Avastin combined with Irinotecan Hydrochloride

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Necrotising Fasciitis Hospitalization 2/22/2008 Male 3/11/2008 Consumer United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 12/30/2007 Male 128 lb 3/21/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Delusion Other Serious 3/8/2008 63 Female 3/25/2008 Consumer United Kingdom
Primary
Concomitant
Necrotising Fasciitis Hospitalization 2/24/2008 Male 146 lb 4/4/2008 Consumer United Kingdom
Primary
Concomitant
Oesophagitis Hospitalization 68 Male 4/18/2008 Physician United Kingdom
Primary
Concomitant
Reflux Oesophagitis Hospitalization 3/29/2008 Male 157 lb 4/30/2008 Physician United Kingdom
Primary
Concomitant
Urine Output Decreased Hospitalization 4/16/2008 Female 5/1/2008 Physician United Kingdom
Primary
Secondary
Pulmonary Embolism Life Threatening 65 Male 168 lb 10/8/2008 Other Health Professional United Kingdom
Primary
Concomitant
Rhabdomyolysis Hospitalization 9/1/2008 Male 10/10/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Sepsis Life Threatening 7/11/2008 Male 10/17/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Penile Ulceration Other Serious 7/24/2008 Male 10/22/2008 Physician United States
Primary
Concomitant
Anaphylactic Shock Other Serious 5/15/2008 Female 10/23/2008 Consumer Japan
Primary
Secondary
Concomitant
Pneumatosis Intestinalis Other Serious 6/26/2008 Female 10/23/2008 Physician Germany
Primary
Concomitant
Uterine Haemorrhage Other Serious 7/1/2008 40 Female 10/27/2008 Consumer Denmark
Primary
Secondary
Abdominal Rigidity Other Serious 7/1/2008 Male 10/29/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Drug Eruption Hospitalization 6/16/2008 Female 11/4/2008 Consumer Japan
Primary
Secondary
Concomitant
Flushing Hospitalization 10/23/2008 Male 123 lb 11/4/2008 Consumer Japan
Primary
Concomitant
Rectal Haemorrhage Other Serious 10/1/2008 45 Female 11/5/2008 Physician Russian Federation
Primary
Secondary
Concomitant
Penile Ulceration Other Serious 7/24/2008 Male 11/7/2008 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 10/28/2008 73 Female 143 lb 11/10/2008 Physician Austria
Primary
Secondary
Concomitant
Disease Progression Death 5/8/2008 Female 157 lb 11/10/2008 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Infarction Life Threatening 10/22/2008 Female 121 lb 11/11/2008 Consumer United Kingdom
Primary
Concomitant
Hyperammonaemia Other Serious 66 Male 11/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Large Intestinal Obstruction Other Serious 7/1/2008 63 Male 11/19/2008 Physician El Salvador
Primary
Concomitant
Anaphylactic Shock Hospitalization 9/1/2008 Female 11/20/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Vitreous Haemorrhage Other Serious 8/4/2008 Male 11/21/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Peritonitis Hospitalization 11/11/2008 Female 108 lb 11/25/2008 Physician United Kingdom
Primary
Concomitant
Vascular Pseudoaneurysm Other Serious Male 130 lb 11/26/2008 Physician United States
Primary
Concomitant
Intention Tremor Hospitalization 1/25/2008 23 Female 12/5/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Death Death Male 12/5/2008 Physician United Kingdom
Primary
Concomitant
Death Death Male 12/5/2008 Consumer United Kingdom
Primary
Concomitant
Death Death Female 12/5/2008 Physician Belgium
Primary
Concomitant
Death Death Male 12/8/2008 Consumer United Kingdom
Primary
Concomitant
Abdominal Rigidity Other Serious 7/1/2008 Male 12/10/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Sudden Death Death 10/31/2008 67 Male 12/15/2008 Physician Japan
Primary
Secondary
