Avastin combined with Leucovorin Calcium

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Metastases To Liver Hospitalization 75 Female 1/4/2006 Physician France
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 12/19/2005 68 Female 152 lb 1/9/2006 Physician Australia
Primary
Secondary
Peritonitis Hospitalization 11/25/2005 53 Male 1/10/2006 Physician Finland
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 10/30/2005 68 Male 198 lb 1/9/2006 Other Health Professional United States
Primary
Secondary
Pneumoperitoneum Hospitalization 12/9/2005 Male 155 lb 1/12/2006 Physician Spain
Primary
Secondary
Vomiting Hospitalization 6/5/2005 57 Male 1/13/2006 Physician United States
Primary
Concomitant
Tremor Hospitalization 11/21/2005 56 Female 106 lb 1/13/2006 Physician Canada
Primary
Secondary
Concomitant
Ileus Hospitalization 10/21/2005 51 Female 1/13/2006 Physician Czech Republic
Primary
Concomitant
Urosepsis Disability 10/8/2005 66 Male 1/18/2006 Netherlands
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/18/2005 68 Female 152 lb 1/18/2006 Physician Australia
Primary
Secondary
Tremor Hospitalization 11/21/2005 56 Female 106 lb 1/18/2006 Physician Canada
Primary
Secondary
Concomitant
Neutropenia Hospitalization 11/28/2005 42 Female 205 lb 1/18/2006 Physician Canada
Primary
Secondary
Concomitant
Post Procedural Vomiting Life Threatening 9/30/2005 62 Male 166 lb 1/18/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Testicular Disorder Hospitalization 10/30/2005 68 Male 198 lb 1/17/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Troponin I Increased Hospitalization 9/7/2005 57 Female 1/19/2006 Physician Australia
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 52 Female 1/20/2006 Physician United States
Primary
Secondary
Gastritis Hospitalization 9/11/2005 57 Female 180 lb 1/20/2006 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/25/2005 63 Female 101 lb 1/24/2006 Other Health Professional Canada
Primary
Secondary
White Blood Cell Count Increased Hospitalization 11/22/2005 74 Male 437 lb 1/24/2006 Physician Australia
Primary
Secondary
Concomitant
Platelet Count Decreased Hospitalization 12/4/2005 53 Male 182 lb 1/25/2006 Physician United Kingdom
Primary
Secondary
Leukopenia Hospitalization 10/25/2005 73 Female 112 lb 1/25/2006 Physician Bulgaria
Primary
Secondary
Concomitant
Death Death 59 Male 1/26/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Small Intestinal Perforation Hospitalization 11/25/2005 53 Male 1/26/2006 Physician Finland
Primary
Concomitant
Pyrexia Life Threatening 12/1/2005 75 Female 1/27/2006 Physician France
Primary
Concomitant
Neuropathy Disability 8/1/2005 55 Female 12/1/2005 Physician United States
Primary
Secondary
Vasculitis Other Serious 1/1/2005 68 Male 1/30/2006 United States
Primary
Secondary
Concomitant
Scab Other Serious 55 Male 2/1/2006 Physician Netherlands
Primary
Concomitant
Appendicitis Hospitalization 9/8/2005 68 Male 211 lb 2/1/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Death Death 59 Male 345 lb 2/2/2006 Canada
Primary
Secondary
Concomitant
Shoulder Pain Hospitalization 12/21/2005 60 Female 126 lb 2/3/2006 Physician United States
Primary
Secondary
Concomitant
Abscess Hospitalization 1/13/2006 25 Male 187 lb 2/3/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 1/17/2006 73 Male 141 lb 2/7/2006 Physician United States
Primary
Secondary
Concomitant
Urticaria Generalised Hospitalization 12/4/2005 53 Male 182 lb 2/9/2006 Physician United Kingdom
Primary
Secondary
White Blood Cell Count Increased Hospitalization 1/24/2006 57 Female 203 lb 2/10/2006 Physician South Africa
Primary
Secondary
Concomitant
Gastrointestinal Infection Hospitalization 12/29/2005 57 2/15/2006 Physician United States
Primary
Secondary
Vomiting Hospitalization 1/22/2006 54 Female 2/15/2006 Physician Canada
Primary
Secondary
Concomitant
Clostridium Colitis Other Serious 11/20/2005 76 Male 2/16/2006 United States
