Avastin combined with Isovorin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Vomiting Hospitalization 8/14/2007 Male 8/29/2007 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 8/14/2007 Male 9/4/2007 Physician United Kingdom
Primary
Concomitant
Vomiting Hospitalization 8/14/2007 Male 11/16/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Aortic Dissection Other Serious 10/29/2007 Male 11/30/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Death Death 10/11/2007 Female 12/5/2007 Physician Japan
Primary
Secondary
Concomitant
Death Death 10/11/2007 Female 12/10/2007 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 9/24/2007 Male 12/18/2007 Physician Japan
Primary
Secondary
Concomitant
Anaphylactic Shock Other Serious 12/8/2007 58 Male 12/27/2007 Physician United Kingdom
Primary
Concomitant
Anaphylactoid Reaction Hospitalization 12/8/2007 Male 143 lb 1/7/2008 Physician United Kingdom
Primary
Concomitant
Neutropenia Other Serious 12/1/2007 Female 1/24/2008 Consumer United Kingdom
Primary
Concomitant
Rectal Perforation Life Threatening 12/6/2007 54 Female 1/24/2008 Other Health Professional Japan
Primary
Secondary
Rash Other Serious Male 128 lb 1/29/2008 Consumer United Kingdom
Primary
Concomitant
Interstitial Lung Disease Other Serious 65 Male 2/15/2008 Physician United Kingdom
Primary
Secondary
Acute Respiratory Distress Syndrome Hospitalization 1/28/2008 Male 2/21/2008 Physician Japan
Primary
Secondary
Vomiting Hospitalization 8/14/2007 Male 2/22/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Acute Respiratory Distress Syndrome Death 1/28/2008 Male 108 lb 2/23/2008 Consumer United Kingdom
Primary
Secondary
Disseminated Intravascular Coagulation Other Serious 1/22/2008 Male 2/23/2008 Physician Japan
Primary
Secondary
Concomitant
Disseminated Intravascular Coagulation Other Serious 1/22/2008 Male 3/6/2008 Physician Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Hospitalization 2/22/2008 70 Male 3/7/2008 Physician Japan
Primary
Secondary
Hepatic Function Abnormal Hospitalization 2/22/2008 70 Male 3/8/2008 Consumer United Kingdom
Primary
Secondary
Neuropathy Peripheral Other Serious 2/8/2008 62 Female 3/11/2008 Physician United Kingdom
Primary
Concomitant
Necrotising Fasciitis Hospitalization 2/22/2008 Male 3/11/2008 Consumer United Kingdom
Primary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 1/12/2008 62 Female 3/14/2008 Physician United Kingdom
Primary
Concomitant
Pyrexia Other Serious 11/28/2007 Male 108 lb 3/14/2008 Physician United Kingdom
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization Male 3/20/2008 Consumer United Kingdom
Primary
Concomitant
Neutrophil Count Decreased Other Serious 7/30/2007 Male 3/21/2008 Physician Japan
Primary
Secondary
Concomitant
Anaphylactic Reaction Other Serious 3/6/2008 Male 3/21/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Rash Generalised Other Serious 12/30/2007 Male 128 lb 3/21/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Delusion Other Serious 3/8/2008 63 Female 3/25/2008 Consumer United Kingdom
Primary
Concomitant
Tumour Haemorrhage Other Serious 2/29/2008 Male 3/25/2008 Consumer United Kingdom
Primary
Concomitant
Tachycardia Other Serious 3/11/2008 Female 154 lb 3/26/2008 Physician United Kingdom
Primary
Concomitant
Respiratory Failure Hospitalization 1/28/2008 Male 3/28/2008 Physician Japan
Primary
Secondary
Acute Respiratory Distress Syndrome Death 1/28/2008 Male 108 lb 3/28/2008 Consumer United Kingdom
Primary
Secondary
Hepatic Function Abnormal Hospitalization 2/22/2008 Male 157 lb 3/31/2008 Consumer United Kingdom
Primary
Concomitant
Tumour Haemorrhage Other Serious 2/29/2008 Male 132 lb 4/1/2008 Consumer United Kingdom
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 2/22/2008 Male 157 lb 4/3/2008 Consumer United Kingdom
Primary
Concomitant
