Ascorbic Acid combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Breast Cancer Other Serious 11/17/2005 Female 175 lb 1/5/2006 Other Health Professional United States
Primary
Concomitant
Lymphoproliferative Disorder Hospitalization 10/20/2005 71 Male 1/11/2006 Other Health Professional Australia
Primary
Secondary
Concomitant
Basal Cell Carcinoma Other Serious 4/1/2005 Male 1/26/2006 Physician United States
Primary
Concomitant
Coronary Artery Disease Hospitalization 2/1/2005 Male 2/3/2006 Physician United States
Primary
Concomitant
Torsade De Pointes Life Threatening 3/31/2005 81 Female 153 lb 2/6/2006 Pharmacist United States
Primary
Concomitant
Disseminated Tuberculosis Other Serious 12/1/2004 Female 160 lb 2/13/2006 Physician United States
Primary
Secondary
Concomitant
Cutaneous Lupus Erythematosus Other Serious 7/1/2004 Female 2/24/2006 Physician United States
Primary
Concomitant
Coronary Artery Disease Hospitalization 2/5/2005 Male 3/1/2006 Physician United States
Primary
Concomitant
Lymphoproliferative Disorder Hospitalization 10/20/2005 71 Male 3/17/2006 Other Health Professional Australia
Primary
Secondary
Concomitant
Renal Failure Life Threatening 2/4/2006 66 Female 3/22/2006 Other Health Professional United Kingdom
Primary
Concomitant
Coronary Artery Disease Hospitalization 5/19/2003 Male 3/31/2006 Physician United States
Primary
Concomitant
Metastatic Neoplasm Other Serious 1/1/2006 Female 143 lb 3/31/2006 Other Health Professional United States
Primary
Concomitant
Mammogram Abnormal Other Serious 1/1/2006 46 Female 80 lb 3/28/2006 Other Health Professional United States
Primary
Concomitant
Staphylococcal Infection Hospitalization 12/1/2005 Female 4/24/2006 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 4/10/2006 62 Female 4/24/2006 Other Health Professional United States
Primary
Concomitant
Metastatic Neoplasm Other Serious 3/13/2006 Female 143 lb 4/26/2006 Other Health Professional United States
Primary
Concomitant
Ventricular Tachycardia Other Serious 3/1/2004 38 Female 4/19/2006 Other Health Professional United Kingdom
Primary
Concomitant
Pancreatic Carcinoma Death Female 5/15/2006 Physician United States
Primary
Concomitant
Gastroenteritis Hospitalization 4/10/2006 62 Female 5/16/2006 Other Health Professional United States
Primary
Concomitant
Septic Shock Life Threatening 3/1/2005 Female 180 lb 5/30/2006 Physician United States
Primary
Concomitant
Urticaria Other Serious 5/17/2006 63 Female 6/22/2006 Physician United States
Primary
Concomitant
Memory Impairment Other Serious 52 Male 6/30/2006
Primary
Secondary
Vasculitis Hospitalization 7/14/2004 Female 203 lb 7/21/2006 Other Health Professional United Kingdom
Primary
Concomitant
Vasculitis Hospitalization 7/14/2004 Female 203 lb 7/27/2006 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 12/1/2005 76 Female 7/13/2006 Consumer United States
Primary
Concomitant
Toothache Other Serious 5/26/2006 65 Female 7/12/2006 Consumer Canada
Primary
Concomitant
Basal Cell Carcinoma Other Serious 7/1/2005 Male 215 lb 7/31/2006 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Male 132 lb 7/31/2006 Consumer United States
Primary
Concomitant
Prothrombin Time Ratio Increased 1/1/2005 57 Female 201 lb 8/1/2006 Consumer United States
Primary
Concomitant
Fracture Other Serious 7/25/2006 Female 114 lb 9/11/2006 Other Health Professional United States
Primary
Concomitant
Pneumonia Hospitalization 7/22/2006 Female 130 lb 9/13/2006 Consumer Canada
Primary
Concomitant
Vision Blurred Male 9/14/2006 Other Health Professional United States
Primary
Secondary
Sepsis Other Serious Female 9/26/2006 Physician United States
Primary
Concomitant
Rheumatoid Arthritis Other Serious 5/17/2004 Female 9/26/2006 Physician United States
Primary
Concomitant
Death Other Serious Female 9/26/2006 Physician United States
Primary
Secondary
Concomitant
Increased Tendency To Bruise 6/7/2006 47 Female 139 lb 10/2/2006 Consumer United States
Primary
Concomitant
Staphylococcal Infection Hospitalization 12/1/2005 Female 10/3/2006 Physician United States
Primary
Concomitant
Cataract Other Serious 51 Male 270 lb 9/25/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Arthropathy Other Serious Female 149 lb 10/9/2006 Consumer Canada
Primary
Concomitant
Cataract Other Serious 51 Male 269 lb 11/1/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Osteonecrosis Required Intervention 8/2/2006 54 Female 202 lb 10/31/2006 Other Health Professional United States
Primary
Concomitant
Incorrect Dose Administered Other Serious 51 Male 270 lb 11/9/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Compression Fracture Other Serious 7/25/2006 Female 114 lb 11/18/2006 Other Health Professional United States
Primary
Concomitant
Vision Blurred Male 4/5/2006 Other Health Professional United States
Primary
Secondary
Vision Blurred Other Serious 51 Male 270 lb 10/23/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Fibrosis Death 4/9/1986 70 Male 12/6/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/11/2006 70 Male 12/6/2006 Consumer United States
