Asparaginase combined with Cyclophosphamide

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Subarachnoid Haemorrhage Other Serious Female 1/30/2006 Other Health Professional France
Primary
Secondary
Respiratory Disorder Other Serious 17 Male 2/2/2006 Other Health Professional Ireland
Primary
Secondary
Therapy Non-responder Death Female 1/27/2006 United Kingdom
Primary
Secondary
Vomiting Death Female 1/31/2006 Other Health Professional United Kingdom
Primary
Secondary
Pseudobulbar Palsy Other Serious 17 Male 2/3/2006 Other Health Professional Ireland
Primary
Secondary
Concomitant
Peripheral Motor Neuropathy Other Serious 1/4/2006 5 Female 35 lb 2/3/2006 Physician United States
Primary
Secondary
Concomitant
Pseudobulbar Palsy Other Serious 17 Male 3/1/2006 Physician Ireland
Primary
Concomitant
Hepatotoxicity Other Serious 52 Male 1/19/2007 Other Health Professional Israel
Primary
Secondary
Concomitant
Hepatotoxicity Other Serious 47 Female 1/19/2007 Other Health Professional Israel
Primary
Secondary
Concomitant
Jaundice Cholestatic 52 Male 1/26/2007 Israel
Primary
Secondary
Concomitant
Hepatotoxicity 47 Female 1/26/2007 Israel
Primary
Secondary
Concomitant
Liver Disorder Other Serious 52 Male 2/7/2007 Israel
Primary
Secondary
Jaundice Cholestatic Other Serious 52 Male 2/23/2007
Primary
Secondary
Hepatotoxicity Other Serious 47 Female 2/23/2007
Primary
Secondary
Somnolence Other Serious 56 Female 3/2/2007
Primary
Secondary
Metastasis Death 11 Male 3/5/2007
Primary
Secondary
Metastasis Death 15 Female 3/5/2007
Primary
Secondary
Metastasis Death 13 Female 3/5/2007
Primary
Secondary
Metastasis Death 12 Male 3/5/2007
Primary
Secondary
Metastasis Death 15 Male 3/5/2007
Primary
Secondary
Glioma Other Serious 2 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Female 3/9/2007 Other Health Professional Finland
Primary
Secondary
Glioma Other Serious 4 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 3 Female 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 5 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 2 Female 3/9/2007 Other Health Professional Finland
Primary
Secondary
Glioma Other Serious 3 Female 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 4 Male 3/9/2007 Consumer Finland
Primary
Secondary
Glioma Other Serious 5 Male 3/12/2007 Consumer Finland
Primary
Secondary
Treatment Related Secondary Malignancy Death 11 Male 3/1/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 15 Male 3/1/2007 Germany
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Death 15 Female 3/1/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 12 Male 3/1/2007 Germany
Primary
Secondary
Glioma Death 13 Female 3/1/2007 Germany
Primary
Secondary
Concomitant
Treatment Related Secondary Malignancy Death 15 Male 3/16/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 15 Female 3/16/2007 Germany
Primary
Secondary
Treatment Related Secondary Malignancy Death 12 Male 3/16/2007 Germany
Primary
Secondary
Glioma Death 13 Female 3/20/2007 Germany
Primary
Secondary
Glioma Death 11 Male 3/20/2007 Germany
Primary
Secondary
Neoplasm Malignant Death 15 Female 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 13 Female 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 11 Male 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 15 Male 3/30/2007 Germany
Primary
Secondary
Concomitant
Neoplasm Malignant Death 12 Male 3/30/2007 Germany
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 3/4/2005 69 Male 5/18/2007 Switzerland
Primary
Secondary
Concomitant
Malignant Melanoma Other Serious 22 Male 6/8/2007 Other Health Professional United States
Primary
Secondary
Malignant Melanoma In Situ Other Serious 22 Male 6/12/2007
Primary
Secondary
Malignant Melanoma In Situ Other Serious Male 6/12/2007 United States
Primary
Secondary
Polyneuropathy Other Serious Female 6/22/2007
Primary
Secondary
Polyneuropathy Other Serious Male 6/22/2007
Primary
Secondary
Pleural Fibrosis Disability 2/1/1994 29 Male 79 lb 6/26/2007 Other Health Professional France
Primary
Secondary
Concomitant
Respiratory Tract Infection Viral Other Serious 8 Male 6/28/2007 Other Health Professional Australia
Primary
Secondary
Polyneuropathy Other Serious Female 7/5/2007
Primary
Secondary
Polyneuropathy Other Serious Male 7/5/2007
Primary
Secondary
Trichostasis Spinulosa Other Serious 6 Male 6/30/2007 Physician Australia
Primary
Secondary
Malignant Melanoma In Situ Other Serious Male 7/16/2007 United States
Primary
Secondary
Precocious Puberty Other Serious Female 9/14/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 21 Male 11/29/2007 Other Health Professional Greece