Necrotising Fasciitis Hospitalization 2/24/2008 Male 146 lb 4/4/2008 Consumer United Kingdom
Primary
Concomitant
Disseminated Intravascular Coagulation Life Threatening 3/16/2008 54 Male 4/8/2008 Consumer United Kingdom
Primary
Secondary
Gastric Ulcer Hospitalization 3/14/2008 70 Male 4/11/2008 Consumer United Kingdom
Primary
Concomitant
Pulmonary Artery Thrombosis Other Serious 2/20/2008 73 Male 133 lb 4/14/2008 Physician Japan
Primary
Secondary
Thrombotic Cerebral Infarction Life Threatening 3/16/2008 54 Male 4/14/2008 Physician Japan
Primary
Secondary
Gastrointestinal Perforation Other Serious 2/13/2008 Female 4/15/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 3/3/2008 Male 110 lb 4/16/2008 Physician United Kingdom
Primary
Secondary
Tumour Haemorrhage Other Serious 2/29/2008 Male 132 lb 4/16/2008 Consumer United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 3/31/2008 Female 4/17/2008 Consumer United Kingdom
Primary
Concomitant
Pancytopenia Death 3/13/2008 Male 106 lb 4/17/2008 Consumer United Kingdom
Primary
Secondary
Duodenal Ulcer Hospitalization 12/6/2007 Female 4/22/2008 Physician Japan
Primary
Secondary
Gastrointestinal Perforation Other Serious 2/13/2008 48 Female 104 lb 4/22/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Neutrophil Count Decreased Other Serious 7/30/2007 Male 4/23/2008 Physician Japan
Primary
Secondary
Concomitant
Gastric Ulcer Hospitalization 3/14/2008 Male 4/23/2008 Physician Japan
Primary
Secondary
Interstitial Lung Disease Hospitalization 3/27/2008 Male 152 lb 4/23/2008 Consumer United Kingdom
Primary
Secondary
Gastric Ulcer Hospitalization 3/14/2008 Male 132 lb 4/24/2008 Consumer United Kingdom
Primary
Secondary
Intestinal Fistula Other Serious 12/6/2007 Male 4/24/2008 Physician Japan
Primary
Secondary
Concomitant
Intestinal Perforation Other Serious 11/27/2007 70 Male 4/24/2008 Physician Japan
Primary
Secondary
Concomitant
Disseminated Intravascular Coagulation Life Threatening 3/16/2008 Male 130 lb 4/25/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Small Intestinal Perforation Life Threatening 4/14/2008 Male 4/28/2008 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 1/28/2008 Male 165 lb 4/29/2008 Consumer United Kingdom
Primary
Concomitant
Renal Failure Acute Hospitalization 3/3/2008 Male 110 lb 4/30/2008 Physician United Kingdom
Primary
Secondary
Sepsis Death 4/4/2008 Female 101 lb 4/30/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Necrotising Fasciitis Hospitalization 4/21/2008 Female 4/30/2008 Consumer United Kingdom
Primary
Concomitant
Urine Output Decreased Hospitalization 4/16/2008 Female 5/1/2008 Physician United Kingdom
Primary
Secondary
Loss Of Consciousness Hospitalization 3/30/2008 70 Female 5/2/2008 Consumer United Kingdom
Primary
Concomitant
Orchitis Other Serious 4/17/2008 Male 5/2/2008 Physician United Kingdom
Primary
Secondary
Orchitis Other Serious 4/17/2008 Male 5/2/2008 Other Health Professional Japan
Primary
Secondary
Sepsis Death 3/13/2008 Male 106 lb 5/5/2008 Consumer United Kingdom
Primary
Secondary
Shock Other Serious 4/24/2008 Male 5/6/2008 Consumer United Kingdom
Primary
Secondary
Perforated Ulcer Hospitalization 4/18/2008 61 Male 5/6/2008 Physician United Kingdom
Primary
Concomitant
Urine Output Decreased Hospitalization 4/16/2008 Female 5/6/2008 Physician United Kingdom
Primary
Secondary
Anaphylactic Shock Hospitalization 4/23/2008 Male 163 lb 5/7/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Respiratory Failure Hospitalization 4/4/2008 Female 5/7/2008 Consumer Japan
Primary
Concomitant
Sneezing Other Serious 3/8/2008 63 Female 5/7/2008 Consumer United Kingdom
Primary
Secondary
Shock Other Serious 4/1/2008 Female 110 lb 5/16/2008 Consumer Japan
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal Hospitalization 2/5/2008 Male 5/20/2008 Physician Japan
Primary
Secondary
Concomitant
