Avastin combined with Irinotecan

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pulmonary Oedema Hospitalization 12/16/2005 65 Male 187 lb 1/13/2006 Physician Czech Republic
Primary
Secondary
Skin Discolouration Other Serious 2/3/2006 36 Female 4/5/2006 Other Health Professional United States
Primary
Concomitant
Red Blood Cell Count Decreased Hospitalization 3/19/2006 75 Male 146 lb 4/10/2006 Physician Germany
Primary
Secondary
Intestinal Obstruction Hospitalization 3/31/2006 68 Male 137 lb 4/14/2006 Physician Italy
Primary
Secondary
Intestinal Obstruction Hospitalization 3/31/2006 68 Male 137 lb 4/24/2006 Physician Italy
Primary
Secondary
Sepsis Death 6/7/2005 55 Female 132 lb 5/1/2006 Physician Spain
Primary
Secondary
Concomitant
Sepsis Death 6/7/2005 Female 5/2/2006 Other Health Professional Spain
Primary
Secondary
Concomitant
Sepsis Hospitalization 6/7/2005 55 Female 132 lb 5/16/2006 Physician Spain
Primary
Secondary
Concomitant
Sepsis Hospitalization 6/7/2005 Female 5/18/2006 Other Health Professional Spain
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/19/2006 75 Male 146 lb 5/31/2006 Physician Germany
Primary
Secondary
Oesophageal Ulcer Hospitalization 3/19/2006 75 Male 146 lb 6/15/2006 Physician Germany
Primary
Secondary
Mucosal Inflammation Hospitalization 5/11/2006 70 Female 117 lb 6/23/2006 Physician Germany
Primary
Secondary
Thrombocytopenia Hospitalization 7/30/2005 56 Female 163 lb 6/29/2006 Other Health Professional Canada
Primary
Secondary
Concomitant
Lymphangitis Other Serious 6/7/2006 35 Female 11/27/2006 Pharmacist Germany
Primary
Secondary
Concomitant
Small Intestinal Obstruction Hospitalization 5/26/2006 Female 167 lb 2/2/2007 Physician United States
Primary
Concomitant
Small Intestinal Obstruction Hospitalization 12/16/2006 Female 2/26/2007 Physician United States
Primary
Concomitant
Sopor Hospitalization 5/2/2007 76 Female 5/15/2007 Consumer Brazil
Primary
Concomitant
Multi-organ Failure Hospitalization 12/21/2007 Male 364 lb 1/3/2008 Consumer United Kingdom
Primary
Concomitant
Blindness Other Serious 1/4/2008 Physician United States
Primary
Concomitant
Septic Shock Life Threatening 12/16/2006 Female 1/8/2008 Physician United States
Primary
Concomitant
Metastases To Liver Other Serious 12/1/2007 Male 1/9/2008 Physician United Kingdom
Primary
Secondary
Bone Disorder Other Serious 12/3/2007 Male 216 lb 1/15/2008 Other Health Professional Germany
Primary
Concomitant
Blindness Other Serious 60 Female 1/15/2008 Consumer United States
Primary
Concomitant
Tumour Lysis Syndrome Death 62 Male 1/15/2008 Physician Germany
Primary
Concomitant
Dermatitis Exfoliative Other Serious 11/8/2007 Female 110 lb 1/18/2008 Pharmacist United Kingdom
Primary
Concomitant
Urinary Fistula Hospitalization 4/1/2006 Male 172 lb 1/22/2008 Other Health Professional United Kingdom
Primary
Concomitant
Blindness Other Serious Female 1/24/2008 Physician United States
Primary
Concomitant
Malnutrition Hospitalization 12/1/2007 82 Female 1/25/2008 Physician United Kingdom
Primary
Secondary
Epilepsy Other Serious 37 Male 1/26/2008 Physician United Kingdom
Primary
Concomitant
Vomiting Other Serious 5/1/2007 82 Female 2/1/2008 Physician Taiwan, Province Of China
Primary
Secondary
Jaundice Hospitalization 8/30/2007 Male 176 lb 2/4/2008 Physician United Kingdom
Primary
Concomitant
Metastases To Liver Hospitalization 12/1/2007 Male 134 lb 2/7/2008 Physician United Kingdom
Primary
Secondary
Liver Function Test Abnormal Other Serious 1/2/2008 Female 152 lb 2/13/2008 Other Health Professional United States