Primary
Concomitant
Peritonitis Life Threatening 7/26/2005 55 Male 176 lb 2/17/2006 Physician Bulgaria
Primary
Secondary
Ascites Required Intervention 11/6/2005 54 Male 177 lb 2/21/2006 United States
Primary
Secondary
Thrombosis Hospitalization 2/7/2006 Female 2/22/2006 Physician Slovakia (Slovak Republic)
Primary
Concomitant
Vocal Cord Paralysis Disability 7/1/2005 52 Female 166 lb 2/22/2006 Physician United States
Primary
Concomitant
Rash Erythematous Hospitalization 2/7/2006 53 Female 214 lb 2/23/2006 Physician Australia
Primary
Secondary
Nasal Septum Perforation Other Serious 53 Male 2/27/2006 Physician United States
Primary
Concomitant
Skin Ulcer Death 10/27/2005 76 Male 2/24/2006 United States
Primary
Secondary
Concomitant
Pyrexia Hospitalization 1/25/2006 40 Female 2/24/2006 Physician Norway
Primary
Concomitant
Metastases To Liver Hospitalization 5/4/2005 84 Male 159 lb 2/27/2006 Physician United States
Primary
Secondary
Concomitant
Liver Function Test Abnormal Other Serious 1/1/2005 3/3/2006 Physician United States
Primary
Secondary
Fatigue Hospitalization 12/1/2005 73 Female 2/28/2006 Physician Canada
Primary
Secondary
Concomitant
Large Intestine Perforation Hospitalization 2/25/2006 70 Male 2/28/2006 Pharmacist United States
Primary
Secondary
Weight Decreased Hospitalization 1/29/2006 52 Male 3/4/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 1/1/2006 73 Male 141 lb 3/10/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 2/11/2006 59 Male 3/6/2006 Consumer United States
Primary
Concomitant
Pyrexia Hospitalization 1/24/2006 57 Female 203 lb 3/9/2006 Physician South Africa
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 2/15/2006 64 Male 243 lb 3/7/2006 Physician United States
Primary
Secondary
Concomitant
Metastases To Lung Other Serious 80 Female 3/6/2006 United States
Primary
Concomitant
Pruritus Generalised Hospitalization 3/2/2006 Male 143 lb 3/15/2006 Other Health Professional United States
Primary
Concomitant
Neutropenia Life Threatening 2/7/2006 66 Female 132 lb 3/13/2006 Other Health Professional Italy
Primary
Secondary
Concomitant
Tachycardia Hospitalization 2/20/2006 76 Female 3/13/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Diverticulitis Hospitalization 9/4/2005 80 Female 147 lb 3/13/2006 Physician United States
Primary
Concomitant
Renal Failure Acute Hospitalization 1/17/2006 73 Male 141 lb 3/13/2006 Physician United States
Primary
Secondary
Concomitant
Hypertriglyceridaemia Other Serious 8/6/2005 54 Male 3/10/2006 Physician Germany
Primary
Secondary
Concomitant
Syncope Other Serious 10/1/2005 69 Male 3/10/2006 Physician Canada
Primary
Secondary
Concomitant
Ascites Required Intervention 11/6/2005 54 Male 177 lb 3/15/2006 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 12/23/2005 69 Female 3/14/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Mental Status Changes Hospitalization 11/6/2005 54 Male 177 lb 3/14/2006 Other Health Professional United States
Primary
Secondary
Ventricular Extrasystoles Hospitalization 2/28/2006 72 Male 173 lb 3/17/2006 Physician Canada
Primary
Secondary
Concomitant
Ventricular Extrasystoles Other Serious 2/2/2006 70 Male 3/17/2006 Physician Thailand
Primary
Secondary
Concomitant
Vomiting Hospitalization 11/25/2005 63 Female 101 lb 3/20/2006 Other Health Professional Canada
Primary
Secondary
Troponin I Increased Hospitalization 9/7/2005 57 Female 3/21/2006 Other Health Professional Australia
Primary
Secondary
Concomitant
Menorrhagia Hospitalization 44 Female 86 lb 3/21/2006 Other Health Professional Hong Kong
Primary
Secondary
Concomitant
Ventricular Fibrillation Life Threatening 2/15/2006 64 Male 243 lb 3/21/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/7/2006 61 Female 3/24/2006 Physician Germany
Primary
Secondary
Drug Hypersensitivity Hospitalization 12/4/2005 53 Male 182 lb 3/24/2006 Other Health Professional United Kingdom
Primary
Secondary