Primary
Secondary
Staphylococcal Infection Other Serious 21 Male 12/3/2007 Other Health Professional Greece
Primary
Secondary
Nervous System Disorder Death 12 Male 11/21/2007 Physician Germany
Primary
Secondary
Bacteraemia Hospitalization 54 Male 12/13/2007 Other Health Professional Saudi Arabia
Primary
Secondary
Wound Infection Pseudomonas Other Serious 21 Male 12/8/2007 Greece
Primary
Secondary
Concomitant
Bacteraemia Hospitalization 54 Male 12/18/2007 Other Health Professional Saudi Arabia
Primary
Secondary
Staphylococcal Infection Death 21 Male 12/5/2007 Physician Greece
Primary
Secondary
Concomitant
Multi-organ Failure Death 9/30/2007 Female 165 lb 12/21/2007 Physician France
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 21 Male 1/11/2008 Greece
Primary
Secondary
Concomitant
Ewing's Sarcoma Other Serious 16 Male 2/13/2008 Other Health Professional Japan
Primary
Secondary
Staphylococcal Infection Other Serious 21 Male 2/29/2008 Other Health Professional United States
Primary
Secondary
Stomatitis Other Serious 16 Male 5/24/2008 Physician Turkey
Primary
Secondary
Reversible Posterior Leukoencephalopathy Syndrome Hospitalization 4/20/2008 Female 6/3/2008 Other Health Professional France
Primary
Secondary
Calculus Urinary Other Serious 11 Male 6/25/2008 Other Health Professional Japan
Primary
Secondary
Calculus Urinary Other Serious 11 Male 6/30/2008 Other Health Professional Japan
Primary
Secondary
Subarachnoid Haemorrhage Death 0 Female 7/14/2008 United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/15/2008 United Kingdom
Primary
Secondary
Vomiting Other Serious 0 Female 7/17/2008 Consumer United States
Primary
Secondary
Subarachnoid Haemorrhage Death 0 Female 7/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/24/2008 Other Health Professional United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 7/28/2008 United Kingdom
Primary
Secondary
Promyelocyte Count Increased Life Threatening 54 Male 7/22/2008 Other Health Professional United Kingdom
Primary
Secondary
Leukaemia Other Serious 39 Female 8/5/2008 United States
Primary
Secondary
Guillain-barre Syndrome Other Serious 39 Female 8/5/2008 Other Health Professional United States
Primary
Secondary
Vomiting Other Serious 0 Female 8/12/2008 Consumer United States
Primary
Secondary
Stem Cell Transplant Death 39 Female 8/9/2008 United States
Primary
Secondary
Subarachnoid Haemorrhage Life Threatening 0 Female 8/11/2008 United Kingdom
Primary
Secondary
Chronic Myeloid Leukaemia Life Threatening 54 Male 8/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Subarachnoid Haemorrhage Death 0 Female 8/18/2008 Other Health Professional United Kingdom
Primary
Secondary
Hepatitis Cholestatic Hospitalization 2/18/2008 11 Male 8/26/2008 Other Health Professional Spain
Primary
Secondary
Cardiac Failure Congestive Other Serious Female 1/12/2009 Other Health Professional United States
Primary
Secondary
Gamma-glutamyltransferase Increased Hospitalization 12/21/2008 4 Male 44 lb 1/7/2009 Physician Germany
Primary
Secondary
Concomitant
Puncture Site Infection Hospitalization 12/21/2008 4 Male 44 lb 1/22/2009 Physician Germany
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 12/21/2008 4 Male 44 lb 2/2/2009 Physician Germany
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 10/24/2008 2 Male 27 lb 3/18/2009 Physician Japan
Primary
Concomitant
Febrile Neutropenia Other Serious 4/14/2009 Consumer United Kingdom
Primary
Secondary
Febrile Neutropenia Other Serious 4/27/2009 Consumer United Kingdom
Primary
Secondary
Respiratory Arrest Hospitalization 5 Male 5/18/2009 Physician Japan
Primary
Concomitant
Insulin-like Growth Factor Decreased Other Serious 12 Female 11/17/2009 Other Health Professional United States
Primary
Secondary
Epiphysiolysis Other Serious 15 Male 11/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Sepsis Other Serious 55 Female 12/17/2009 Consumer United Kingdom
Primary
Secondary
Pyrexia Hospitalization 9/26/2008 Male 198 lb 12/18/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Leukoencephalopathy Other Serious Male 1/4/2010 Other Health Professional Australia
Primary
Secondary
Leukoencephalopathy Other Serious 6 Male 1/5/2010 Other Health Professional Australia
Primary
Secondary
Leukoencephalopathy Other Serious 8 Male 1/14/2010 Other Health Professional Australia
Primary
Secondary
Hepatotoxicity Life Threatening 4/2/2009 Male 1/26/2010 Physician Italy
Primary
Secondary
Pulmonary Mycosis Life Threatening 5/26/2009 20 Female 2/1/2010 Physician Italy
Primary
Secondary
Concomitant
