Avapro combined with Metformin Hcl

Reports:

---

Reaction	Outcome	Event Date	Age	Sex	Weight	Reported	Reporter	Country	Treatment
									Role	Name
Rhabdomyolysis	Other Serious	1/1/2005	75	Female		1/16/2006		Canada	Primary Secondary Concomitant
Asthma	Other Serious	12/27/2005	58	Female		6/6/2006	Physician	United States	Primary Concomitant
Dermatitis Exfoliative		5/1/2006	64	Female	270 lb	7/19/2006	Consumer	United States	Primary Concomitant
Hypoglycaemia	Other Serious	9/1/2004	75	Male	185 lb	9/29/2006	Physician	United States	Primary Concomitant
Macular Oedema	Other Serious	1/30/2006	74	Male	185 lb	10/12/2006	Pharmacist	Australia	Primary Concomitant
Vision Blurred	Other Serious	1/30/2006	74	Male	185 lb	10/17/2006	Pharmacist	Australia	Primary Concomitant
Vision Blurred	Other Serious	1/30/2006	74	Male	185 lb	10/18/2006	Pharmacist	Australia	Primary Concomitant
Weight Fluctuation	Hospitalization	9/9/2006	67	Male	251 lb	10/16/2006	Consumer	United States	Primary Concomitant
Bone Pain		3/1/2006	72	Female	271 lb	8/22/2006		United States	Primary Concomitant
Vomiting	Other Serious	3/2/2005	58	Female	243 lb	11/13/2006	Consumer	Australia	Primary Secondary
Weight Fluctuation	Hospitalization	9/9/2006	67	Male	255 lb	11/15/2006	Physician	United States	Primary Concomitant
Joint Swelling	Other Serious	10/16/2006	61	Male	225 lb	11/16/2006		United States	Primary Secondary Concomitant
Vomiting	Other Serious	3/2/2005	58	Female	243 lb	12/7/2006	Consumer	France	Primary Secondary
Post Herpetic Neuralgia	Other Serious	1/1/2005	64	Female	214 lb	12/7/2006		United States	Primary Concomitant
Joint Swelling	Other Serious	10/16/2006	61	Male	255 lb	12/19/2006		United States	Primary Secondary Concomitant
Insomnia		1/1/2006	72	Female	196 lb	10/11/2006	Consumer	United States	Primary Concomitant
Weight Fluctuation	Hospitalization		67	Male	255 lb	1/18/2007	Physician	United States	Primary Concomitant
Drug Ineffective			72	Female	196 lb	11/6/2006	Consumer	United States	Primary Concomitant
Weight Decreased		4/1/2006	67	Female	214 lb	10/16/2006	Consumer	United States	Primary Concomitant
Oropharyngeal Swelling		5/1/2006	61	Male		10/16/2006	Other Health Professional	United States	Primary Concomitant
Weight Loss Poor	Other Serious	1/12/2007	78	Male		1/31/2007	Consumer	United States	Primary Concomitant
Hypoglycaemia	Life Threatening	5/9/2006	53	Male	260 lb	2/2/2007	Physician	Canada	Primary Concomitant
Hypoglycaemia	Life Threatening	5/9/2006	53	Male	260 lb	2/5/2007	Physician	Canada	Primary Concomitant
Drug Effect Decreased		9/10/2006	61	Female	202 lb	10/16/2006	Consumer	United States	Primary Concomitant
Weight Decreased			84	Female		10/16/2006	Consumer	United States	Primary Concomitant
Nausea			58	Female	170 lb	10/16/2006	Consumer	United States	Primary Concomitant
Drug Dose Omission		6/1/2006	65	Female	135 lb	11/30/2006	Consumer	United States	Primary Concomitant
Tremor		9/1/2006	56	Female	147 lb	3/7/2007	Consumer	United States	Primary Concomitant
Weight Increased	Hospitalization	8/1/2006	52	Male	290 lb	3/15/2007	Consumer	United States	Primary Concomitant
Weight Decreased			60	Female	181 lb	1/12/2007	Consumer	United States	Primary Concomitant
Vision Blurred	Other Serious	1/1/2007	87	Female		5/3/2007	Consumer	United States	Primary Concomitant
Sleep Apnoea Syndrome	Hospitalization	2/15/2007	56	Female		5/9/2007	Consumer	United States	Primary Concomitant
Blood Glucose Increased	Other Serious			Male		5/29/2007	Pharmacist	Australia	Primary Concomitant
Increased Upper Airway Secretion	Other Serious	1/1/2007		Male	195 lb	6/1/2007	Physician	United States	Primary Concomitant
Myalgia		3/10/2007	64	Female		5/17/2007		United States	Primary Concomitant
Hypotension		1/24/2007	84	Female		5/17/2007		United States	Primary Concomitant
Blood Glucose Increased	Other Serious			Male	218 lb	6/12/2007	Pharmacist	Australia	Primary Concomitant