Primary
Concomitant
Skin Disorder Other Serious 1/21/2008 Female 183 lb 2/18/2008 Pharmacist United States
Primary
Concomitant
Blindness Other Serious 11/1/2007 Female 2/21/2008 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 8/14/2007 Male 2/22/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Sudden Death Death 12/1/2007 Male 2/22/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Skin Disorder Other Serious 1/9/2008 Female 185 lb 2/26/2008 Consumer United States
Primary
Concomitant
Skin Disorder Other Serious 1/9/2008 Female 185 lb 2/29/2008 Consumer United States
Primary
Concomitant
Nephrotic Syndrome Other Serious 3/18/2006 Male 186 lb 3/11/2008 Other Health Professional Canada
Primary
Concomitant
Haemorrhage Other Serious Male 3/11/2008 Consumer United Kingdom
Primary
Concomitant
Anaphylactic Shock Other Serious 5/15/2008 Female 7/3/2008 Consumer Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 6/11/2008 51 Female 135 lb 7/3/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Bone Marrow Failure Other Serious 6/19/2008 Female 108 lb 7/3/2008 Physician United Kingdom
Primary
Concomitant
Anaphylactic Shock Hospitalization Female 7/3/2008 Physician United Kingdom
Primary
Concomitant
Sepsis Hospitalization 5/24/2008 Male 157 lb 7/3/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Aphasia Other Serious 6/11/2008 Male 7/11/2008 Other Health Professional United Kingdom
Primary
Concomitant
Prothrombin Level Decreased Other Serious Female 7/14/2008 Physician United Kingdom
Primary
Concomitant
Haemolysis Life Threatening 12/1/2008 Female 1/16/2009 Physician United Kingdom
Primary
Concomitant
Intestinal Obstruction Life Threatening 3/15/2010 Physician Hong Kong
Primary
Concomitant
Thrombosis Other Serious 50 Male 3/18/2010 Physician Japan
Primary
Concomitant
Tumour Perforation Hospitalization 9/16/2009 Female 132 lb 3/18/2010 Physician France
Primary
Concomitant
Neutropenia Hospitalization 1/1/2010 63 Male 154 lb 5/13/2010 Physician France
Primary
Concomitant
Lividity Other Serious 4/23/2010 34 Male 185 lb 5/18/2010 Consumer Poland
Primary
Concomitant
Lividity Death 4/23/2010 34 Male 185 lb 5/21/2010 Consumer Poland
Primary
Concomitant
Wound Dehiscence Other Serious 9/1/2007 46 Female 5/28/2010 Consumer United States
Primary
Secondary
Concomitant
Neutropenia Hospitalization 1/1/2010 63 Male 154 lb 6/1/2010 Physician France
Primary
Secondary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 11/1/2009 Female 6/7/2010 Other Health Professional United States
Primary
Concomitant
Wound Dehiscence Other Serious 9/1/2007 46 Female 6/8/2010 Consumer United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 6/11/2010 United States
Primary
Concomitant
Death Death 5/1/2010 Female 6/11/2010 Physician Belgium
Primary
Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome Other Serious 11/1/2009 Female 6/14/2010 Other Health Professional United States
Primary
Concomitant
Disease Progression Death 58 Female 6/15/2010 Other Health Professional Spain
Primary
Secondary
Optic Neuropathy Other Serious 41 Female 10/11/2010 Physician Germany
Primary
Concomitant
Congestive Cardiomyopathy Hospitalization 11/22/2010 Physician Japan
Primary
Secondary
Protein Urine Present Hospitalization 10/1/2010 Male 11/30/2010 Consumer China
Primary
Concomitant
Malignant Neoplasm Progression Other Serious Male 11/30/2010 Other Health Professional Australia
Primary
Concomitant
Bone Marrow Failure Other Serious Female 11/30/2010 Other Health Professional Australia