Interstitial Lung Disease Hospitalization 11/1/2008 71 Male 12/15/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Anaphylactic Shock Hospitalization 9/1/2008 Female 12/23/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Stomatitis Hospitalization 10/27/2008 Female 128 lb 12/30/2008 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Abnormal Other Serious 8/4/2008 Male 12/31/2008 Consumer Japan
Primary
Secondary
Concomitant
Anaphylactoid Reaction Other Serious 11/4/2008 Male 110 lb 1/16/2009 Consumer Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 1/5/2009 69 Male 1/23/2009 Physician United Kingdom
Primary
Secondary
Anaphylactoid Reaction Other Serious 11/4/2008 Male 110 lb 2/3/2009 Consumer Japan
Primary
Concomitant
Peritonitis Life Threatening 10/6/2008 Female 2/3/2009 Physician United Kingdom
Primary
Concomitant
Interstitial Lung Disease Other Serious 1/5/2009 69 Male 2/4/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 1/5/2009 Male 2/18/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 10/8/2008 Male 132 lb 2/19/2009 Consumer Japan
Primary
Secondary
Concomitant
Gastrointestinal Perforation Hospitalization 1/20/2009 60 Male 2/20/2009 Physician Japan
Primary
Secondary
Convulsion Other Serious 5/20/2008 Male 123 lb 2/24/2009 Consumer Japan
Primary
Secondary
Concomitant
Peritonitis Death 12/21/2008 Male 171 lb 2/25/2009 Physician United Kingdom
Primary
Concomitant
Interstitial Lung Disease Other Serious 12/8/2008 Male 101 lb 2/27/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 12/8/2008 Male 101 lb 3/11/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Pneumothorax Hospitalization 1/24/2009 Male 117 lb 3/13/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Stomatitis Hospitalization 10/27/2008 Female 128 lb 3/13/2009 Physician Japan
Primary
Secondary
Concomitant
Arteriosclerosis Hospitalization 1/28/2009 Male 120 lb 3/13/2009 Consumer Japan
Primary
Concomitant
Pyrexia Hospitalization 2/28/2009 59 Male 154 lb 3/20/2009 Consumer Japan
Primary
Concomitant
Peritonitis Death 12/21/2008 Male 171 lb 3/20/2009 Physician United Kingdom
Primary
Concomitant
Neutrophil Count Decreased Other Serious 11/7/2007 Male 3/21/2009 Other Health Professional Japan
Primary
Secondary
Duodenal Ulcer Perforation Hospitalization 1/20/2009 Male 3/25/2009 Physician Japan
Primary
Secondary
Concomitant
Hypertension Other Serious 12/23/2007 Male 3/31/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Death Death 3/23/2009 72 Male 4/16/2009 Consumer United Kingdom
Primary
Secondary
Pyrexia Hospitalization 2/27/2009 Male 154 lb 4/21/2009 Consumer Japan
Primary
Secondary
Concomitant
Hypertension Other Serious 12/23/2007 Male 5/6/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Pulmonary Infarction Life Threatening 10/22/2008 Female 121 lb 5/13/2009 Consumer United Kingdom
Primary
Concomitant
Gastric Ulcer Hospitalization 2/26/2009 Male 207 lb 5/22/2009 Consumer United Kingdom
Primary
Concomitant
Gastric Ulcer Hospitalization 2/26/2009 Male 207 lb 6/12/2009 Consumer United Kingdom
Primary
Concomitant
Hepatitis Other Serious 6/11/2008 Female 135 lb 6/29/2009 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/5/2009 55 Female 6/29/2009 Physician Japan
Primary
Concomitant
Hepatitis Other Serious 6/11/2008 Female 135 lb 7/1/2009 Consumer Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/5/2009 55 Female 7/20/2009 Physician Japan
Primary
Secondary
Concomitant
Myocardial Infarction Death 3/12/2009 Male 8/5/2009 Consumer United Kingdom
Primary
Concomitant
Respiratory Arrest Hospitalization 6/17/2009 Male 8/20/2009 Physician United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 1/1/2009 Male 9/10/2009 Physician Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 9/14/2009 9/30/2009 Physician United Kingdom
Primary
Secondary
Hepatitis Other Serious 6/11/2008 Female 135 lb 10/6/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2009 Male 10/6/2009 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Other Serious 7/1/2009 Male 119 lb 10/8/2009 Pharmacist Japan