Weight Decreased		1/1/2006	64	Female	190 lb	4/10/2007	Consumer	United States	Primary Secondary Concomitant
Weight Decreased	Hospitalization	4/3/2007	60	Male		6/21/2007	Consumer	United States	Primary Concomitant
Pericardial Effusion	Other Serious	7/11/2006	72	Female		4/24/2007	Other Health Professional	United States	Primary Concomitant
Weight Increased	Other Serious	1/1/2006	53	Male	216 lb	4/26/2007	Physician	United States	Primary Secondary Concomitant
Rash	Other Serious	6/29/2007		Male	180 lb	7/10/2007	Consumer	United States	Primary Concomitant
Pharmaceutical Product Complaint	Other Serious	6/13/2007	62	Male	210 lb	6/19/2007	Pharmacist	United States	Primary Concomitant
Post Procedural Haemorrhage	Other Serious	7/5/2007	77	Male		7/18/2007	Consumer	Australia	Primary Secondary Concomitant
Weight Loss Poor			67	Female		7/23/2007	Consumer	United States	Primary Concomitant
Weight Increased		11/17/2006	63	Female	272 lb	7/23/2007	Consumer	United States	Primary Concomitant
Joint Swelling		1/1/2002	63	Female		7/23/2007	Consumer	United States	Primary Concomitant
Heart Rate Increased			81	Female		7/23/2007	Consumer	United States	Primary Concomitant
Adenocarcinoma Pancreas	Hospitalization	6/14/2007	83	Female	110 lb	7/19/2007	Physician	United States	Primary Secondary Concomitant
Muscle Spasms		4/13/2007	64	Female		7/11/2007	Physician	United States	Primary Concomitant
Weight Decreased		7/1/2005	75	Female	122 lb	7/11/2007	Consumer	United States	Primary Concomitant
Visual Acuity Reduced		1/1/2006	67	Female		7/11/2007	Consumer	United States	Primary Concomitant
Blood Pressure Increased		12/1/2006	73	Female	171 lb	8/27/2007	Consumer	United States	Primary Concomitant
Retinal Disorder	Other Serious			Female		8/30/2007	Physician	Puerto Rico	Primary Concomitant
Injection Site Pain		4/1/2007	70	Male		7/11/2007	Consumer	United States	Primary Concomitant
Drug Dose Omission	Hospitalization	6/22/2007		Male	178 lb	8/20/2007		United States	Primary Concomitant
Poor Quality Sleep		1/1/2005	65	Male		7/11/2007	Consumer	United States	Primary Concomitant
Treatment Noncompliance	Other Serious		71	Male		9/18/2007	Consumer	Canada	Primary Secondary Concomitant
Gastric Haemorrhage	Hospitalization	7/1/2007	70	Male	198 lb	9/25/2007	Consumer	Canada	Primary Concomitant
Urticaria		12/19/2006	55	Male		8/16/2007	Other Health Professional	United States	Primary Concomitant
Renal Function Test Abnormal		1/1/2006	68	Female	220 lb	10/4/2007	Consumer	United States	Primary Secondary Concomitant
Blood Creatinine Increased				Male		10/4/2007	Physician	United States	Primary Concomitant
Dyspnoea	Disability	1/5/2007	81	Female		10/4/2007	Physician	United States	Primary Concomitant
Myalgia		7/2/2007	65	Female	205 lb	10/4/2007	Consumer	United States	Primary Concomitant
Injection Site Extravasation	Other Serious	1/1/2006		Female		10/16/2007	Consumer	United States	Primary Concomitant
Pharmaceutical Product Complaint		1/11/2007	50	Male	225 lb	10/25/2007	Consumer	United States	Primary Concomitant
Wrong Technique In Drug Usage Process	Hospitalization	1/1/2006		Female		10/30/2007	Consumer	United States	Primary Concomitant
Dyspepsia	Other Serious	7/21/2006	65	Female		9/7/2007	Physician	United States	Primary Concomitant
Stupor	Other Serious	1/1/2007		Male	199 lb	11/14/2007	Consumer	United States	Primary Concomitant
Overdose		8/20/2007	75	Male		11/16/2007	Consumer	United States	Primary Concomitant
Self-medication	Required Intervention		83	Male		11/14/2007		Taiwan, Province Of China	Primary Secondary Concomitant
Blood Glucose Abnormal	Disability		60	Female	236 lb	11/26/2007	Other Health Professional	Australia	Primary Secondary Concomitant
Blood Glucose Abnormal	Disability		60	Female	236 lb	12/3/2007	Other Health Professional	Australia	Primary Concomitant
Blood Urea Increased			78	Female		11/16/2007	Physician	United States	Primary Concomitant
