Asparaginase combined with Dexamethasone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Therapy Non-responder Death Female 1/27/2006 United Kingdom
Primary
Secondary
Vomiting Death Female 1/31/2006 Other Health Professional United Kingdom
Primary
Secondary
Hepatotoxicity Other Serious 52 Male 1/19/2007 Other Health Professional Israel
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 47 Female 1/19/2007 Other Health Professional Israel
Primary
Secondary
Concomitant
Liver Disorder Other Serious 52 Male 2/7/2007 Israel
Primary
Secondary
Jaundice Cholestatic Other Serious 52 Male 2/23/2007
Primary
Secondary
Hepatotoxicity Other Serious 47 Female 2/23/2007
Primary
Secondary
Polyneuropathy Other Serious Male 7/5/2007
Primary
Secondary
Conjunctivitis Other Serious 7/28/2006 17 Male 77 lb 9/8/2006 Pharmacist United States
Primary
Concomitant
Renal Failure Hospitalization Male 7/8/2008 Other Health Professional United Kingdom
Primary
Secondary
Renal Failure Hospitalization 1 Male 7/10/2008 Other Health Professional United Kingdom
Primary
Secondary
Subarachnoid Haemorrhage Death 0 Female 7/14/2008 United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/15/2008 United Kingdom
Primary
Secondary
Renal Failure Hospitalization 1 Male 7/15/2008 Other Health Professional United Kingdom
Primary
Secondary
Staphylococcal Infection Hospitalization 1 Male 7/16/2008 Other Health Professional United Kingdom
Primary
Secondary
Vomiting Other Serious 0 Female 7/17/2008 Consumer United States
Primary
Secondary
Staphylococcal Infection Hospitalization 1 Male 7/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Subarachnoid Haemorrhage Death 0 Female 7/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/28/2008 United Kingdom
Primary
Secondary
Staphylococcal Infection Hospitalization 2 Male 7/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Promyelocyte Count Increased Life Threatening 54 Male 7/22/2008 Other Health Professional United Kingdom
Primary
Secondary
Hepatic Encephalopathy Hospitalization 2 Male 8/8/2008 Physician United Kingdom
Primary
Secondary
Vomiting Other Serious 0 Female 8/12/2008 Consumer United States
Primary
Secondary
Viral Infection Other Serious 2 Male 9/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Stevens-johnson Syndrome Hospitalization 1/1/2008 14 Male 143 lb 9/26/2008 Consumer United States
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 5/1/2008 Male 205 lb 9/30/2008 France
Primary
Secondary
Concomitant
Renal Failure Hospitalization 2 Male 10/21/2008 Physician United Kingdom
Primary
Secondary
Gamma-glutamyltransferase Increased Hospitalization 12/21/2008 4 Male 44 lb 1/7/2009 Physician Germany
Primary
Secondary
Concomitant
Neutropenia Required Intervention 9 Female 5/20/2009 Pharmacist France
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 5/1/2008 Male 205 lb 6/2/2009 Other Health Professional France
Primary
Secondary
Concomitant
Syncope Hospitalization 1/23/2009 14 Female 5/28/2009 Netherlands
Primary
Secondary
Concomitant
Venous Thrombosis 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Intracranial Venous Sinus Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Venous Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Male 7/22/2009 Physician United Kingdom
Primary
Secondary
Venous Thrombosis Male 7/22/2009 Physician United Kingdom
Primary
Secondary
Venous Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Venous Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Venous Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Venous Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Venous Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Female 7/22/2009 United States
Primary
Secondary
Renal Vein Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Fusarium Infection Other Serious 5 Female 7/28/2009 United Kingdom
Primary
Secondary
Venous Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Venous Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Concomitant
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Concomitant
Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Concomitant
Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Venous Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Thrombosis Male 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Renal Vein Thrombosis Female 7/22/2009 United Kingdom
Primary
Secondary
Sepsis Other Serious 55 Female 12/17/2009 Consumer United Kingdom
Primary
Secondary
Cerebral Ischaemia Other Serious 1/1/2009 9 Male 12/17/2009 Other Health Professional Poland
Primary
Secondary
Septic Shock Death Female 116 lb 12/31/2009 Pharmacist United States
Primary
Concomitant
Swelling Face Death 10 Female 1/8/2010 Other Health Professional India
Primary
Secondary
Grand Mal Convulsion Other Serious 1/1/2009 9 Male 1/8/2010 Other Health Professional Poland
Primary
Secondary
Concomitant
Fungal Infection Death 10 Female 1/11/2010 Other Health Professional India
Primary
Secondary
Concomitant
Septic Shock Death Female 116 lb 1/19/2010 Pharmacist United States
Primary
Secondary
Concomitant
Pulmonary Mycosis Life Threatening 5/26/2009 20 Female 2/1/2010 Physician Italy
Primary
Secondary
Concomitant
Zygomycosis Other Serious 15 Female 3/1/2010 Austria
Primary
Secondary
Acute Respiratory Distress Syndrome Other Serious 1/1/2009 15 Female 3/18/2010 Other Health Professional Austria
Primary
Secondary
