Asparaginase combined with Cytarabine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Subarachnoid Haemorrhage Other Serious Female 1/30/2006 Other Health Professional France
Primary
Secondary
Therapy Non-responder Death Female 1/27/2006 United Kingdom
Primary
Secondary
Vomiting Death Female 1/31/2006 Other Health Professional United Kingdom
Primary
Secondary
Peripheral Motor Neuropathy Other Serious 1/4/2006 5 Female 35 lb 2/3/2006 Physician United States
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 52 Male 1/19/2007 Other Health Professional Israel
Primary
Secondary
Concomitant
Jaundice Cholestatic 52 Male 1/26/2007 Israel
Primary
Secondary
Concomitant
Liver Disorder Other Serious 52 Male 2/7/2007 Israel
Primary
Secondary
Jaundice Cholestatic Other Serious 52 Male 2/23/2007
Primary
Secondary
Somnolence Other Serious 56 Female 3/2/2007
Primary
Secondary
Metastasis Death 11 Male 3/5/2007
Primary
Secondary
Metastasis Death 15 Female 3/5/2007
Primary
Secondary
Metastasis Death 13 Female 3/5/2007
Primary
Secondary
Metastasis Death 12 Male 3/5/2007
Primary
Secondary
Metastasis Death 15 Male 3/5/2007
Primary
Secondary
Glioma Other Serious 2 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Female 3/9/2007 Other Health Professional Finland
Primary
Secondary
Glioma Other Serious 4 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 3 Female 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 5 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Female 3/9/2007 Other Health Professional Finland
Primary
Secondary
Glioma Other Serious 3 Female 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 4 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 5 Male 3/12/2007 Consumer Finland
Primary
Secondary
Treatment Related Secondary Malignancy Death 11 Male 3/1/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 15 Male 3/1/2007 Germany
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Death 15 Female 3/1/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 12 Male 3/1/2007 Germany
Primary
Secondary
Glioma Death 13 Female 3/1/2007 Germany
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Death 15 Male 3/16/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 15 Female 3/16/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 12 Male 3/16/2007 Germany
Primary
Secondary
Glioma Death 13 Female 3/20/2007 Germany
Primary
Secondary
Glioma Death 11 Male 3/20/2007 Germany
Primary
Secondary
Neoplasm Malignant Death 15 Female 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 13 Female 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 11 Male 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 15 Male 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 12 Male 3/30/2007 Germany
Primary
Secondary
Concomitant
Ventricular Dysfunction Other Serious 3/28/2006 7 Male 4/12/2007 United States
Primary
Secondary
Concomitant
Polyneuropathy Other Serious Female 6/22/2007
Primary
Secondary
Polyneuropathy Other Serious Male 6/22/2007
Primary
Secondary
Respiratory Tract Infection Viral Other Serious 8 Male 6/28/2007 Other Health Professional Australia
Primary
Secondary
Polyneuropathy Other Serious Female 7/5/2007
Primary
Secondary
Polyneuropathy Other Serious Male 7/5/2007
Primary
Secondary
Trichostasis Spinulosa Other Serious 6 Male 6/30/2007 Physician Australia
Primary
Secondary
Retinal Vein Thrombosis Hospitalization 4/21/2007 8 8/15/2007 Physician United States
Primary
Concomitant
Precocious Puberty Other Serious Female 9/14/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Retinal Vein Thrombosis Hospitalization 4/21/2007 8 Male 9/19/2007 Physician United States
Primary
Concomitant
Conjunctivitis Other Serious 7/24/2006 16 Male 101 lb 9/8/2006 Pharmacist United States
Primary
Concomitant
Conjunctivitis Other Serious 7/28/2006 17 Male 77 lb 9/8/2006 Pharmacist United States
Primary
Concomitant
Nervous System Disorder Death 12 Male 11/21/2007 Physician Germany
Primary
Secondary
Dysthymic Disorder Hospitalization 6/19/2007 Male 2/22/2008 Physician France
Primary
Secondary
Concomitant
Lymphoproliferative Disorder Other Serious 4 Female 3/20/2008 United States
Primary
Secondary
Splenomegaly Death 4 Female 3/24/2008 Other Health Professional United States
Primary
Secondary
Sinusitis Fungal Other Serious Female 3/31/2008 Physician United States
Primary
Secondary
Vomiting Other Serious 29 Female 5/12/2008 Other Health Professional Turkey
Primary
Secondary
Vomiting Other Serious 29 Female 5/14/2008 Other Health Professional Turkey