Primary
Concomitant
Chest Pain Hospitalization 4/11/2009 69 Female 12/14/2010 Consumer United States
Primary
Secondary
Odynophagia Other Serious 30 Female 12/17/2010 Physician Brazil
Primary
Secondary
Dystonia Other Serious 8/18/2010 66 Female 12/23/2010 Other Health Professional Spain
Primary
Secondary
Musculoskeletal Stiffness Hospitalization 1/5/2011 58 Female 1/11/2011 Other Health Professional Italy
Primary
Concomitant
Epilepsy Hospitalization 12/28/2010 50 Male 1/18/2011 Other Health Professional Italy
Primary
Secondary
Concomitant
Musculoskeletal Stiffness Hospitalization 1/5/2011 58 Female 1/20/2011 Other Health Professional Italy
Primary
Concomitant
Focal Segmental Glomerulosclerosis Hospitalization 4/1/2010 60 Male 1/20/2011 Physician France
Primary
Concomitant
Febrile Bone Marrow Aplasia Hospitalization 12/25/2010 69 Male 1/26/2011 Physician France
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 64 Male 1/26/2011 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Intestinal Obstruction Other Serious Male 152 lb 2/14/2011 Physician Australia
Primary
Secondary
Concomitant
Death Death 10/25/2010 43 Female 2/16/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Diarrhoea Hospitalization 12/10/2010 Male 170 lb 2/16/2011 Physician United States
Primary
Secondary
Concomitant
Intestinal Obstruction Other Serious 10/18/2007 38 Male 2/18/2011 Physician Japan
Primary
Secondary
Concomitant
Neoplasm Malignant Other Serious Male 152 lb 2/21/2011 Physician Australia
Primary
Secondary
Concomitant
Disease Progression Other Serious Male 2/28/2011 Physician United States
Primary
Secondary
Concomitant
Gastrointestinal Perforation Death 1/1/2010 3/1/2011 Consumer Canada
Primary
Concomitant
Disease Progression Death 4/16/2009 69 Male 3/8/2011 Consumer Japan
Primary
Secondary
Concomitant
Enterocutaneous Fistula Hospitalization 12/27/2010 47 Male 3/8/2011 Other Health Professional Italy
Primary
Secondary
Abnormal Behaviour Hospitalization 2/4/2011 66 Male 3/9/2011 Other Health Professional Italy
Primary
Concomitant
Enterocutaneous Fistula Hospitalization 12/27/2010 47 Male 3/11/2011 Other Health Professional Italy
Primary
Secondary
Volvulus Hospitalization 2/1/2011 77 Male 3/14/2011 Consumer United States
Primary
Secondary
Concomitant
Jaundice Hospitalization 12/16/2010 4/1/2011 Physician Japan
Primary
Concomitant
Malaise Hospitalization 12/10/2010 Male 170 lb 4/4/2011 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/20/2011 66 Male 152 lb 4/7/2011 Consumer Austria
Primary
Secondary
Concomitant
Hypersensitivity Hospitalization 11/8/2010 63 Male 4/13/2011 Other Health Professional United States
Primary
Concomitant
Intestinal Perforation Hospitalization 2/25/2011 67 Male 4/18/2011 Other Health Professional Germany
Primary
Concomitant
Neoplasm Malignant Other Serious 12/1/2010 47 Male 181 lb 4/19/2011 Consumer Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/27/2009 53 Female 5/2/2011 Other Health Professional France
Primary
Concomitant
Pyrexia Other Serious 11/3/2005 73 Male 10/16/2012 Physician Us
Primary
Concomitant
Pneumoperitoneum Hospitalization 1/3/2012 58 Male 9/10/2012 Physician Fr
Primary
Secondary
Pyrexia Hospitalization 8/6/2012 61 Female 135 lb 10/26/2012 Other Health Professional Us
Primary
Concomitant
Death Death Male 8/28/2012 Physician Br
Primary
Concomitant
Osteonecrosis Other Serious 7/2012 Female 8/28/2012 Physician Us
Primary
Concomitant
Death Death Male 8/29/2012 Physician Br
Primary
