Aspirin combined with Valproic Acid

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Mental Status Changes Hospitalization 10/25/2005 Male 1/19/2006 Pharmacist United States
Primary
Concomitant
Completed Suicide Death 44 3/9/2006 United States
Primary
Secondary
Completed Suicide Death 30 3/9/2006 United States
Primary
Secondary
White Blood Cell Count Increased Hospitalization 61 Male 4/6/2006 Canada
Primary
Secondary
Concomitant
Musculoskeletal Chest Pain Hospitalization 11/21/2005 42 Male 138 lb 1/25/2006 Other Health Professional United States
Primary
Concomitant
Hyperammonaemia Required Intervention 79 Male 8/29/2005 Other Health Professional United States
Primary
Concomitant
Intentional Drug Misuse Death 44 5/23/2006 Physician United States
Primary
Secondary
Infection Hospitalization 4/24/2006 79 Male 107 lb 7/5/2006 Pharmacist United States
Primary
Concomitant
Somnolence Death 6/14/2006 89 8/2/2006 United Kingdom
Primary
Concomitant
Renal Failure Acute Hospitalization 7/31/2006 62 Female 140 lb 8/15/2006 Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 8/10/2006 Other Health Professional United States
Primary
Concomitant
Epistaxis Hospitalization 4/26/2006 Female 9/15/2006 United Kingdom
Primary
Secondary
Concomitant
Haematemesis Hospitalization 7/25/2006 Male 9/20/2006 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 9/27/2006 77 Male Pharmacist United States
Primary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 10/4/2006 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 6/18/2006 60 Female 10/5/2006 Other Health Professional United States
Primary
Concomitant
Tremor Other Serious 2/6/2005 80 Female 11/2/2006 Other Health Professional Canada
Primary
Concomitant
Haemoglobin Decreased Other Serious 74 Female 12/8/2006 Pharmacist Canada
Primary
Concomitant
Thrombocytopenia Other Serious 7/11/2006 68 Male 154 lb 12/19/2006 Germany
Primary
Concomitant
Postictal State Other Serious 7/13/2006 42 Female 1/3/2007 United Kingdom
Primary
Concomitant
Myocardial Haemorrhage Death 3/23/2007 France
Primary
Concomitant
Death Death 1/1/2004 65 3/21/2007 Pharmacist United States
Primary
Secondary
Post Procedural Haemorrhage Death 3/24/2007 Physician Canada
Primary
Secondary
Faecaloma Hospitalization 10/2/2006 Male 115 lb 3/11/2007 Pharmacist United States
Primary
Secondary
Concomitant
Weight Decreased 11/1/2006 39 Male 1/12/2007 Consumer United States
Primary
Concomitant
Subarachnoid Haemorrhage Other Serious 5/19/2005 73 Male 5/24/2007 United Kingdom
Primary
Concomitant
Grand Mal Convulsion Other Serious 68 Female 6/18/2007 Other Health Professional United Kingdom
Primary
Interacting
Post Procedural Haemorrhage Death 6/12/2007 Physician Canada
Primary
Concomitant
Mental Status Changes Hospitalization 1/24/2007 Female 263 lb 6/19/2007 Other Health Professional United States
Primary
Concomitant
Rhabdomyolysis Hospitalization 191 lb Physician United States
Primary
Secondary
Concomitant
Grand Mal Convulsion Other Serious 68 Female 7/11/2007 Other Health Professional United Kingdom
Primary
Interacting
Erythema Multiforme Disability 6/27/2007 78 Female 104 lb 11/23/2007 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death 8/6/2007 86 Male 12/18/2007 Physician Switzerland
Primary
Concomitant
Drug Toxicity Death 55 Male 1/14/2008 Physician United States
Primary
Secondary
Completed Suicide Death 1/1/2006 55 Male 1/17/2008 United States
Primary
Secondary
Drug Toxicity Death 55 Male 1/25/2008 Other Health Professional United States
Primary
Secondary
Completed Suicide Death 55 Male 2/8/2008 United States
Primary
Secondary
Poisoning Death 55 Male 2/6/2008 Physician United States
Primary
Secondary
Supraventricular Tachycardia Life Threatening 62 Female 2/20/2008 Netherlands
