Avastin combined with Calcium Levofolinate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Ileal Perforation Life Threatening 7/7/2006 Male 148 lb 7/20/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Gastrointestinal Perforation Life Threatening 7/7/2006 Male 148 lb 7/24/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Gastrointestinal Perforation Life Threatening 7/7/2006 Male 8/11/2006 Physician Japan
Primary
Secondary
Peritonitis Life Threatening 7/7/2006 Male 9/12/2006 Physician Japan
Primary
Secondary
Psychomotor Skills Impaired Hospitalization 9/13/2007 Female 1/17/2008 Physician United Kingdom
Primary
Secondary
Small Intestinal Perforation Life Threatening 1/25/2008 Male 3/21/2008 Physician Japan
Primary
Secondary
Concomitant
Oesophageal Varices Haemorrhage Hospitalization 11/21/2007 Female 4/2/2008 Physician France
Primary
Concomitant
Oesophageal Varices Haemorrhage Hospitalization 11/21/2007 Female 4/11/2008 Physician France
Primary
Concomitant
Small Intestinal Perforation Life Threatening 1/25/2008 Male 4/18/2008 Physician Japan
Primary
Secondary
Concomitant
Convulsion Other Serious 5/20/2008 Male 123 lb 6/17/2008 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Ileal Perforation Disability 12/6/2007 Male 117 lb 6/18/2008 Other Health Professional Japan
Primary
Secondary
Hepatic Encephalopathy Other Serious Male 6/18/2008 Physician United Kingdom
Primary
Concomitant
Pulmonary Thrombosis Death 2/8/2008 Female 124 lb 6/19/2008 Physician Japan
Primary
Secondary
Concomitant
Renal Disorder Other Serious 6/9/2008 Male 7/1/2008 Physician Japan
Primary
Concomitant
Hyperthermia Life Threatening 4/24/2008 Male 110 lb 7/2/2008 Consumer Japan
Primary
Concomitant
Anaphylactic Shock Other Serious 5/15/2008 Female 7/3/2008 Consumer Japan
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 6/11/2008 51 Female 135 lb 7/3/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Gastric Ulcer Hospitalization 3/14/2008 Male 7/3/2008 Physician Japan
Primary
Secondary
Gastric Ulcer Hospitalization 3/14/2008 Male 132 lb 7/3/2008 Consumer United Kingdom
Primary
Secondary
Sepsis Hospitalization 5/24/2008 Male 157 lb 7/3/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Anaphylactic Shock Other Serious 6/24/2008 54 Male 7/10/2008 Physician United Kingdom
Primary
Secondary
Anaphylactoid Reaction Hospitalization 6/18/2008 65 Female 7/11/2008 Consumer Japan
Primary
Secondary
Tumour Haemorrhage Other Serious 5/26/2008 28 Male 121 lb 7/15/2008 Physician Japan
Primary
Secondary
Pyrexia Other Serious 7/3/2008 Male 95 lb 7/22/2008 Consumer United Kingdom
Primary
Secondary
Prinzmetal Angina Other Serious 12/9/2007 Male 7/23/2008 Physician Japan
Primary
Secondary
Concomitant
Anastomotic Complication Disability 5/19/2008 70 Male 110 lb 7/24/2008 Physician United Kingdom
Primary
Concomitant
Ulcer Disability 6/4/2008 Female 1/2/2009 Physician Japan
Primary
Secondary
Acute Myocardial Infarction Hospitalization 12/11/2008 Male 1/2/2009 Physician Japan
Primary
Secondary
Concomitant
Cardiac Failure Death 11/10/2008 67 Male 148 lb 1/6/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Hospitalization 8/18/2008 Female 1/7/2009 Pharmacist United Kingdom
Primary
Secondary
Arrhythmia Death 10/31/2008 67 Male 1/8/2009 Physician Japan
Primary
Secondary
Intestinal Perforation Other Serious 61 Female 1/15/2009 Consumer Japan
Primary
Concomitant
Intestinal Obstruction Hospitalization 11/5/2008 Female 1/16/2009 Consumer United Kingdom
Primary
Concomitant
Shock Other Serious 11/6/2008 59 Male 1/23/2009 Physician Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 1/5/2009 69 Male 1/23/2009 Physician United Kingdom
Primary
Secondary
Platelet Count Decreased Other Serious 8/20/2008 Male 110 lb 1/24/2009 Consumer Japan
Primary
Secondary
Concomitant
Thrombosis Other Serious 11/1/2008 Male 152 lb 1/26/2009 Consumer Japan
Primary