Pulmonary Mycosis Life Threatening 5/26/2009 Female 3/4/2010 Physician Italy
Primary
Secondary
Concomitant
Idiopathic Thrombocytopenic Purpura Hospitalization 7 Female 3/29/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Hemiparesis Life Threatening 12/30/2009 43 Female 6/17/2010 Other Health Professional France
Primary
Secondary
Hemiparesis Other Serious 13 Male 8/17/2010 Other Health Professional Belgium
Primary
Secondary
Stomatitis Other Serious 13 Male 9/6/2010 Belgium
Primary
Secondary
Concomitant
Hepatitis B Other Serious 57 Female 9/28/2010 Physician Turkey
Primary
Secondary
Pulmonary Fibrosis Other Serious 5/1/2008 27 Male 11/21/2010 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
Neutrophil Count Decreased Hospitalization 6/22/2010 8 Female 60 lb 12/2/2010 Physician United States
Primary
Secondary
Subclavian Vein Thrombosis Other Serious 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Neutropenia Other Serious 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Subclavian Vein Thrombosis Life Threatening 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Life Threatening 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Other Serious 7 Female 12/29/2010 Other Health Professional Germany
Primary
Secondary
Neurotoxicity Hospitalization 5 Female 2/17/2011 Other Health Professional Spain
Primary
Concomitant
Neurotoxicity Hospitalization 5 Female 2/17/2011 Other Health Professional Spain
Primary
Concomitant
Neurotoxicity Other Serious 5 Female 2/23/2011 Other Health Professional Spain
Primary
Secondary
Pleural Effusion Death 5 Male 3/18/2011 Other Health Professional Japan
Primary
Secondary
Anxiety Death 3/8/2011 15 Female 144 lb 3/23/2011 Physician United States
Primary
Secondary
Skin Erosion Death 12 Male 3/23/2011 Physician Japan
Primary
Secondary
Concomitant
Skin Erosion Death 12 Male 3/23/2011 Physician Japan
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Death 12 Male 3/23/2011 Physician Japan
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Death 12 Male 3/23/2011 Physician Japan
Primary
Secondary
Concomitant
Ileus Paralytic Death 12 Male 3/23/2011 Physician Japan
Primary
Secondary
Concomitant
Cardiotoxicity Other Serious 17 Female 4/7/2011 Other Health Professional Germany
Primary
Secondary
Subclavian Vein Thrombosis Hospitalization 7 Female 3/31/2011 Physician Germany
Primary
Concomitant
Precursor T-lymphoblastic Lymphoma/leukaemia Death 11 Male 4/26/2011 Other Health Professional Japan
Primary
Secondary
Encephalopathy Hospitalization 3/7/2011 30 Female 4/28/2011 Other Health Professional France
Primary
Secondary
Pleural Effusion Death 3/8/2011 15 Female 144 lb 5/24/2011 Physician United States
Primary
Secondary
Precursor T-lymphoblastic Lymphoma/leukaemia Death 11 Male 5/24/2011 Other Health Professional Japan
Primary
Secondary
Precursor T-lymphoblastic Lymphoma/leukaemia Death 3 Male 5/24/2011 Physician Japan
Primary
Secondary
Epstein-barr Virus Associated Lymphoproliferative Disorder Death 2/8/2010 45 Male 5/25/2011 Physician Belgium
Primary
Secondary
Concomitant
Anaphylactic Reaction Other Serious 12/2/2010 30 Female 165 lb 5/26/2011 Physician Germany
Primary
Secondary
Concomitant
Epstein-barr Virus Associated Lymphoproliferative Disorder Hospitalization 2/8/2010 45 Male 5/25/2011 Physician Belgium
Primary
Secondary
Concomitant
Affective Disorder Other Serious 14 Male 6/14/2011 Other Health Professional Turkey
Primary
Secondary
Bronchopulmonary Aspergillosis Death Female 6/15/2011 Physician United Kingdom
Primary
Secondary
Mania Hospitalization 14 Male 6/17/2011 Other Health Professional Turkey
Primary
Secondary
Pressure Of Speech Hospitalization 14 Male 6/21/2011 Physician Turkey
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Death 5/17/2011 57 Female 6/22/2011 Consumer United Kingdom
Primary
Secondary
Thrombocytopenia Hospitalization 6/30/2011 5 Female 31 lb 9/1/2011 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Colitis Hospitalization 8/19/2011 10 Male 71 lb 9/5/2011 Consumer United States
Primary
Secondary
Concomitant
Colitis Hospitalization 8/19/2011 10 Male 9/16/2011 Physician United States
Primary
Secondary
Concomitant
Hypotension Hospitalization 8/19/2011 10 Male 9/26/2011 Physician United States
Primary
Secondary
Concomitant
Hypotension Hospitalization 8/19/2011 10 Male 71 lb 10/10/2011 Consumer United States
Primary
Secondary
Concomitant
Hypotension Hospitalization 8/19/2011 10 Male 10/18/2011 Physician United States
Primary
Secondary
Concomitant
Nausea Hospitalization 7/31/2011 10 Male 71 lb 10/31/2011 Consumer United States
Primary
Secondary
Concomitant

Drug Data