Primary
Concomitant
Supraventricular Tachycardia Life Threatening 62 Female 2/22/2008 France
Primary
Concomitant
Supraventricular Tachycardia Life Threatening 62 Female 2/22/2008 France
Primary
Concomitant
Supraventricular Tachycardia Life Threatening 62 Female 3/14/2008 Netherlands
Primary
Concomitant
Supraventricular Tachycardia Life Threatening 62 Female 6/12/2008 France
Primary
Concomitant
Transaminases Increased Other Serious 10/10/2003 Female 6/13/2008 France
Primary
Concomitant
Completed Suicide Death 65 6/19/2008 Physician United States
Primary
Secondary
Tremor Hospitalization 76 Female 6/27/2008 Other Health Professional France
Primary
Concomitant
Therapeutic Response Decreased Male 162 lb 7/25/2008 Physician United States
Primary
Concomitant
Hypersomnia Male 9/23/2008 Consumer United States
Primary
Concomitant
Completed Suicide Death 55 Male 11/2/2008 Physician United States
Primary
Secondary
Neutropenia Other Serious 9/4/2008 Female 11/12/2008 Physician Germany
Primary
Secondary
Concomitant
Death Death 8/16/2008 Female 287 lb 11/14/2008 Physician United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Death 8/15/2008 Female 287 lb 11/24/2008 Physician United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Death 8/15/2008 Female 287 lb 12/22/2008 Physician United States
Primary
Concomitant
Completed Suicide Death 39 Female 12/29/2008 Pharmacist United States
Primary
Secondary
Drug Toxicity Death 39 Female 1/8/2009 Other Health Professional United States
Primary
Secondary
Cardio-respiratory Arrest Death 39 Female 1/16/2009 United States
Primary
Secondary
Drug Toxicity Death 39 Female 1/23/2009 Other Health Professional United States
Primary
Secondary
Respiratory Arrest Other Serious 39 Female 1/23/2009 Physician United States
Primary
Secondary
Completed Suicide Death 39 Female 1/28/2009 Other Health Professional United States
Primary
Secondary
Respiratory Arrest Death 39 Female 1/26/2009 Physician United States
Primary
Secondary
Cardio-respiratory Arrest Death 1/1/2007 39 Female 2/3/2009 Pharmacist United States
Primary
Secondary
Urinary Incontinence Life Threatening 9/15/2008 70 Male 2/23/2009 Pharmacist Switzerland
Primary
Concomitant
Interacting
Urinary Incontinence Other Serious 12/15/2008 Female 3/6/2009 Canada
Primary
Concomitant
Respiratory Arrest Death 39 Female 3/5/2009 Physician United States
Primary
Secondary
Liver Injury Hospitalization 9/12/2008 63 Female 3/18/2009 Other Health Professional France
Primary
Secondary
Concomitant
Urinary Incontinence Life Threatening 9/15/2008 70 Male 4/6/2009 Pharmacist Switzerland
Primary
Concomitant
Interacting
Urinary Incontinence Other Serious 12/15/2008 Female 4/13/2009 Physician Canada
Primary
Concomitant
Upper Respiratory Tract Infection Other Serious 6/15/2004 49 Male 276 lb 4/21/2009 United States
Primary
Concomitant
Suicide Attempt Other Serious 8/2/1999 33 Female 125 lb 5/15/2009 United States
Primary
Secondary
Concomitant
Tinea Pedis Other Serious 5/29/2004 50 Male 5/20/2009 United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Death 8/15/2008 Female 287 lb 7/13/2009 Physician United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 56 Male 124 lb 8/5/2009 Pharmacist United States
Primary
Concomitant
Interacting
Wound Other Serious 1/1/2009 60 Male 8/13/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Myopathy Other Serious 85 Female 8/20/2009 Pharmacist Germany
Primary
Concomitant
Interacting
Myopathy Hospitalization 85 Female 8/18/2009 Other Health Professional Germany
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 12/1/2002 53 Male 8/28/2009
Primary
Secondary
Neuropathy Peripheral Other Serious 10/1/2004 47 Female 237 lb 9/14/2009 United States