Retinal Detachment Hospitalization 5/7/2008 Male 123 lb 5/22/2008 Consumer Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 5/4/2008 Male 143 lb 5/22/2008 Physician United Kingdom
Primary
Concomitant
Colitis Ischaemic Other Serious Male 5/22/2008 Consumer Japan
Primary
Concomitant
Ischaemia Other Serious 4/18/2008 76 Male 5/22/2008 Physician Japan
Primary
Secondary
Anaphylactoid Reaction Other Serious 3/19/2008 Male 110 lb 5/22/2008 Consumer Japan
Primary
Secondary
Concomitant
Duodenal Ulcer Perforation Other Serious 4/18/2008 Male 146 lb 5/22/2008 Physician United Kingdom
Primary
Concomitant
Anaphylactic Shock Hospitalization 4/10/2008 Male 150 lb 5/23/2008 Physician Japan
Primary
Concomitant
Sneezing Other Serious 3/6/2008 Female 141 lb 5/23/2008 Consumer United Kingdom
Primary
Concomitant
Shock Other Serious 4/24/2008 Male 5/29/2008 Consumer United Kingdom
Primary
Secondary
Respiratory Failure Hospitalization 4/4/2008 Female 5/30/2008 Consumer Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 5/9/2008 Female 6/2/2008 Consumer United Kingdom
Primary
Concomitant
Leukopenia Life Threatening 3/1/2008 Female 6/3/2008 Physician Japan
Primary
Secondary
Concomitant
Shock Other Serious 4/24/2008 Male 6/3/2008 Physician Japan
Primary
Secondary
Small Intestinal Perforation Life Threatening 4/14/2008 Male 6/4/2008 Physician Japan
Primary
Secondary
Concomitant
Shock Other Serious 5/9/2008 65 Male 6/4/2008 Consumer United Kingdom
Primary
Concomitant
Retinal Detachment Hospitalization 5/7/2008 Male 6/4/2008 Consumer Japan
Primary
Secondary
Concomitant
Bipolar I Disorder Hospitalization 12/5/2007 Female 6/5/2008 Physician Japan
Primary
Secondary
White Blood Cell Count Decreased Hospitalization 12/4/2007 Male 6/5/2008 Physician Japan
Primary
Secondary
Concomitant
Shock Life Threatening 4/23/2008 Male 176 lb 6/5/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Shock Other Serious 5/23/2008 63 Male 132 lb 6/6/2008 Physician Japan
Primary
Secondary
Concomitant
Shock Other Serious 5/23/2008 63 Male 6/6/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 3/27/2008 Male 152 lb 6/7/2008 Consumer United Kingdom
Primary
Concomitant
Altered State Of Consciousness Hospitalization 11/27/2007 Male 6/9/2008 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious Male 6/11/2008 Pharmacist United Kingdom
Primary
Concomitant
Purpura Hospitalization 5/10/2008 Male 155 lb 6/11/2008 Physician United Kingdom
Primary
Concomitant
Anaphylactic Shock Other Serious 5/27/2008 Female 6/11/2008 Physician United Kingdom
Primary
Concomitant
Shock Other Serious 5/9/2008 Male 110 lb 6/12/2008 Consumer United Kingdom
Primary
Concomitant
Hepatic Function Abnormal Hospitalization 2/22/2008 Male 157 lb 6/12/2008 Consumer United Kingdom
Primary
Concomitant
Extrapyramidal Disorder Hospitalization 5/9/2008 Female 86 lb 6/16/2008 Consumer United Kingdom
Primary
Concomitant
Disseminated Intravascular Coagulation Other Serious 1/22/2008 Male 6/18/2008 Physician Japan
Primary
Secondary
Concomitant
Loss Of Consciousness Hospitalization 4/13/2008 Female 6/21/2008 Consumer United Kingdom
Primary
Concomitant
Interstitial Lung Disease Life Threatening 3/27/2008 Male 152 lb 7/1/2008 Consumer United Kingdom
Primary
Concomitant
Shock Other Serious 3/29/2008 Male 110 lb 7/2/2008 Consumer United Kingdom
Primary
Secondary
Neutrophil Count Decreased Hospitalization 7/30/2007 Male 7/8/2008 Physician Japan
Primary
Secondary
Concomitant
Intestinal Fistula Life Threatening 9/5/2007 Female 7/8/2008 Physician Japan
Primary
Secondary
Concomitant
Tachycardia Other Serious 3/11/2008 Female 154 lb 7/11/2008 Physician United Kingdom
Primary
Concomitant
Shock Other Serious 4/24/2008 Male 7/11/2008 Consumer United Kingdom
Primary
Secondary
Loss Of Consciousness Hospitalization 4/13/2008 Female 7/11/2008 Consumer United Kingdom
Primary
Concomitant
Shock Other Serious 4/24/2008 Male 7/12/2008 Physician Japan
Primary