Primary
Secondary
Stomatitis Other Serious 16 Male 5/24/2008 Physician Turkey
Primary
Secondary
Thrombocytopenia Other Serious 15 Male 5/24/2008 Physician Turkey
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Hospitalization 6 Female 6/3/2008 Spain
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Hospitalization 4/20/2008 Female 6/3/2008 Other Health Professional France
Primary
Secondary
Renal Failure Other Serious 6/3/2008 Consumer United States
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Hospitalization 6 Female 6/13/2008 Spain
Primary
Secondary
Calculus Urinary Other Serious 11 Male 6/25/2008 Other Health Professional Japan
Primary
Secondary
Calculus Urinary Other Serious 11 Male 6/30/2008 Other Health Professional Japan
Primary
Secondary
Subarachnoid Haemorrhage Death 0 Female 7/14/2008 United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/15/2008 United Kingdom
Primary
Secondary
Vomiting Other Serious 0 Female 7/17/2008 Consumer United States
Primary
Secondary
Subarachnoid Haemorrhage Death 0 Female 7/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/28/2008 United Kingdom
Primary
Secondary
Promyelocyte Count Increased Life Threatening 54 Male 7/22/2008 Other Health Professional United Kingdom
Primary
Secondary
Leukaemia Other Serious 39 Female 8/5/2008 United States
Primary
Secondary
Guillain-barre Syndrome Other Serious 39 Female 8/5/2008 Other Health Professional United States
Primary
Secondary
Vomiting Other Serious 0 Female 8/12/2008 Consumer United States
Primary
Secondary
Stem Cell Transplant Death 39 Female 8/9/2008 United States
Primary
Secondary
Subarachnoid Haemorrhage Life Threatening 0 Female 8/11/2008 United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 8/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Subarachnoid Haemorrhage Death 0 Female 8/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Tumour Lysis Syndrome Other Serious 30 Male 12/9/2008 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Gamma-glutamyltransferase Increased Hospitalization 12/21/2008 4 Male 44 lb 1/7/2009 Physician Germany
Primary
Secondary
Concomitant
Urticaria Other Serious 12/11/2008 17 Female 1/27/2009 Consumer France
Primary
Secondary
Concomitant
Chronic Graft Versus Host Disease Other Serious 21 Male 3/10/2009 Physician United Kingdom
Primary
Secondary
Bone Marrow Disorder Death 17 Female 3/10/2009 Physician United Kingdom
Primary
Secondary
Rhabdomyolysis Other Serious 10/24/2008 2 Male 27 lb 3/18/2009 Physician Japan
Primary
Concomitant
Febrile Neutropenia Other Serious 4/14/2009 Consumer United Kingdom
Primary
Secondary
Febrile Neutropenia Other Serious 4/27/2009 Consumer United Kingdom
Primary
Secondary
Vision Blurred Hospitalization 4/1/2009 Male 75 lb 5/18/2009 Consumer France
Primary
Secondary
Peripheral Motor Neuropathy Hospitalization 4/7/2009 9 5/18/2009 Other Health Professional France
Primary
Secondary
Respiratory Arrest Hospitalization 5 Male 5/18/2009 Physician Japan
Primary
Concomitant
Neutropenia Required Intervention 9 Female 5/20/2009 Pharmacist France
Primary
Secondary
Concomitant
Syncope Hospitalization 1/23/2009 14 Female 5/28/2009 Netherlands
Primary
Secondary
Concomitant
Peripheral Motor Neuropathy Hospitalization 4/7/2009 9 6/5/2009 Other Health Professional France
Primary
Secondary
Vision Blurred Hospitalization 4/1/2009 Male 75 lb 6/8/2009 Consumer France
Primary
Secondary
Peripheral Motor Neuropathy Hospitalization 4/7/2009 9 7/24/2009 Other Health Professional France
Primary
Secondary
Vision Blurred Hospitalization 4/1/2009 Male 75 lb 7/27/2009 Consumer France
Primary
Secondary
Syncope Hospitalization 1/23/2009 Female 10/1/2009 Physician Netherlands
Primary
Secondary
Concomitant
Insulin-like Growth Factor Decreased Other Serious 12 Female 11/17/2009 Other Health Professional United States
Primary
Secondary
Epiphysiolysis Other Serious 15 Male 11/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Neurotoxicity Hospitalization 17 Male 12/16/2009 Physician United States
Primary
Concomitant
Leukoencephalopathy Other Serious Male 1/4/2010 Other Health Professional Australia
Primary
Secondary
Leukoencephalopathy Other Serious 6 Male 1/5/2010 Other Health Professional Australia
Primary
Secondary
Leukoencephalopathy Other Serious 8 Male 1/14/2010 Other Health Professional Australia
Primary
Secondary
Urinary Retention Other Serious 4 Female 1/19/2010 Turkey
Primary
Concomitant
Pulmonary Mycosis Life Threatening 5/26/2009 20 Female 2/1/2010 Physician Italy
Primary
