Avastin combined with Levofolinate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vitreous Haemorrhage Other Serious 8/4/2008 Male 9/8/2008 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Life Threatening 8/6/2008 Male 9/8/2008 Physician Japan
Primary
Secondary
Concomitant
Hepatitis Other Serious 6/11/2008 Female 135 lb 12/16/2008 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Artery Thrombosis Other Serious 2/20/2008 73 Male 133 lb 2/11/2009 Physician Japan
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 8/6/2008 Female 3/16/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Increased Other Serious 1/6/2009 Female 3/23/2009 Physician Japan
Primary
Concomitant
Gastrointestinal Perforation Hospitalization 11/5/2008 68 Male 3/31/2009 Physician Japan
Primary
Secondary
Intestinal Perforation Life Threatening 3/25/2009 41 Male 4/7/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Peritonitis Hospitalization 2/22/2009 Male 132 lb 4/8/2009 Physician Japan
Primary
Secondary
Concomitant
Urticaria Other Serious 2/4/2009 Female 121 lb 4/21/2009 Other Health Professional Japan
Primary
Concomitant
White Blood Cell Count Increased Other Serious 1/7/2009 Female 4/22/2009 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Perforation Life Threatening 3/23/2009 Male 123 lb 4/23/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 2/2/2009 Female 7/8/2009 Physician Japan
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 2/2/2009 Female 8/11/2009 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 12/3/2008 Male 146 lb 9/10/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2009 Male 9/10/2009 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Hospitalization 8/18/2009 Male 161 lb 9/18/2009 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 12/13/2007 Male 9/28/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2009 Male 10/6/2009 Physician Japan
Primary
Secondary
Concomitant
Varicose Vein Ruptured Other Serious 9/28/2009 Female 11/4/2009 Physician Japan
Primary
Secondary
Ventricular Extrasystoles Life Threatening 9/17/2009 Female 117 lb 12/12/2009 Physician Japan
Primary
Secondary
Concomitant
Aortic Dissection Rupture Death 2/17/2009 Male 119 lb 12/15/2009 Pharmacist Japan
Primary
Concomitant
Nephrotic Syndrome Other Serious 8/10/2009 Male 159 lb 12/16/2009 Physician Japan
Primary
Secondary
Concomitant
Hypersensitivity Hospitalization 60 Female 12/18/2009 Pharmacist Japan
Primary
Concomitant
Rectal Perforation Hospitalization 6/18/2009 Male 141 lb 12/21/2009 Physician Japan
Primary
Concomitant
Nephrotic Syndrome Other Serious 8/10/2009 Male 159 lb 12/22/2009 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Disability 10/1/2008 Male 121 lb 12/23/2009 Pharmacist Japan
Primary
Concomitant
Nephrotic Syndrome Other Serious 8/10/2009 Male 159 lb 12/24/2009 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 9/30/2009 Male 12/24/2009 Physician Japan
Primary
Secondary
Concomitant
Nephrotic Syndrome Other Serious 8/10/2009 Male 159 lb 12/30/2009 Physician Japan
Primary
Secondary
Concomitant
Shock Haemorrhagic Life Threatening 7/1/2009 Male 139 lb 12/31/2009 Physician Japan
Primary
Concomitant
Shock Haemorrhagic Life Threatening 7/1/2009 Male 139 lb 1/4/2010 Physician Japan
Primary
Secondary
Pneumonia Aspiration Death Male 1/4/2010 Physician Japan
Primary
Concomitant
Stomatitis Death 11/7/2009 Male 88 lb 1/13/2010 Physician Japan
Primary
Concomitant
Hypoaesthesia Other Serious 50 Male 1/19/2010 Physician Japan
Primary
Concomitant
Multi-organ Failure Hospitalization 62 Male 1/19/2010 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 70 Male 1/20/2010 Pharmacist Japan
Primary
Concomitant
Shock Haemorrhagic Life Threatening 7/1/2009 Male 139 lb 1/20/2010 Physician Japan