Secondary
White Blood Cell Count Decreased Other Serious 1/23/2008 Male 7/15/2008 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 3/31/2008 Female 7/15/2008 Consumer Japan
Primary
Concomitant
Enterocutaneous Fistula Other Serious 6/1/2008 Male 79 lb 7/18/2008 Physician Japan
Primary
Secondary
Concomitant
Hypothyroidism Other Serious Female 95 lb 7/23/2008 Consumer Japan
Primary
Secondary
Concomitant
Disseminated Intravascular Coagulation Other Serious 7/4/2008 75 Male 7/26/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Pneumonia Life Threatening 1/1/2008 Male 132 lb 7/28/2008 Physician Japan
Primary
Secondary
Concomitant
Shock Other Serious 4/24/2008 Male 7/29/2008 Consumer United Kingdom
Primary
Secondary
Gastrointestinal Perforation Life Threatening 12/15/2007 Female 7/29/2008 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Perforation Life Threatening Female 104 lb 8/1/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Small Intestinal Perforation Life Threatening 3/13/2008 Female 8/4/2008 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Hospitalization 10/18/2007 Male 8/6/2008 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Perforation Life Threatening 12/15/2007 Female 8/7/2008 Physician Japan
Primary
Secondary
Concomitant
Shock Other Serious 4/24/2008 Male 8/7/2008 Physician Japan
Primary
Secondary
Hypothyroidism Other Serious 6/16/2008 Female 95 lb 8/8/2008 Consumer Japan
Primary
Secondary
Concomitant
Shock Other Serious 4/24/2008 Male 8/8/2008 Consumer United Kingdom
Primary
Secondary
Anaphylactic Shock Other Serious 5/27/2008 Female 8/11/2008 Physician Japan
Primary
Concomitant
Small Intestinal Perforation Life Threatening 8/1/2008 62 Male 8/14/2008 Physician Japan
Primary
Secondary
Concomitant
Shock Other Serious 4/24/2008 Male 8/18/2008 Consumer United Kingdom
Primary
Secondary
Shock Other Serious 4/24/2008 Male 8/18/2008 Physician Japan
Primary
Secondary
Nausea Life Threatening 6/25/2008 Female 118 lb 8/18/2008 Physician Japan
Primary
Secondary
Concomitant
Sneezing Other Serious 3/6/2008 Female 141 lb 8/19/2008 Consumer Japan
Primary
Concomitant
Renal Failure Acute Hospitalization 3/4/2008 Male 110 lb 8/26/2008 Physician United Kingdom
Primary
Secondary
Interstitial Lung Disease Hospitalization 7/22/2008 Male 8/27/2008 Consumer United Kingdom
Primary
Secondary
Disseminated Intravascular Coagulation Death 4/12/2008 Male 148 lb 9/2/2008 Consumer United Kingdom
Primary
Concomitant
Pneumonia Life Threatening 1/1/2008 Male 132 lb 9/4/2008 Physician Japan
Primary
Secondary
Concomitant
Duodenal Ulcer Perforation Other Serious 4/18/2008 Male 146 lb 9/4/2008 Physician United Kingdom
Primary
Concomitant
Urine Output Decreased Hospitalization 4/16/2008 Female 9/5/2008 Physician United Kingdom
Primary
Secondary
Sepsis Other Serious 1/22/2008 Male 148 lb 9/9/2008 Physician Japan
Primary
Secondary
Concomitant
Haemorrhage Hospitalization 5/21/2008 Male 9/12/2008 Consumer Japan
Primary
Secondary
Concomitant
Haemorrhage Hospitalization 5/21/2008 Male 9/17/2008 Consumer Japan
Primary
Secondary
Concomitant
Pneumonia Bacterial Hospitalization 4/16/2008 Male 9/23/2008 Consumer Japan
Primary
Secondary
Disorientation Hospitalization 2/13/2008 Male 119 lb 9/26/2008 Physician United Kingdom
Primary
Concomitant
Pyrexia Hospitalization 4/1/2008 Female 188 lb 9/26/2008 Consumer United Kingdom
Primary
Concomitant
Haemorrhage Hospitalization 5/21/2008 Male 10/10/2008 Consumer Japan
Primary
Secondary
Concomitant
Hypoglycaemia Other Serious 6/28/2008 Female 10/15/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 3/4/2008 Male 110 lb 10/15/2008 Physician United Kingdom
Primary
Secondary
White Blood Cell Count Decreased Other Serious 1/23/2008 Male 10/15/2008 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 7/22/2008 Male 10/15/2008 Consumer United Kingdom
Primary
Secondary

Drug Data