Leukoencephalopathy Other Serious 3/13/2010 7 4/19/2010 China
Primary
Concomitant
Stomatitis Other Serious 13 Male 9/6/2010 Belgium
Primary
Secondary
Concomitant
Progressive Multifocal Leukoencephalopathy Other Serious 12 Male 11/5/2010 Physician Czech Republic
Primary
Secondary
Subclavian Vein Thrombosis Other Serious 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Subclavian Vein Thrombosis Life Threatening 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Life Threatening 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Other Serious 7 Female 12/29/2010 Other Health Professional Germany
Primary
Secondary
Cholestasis Hospitalization 5/1/2008 14 Male 205 lb 1/11/2011 Other Health Professional France
Primary
Secondary
Concomitant
Posterior Reversible Encephalopathy Syndrome Other Serious 4 Male 3/22/2011 Physician Hong Kong
Primary
Secondary
Posterior Reversible Encephalopathy Syndrome Other Serious 8 Female 3/22/2011 Physician Hong Kong
Primary
Secondary
Posterior Reversible Encephalopathy Syndrome Other Serious 11 Male 3/22/2011 Physician Hong Kong
Primary
Secondary
Posterior Reversible Encephalopathy Syndrome Other Serious 4 Male 3/22/2011 Physician Hong Kong
Primary
Secondary
Hypophosphataemia Other Serious 9 Female 3/7/2011 Other Health Professional France
Primary
Secondary
Concomitant
Blood Pressure Increased Other Serious 4 Male 3/23/2011 Other Health Professional Hong Kong
Primary
Secondary
Visual Impairment Other Serious 4 Male 3/23/2011 Other Health Professional Hong Kong
Primary
Secondary
Blood Pressure Increased Other Serious 8 Female 3/23/2011 Other Health Professional Hong Kong
Primary
Secondary
Hyperglycaemia Hospitalization 3/1/2011 68 Male 231 lb 3/23/2011 Physician United States
Primary
Secondary
Abdominal Pain Other Serious 6/25/2007 9 Female 3/15/2011 Other Health Professional France
Primary
Secondary
Concomitant
Pancytopenia Hospitalization 2/21/2011 16 Female 4/11/2011 Physician Spain
Primary
Secondary
Concomitant
Posterior Reversible Encephalopathy Syndrome Other Serious 1/1/2010 4 Male 4/26/2011 Other Health Professional Hong Kong
Primary
Secondary
Posterior Reversible Encephalopathy Syndrome Other Serious 1/1/2010 4 Male 4/26/2011 Other Health Professional Hong Kong
Primary
Secondary
Posterior Reversible Encephalopathy Syndrome Other Serious 1/1/2010 11 Male 4/26/2011 Other Health Professional Hong Kong
Primary
Secondary
Posterior Reversible Encephalopathy Syndrome Other Serious 1/1/2010 4 Male 5/24/2011 Other Health Professional Hong Kong
Primary
Secondary
Posterior Reversible Encephalopathy Syndrome Other Serious 1/1/2010 8 Female 5/24/2011 Other Health Professional Hong Kong
Primary
Secondary
Posterior Reversible Encephalopathy Syndrome Other Serious 1/1/2010 4 Male 5/24/2011 Other Health Professional Hong Kong
Primary
Secondary
Posterior Reversible Encephalopathy Syndrome Other Serious 1/1/2010 11 Male 5/24/2011 Other Health Professional Hong Kong
Primary
Secondary
Hyperglycaemia Hospitalization 3/1/2011 68 Male 239 lb 6/1/2011 Consumer United States
Primary
Secondary
Decreased Appetite Hospitalization 10 Female 6/1/2011 Other Health Professional Spain
Primary
Secondary
Affective Disorder Other Serious 14 Male 6/14/2011 Other Health Professional Turkey
Primary
Secondary
Mania Hospitalization 14 Male 6/17/2011 Other Health Professional Turkey
Primary
Secondary
Pressure Of Speech Hospitalization 14 Male 6/21/2011 Physician Turkey
Primary
Secondary
Concomitant
Blood Pressure Increased Death 11 Male 6/29/2011 Physician Hong Kong
Primary
Concomitant
Altered State Of Consciousness Life Threatening 7/27/2011 5 Male 8/11/2011 Consumer Brazil
Primary
Concomitant
Thrombocytopenia Hospitalization 6/30/2011 5 Female 31 lb 9/1/2011 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Colitis Hospitalization 8/19/2011 10 Male 71 lb 9/5/2011 Consumer United States
Primary
Secondary
Concomitant
Colitis Hospitalization 8/19/2011 10 Male 9/16/2011 Physician United States
Primary
Secondary
Concomitant
Hypotension Hospitalization 8/19/2011 10 Male 9/26/2011 Physician United States
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 18 Female 9/30/2011 Physician India
Primary
Secondary
Concomitant
Gallbladder Disorder Other Serious 18 Female 10/4/2011 Other Health Professional India
Primary
Secondary
Hypotension Hospitalization 8/19/2011 10 Male 71 lb 10/10/2011 Consumer United States
Primary
Secondary
Concomitant
Oedema Peripheral Other Serious 18 Female 10/17/2011 Other Health Professional India
Primary
Secondary
Pneumocystis Jiroveci Infection Death 6/12/2009 67 Female 10/18/2011 Physician France
Primary
Secondary
Concomitant
Hypotension Hospitalization 8/19/2011 10 Male 10/18/2011 Physician United States
Primary
Secondary
Concomitant
Hypotension Hospitalization 8/19/2011 10 Male 10/24/2011 Physician United States
Primary
Secondary
Concomitant
Nausea Hospitalization 7/31/2011 10 Male 71 lb 10/31/2011 Consumer United States
Primary
Secondary
Concomitant
Vomiting Required Intervention 4 Male 10/27/2011 Physician Ireland
Primary
Concomitant
Headache Hospitalization 6/1/2011 22 Female 11/10/2011 Physician United States
Primary
Secondary
Necrotising Colitis Other Serious 8/1/2010 40 12/28/2011 Other Health Professional Russian Federation
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 8/1/2010 40 12/28/2011 Other Health Professional Russian Federation
Primary
Secondary
Concomitant

Drug Data