Primary
Secondary
Retroperitoneal Abscess Life Threatening 7/14/2009 Male 137 lb 1/21/2010 Physician Japan
Primary
Concomitant
Gastroduodenal Ulcer Hospitalization 1/7/2010 74 Female 1/26/2010 Physician Japan
Primary
Concomitant
Peritonitis Other Serious 12/2/2009 Male 1/27/2010 Physician Japan
Primary
Concomitant
Suture Rupture Hospitalization 78 Male 1/28/2010 Physician Japan
Primary
Concomitant
Pyrexia Other Serious 9/30/2009 Male 2/1/2010 Physician Japan
Primary
Secondary
Concomitant
Ventricular Tachycardia Life Threatening 7/1/2009 Male 139 lb 2/1/2010 Physician Japan
Primary
Secondary
Sepsis Hospitalization 12/1/2009 58 Male 121 lb 2/2/2010 Physician Japan
Primary
Concomitant
Cerebral Artery Embolism Death 1/8/2010 Male 97 lb 2/4/2010 Physician Japan
Primary
Concomitant
Shock Life Threatening 12/2/2009 Male 130 lb 2/8/2010 Physician Japan
Primary
Concomitant
Peritonitis Hospitalization 4/19/2009 Male 159 lb 2/11/2010 Physician Japan
Primary
Concomitant
Small Intestinal Perforation Hospitalization 1/1/2009 Male 137 lb 2/11/2010 Physician Japan
Primary
Concomitant
Leukoencephalopathy Other Serious 9/14/2009 Male 2/11/2010 Physician Japan
Primary
Secondary
White Blood Cell Count Decreased Other Serious 10/8/2008 Male 128 lb 2/16/2010 Physician Japan
Primary
Secondary
Concomitant
Peritonitis Hospitalization 1/1/2009 Male 137 lb 2/16/2010 Physician Japan
Primary
Concomitant
Gastric Ulcer Hospitalization 1/13/2010 Female 108 lb 2/16/2010 Physician Japan
Primary
Secondary
Concomitant
Suture Rupture Hospitalization 1/1/2009 78 Male 82 lb 2/16/2010 Physician Japan
Primary
Concomitant
Hyperammonaemia Hospitalization 10/22/2009 Male 2/16/2010 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Other Serious 11/5/2008 Male 150 lb 2/17/2010 Physician Japan
Primary
Secondary
Concomitant
Dyschezia Other Serious 1/1/2009 Male 2/18/2010 Other Health Professional Japan
Primary
Concomitant
Respiratory Failure Other Serious 1/26/2010 58 Male 2/22/2010 Physician Japan
Primary
Concomitant
Peritonitis Life Threatening 1/18/2010 Male 139 lb 2/22/2010 Physician Japan
Primary
Concomitant
Peritonitis Life Threatening 1/18/2010 Male 139 lb 2/22/2010 Physician Japan
Primary
Concomitant
Hepatic Neoplasm Malignant Other Serious 80 Male 2/24/2010 Japan
Primary
Concomitant
Hepatic Neoplasm Malignant Other Serious 80 Male 2/25/2010 Japan
Primary
Concomitant
Peritonitis Hospitalization 43 Female 2/26/2010 Physician Japan
Primary
Secondary
Shock Haemorrhagic Other Serious 11/29/2008 Female 119 lb 3/1/2010 Physician Japan
Primary
Concomitant
Ileal Ulcer Other Serious 9/1/2009 Female 84 lb 3/1/2010 Physician Japan
Primary
Concomitant
Hyperammonaemia Hospitalization 10/22/2009 Male 3/1/2010 Physician Japan
Primary
Secondary
Concomitant
Melaena Other Serious 59 Female 3/4/2010 Physician Japan
Primary
Concomitant
Pulmonary Fibrosis Death 2/3/2010 62 Male 3/5/2010 Physician Japan
Primary
Secondary
Stomatitis Hospitalization 11/26/2007 Male 112 lb 3/9/2010 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Hospitalization 11/26/2007 Male 112 lb 3/11/2010 Physician Japan
Primary
Secondary
Concomitant
Necrotising Fasciitis Other Serious 5/1/2009 65 Male 3/15/2010 Physician Japan
Primary
Concomitant
Dyschezia Other Serious 1/1/2009 64 Male 3/18/2010 Physician Japan
Primary
Concomitant
Pulmonary Oedema Life Threatening 3/2/2010 Female 3/18/2010 Physician Japan
Primary
Secondary
Thrombosis Other Serious 50 Male 3/18/2010 Physician Japan
Primary
Concomitant
Septic Shock Other Serious 9/1/2009 Female 84 lb 3/18/2010 Physician Japan
Primary
Concomitant
Neutrophil Count Decreased Other Serious 10/10/2007 Male 3/22/2010 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Hospitalization 11/26/2007 Male 112 lb 3/23/2010 Physician Japan
