization 9/9/2010 81 Female 95 lb 12/29/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Abdominal Pain Hospitalization 6/24/2011 51 Male 12/29/2011 Other Health Professional Italy
Primary
Concomitant
Nausea Other Serious 11/8/2011 72 Female 12/30/2011 Physician France
Primary
Secondary
Infectious Peritonitis Death 4/1/2009 73 Male 1/2/2012 Physician Japan
Primary
Concomitant
Hydronephrosis Other Serious 9/29/2011 59 Female 161 lb 1/2/2012 Pharmacist Japan
Primary
Secondary
Concomitant
Compression Fracture Other Serious 67 Female 68 lb 1/3/2012 Pharmacist Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 72 Male 1/3/2012 Japan
Primary
Concomitant
Diarrhoea Hospitalization 10/30/2011 58 Male 12/28/2011 Other Health Professional Italy
Primary
Secondary
Concomitant
Pulmonary Oedema Hospitalization 12/10/2011 68 Female 1/4/2012 Physician Japan
Primary
Concomitant
Platelet Count Decreased Death 11/1/2011 70 Female 112 lb 1/4/2012 Physician Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 72 Male 1/5/2012 Japan
Primary
Secondary
Concomitant
Decreased Appetite Hospitalization 8/2/2010 57 Female 136 lb 1/11/2012 Physician Belgium
Primary
Secondary
Concomitant
Cardiac Failure Hospitalization 7/26/2011 66 Male 174 lb 1/17/2012 France
Primary
Concomitant
Atrial Fibrillation Other Serious 5/31/2011 66 Male 201 lb 1/17/2012 France
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 11/1/2011 70 Female 112 lb 1/17/2012 Physician Japan
Primary
Secondary
Concomitant
Pancreatic Enlargement Death 1/1/2011 58 Female 161 lb 1/18/2012 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 9/6/2010 55 Male 137 lb 1/18/2012 Other Health Professional Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Hospitalization 1/1/2010 76 Male 141 lb 1/18/2012 Physician Japan
Primary
Secondary
Device Related Sepsis Other Serious 7/8/2011 72 Female 123 lb 1/25/2012 Physician Japan
Primary
Secondary
Concomitant
Unevaluable Event Death 60 Female 1/25/2012 Japan
Primary
Concomitant
Asthenia Hospitalization 10/1/2011 35 Male 1/27/2012 Other Health Professional France
Primary
Secondary
Concomitant
Hypoaesthesia Other Serious 60 Female 2/2/2012 Pharmacist Japan
Primary
Concomitant
Glucose Urine Hospitalization 1/1/2010 76 Male 141 lb 2/6/2012 Physician Japan
Primary
Secondary
Supraventricular Tachycardia Hospitalization 11/21/2011 54 Female 121 lb 2/9/2012 Physician Japan
Primary
Concomitant
Vasculitis Other Serious 60 Female 2/15/2012 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 8/10/2011 71 Male 115 lb 2/15/2012 Physician Japan
Primary
Secondary
Jaundice Other Serious 74 Female 2/15/2012 Japan
Primary
Concomitant
Malaise Other Serious 61 Female 2/15/2012 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 9/29/2011 59 Female 161 lb 2/20/2012 Physician Japan
Primary
Secondary
Concomitant
Infectious Peritonitis Death 12/8/2011 69 Male 141 lb 2/20/2012 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 79 Male 2/20/2012 Pharmacist Japan
Primary
Concomitant
Deep Vein Thrombosis Other Serious 3/8/2011 78 Male 112 lb 2/22/2012 Physician Japan
Primary
Concomitant
Cerebral Infarction Hospitalization 3/1/2010 68 Male 132 lb 2/23/2012 Physician Japan
Primary
Concomitant
Altered State Of Consciousness Other Serious 2/16/2012 69 Male 2/24/2012 Pharmacist Japan
Primary
Concomitant
Pulmonary Fibrosis Other Serious Male 2/24/2012 Pharmacist Japan
Primary
Concomitant
Malignant Pleural Effusion Hospitalization 1/23/2012 76 Female 123 lb 2/24/2012 Pharmacist Japan
Primary
Concomitant
Platelet Count Decreased Other Serious 11/1/2011 70 Female 112 lb 2/27/2012 Physician Japan
Primary
Secondary
Concomitant
Cholangitis Sclerosing Hospitalization 9/29/2011 59 Female 161 lb 2/28/2012 Pharmacist Japan
Primary
Secondary
Concomitant
Tumour Haemorrhage Other Serious 12/26/2009 60 Male 168 lb 2/29/2012 Consumer Japan
Primary
Secondary
Concomitant
Gastrointestinal Perforation Other Serious 2/22/2012 Female 2/29/2012 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Disability 10/21/2010 67 Female 101 lb 3/1/2012 Physician Japan
Primary
Secondary
Concomitant
Death Death 7/6/2011 79 Male 79 lb 3/1/2012 Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 79 Male 3/2/2012 Pharmacist Japan
Primary
Secondary
Concomitant
Nausea Hospitalization 1/21/2012 59 Female 126 lb 3/2/2012 Physician Germany
Primary
Secondary
Dyschezia Other Serious 8/10/2010 50 Male 132 lb 3/2/2012 Physician Japan
Primary
Secondary
Concomitant
Nausea Hospitalization 12/11/2009 64 Female 110 lb 3/2/2012 Physician Japan
Primary
Secondary
Concomitant
Atrial Flutter Hospitalization 7/26/2011 66 Male 174 lb 3/2/2012 France
Primary
Concomitant
Interstitial Lung Disease Other Serious Female 3/5/2012 Pharmacist Japan
Primary
Concomitant

Drug Data