Concomitant
Death Death Male 8/29/2012 Physician Br
Primary
Concomitant
Death Death Male 8/29/2012 Physician Br
Primary
Concomitant
Death Death Male 8/29/2012 Physician Br
Primary
Concomitant
Death Death Male 8/29/2012 Physician Br
Primary
Concomitant
Death Death Male 8/29/2012 Physician Br
Primary
Concomitant
Death Death Male 8/29/2012 Physician Br
Primary
Concomitant
Death Death Male 8/29/2012 Physician Br
Primary
Concomitant
Death Death Female 8/29/2012 Physician Br
Primary
Concomitant
Death Death Male 8/29/2012 Physician Br
Primary
Concomitant
Death Death Female 8/29/2012 Physician Br
Primary
Concomitant
Death Death Male 8/29/2012 Physician Br
Primary
Concomitant
Death Death Male 8/29/2012 Physician Br
Primary
Concomitant
Death Death Male 8/30/2012 Physician Br
Primary
Concomitant
Death Death Male 8/30/2012 Physician Br
Primary
Concomitant
Death Death Female 8/30/2012 Physician Br
Primary
Concomitant
Death Death Male 8/31/2012 Physician Br
Primary
Concomitant
Death Death Male 8/31/2012 Physician Br
Primary
Concomitant
Rectal Haemorrhage Hospitalization 7/2/2012 8/31/2012 Consumer It
Primary
Concomitant
Death Death Female 8/31/2012 Physician Br
Primary
Concomitant
Death Death Female 8/31/2012 Physician Br
Primary
Concomitant
Death Death Male 8/31/2012 Physician Br
Primary
Concomitant
Metastases To Liver Hospitalization 8/13/2012 9/4/2012 Physician At
Primary
Secondary
Unevaluable Event Death 6/26/2012 9/6/2012 Physician Se
Primary
Secondary
Hypokalaemia Hospitalization 6/11/2012 71 Male 9/5/2012 Other Health Professional Fr
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 5/28/2010 61 Male 9/12/2012 Physician At
Primary
Secondary
Concomitant
Vomiting Other Serious 9/6/2012 Other Health Professional Country Not Specified
Primary
Secondary
Disease Progression Death Female 9/5/2012 Physician Us
Primary
Secondary
Concomitant
Skin Toxicity Other Serious 9/10/2012 Physician Us
Primary
Concomitant
Disease Progression Other Serious 53 9/12/2012 Physician Ca
Primary
Secondary
Death Death 65 9/12/2012 Physician Ca
Primary
Secondary
Colon Cancer Metastatic Death Male 178 lb 11/9/2012 Other Health Professional Us
Primary
Concomitant
Disease Progression Death Female 11/27/2012 Physician Us
Primary
Concomitant
Respiratory Failure Death Female 10/16/2012 Physician Us
Primary
Secondary
Concomitant
Disease Progression Death Female 11/1/2012 Physician Us
Primary
Concomitant
Toxicity To Various Agents Other Serious 5/2/2011 64 Female 9/17/2012 Physician Us
Primary
Concomitant
Death Death 70 9/20/2012 Physician Ca
Primary
Secondary
Disease Progression Death 6/1/2005 64 Female 10/18/2012 Physician Us
Primary
Concomitant
Death Death Female 9/25/2012 Physician Us
Primary
Concomitant
Disease Progression Other Serious 8/9/2012 44 Female 99 lb 9/20/2012 Physician Ru
Primary
Secondary
Concomitant
Death Death 52 9/20/2012 Physician Ca
Primary
Secondary
Anaphylactic Reaction Life Threatening 1/9/2006 56 Male 10/15/2012 Physician Us
Primary
Secondary
Disease Progression Death Female 9/27/2012 Physician Us
Primary
Secondary
Concomitant
Disease Progression Death Female 9/24/2012 Physician Us
Primary
Concomitant
Disease Progression Death Male 9/24/2012 Physician Us
Primary
Concomitant
Death Death Female 9/24/2012 Physician Us
Primary
Concomitant
Vision Blurred Death Male 9/24/2012 Physician Us
Primary
Secondary
Concomitant
Vomiting Other Serious Female 12/27/2012 Physician Us
Primary
Concomitant
Hypoaesthesia Death Male 9/25/2012 Physician Us
Primary
Concomitant

Drug Data