Primary
Secondary
Concomitant
Non-cardiogenic Pulmonary Oedema Life Threatening 3/2/2010 Female 95 lb 3/23/2010 Physician Japan
Primary
Secondary
Concomitant
Suture Rupture Hospitalization 1/1/2009 78 Male 82 lb 3/25/2010 Physician Japan
Primary
Concomitant
Sepsis Life Threatening 12/12/2009 Male 121 lb 3/25/2010 Physician Japan
Primary
Concomitant
Pulmonary Thrombosis Life Threatening 1/26/2010 Male 117 lb 3/26/2010 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 2/16/2010 Male 104 lb 3/26/2010 Physician Japan
Primary
Concomitant
Disease Progression Death 55 Female 3/31/2010 Physician Japan
Primary
Concomitant
Septic Shock Other Serious 9/1/2009 66 Female 84 lb 4/2/2010 Physician Japan
Primary
Concomitant
Septic Shock Other Serious 76 Female 4/2/2010 Physician Japan
Primary
Concomitant
Vomiting Other Serious 1/6/2010 56 Male 148 lb 4/5/2010 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 3/31/2009 79 Male 115 lb 11/5/2010 Physician Japan
Primary
Secondary
Concomitant
Volvulus Of Small Bowel Other Serious 1/1/2009 62 Male 148 lb 11/11/2010 Physician Japan
Primary
Secondary
Concomitant
Polymyositis Hospitalization 5/27/2009 57 Male 110 lb 11/22/2010 Physician Japan
Primary
Secondary
Congestive Cardiomyopathy Hospitalization 11/22/2010 Physician Japan
Primary
Secondary
Shock Haemorrhagic Death 7/14/2010 68 Female 84 lb 11/24/2010 Physician Japan
Primary
Secondary
Concomitant
Myelodysplastic Syndrome Hospitalization 2/16/2009 55 Male 198 lb 11/29/2010 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 7/8/2009 71 Male 139 lb 11/29/2010 Physician Japan
Primary
Concomitant
White Blood Cell Count Increased Death 7/7/2009 70 Male 134 lb 11/29/2010 Physician Japan
Primary
Secondary
Concomitant
Anaphylactic Shock Other Serious 8/2/2010 60 Female 86 lb 11/29/2010 Pharmacist Japan
Primary
Secondary
Concomitant
Anaphylactic Shock Other Serious 8/2/2010 60 Female 86 lb 11/29/2010 Pharmacist Japan
Primary
Secondary
Concomitant
Peritonitis Other Serious 51 Female 11/29/2010 Physician Japan
Primary
Concomitant
Renal Failure Acute Other Serious 9/17/2009 61 Male 11/30/2010 Physician Japan
Primary
Concomitant
Restlessness Hospitalization 60 Female 11/30/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Cataract Hospitalization 1/1/2010 Male 121 lb 11/30/2010 Physician Japan
Primary
Concomitant
Large Intestine Perforation Hospitalization 10/1/2009 67 Male 168 lb 12/2/2010 Physician Japan
Primary
Concomitant
Sepsis Death 1/1/2008 77 Female 79 lb 12/3/2010 Physician Japan
Primary
Concomitant
Varicose Vein Ruptured Other Serious 11/1/2010 55 Female 12/3/2010 Physician Japan
Primary
Concomitant
Large Intestine Perforation Life Threatening 6/25/2010 72 Male 139 lb 12/6/2010 Other Health Professional Japan
Primary
Concomitant
Large Intestinal Ulcer Other Serious 65 Female 12/8/2010 Physician Japan
Primary
Concomitant
Shock Other Serious 7/7/2009 70 Male 134 lb 12/10/2010 Physician Japan
Primary
Secondary
Concomitant
Large Intestinal Ulcer Other Serious 65 Female 12/14/2010 Physician Japan
Primary
Concomitant
Sepsis Death 1/1/2008 77 Female 79 lb 12/16/2010 Physician Japan
Primary
Concomitant
Large Intestine Perforation Hospitalization 10/1/2009 67 Male 168 lb 12/16/2010 Physician Japan
Primary
Concomitant
Decreased Appetite Death 6/1/2010 70 Male 12/17/2010 Physician Japan
Primary
Concomitant
Tachycardia Death 8/1/2009 52 Male 150 lb 12/17/2010 Physician Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Death 1/6/2009 78 Male 12/20/2010 Pharmacist Japan
Primary
Concomitant
Cardio-respiratory Arrest Death 12/10/2010 70 Male 12/20/2010 Physician Japan
Primary
Secondary
Shock Other Serious 10/14/2010 47 Male 12/22/2010 Physician Japan
Primary
Concomitant