Primary
Concomitant
Hepatitis Other Serious 6/11/2008 Female 135 lb 10/9/2009 Consumer Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 12/8/2008 Male 150 lb 10/16/2009 Other Health Professional United States
Primary
Secondary
Abdominal Pain Death Female 10/14/2009 Other Health Professional Norway
Primary
Concomitant
Melaena Other Serious 63 Male 11/5/2009 Consumer Japan
Primary
Secondary
Intestinal Obstruction Other Serious 62 Female 12/3/2009 Consumer United Kingdom
Primary
Concomitant
Pyrexia Other Serious 7/1/2009 Male 119 lb 12/4/2009 Pharmacist Japan
Primary
Concomitant
Interstitial Lung Disease Hospitalization 1/1/2008 64 Female 2/4/2010 Physician Japan
Primary
Secondary
Concomitant
Small Intestinal Perforation Hospitalization 1/1/2009 Male 137 lb 2/11/2010 Physician Japan
Primary
Concomitant
Leukoencephalopathy Other Serious 9/14/2009 Male 2/11/2010 Physician Japan
Primary
Secondary
White Blood Cell Count Decreased Other Serious 10/8/2008 Male 128 lb 2/16/2010 Physician Japan
Primary
Secondary
Concomitant
Peritonitis Hospitalization 1/1/2009 Male 137 lb 2/16/2010 Physician Japan
Primary
Concomitant
Suture Rupture Hospitalization 1/1/2009 78 Male 82 lb 2/16/2010 Physician Japan
Primary
Concomitant
Hyperammonaemia Hospitalization 10/22/2009 Male 2/16/2010 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Other Serious 11/5/2008 Male 150 lb 2/17/2010 Physician Japan
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 9/14/2009 Male 2/17/2010 Physician Japan
Primary
Secondary
Concomitant
Hepatic Neoplasm Malignant Other Serious 80 Male 2/24/2010 Japan
Primary
Concomitant
Hepatic Neoplasm Malignant Other Serious 80 Male 2/25/2010 Japan
Primary
Concomitant
Arteriosclerosis Obliterans Hospitalization 1/28/2009 Male 121 lb 3/1/2010 Physician Japan
Primary
Concomitant
Hyperammonaemia Hospitalization 10/22/2009 Male 3/1/2010 Physician Japan
Primary
Secondary
Concomitant
Suture Rupture Hospitalization 1/1/2009 78 Male 82 lb 3/25/2010 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 2/16/2010 Male 104 lb 3/26/2010 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 1/12/2010 59 Male 4/12/2010 Physician Japan
Primary
Secondary
Concomitant
Vomiting Hospitalization 2/15/2010 69 Male 104 lb 4/13/2010 Physician Japan
Primary
Concomitant
Pulmonary Embolism Other Serious 7/8/2009 71 Male 139 lb 4/13/2010 Physician Japan
Primary
Concomitant
Venous Thrombosis Other Serious 9/22/2008 59 Male 152 lb 4/15/2010 Physician Japan
Primary
Concomitant
Angina Pectoris Hospitalization 12/31/2009 59 Female 4/16/2010 Other Health Professional Italy
Primary
Secondary
Concomitant
Renal Impairment Other Serious 12/2/2008 71 Male 143 lb 4/19/2010 Physician Japan
Primary
Secondary
Concomitant
Lymphangiosis Carcinomatosa Other Serious Male 4/28/2010 Physician Japan
Primary
Secondary
Renal Failure Acute Hospitalization 4/27/2010 Female 5/3/2010 Physician Japan
Primary
Secondary
Concomitant
Trismus Hospitalization 12/30/2009 72 Male 5/4/2010 Other Health Professional Italy
Primary
Concomitant
Intestinal Obstruction Other Serious 4/11/2010 50 Male 192 lb 5/4/2010 Physician United Arab Emirates
Primary
Secondary
Concomitant
Wound Decomposition Other Serious 9/27/2007 58 Male 5/6/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Gastrointestinal Necrosis Life Threatening 4/27/2010 61 Female 117 lb 5/19/2010 Physician Japan
Primary
Secondary
Concomitant
Hydronephrosis Other Serious 1/1/2009 56 Male 5/28/2010 Other Health Professional Japan
Primary
Concomitant
Gastrointestinal Necrosis Death 4/27/2010 61 Female 117 lb 6/2/2010 Physician Japan
Primary
Secondary
Concomitant
Small Intestinal Perforation Other Serious 11/1/2008 60 Male 119 lb 6/8/2010 Physician Japan
Primary
Secondary
Concomitant