Secondary
Concomitant
Large Intestine Perforation Hospitalization 12/8/2008 Female 1/27/2009 Consumer Japan
Primary
Concomitant
Shock Hospitalization 12/8/2008 49 Male 1/28/2009 Physician Japan
Primary
Secondary
Concomitant
Gastric Haemorrhage Hospitalization 12/9/2008 69 Male 1/28/2009 Consumer Japan
Primary
Secondary
Rectal Ulcer Other Serious 7/1/2008 Male 132 lb 1/29/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 12/3/2008 74 Male 110 lb 1/29/2009 Consumer Japan
Primary
Concomitant
Rash Hospitalization 1/20/2009 Male 126 lb 2/2/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Peritonitis Life Threatening 10/6/2008 Female 2/3/2009 Physician United Kingdom
Primary
Concomitant
Interstitial Lung Disease Other Serious 1/5/2009 69 Male 2/4/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Shock Hospitalization 12/8/2008 Male 132 lb 2/5/2009 Consumer Japan
Primary
Concomitant
Hypoaesthesia Life Threatening 5/19/2008 Male 110 lb 2/6/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Hypoaesthesia Oral Life Threatening 1/15/2008 Male 110 lb 2/11/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Rash Hospitalization 1/20/2009 Male 126 lb 2/11/2009 Consumer United Kingdom
Primary
Secondary
Interstitial Lung Disease Death 1/22/2009 Male 127 lb 2/11/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Ileal Perforation Disability 12/6/2007 Male 117 lb 2/12/2009 Physician Japan
Primary
Secondary
Toxic Encephalopathy Hospitalization 4/30/2008 69 Male 2/12/2009 Consumer France
Primary
Secondary
Spinal Cord Infarction Disability 11/25/2008 Male 144 lb 2/12/2009 Physician Japan
Primary
Concomitant
Toxic Encephalopathy Hospitalization 4/30/2008 69 Male 2/13/2009 Consumer France
Primary
Secondary
Sepsis Other Serious 11/9/2008 Male 2/13/2009 Consumer Japan
Primary
Secondary
Concomitant
Shock Hospitalization 12/8/2008 Male 132 lb 2/13/2009 Consumer Japan
Primary
Concomitant
Interstitial Lung Disease Other Serious 2/3/2009 Male 128 lb 2/17/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Leukoencephalopathy Life Threatening 1/18/2009 72 Female 2/17/2009 Consumer United Kingdom
Primary
Secondary
Interstitial Lung Disease Other Serious 1/5/2009 Male 2/18/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Neuropathy Peripheral Life Threatening 1/23/2009 Female 2/19/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 10/8/2008 Male 132 lb 2/19/2009 Consumer Japan
Primary
Secondary
Concomitant
Haemoptysis Life Threatening 9/5/2008 Male 2/20/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Gastrointestinal Perforation Hospitalization 1/20/2009 60 Male 2/20/2009 Physician Japan
Primary
Secondary
Leukoencephalopathy Life Threatening 1/18/2009 72 Female 2/20/2009 Physician Japan
Primary
Secondary
Glomerulonephritis Hospitalization 12/1/2008 71 2/20/2009 Physician United Kingdom
Primary
Secondary
Intestinal Obstruction Life Threatening 11/21/2008 Female 110 lb 2/20/2009 Physician Japan
Primary
Secondary
Concomitant
Rash Hospitalization 1/20/2009 Male 126 lb 2/20/2009 Consumer United Kingdom
Primary
Secondary
Shock Other Serious Male 146 lb 2/24/2009 Consumer United Kingdom
Primary
Concomitant
Convulsion Other Serious 5/20/2008 Male 123 lb 2/24/2009 Consumer Japan
Primary
Secondary
Concomitant
Gastrointestinal Perforation Death 2/2/2009 66 Male 2/25/2009 Physician Japan
Primary
Secondary
Neutropenia Other Serious 7/1/2008 2/26/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 11/9/2008 Male 2/26/2009 Consumer Japan
Primary
Secondary
Concomitant
Intestinal Obstruction Life Threatening 11/21/2008 Female 110 lb 2/26/2009 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 12/8/2008 Male 101 lb 2/27/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Pneumothorax Hospitalization 1/24/2009 Male 3/4/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Other Serious Male 130 lb 3/5/2009 Consumer Japan