Primary
Concomitant
Weight Decreased Other Serious 1/1/2008 Female 202 lb 9/15/2009 Consumer United States
Primary
Concomitant
Weight Increased 8/4/2003 36 Male 274 lb 9/23/2009 United States
Primary
Concomitant
Incorrect Dose Administered Other Serious 75 Male 198 lb 10/5/2009 Physician United States
Primary
Concomitant
Interacting
Lip Exfoliation 8/6/2008 77 Female 10/6/2009 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/2004 51 Male 286 lb 10/15/2009 United States
Primary
Concomitant
Overdose Hospitalization 1/15/2009 61 Male 10/22/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Syncope Other Serious 56 Male 123 lb 10/23/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Application Site Rash 4/1/2009 67 Male 10/29/2009 Consumer
Primary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 6/1/2006 34 Female 213 lb 11/2/2009 United States
Primary
Concomitant
Upper Gastrointestinal Haemorrhage Required Intervention Male 124 lb 10/23/2009 Pharmacist United States
Primary
Secondary
Concomitant
Off Label Use Hospitalization 10/21/2009 52 Female 11/9/2009 Consumer Colombia
Primary
Concomitant
Overdose Hospitalization 61 Male 11/5/2009 United Kingdom
Primary
Secondary
Concomitant
Rash Pruritic 4/1/2009 66 Male 11/13/2009 Physician
Primary
Concomitant
Urine Colour Abnormal Hospitalization 84 Female 11/20/2009 Other Health Professional Italy
Primary
Concomitant
Diarrhoea 9/14/2009 Male 238 lb 11/25/2009 United States
Primary
Concomitant
Polyuria Hospitalization 10/20/2009 52 Female 104 lb 11/26/2009 Consumer Colombia
Primary
Concomitant
Grand Mal Convulsion Other Serious 68 Female 12/4/2009 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased 7/16/2009 51 Male 209 lb 12/9/2009 Consumer United States
Primary
Concomitant
Mental Status Changes Hospitalization 1/24/2007 49 Female 263 lb 12/8/2009 Other Health Professional United States
Primary
Concomitant
Syncope Other Serious 56 Male 123 lb 1/12/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Type 2 Diabetes Mellitus Hospitalization 6/1/2006 34 Female 213 lb 1/25/2010 United States
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 7/20/2007 53 Male 1/21/2010 Other Health Professional Taiwan, Province Of China
Primary
Concomitant
Liver Injury Hospitalization 9/5/2008 63 Female 190 lb 2/8/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Hepatotoxicity Hospitalization 9/5/2008 63 Female 2/10/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Liver Injury Hospitalization 9/12/2008 63 Female 2/15/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Liver Injury Hospitalization 9/12/2008 63 Female 2/15/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Liver Injury Hospitalization 9/12/2008 63 Female 2/15/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Hyponatraemia Hospitalization 12/22/2009 64 Female 2/18/2010 Pharmacist United States
Primary
Concomitant
Delirium Hospitalization 75 Female 3/24/2010 Other Health Professional Italy
Primary
Concomitant
Weight Decreased Other Serious 4/1/2006 54 Male 4/14/2010 United States
Primary
Secondary
Concomitant
Mental Disorder Other Serious 62 Female 4/19/2010 Consumer Colombia
Primary
Concomitant
Vitamin B12 Deficiency Other Serious 1/16/2004 59 Male 6/11/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 4/1/2006 54 Male 6/21/2010 United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 4/4/2010 55 Male 180 lb 4/6/2010 Pharmacist United States
Primary
Concomitant
Vitamin B12 Deficiency Other Serious 1/16/2004 59 Male 7/14/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 4/1/2006 54 Male 7/29/2010 United States
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Other Serious 5/29/2004 50 Male 211 lb 8/9/2010 United States