Hepatic Neoplasm Malignant Other Serious 80 Male 6/8/2010 Japan
Primary
Concomitant
Small Intestinal Perforation Other Serious 8/7/2007 47 Male 134 lb 6/14/2010 Pharmacist Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 6/1/2009 70 Female 104 lb 6/18/2010 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 55 Male 6/18/2010 Physician Japan
Primary
Concomitant
Septic Shock Other Serious 2/18/2010 64 Female 115 lb 6/22/2010 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 4/27/2010 Female 6/29/2010 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 8/28/2009 74 Male 93 lb 7/6/2010 Physician Japan
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 9 Female 7/8/2010 Physician Japan
Primary
Concomitant
Septic Shock Other Serious 2/18/2010 64 Female 115 lb 7/8/2010 Physician Japan
Primary
Secondary
Concomitant
Necrotising Fasciitis Hospitalization 70 Male 7/16/2010 Physician Japan
Primary
Secondary
Visual Impairment Other Serious 7/29/2010 Female 8/9/2010 Physician Japan
Primary
Concomitant
Ventricular Fibrillation Other Serious 1/1/2009 62 Male 148 lb 8/11/2010 Physician Japan
Primary
Secondary
Concomitant
Ventricular Fibrillation Other Serious 1/1/2009 Male 8/16/2010 Consumer Japan
Primary
Secondary
Concomitant
Visual Impairment 7/29/2010 Male 8/19/2010 Physician Japan
Primary
Concomitant
Large Intestine Perforation Life Threatening 1/1/2010 81 Female 71 lb 8/30/2010 Physician Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Life Threatening 1/1/2010 81 Female 71 lb 9/2/2010 Physician Japan
Primary
Secondary
Concomitant
Vesical Fistula Other Serious 8/7/2010 60 Female 9/20/2010 Pharmacist Japan
Primary
Secondary
Concomitant
Small Intestine Ulcer Other Serious 7/28/2010 55 Male 115 lb 9/24/2010 Physician Japan
Primary
Concomitant
Abdominal Pain Other Serious Female 9/22/2010 Other Health Professional Norway
Primary
Secondary
White Blood Cell Count Decreased Other Serious 1/1/2009 54 Male 165 lb 10/6/2010 Physician Japan
Primary
Secondary
Concomitant
Oesophagitis Other Serious Male 10/11/2010 Pharmacist Canada
Primary
Secondary
Peptic Ulcer Other Serious 7/31/2010 60 Female 88 lb 10/13/2010 Physician Japan
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 7/28/2010 55 Male 115 lb 10/15/2010 Physician Japan
Primary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Other Serious 9/14/2009 52 Male 10/15/2010 Physician Japan
Primary
Secondary
Concomitant
Blood Urea Increased Other Serious 69 Male 10/21/2010 Pharmacist Japan
Primary
Secondary
Varicose Vein Other Serious 1/1/2008 69 Female 115 lb 10/22/2010 Physician Japan
Primary
Concomitant
Hyperammonaemia Hospitalization 6/14/2010 60 Female 10/29/2010 Physician Japan
Primary
Secondary
Concomitant
Thrombosis Other Serious 4/27/2010 61 Female 117 lb 11/3/2010 Physician Japan
Primary
Secondary
Concomitant
Small Intestinal Ulcer Haemorrhage Other Serious 7/28/2010 55 Male 115 lb 11/4/2010 Pharmacist Japan
Primary
Concomitant
Wound Abscess Other Serious 1/1/2009 73 Female 11/9/2010 Physician Japan
Primary
Secondary
Concomitant
Volvulus Of Small Bowel Other Serious 1/1/2009 62 Male 148 lb 11/11/2010 Physician Japan
Primary
Secondary
Concomitant
Shock Other Serious 70 Male 11/15/2010 Other Health Professional Japan
Primary
Secondary
Blood Urea Increased Other Serious 69 Male 11/15/2010 Pharmacist Japan
Primary
Secondary
Dermatitis Acneiform Hospitalization 9/9/2010 11/26/2010 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 7/8/2009 71 Male 139 lb 11/29/2010 Physician Japan
Primary
Concomitant
Thrombosis Other Serious 1/1/2010 60 Female 117 lb 12/14/2010 Physician Japan
Primary
Secondary
Concomitant
Decreased Appetite Death 6/1/2010 70 Male 12/17/2010 Physician Japan
Primary
Concomitant
Dystonia Other Serious 1/13/2010 53 Female 12/21/2010 Other Health Professional Spain
Primary
Secondary

Drug Data