Primary
Concomitant
Rash Hospitalization 8/12/2007 Female 3/5/2009 Consumer United Kingdom
Primary
Concomitant
Rectal Ulcer Other Serious 7/1/2008 Male 132 lb 3/6/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Other Serious 12/8/2008 Male 101 lb 3/11/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 2/17/2009 Female 3/12/2009 Physician United Kingdom
Primary
Secondary
Interstitial Lung Disease Other Serious 2/3/2009 Male 128 lb 3/13/2009 Consumer United Kingdom
Primary
Secondary
Stomatitis Hospitalization 10/27/2008 Female 128 lb 3/13/2009 Physician Japan
Primary
Secondary
Concomitant
Arteriosclerosis Hospitalization 1/28/2009 Male 120 lb 3/13/2009 Consumer Japan
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 7/4/2008 Male 181 lb 3/17/2009 Physician Japan
Primary
Secondary
Interstitial Lung Disease Death 1/22/2009 Male 127 lb 3/17/2009 Consumer Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Death 2/17/2009 Female 3/17/2009 Physician Japan
Primary
Secondary
Metastases To Lung Hospitalization 1/20/2009 Male 126 lb 3/19/2009 Consumer United Kingdom
Primary
Secondary
Leukoencephalopathy Hospitalization 1/18/2009 Female 132 lb 3/20/2009 Consumer United Kingdom
Primary
Secondary
Pyrexia Hospitalization 2/28/2009 59 Male 154 lb 3/20/2009 Consumer Japan
Primary
Concomitant
Proteinuria Death 2/17/2009 Male 3/20/2009 Physician United Kingdom
Primary
Secondary
Neutrophil Count Decreased Other Serious 11/7/2007 Male 3/21/2009 Other Health Professional Japan
Primary
Secondary
Interstitial Lung Disease Other Serious 64 Male 3/25/2009 Pharmacist United Kingdom
Primary
Concomitant
Duodenal Ulcer Perforation Hospitalization 1/20/2009 Male 3/25/2009 Physician Japan
Primary
Secondary
Concomitant
Anorexia Life Threatening 3/1/2008 66 Male 3/25/2009 Physician Japan
Primary
Secondary
Concomitant
Peritonitis Hospitalization 11/11/2008 Female 108 lb 3/25/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Proteinuria Death 2/17/2009 Male 3/26/2009 Physician United Kingdom
Primary
Secondary
Interstitial Lung Disease Death 1/22/2009 Male 127 lb 3/27/2009 Physician Japan
Primary
Secondary
Concomitant
Anaphylactic Shock Other Serious 9/19/2008 Male 146 lb 4/6/2009 Consumer United Kingdom
Primary
Concomitant
Convulsion Hospitalization 11/2/2008 Female 4/6/2009 Physician United Kingdom
Primary
Concomitant
Gastrointestinal Perforation Life Threatening 8/27/2008 Female 100 lb 4/7/2009 Physician Japan
Primary
Secondary
Concomitant
Oesophageal Perforation Death 11/30/2008 Male 4/8/2009 Consumer United Kingdom
Primary
Concomitant
Vomiting Life Threatening 2/18/2009 Female 121 lb 4/9/2009 Consumer Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 1/20/2009 Male 126 lb 4/9/2009 Consumer United Kingdom
Primary
Secondary
Intestinal Obstruction Life Threatening 11/21/2008 Female 110 lb 4/9/2009 Pharmacist Japan
Primary
Secondary
Concomitant
Oxygen Saturation Decreased Other Serious 9/30/2008 63 Male 130 lb 4/9/2009 Consumer Japan
Primary
Concomitant
Hepatic Enzyme Increased Hospitalization 8/18/2008 Female 4/10/2009 Pharmacist United Kingdom
Primary
Secondary
Leukoencephalopathy Hospitalization 1/18/2009 Female 132 lb 4/10/2009 Consumer United Kingdom
Primary
Secondary
Rash Hospitalization 4/16/2009 Consumer Japan
Primary
Concomitant
Death Death 3/23/2009 72 Male 4/16/2009 Consumer United Kingdom
Primary
Secondary
Interstitial Lung Disease Other Serious 2/3/2009 Male 128 lb 4/16/2009 Consumer United Kingdom
Primary
Secondary
Coma Other Serious 3/12/2009 76 Male 112 lb 4/17/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Rash Hospitalization Male 4/21/2009 Consumer Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 2/27/2009 Male 154 lb 4/21/2009 Consumer Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 2/18/2009 Female 121 lb 4/22/2009 Consumer Japan
Primary
Secondary
Concomitant