Secondary
Concomitant
Respiratory Alkalosis Life Threatening 1 Male 2/22/2010 Taiwan, Province Of China
Primary
Secondary
Hyperammonaemic Encephalopathy Other Serious Male 3/1/2010 Physician Taiwan, Province Of China
Primary
Secondary
Vomiting Hospitalization 7 Male 3/3/2010 Other Health Professional France
Primary
Concomitant
Pulmonary Mycosis Life Threatening 5/26/2009 Female 3/4/2010 Physician Italy
Primary
Secondary
Concomitant
Hemiplegia Life Threatening 12/30/2009 43 Female 6/14/2010 Other Health Professional France
Primary
Secondary
Hemiparesis Life Threatening 12/30/2009 43 Female 6/17/2010 Other Health Professional France
Primary
Secondary
Hemiparesis Other Serious 13 Male 8/17/2010 Other Health Professional Belgium
Primary
Secondary
Stomatitis Other Serious 13 Male 9/6/2010 Belgium
Primary
Secondary
Concomitant
Poor Peripheral Circulation Other Serious 6/29/2010 69 Female 9/24/2010 Physician Germany
Primary
Concomitant
Hepatitis B Other Serious 57 Female 9/28/2010 Physician Turkey
Primary
Secondary
Pulmonary Embolism Hospitalization 9/16/2010 14 Female 10/6/2010 Other Health Professional France
Primary
Secondary
Pulmonary Embolism Hospitalization 11/4/2009 17 Male 10/14/2010 Other Health Professional France
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious 5/1/2008 27 Male 11/21/2010 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
Petechiae Death 6/15/2010 75 Male 153 lb 11/29/2010 Pharmacist United States
Primary
Secondary
Concomitant
Neutrophil Count Decreased Hospitalization 6/22/2010 8 Female 60 lb 12/2/2010 Physician United States
Primary
Secondary
Subclavian Vein Thrombosis Other Serious 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Neutropenia Other Serious 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Subclavian Vein Thrombosis Life Threatening 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Life Threatening 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Other Serious 7 Female 12/29/2010 Other Health Professional Germany
Primary
Secondary
Cholestasis Hospitalization 5/1/2008 14 Male 205 lb 1/11/2011 Other Health Professional France
Primary
Secondary
Concomitant
Fungal Infection Other Serious Male 2/15/2011 Other Health Professional Brazil
Primary
Secondary
Neurotoxicity Hospitalization 5 Female 2/17/2011 Other Health Professional Spain
Primary
Concomitant
Neurotoxicity Hospitalization 5 Female 2/17/2011 Other Health Professional Spain
Primary
Concomitant
Neurotoxicity Other Serious 5 Female 2/23/2011 Other Health Professional Spain
Primary
Secondary
Visual Impairment Other Serious 11 Male 3/15/2011 Other Health Professional Hong Kong
Primary
Secondary
Pleural Effusion Death 5 Male 3/18/2011 Other Health Professional Japan
Primary
Secondary
Posterior Reversible Encephalopathy Syndrome Other Serious 11 Male 3/22/2011 Physician Hong Kong
Primary
Secondary
Hypophosphataemia Other Serious 9 Female 3/7/2011 Other Health Professional France
Primary
Secondary
Concomitant
Anxiety Death 3/8/2011 15 Female 144 lb 3/23/2011 Physician United States
Primary
Secondary
Skin Erosion Death 12 Male 3/23/2011 Physician Japan
Primary
Secondary
Concomitant
Skin Erosion Death 12 Male 3/23/2011 Physician Japan
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Death 12 Male 3/23/2011 Physician Japan
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Death 12 Male 3/23/2011 Physician Japan
Primary
Secondary
Concomitant
Ileus Paralytic Death 12 Male 3/23/2011 Physician Japan
Primary
Secondary
Concomitant
Abdominal Pain Other Serious 6/25/2007 9 Female 3/15/2011 Other Health Professional France
Primary
Secondary
Concomitant
Cardiotoxicity Other Serious 17 Female 4/7/2011 Other Health Professional Germany
Primary
Secondary
Subclavian Vein Thrombosis Hospitalization 7 Female 3/31/2011 Physician Germany
Primary
Concomitant
Pancytopenia Hospitalization 2/21/2011 16 Female 4/11/2011 Physician Spain
Primary
Secondary
Concomitant
Posterior Reversible Encephalopathy Syndrome Other Serious 1/1/2010 11 Male 4/26/2011 Other Health Professional Hong Kong
Primary
Secondary
Precursor T-lymphoblastic Lymphoma/leukaemia Death 11 Male 4/26/2011 Other Health Professional Japan
Primary
Secondary
Encephalopathy Hospitalization 3/7/2011 30 Female 4/28/2011 Other Health Professional France
Primary
Secondary
Pancytopenia Hospitalization 2/21/2011 16 Female 4/18/2011 Physician Spain
Primary
Secondary
Concomitant
Subileus Other Serious 4/20/2011 4 37 lb 4/29/2011 Physician Netherlands
Primary
Secondary
Concomitant

Drug Data