Acute Myocardial Infarction	Hospitalization	2/2/2007		Male		12/3/2007	Physician	United States	Primary Concomitant
Tremor		4/1/2007	63	Female		10/9/2007	Consumer	United States	Primary Concomitant
Blood Pressure Increased		9/3/2007	65	Female		10/9/2007	Consumer	United States	Primary Concomitant
Hypotension	Other Serious	8/19/2007	72	Male	220 lb	12/17/2007	Physician	Australia	Primary Concomitant
Speech Disorder	Hospitalization	11/1/2007		Male		12/12/2007	Consumer	United States	Primary Concomitant
Wrist Fracture	Other Serious	11/12/2007		Female	218 lb	12/19/2007	Physician	Australia	Primary Concomitant
Rhinorrhoea		8/1/2007	63	Female		10/8/2007	Consumer	United States	Primary Concomitant
Oedema Peripheral		8/5/2007	59	Male	192 lb	10/8/2007	Consumer	United States	Primary Concomitant
Tremor	Other Serious	12/18/2007	48	Female		12/28/2007	Consumer	United States	Primary Secondary Concomitant
Reflux Gastritis		7/1/2007	63	Female		10/8/2007	Consumer	United States	Primary Concomitant
Weight Decreased		8/1/2007	65	Male		10/9/2007	Consumer	United States	Primary Concomitant
Weight Decreased		1/1/2007	63	Male	276 lb	10/8/2007	Consumer	United States	Primary Concomitant
Presyncope		1/1/2005	65	Male		10/9/2007	Consumer	United States	Primary Concomitant
Blood Glucose Abnormal	Disability		60	Female	236 lb	1/10/2008	Other Health Professional	Australia	Primary Concomitant
Dyspnoea				Male		1/17/2008	Consumer	United States	Primary Secondary Concomitant
Hypokalaemia	Other Serious	1/1/2007		Male		1/28/2008	Pharmacist	Canada	Primary Concomitant
Thrombocytopenia	Other Serious	8/19/2007				2/11/2008	Physician	Australia	Primary Concomitant
Wound	Hospitalization	12/15/2007	71	Female		2/19/2008	Other Health Professional	United States	Primary Secondary Concomitant
Therapeutic Response Unexpected With Drug Substitution	Required Intervention	6/1/2007		Male		2/8/2008	Physician	United States	Primary Concomitant
Radius Fracture	Other Serious	11/12/2007		Female	218 lb	2/19/2008	Physician	Australia	Primary Concomitant
Drug Ineffective		10/1/2007	69	Male		1/10/2008	Consumer	United States	Primary Concomitant
Weight Decreased		1/1/2007	77	Female		1/10/2008	Other Health Professional	United States	Primary Concomitant
Weight Decreased		1/1/2007	50	Female	207 lb	1/10/2008	Physician	United States	Primary Concomitant
Weight Decreased		1/1/2007	70	Female	147 lb	1/10/2008	Consumer	United States	Primary Concomitant
Weight Decreased		9/2/2007	70	Female	220 lb	1/10/2008	Consumer	United States	Primary Concomitant
Dyspnoea				Male		3/6/2008	Consumer	United States	Primary Secondary Concomitant
Stomach Discomfort		10/1/2007	86	Male		3/7/2008	Consumer	United States	Primary Concomitant
Dyskinesia				Male		3/7/2008	Consumer	United States	Primary Concomitant
Pharmaceutical Product Complaint	Other Serious	9/8/2007		Female		3/8/2008	Physician	United States	Primary Concomitant
Pain In Extremity	Required Intervention		71	Female	175 lb	3/28/2008	Consumer	United States	Primary Secondary Concomitant
Stridor	Hospitalization	3/31/2008	56	Female	212 lb	4/11/2008	Physician	United States	Primary Concomitant
Radius Fracture	Other Serious	11/12/2007		Female	218 lb	4/28/2008	Physician	Australia	Primary Concomitant
Application Site Rash		1/1/2008	66	Female		5/5/2008	Physician	United States	Primary Concomitant
Vomiting	Hospitalization	5/1/2006		Female	240 lb	5/2/2008	Physician	United States	Primary Concomitant
Polyarthritis	Hospitalization	1/1/2007	70	Female	204 lb	4/11/2008	Physician	United States	Primary Concomitant
Pharmaceutical Product Complaint	Other Serious	5/26/2008	60	Female		6/10/2008	Consumer	United States	Primary Concomitant
Renal Failure Chronic		10/1/2007	62	Female		4/10/2008	Consumer	United States	Primary Concomitant
Pain In Extremity		10/1/2007	54	Female	215 lb	4/10/2008	Consumer	United States	Primary Concomitant
Weight Decreased		9/2/2007	70	Female	216 lb	4/10/2008	Consumer	United States	Primary Concomitant