Nausea Other Serious 3/14/2006 61 Female 157 lb 3/29/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Ventricular Extrasystoles Other Serious 2/2/2006 70 Male 3/29/2006 Physician Thailand
Primary
Secondary
Concomitant
Ventricular Hypertrophy Hospitalization 2/28/2006 72 Male 173 lb 3/29/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/18/2006 78 Female 100 lb 3/30/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 8/8/2005 55 Male 181 lb 3/30/2006 Physician Canada
Primary
Secondary
Concomitant
Vertigo Hospitalization 11/29/2005 62 Female 3/31/2006 Physician United States
Primary
Secondary
Concomitant
Pneumonia Other Serious 2/28/2006 80 Male 4/3/2006 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 3/19/2006 55 Male 159 lb 4/3/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Tachycardia Hospitalization 2/20/2006 76 Female 4/3/2006 Physician United States
Primary
Secondary
Concomitant
Unresponsive To Pain Stimuli Hospitalization 12/14/2005 68 Female 143 lb 4/4/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/18/2006 78 Female 100 lb 4/6/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 5/4/2005 84 Male 159 lb 4/7/2006 Physician United States
Primary
Secondary
Concomitant
Pneumonia Other Serious 2/28/2006 80 Male 4/7/2006 Physician United States
Primary
Concomitant
Troponin I Increased Hospitalization 10/8/2005 57 Female 4/6/2006 Physician Australia
Primary
Secondary
Concomitant
Oesophagitis Death 67 Female 4/7/2006 Other Health Professional Australia
Primary
Secondary
Concomitant
Pulmonary Embolism Death 64 Female 4/7/2006 Physician France
Primary
Concomitant
Proteinuria Death 51 Female 4/7/2006 Physician France
Primary
Concomitant
Vocal Cord Paralysis Other Serious Unknown 4/10/2006 Pharmacist United States
Primary
Concomitant
Troponin I Increased Hospitalization 10/8/2005 57 Female 4/10/2006 Other Health Professional Australia
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 9/15/2005 63 Male 132 lb 4/6/2006 Other Health Professional France
Primary
Secondary
Concomitant
Skin Exfoliation Required Intervention 2/15/2006 63 Male 221 lb 4/14/2006 Physician United States
Primary
Concomitant
Thalassaemia Trait Hospitalization 3/19/2006 55 Male 159 lb 4/14/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/17/2006 73 Female 97 lb 4/12/2006 Physician Mexico
Primary
Secondary
Oesophagitis Death 68 Female 163 lb 4/12/2006 Other Health Professional Australia
Primary
Secondary
Concomitant
Deep Vein Thrombosis Death 3/15/2006 59 Male 4/17/2006 Physician Mexico
Primary
Secondary
Concomitant
Deep Vein Thrombosis Death 3/15/2006 59 Male 4/20/2006 Physician Mexico
Primary
Secondary
Concomitant
Pneumonia Hospitalization 1/16/2006 55 Male 156 lb 4/21/2006 Physician Canada
Primary
Secondary
Concomitant
Hypotension Hospitalization 2/21/2006 52 Male 4/24/2006 Physician United States
Primary
Secondary
Vomiting Hospitalization 5/18/2005 57 Female 142 lb 4/26/2006 Physician Australia
Primary
Secondary
Concomitant
Urosepsis Hospitalization 8/14/2005 68 Male 150 lb 4/26/2006 Physician Australia
Primary
Secondary
Concomitant
Blood Bilirubin Increased Hospitalization 4/7/2006 62 Male 190 lb 4/26/2006 Physician Canada
Primary
Secondary
Vomiting Hospitalization 5/2/2006 Male 250 lb 5/3/2006 Consumer United States
Primary
Secondary
Concomitant
Sinus Bradycardia Hospitalization 2/21/2006 52 Male 5/2/2006 Physician United States
Primary
Secondary
Platelet Count Decreased Death 3/15/2006 59 Male 5/3/2006 Physician Mexico
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Life Threatening 1/17/2006 63 Female 102 lb 5/5/2006 Physician United States
Primary
Secondary
Concomitant
Vasculitis Hospitalization 74 Male 5/5/2006 Other Health Professional Ireland
Primary
Secondary
Peritonitis Bacterial Hospitalization 4/14/2006 20 Male 185 lb 5/10/2006 Physician Bulgaria
Primary
Concomitant
Vasculitis Hospitalization 74 Male 5/11/2006 Other Health Professional Ireland
Primary
Concomitant