Primary
Concomitant
Mental Disorder Other Serious 62 Female 8/17/2010 Consumer Colombia
Primary
Concomitant
Visual Impairment Other Serious 1/1/1999 44 Male 235 lb 8/23/2010 United States
Primary
Concomitant
Weight Decreased Other Serious 4/1/2006 54 Male 8/23/2010 United States
Primary
Secondary
Concomitant
Sick Sinus Syndrome Other Serious 51 Male 8/24/2010 Physician Taiwan, Province Of China
Primary
Concomitant
Weight Decreased Other Serious 4/1/2006 54 Male 8/26/2010 United States
Primary
Secondary
Concomitant
Flushing 8/29/2010 Consumer United States
Primary
Concomitant
Pruritus Male 200 lb 8/29/2010 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Hospitalization 5/29/2004 50 Male 211 lb 9/3/2010 United States
Primary
Concomitant
Pancreatitis Chronic Other Serious 1/1/2005 56 Male 187 lb 9/17/2010 United States
Primary
Concomitant
Thrombocytopenia Other Serious 6/1/2008 29 Male 10/7/2010 Physician United Kingdom
Primary
Secondary
Concomitant
Wheezing Life Threatening 5/31/2010 56 Female 10/15/2010 Physician
Primary
Secondary
Concomitant
Tic Other Serious 6/3/2010 9 Male 11/2/2010 Pharmacist Japan
Primary
Secondary
Concomitant
Wheezing Life Threatening 5/31/2010 56 Female 11/3/2010 Physician
Primary
Secondary
Concomitant
Somnolence Hospitalization 10/8/2010 38 Male 141 lb 11/3/2010 Pharmacist United States
Primary
Concomitant
Completed Suicide Death 55 Male 1/11/2011 Other Health Professional United States
Primary
Secondary
Urinary Retention Hospitalization 1/24/2011 40 Male 289 lb 2/3/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastrointestinal Disorder Other Serious 81 Male 1/11/2011 Netherlands
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 1/24/2011 40 Male 289 lb 2/16/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Back Pain Other Serious 5/1/2002 50 Female 230 lb 3/2/2011 United States
Primary
Concomitant
Weight Increased Other Serious Male 215 lb 3/17/2011 Physician Canada
Primary
Secondary
Concomitant
Hydrocephalus Other Serious 1/1/2010 47 Male 240 lb 3/18/2011 Consumer United States
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious 71 Male 3/23/2011 Physician Germany
Primary
Secondary
Concomitant
Mental Disorder Other Serious 4/1/2011 39 5/2/2011 Other Health Professional United Kingdom
Primary
Concomitant
Superficial Siderosis Of Central Nervous System Other Serious 72 Male 5/3/2011 Other Health Professional Belgium
Primary
Secondary
Concomitant
Grandiosity Hospitalization 75 Female 5/3/2011 Other Health Professional Brazil
Primary
Concomitant
Interacting
Intra-abdominal Haemorrhage Death 2/27/2011 78 Female 71 lb 5/6/2011 Physician Colombia
Primary
Concomitant
Weight Increased Other Serious 9/1/2004 61 Female 5/3/2011 Consumer Canada
Primary
Concomitant
Amnestic Disorder Other Serious 71 Male 5/3/2011 Physician Germany
Primary
Secondary
Concomitant
Camptocormia Hospitalization 5/21/2006 74 Male 152 lb 5/19/2011 Physician Germany
Primary
Concomitant
Myoclonus Other Serious 6/1/2008 29 Male 6/3/2011 Physician United Kingdom
Primary
Secondary
Concomitant
Gastritis Hospitalization 2/28/2011 56 Male 165 lb 6/6/2011 Other Health Professional Ireland
Primary
Concomitant
Parkinsonian Gait Other Serious 5/17/2011 86 Female 6/7/2011 Physician Japan
Primary
Secondary
Concomitant
Constipation Hospitalization 2/22/2011 72 Male 6/8/2011 Other Health Professional United Kingdom
Primary
Concomitant
Decreased Appetite Other Serious Female 6/4/2011 Physician United Kingdom
Primary
Concomitant
Blood Creatine Increased Other Serious Female 6/10/2011 Physician Canada
Primary
Concomitant
Liver Injury Hospitalization 9/5/2008 63 Female 190 lb 6/16/2011 Other Health Professional Germany
Primary
Secondary
Concomitant

Drug Data