Gastrointestinal Perforation Hospitalization 11/5/2008 Male 4/24/2009 Physician Japan
Primary
Secondary
Concomitant
Stomatitis Hospitalization 11/1/2007 Male 4/24/2009 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 7/4/2008 Male 181 lb 4/27/2009 Physician Japan
Primary
Secondary
Interstitial Lung Disease Hospitalization 4/6/2009 54 Male 4/29/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Haemothorax Hospitalization 3/31/2009 60 Male 4/29/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Convulsion Hospitalization 1/1/2008 Female 101 lb 4/30/2009 Pharmacist Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 12/22/2008 Male 110 lb 4/30/2009 Physician Japan
Primary
Secondary
Concomitant
Anaphylactoid Reaction Hospitalization 70 Female 5/21/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Anaphylactoid Reaction Hospitalization 70 Male 5/21/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Small Intestinal Perforation Death 5/3/2009 Female 130 lb 5/21/2009 Consumer United Kingdom
Primary
Concomitant
Gastric Ulcer Hospitalization 2/26/2009 Male 207 lb 5/22/2009 Consumer United Kingdom
Primary
Concomitant
Disseminated Intravascular Coagulation Life Threatening 5/14/2009 Female 5/25/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Vaginal Fistula Hospitalization 4/30/2009 Female 5/27/2009 Physician Japan
Primary
Secondary
Disseminated Intravascular Coagulation Life Threatening 5/14/2009 Female 5/27/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Anorexia Life Threatening 3/1/2008 66 Male 165 lb 5/25/2009 Physician Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 4/10/2009 Male 5/28/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Disseminated Intravascular Coagulation Life Threatening 5/14/2009 Female 104 lb 5/28/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Anaphylactic Shock Other Serious 5/7/2009 Male 5/29/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Disseminated Intravascular Coagulation Life Threatening 5/14/2009 Female 6/2/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Multi-organ Failure Other Serious 4/1/2009 Female 6/2/2009 Other Health Professional Japan
Primary
Secondary
Multi-organ Failure Other Serious 4/17/2009 Female 6/2/2009 Consumer United Kingdom
Primary
Secondary
Interstitial Lung Disease Other Serious 3/31/2009 Male 128 lb 6/3/2009 Consumer United Kingdom
Primary
Secondary
Interstitial Lung Disease Other Serious 12/8/2008 Male 101 lb 6/4/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Small Intestinal Perforation Death 5/3/2009 Female 130 lb 6/5/2009 Consumer United Kingdom
Primary
Concomitant
Urinary Retention Hospitalization 4/28/2009 Male 6/5/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Stomatitis Hospitalization 4/10/2009 Male 6/5/2009 Consumer United Kingdom
Primary
Secondary
Concomitant
Interstitial Lung Disease Hospitalization 7/9/2008 Male 6/9/2009 Physician United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/30/2009 Male 6/9/2009 Physician United Kingdom
Primary
Concomitant
Convulsion Other Serious 5/20/2008 Male 123 lb 6/9/2009 Consumer Japan
Primary
Secondary
Concomitant
Gastric Ulcer Hospitalization 2/26/2009 Male 207 lb 6/12/2009 Consumer United Kingdom
Primary
Concomitant
Interstitial Lung Disease Other Serious 2/7/2009 Male 6/10/2009 Pharmacist United Kingdom
Primary
Concomitant
Neuropathy Peripheral Life Threatening 1/23/2009 Female 6/10/2009 Consumer United Kingdom
Primary
Concomitant
Pulmonary Alveolar Haemorrhage Other Serious 74 Male 6/11/2009 Physician Japan
Primary
Secondary
Anaphylactoid Reaction Hospitalization 5/1/2009 Female 6/11/2009 Consumer Japan
Primary
Secondary
Concomitant
Anaphylactoid Reaction Hospitalization 5/2/2009 Male 151 lb 6/11/2009 Consumer Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 3/30/2009 Male 6/16/2009 Physician United Kingdom
Primary
Concomitant

Drug Data