Nausea		3/1/2008	64	Male		4/10/2008	Consumer	United States	Primary Concomitant
Weight Decreased		12/1/2007	51	Female	280 lb	4/10/2008	Consumer	United States	Primary Concomitant
Vision Blurred		1/7/2008	64	Female	180 lb	4/10/2008	Consumer	United States	Primary Concomitant
Visual Acuity Reduced	Other Serious	4/8/2008		Male	321 lb	7/2/2008	Physician	United States	Primary Concomitant
Visual Acuity Reduced	Other Serious	4/1/2008		Male	321 lb	7/10/2008	Physician	United States	Primary Concomitant
Muscle Spasms		3/1/2007	55	Female		4/10/2008	Consumer	United States	Primary Concomitant
Weight Decreased		3/1/2008	74	Female	175 lb	7/7/2008	Consumer	United States	Primary Concomitant
Oedema Peripheral		7/2/2008	69	Male		8/4/2008	Consumer	United States	Primary Concomitant
Weight Decreased		1/1/2007	70	Female	147 lb	7/7/2008	Consumer	United States	Primary Concomitant
Septic Embolus	Other Serious	7/14/2008		Female	205 lb	8/19/2008		United States	Primary Concomitant
Glycosylated Haemoglobin Increased		3/1/2008	46	Female		7/7/2008	Consumer	United States	Primary Concomitant
Pulmonary Arterial Hypertension	Hospitalization	11/9/2005	74	Female	130 lb	8/26/2008	Consumer	United States	Primary Secondary Concomitant
Productive Cough		1/24/2007	84	Female		8/15/2008		United States	Primary Concomitant
Renal Failure	Other Serious	2/1/2008	63	Male	142 lb	8/25/2008	Physician	United States	Primary Concomitant
Skin Infection		4/1/2008	49	Male	230 lb	8/15/2008	Other Health Professional	United States	Primary Concomitant
Back Pain		8/22/2007		Male	170 lb	9/4/2008	Consumer	United States	Primary Concomitant
White Blood Cells Urine Positive	Hospitalization	8/5/2008	71	Male	223 lb	8/22/2008	Physician	Canada	Primary Concomitant
Vomiting	Hospitalization	8/5/2008	71	Male	223 lb	9/8/2008	Physician	Canada	Primary Concomitant
Rhabdomyolysis	Other Serious	11/27/2006		Female	174 lb	9/30/2008	Physician	United States	Primary Secondary Concomitant
Nausea	Other Serious	1/1/2007		Male	265 lb	9/23/2008	Consumer	United States	Primary Concomitant
Wrong Technique In Drug Usage Process	Other Serious			Male	210 lb	10/3/2008	Physician	United States	Primary Secondary Concomitant
Dysgeusia				Male	205 lb	10/7/2008	Consumer	United States	Primary Concomitant
Gastrointestinal Disorder		1/1/2006	63	Female		10/7/2008	Consumer	United States	Primary Secondary Concomitant
Rash		3/15/2008	62	Male		10/7/2008	Consumer	United States	Primary Concomitant
Weight Decreased	Hospitalization	1/1/2006		Female	220 lb	10/1/2008	Consumer	United States	Primary Concomitant
Death	Death			Male	212 lb	10/10/2008	Consumer	United States	Primary Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome	Life Threatening	10/21/2008				11/11/2008	Physician	United States	Primary Secondary Concomitant
Weight Decreased	Hospitalization	1/1/2006		Female	220 lb	11/7/2008	Physician	United States	Primary Concomitant
Bladder Operation	Hospitalization	11/4/2008	39	Female	226 lb	11/7/2008	Consumer	United States	Primary Concomitant
Death	Death			Male	212 lb	11/14/2008	Other Health Professional	United States	Primary Concomitant
Palmar-plantar Erythrodysaesthesia Syndrome	Life Threatening	10/21/2008				11/17/2008	Physician	United States	Primary Secondary Concomitant
Weight Decreased	Hospitalization	1/1/2006		Female	220 lb	11/19/2008	Physician	United States	Primary Concomitant
Nausea	Other Serious	1/1/2006		Male	260 lb	11/25/2008	Physician	United States	Primary Concomitant
No Adverse Event			39	Female	226 lb	12/2/2008	Physician	United States	Primary Concomitant
Vomiting		1/1/2008		Male		12/17/2008	Consumer	United States	Primary Concomitant
Urinary Incontinence		9/1/2006		Male		1/9/2009	Consumer		Primary Concomitant
Thrombocytopenia	Hospitalization	12/22/2008	63	Male	289 lb	1/16/2009	Other Health Professional	United States	Primary Secondary Concomitant