Loss Of Consciousness Other Serious 12/10/2010 61 Female 90 lb 12/22/2010 Physician Japan
Primary
Secondary
Concomitant
Shock Other Serious 63 Male 12/22/2010 Physician Japan
Primary
Secondary
Interstitial Lung Disease Other Serious 12/14/2010 77 Male 12/23/2010 Other Health Professional Japan
Primary
Secondary
Congestive Cardiomyopathy Hospitalization 5/24/2010 68 Male 12/23/2010 Physician Japan
Primary
Secondary
Concomitant
Peritonitis Other Serious 11/11/2009 43 Female 134 lb 12/27/2010 Physician Japan
Primary
Secondary
Concomitant
Shock Other Serious 63 Male 12/29/2010 Physician Japan
Primary
Secondary
Interstitial Lung Disease Other Serious 9/1/2009 60 Male 12/29/2010 Physician Japan
Primary
Concomitant
Sepsis Other Serious 11/1/2010 65 Male 12/30/2010 Physician Japan
Primary
Concomitant
Large Intestine Perforation Life Threatening 6/25/2010 72 Male 139 lb 12/30/2010 Other Health Professional Japan
Primary
Concomitant
Femoral Neck Fracture Other Serious 68 Male 12/30/2010 Pharmacist Japan
Primary
Concomitant
Malaise Other Serious 61 Female 12/30/2010 Physician Japan
Primary
Secondary
Concomitant
Pyothorax Hospitalization 6/18/2010 74 Female 121 lb 1/3/2011 Other Health Professional Japan
Primary
Concomitant
Peritonitis Life Threatening 6/24/2010 66 Male 104 lb 1/3/2011 Physician Japan
Primary
Concomitant
Chills Other Serious 6/18/2010 59 Female 132 lb 1/3/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Cytomegalovirus Gastrointestinal Infection Death 6/1/2010 70 Male 1/3/2011 Other Health Professional Japan
Primary
Concomitant
Hypoaesthesia Death 9/1/2009 75 Male 1/3/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Death 11/29/2010 50 Female 88 lb 1/18/2011 Other Health Professional Japan
Primary
Secondary
Small Intestinal Perforation Hospitalization 12/2/2010 65 Male 1/20/2011 Physician Japan
Primary
Secondary
Ileal Ulcer Death 6/30/2008 63 Male 1/21/2011 Physician Japan
Primary
Secondary
Concomitant
Fibrin D Dimer Increased Hospitalization 1/1/2011 70 Male 1/24/2011 Other Health Professional Japan
Primary
Secondary
Disease Progression Death 4/6/2010 79 Male 148 lb 1/24/2011 Other Health Professional Japan
Primary
Concomitant
Respiratory Failure Death 9/1/2009 75 Male 1/25/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 11/20/2007 69 Female 101 lb 2/4/2011 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 12/20/2010 78 Female 2/4/2011 Other Health Professional Japan
Primary
Secondary
Ileal Ulcer Other Serious 6/30/2008 63 Male 2/7/2011 Physician Japan
Primary
Secondary
Concomitant
Wound Infection Death 2/22/2010 65 Male 104 lb 2/8/2011 Other Health Professional Japan
Primary
Concomitant
Blood Pressure Decreased Other Serious 6/30/2008 63 Male 2/11/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Constipation Other Serious 2/22/2010 65 Male 104 lb 2/11/2011 Other Health Professional Japan
Primary
Concomitant
Nausea Hospitalization 4/2/2010 59 Female 132 lb 2/11/2011 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Death 9/28/2010 65 Male 2/11/2011 Physician Japan
Primary
Secondary
Concomitant
Dyspnoea Other Serious 12/10/2010 61 Female 90 lb 2/14/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Hyperglycaemia Other Serious 6/10/2010 58 Female 121 lb 2/15/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Carotid Artery Occlusion Life Threatening 11/1/2010 50 Male 176 lb 2/16/2011 Other Health Professional Japan
Primary
Concomitant
Gastrointestinal Perforation Death 11/20/2007 69 Female 101 lb 2/16/2011 Physician Japan
Primary
Concomitant
Gastrointestinal Perforation Other Serious 10/11/2010 54 Male 128 lb 2/17/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 9/17/2010 75 Male 132 lb 2/18/2011 Physician Japan
Primary
Concomitant

Drug Data