Duodenal Perforation Required Intervention 64 Female 101 lb 5/9/2006 Physician United States
Primary
Concomitant
Gastritis Hospitalization 9/11/2005 57 Female 180 lb 5/11/2006 Other Health Professional Germany
Primary
Concomitant
Dermatitis Exfoliative Hospitalization 2/17/2006 55 Female 146 lb 5/12/2006 Physician Austria
Primary
Secondary
Nausea 64 Male 3/1/2006 Consumer United States
Primary
Concomitant
Abdominal Pain 58 Male 3/1/2006 Physician United States
Primary
Concomitant
Dermatitis Acneiform 10/17/2005 78 Male 159 lb 3/1/2006 Other Health Professional United States
Primary
Concomitant
Deep Vein Thrombosis 12/1/2005 Male 3/1/2006 United States
Primary
Concomitant
Impaired Healing Female 3/1/2006 Other Health Professional United States
Primary
Concomitant
Catheter Related Complication 12/16/2005 62 Male 3/1/2006 Physician United States
Primary
Concomitant
Vision Blurred 70 Male 3/1/2006 United States
Primary
Concomitant
Medication Error 2/16/2006 40 Male 3/1/2006 Pharmacist United States
Primary
Secondary
Vision Blurred 2/6/2006 56 Male 3/1/2006 Pharmacist United States
Primary
Secondary
Concomitant
Ascites 9/1/2005 47 Female 3/1/2006 Consumer United States
Primary
Concomitant
Neuropathy 11/16/2005 63 Male 3/1/2006 Other Health Professional United States
Primary
Concomitant
Carcinoembryonic Antigen Increased 47 Male 3/1/2006 Consumer United States
Primary
Concomitant
Hypersensitivity Required Intervention 12/14/2005 62 Female 222 lb 3/1/2006 Other Health Professional United States
Primary
Concomitant
Duodenal Perforation Required Intervention 2/12/2006 81 Male 143 lb 3/1/2006 Physician United States
Primary
Concomitant
Pneumoperitoneum Hospitalization 12/9/2005 Male 155 lb 5/16/2006 Physician Spain
Primary
Secondary
Gastrointestinal Fistula Hospitalization 9/10/2005 60 Male 3/1/2006 Other Health Professional United States
Primary
Concomitant
Hypertensive Emergency Hospitalization 10/5/2005 56 Male 3/1/2006 Pharmacist United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 10/13/2005 51 Male 3/1/2006 Other Health Professional United States
Primary
Secondary
Neutropenia Other Serious 12/8/2005 52 Male 3/1/2006 Pharmacist United States
Primary
Concomitant
Blood Bilirubin Increased Other Serious 11/21/2005 57 Female 3/1/2006 Physician United States
Primary
Concomitant
Proteinuria Other Serious Male 3/1/2006 Other Health Professional United States
Primary
Concomitant
Vision Blurred Other Serious 69 Male 3/1/2006 Other Health Professional United States
Primary
Concomitant
Weight Decreased Hospitalization 57 Female 5/16/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Hypersensitivity Other Serious 4/24/2006 62 Male 165 lb 5/17/2006 Physician Australia
Primary
Secondary
Concomitant
Tremor Hospitalization 11/21/2005 56 Female 106 lb 5/16/2006 Physician Canada
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/4/2005 44 Male 5/16/2006 Physician Czech Republic
Primary
Secondary
Therapy Non-responder Hospitalization 8/26/2005 67 Male 386 lb 5/19/2006 Other Health Professional United States
Primary
Secondary
Peritonitis Life Threatening 47 Male 139 lb 5/19/2006 Physician France
Primary
Concomitant
Pneumonia Hospitalization 3/6/2006 74 Female 194 lb 5/19/2006 Physician Belgium
Primary
Concomitant
Nausea Hospitalization 9/26/2004 65 Female 370 lb 5/20/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Death Death 59 Male 346 lb 5/20/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Uterine Leiomyoma Hospitalization 44 Female 86 lb 5/20/2006 Other Health Professional Hong Kong
Primary
Secondary
Concomitant
Oesophagitis Death 68 Female 163 lb 5/20/2006 Other Health Professional Australia
Primary
Secondary
Concomitant
Proteinuria Death 51 Female 5/20/2006 Physician France
Primary
Concomitant
Pulmonary Embolism Death 64 Female 5/20/2006 Physician France
Primary
Concomitant
Jaundice Other Serious 80 Female 5/23/2006 Physician United States
Primary
Concomitant

Drug Data