Primary
Secondary
Concomitant
Carotid Endarterectomy Hospitalization 1/1/2006 Female 12/11/2006 Physician United States
Primary
Concomitant
Basal Cell Carcinoma Other Serious 6/1/2006 Female 126 lb 12/11/2006 Physician United States
Primary
Concomitant
Lower Respiratory Tract Infection 9/6/2006 75 Female 170 lb 12/22/2006 Consumer United States
Primary
Concomitant
Hodgkin's Disease Nodular Sclerosis Stage Iii Other Serious 7/28/2006 Female 108 lb 12/29/2006 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 7/25/2006 77 Female 122 lb 12/22/2006 Pharmacist United States
Primary
Concomitant
Pain Hospitalization 9/4/2006 Female 209 lb 1/8/2007 Consumer Canada
Primary
Concomitant
Oligodendroglioma Hospitalization 3/18/2005 66 Female 181 lb 1/12/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Osteonecrosis Required Intervention 8/2/2006 54 Female 202 lb 1/12/2007 Other Health Professional United States
Primary
Concomitant
Depression Hospitalization 9/4/2006 Female 209 lb 2/12/2007 Physician Canada
Primary
Concomitant
Malignant Melanoma Other Serious 7/1/2006 Male 3/1/2007 Physician United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/11/2006 70 Male 3/13/2007 Consumer United States
Primary
Secondary
Concomitant
Vertebral Injury Hospitalization 9/4/2006 Female 209 lb 3/16/2007 Physician Canada
Primary
Concomitant
Basal Cell Carcinoma Other Serious 1/1/2006 Male 3/27/2007 Physician United States
Primary
Concomitant
B-cell Lymphoma Hospitalization 8/25/2006 Female 3/27/2007 Physician United States
Primary
Concomitant
Fatigue 12/22/2006 39 Female 146 lb 3/27/2007 Consumer United States
Primary
Concomitant
Feeling Jittery 12/31/2006 43 Female 123 lb 3/27/2007 Consumer United States
Primary
Concomitant
Pancytopenia Required Intervention 9/27/2006 64 Female 3/16/2007 Pharmacist United States
Primary
Concomitant
Cataract Other Serious 51 Male 270 lb 1/5/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Nervous System Disorder Other Serious 1/1/2007 Female 150 lb 4/13/2007 Other Health Professional United States
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 6/11/2006 70 Male 5/10/2007 Consumer United States
Primary
Secondary
Concomitant
Resorption Bone Increased Hospitalization 2/9/2007 Male 160 lb 6/25/2007 United States
Primary
Concomitant
Resorption Bone Increased Hospitalization 2/9/2007 Male 160 lb 7/6/2007 United States
Primary
Concomitant
Vomiting Other Serious 3/31/2007 Female 7/13/2007 Other Health Professional Canada
Primary
Concomitant
Renal Failure Acute Other Serious 1/1/2007 83 Female 7/10/2007 Consumer United States
Primary
Concomitant
Fistula Other Serious 3/1/2007 Male 163 lb 8/14/2007 Physician Canada
Primary
Secondary
Concomitant
Cerebrovascular Accident Other Serious 12/5/2004 70 Female 7/9/2007 Consumer United States
Primary
Concomitant
Temperature Intolerance Other Serious 10/1/2006 Female 159 lb 8/20/2007 Other Health Professional Canada
Primary
Concomitant
Metastases To Central Nervous System Life Threatening 7/25/2007 Male 144 lb 8/21/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Metastases To Central Nervous System Other Serious 8/3/2007 Male 154 lb 8/27/2007 Other Health Professional United Kingdom
Primary
Concomitant
Osteonecrosis Other Serious 8/2/2006 Female 202 lb 9/7/2007 Physician United States
Primary
Concomitant
Genital Herpes 3/1/2007 64 Female 9/26/2007 Consumer United States
Primary
Concomitant
Musculoskeletal Stiffness Other Serious 7/19/2007 Female 10/2/2007 Physician United States
Primary
Concomitant
Musculoskeletal Stiffness Other Serious 7/19/2007 Female 10/12/2007 Physician United States
Primary
Concomitant
Tooth Disorder Hospitalization 45 Female 154 lb 10/17/2007 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 11/4/2005 Male 10/29/2007 Other Health Professional United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 5/4/2000 48 Female 154 lb 11/1/2007 Other Health Professional United States
Primary
Concomitant
Initial Insomnia 5/31/2007 59 Male 200 lb 11/8/2007 Consumer United States
Primary
Secondary
Concomitant
Thrombophlebitis Hospitalization 10/29/2007 53 Male 12/11/2007 Physician United States
Primary
Concomitant
Visual Acuity Reduced 9/1/2006 Female 12/11/2007 Consumer United States
Primary
Concomitant
Urinary Tract Infection 9/13/2007 Female 147 lb 12/14/2007 Physician United States
Primary
Concomitant
Rash 1/1/2005 Female 12/14/2007 Consumer United States
Primary
Secondary
Concomitant
Nasopharyngitis 11/7/2007 Female 155 lb 12/14/2007 United States
Primary
Concomitant
Skin Cancer Other Serious 11/2/2005 Female 132 lb 12/19/2007 Physician United Kingdom
Primary
Concomitant
Weight Decreased Hospitalization 5/4/2000 48 Female 154 lb 12/20/2007 Other Health Professional United States
Primary
Concomitant
Sinus Disorder 1/1/2006 57 Female 214 lb 12/21/2007 Consumer United States
Primary
Concomitant
Resorption Bone Increased Hospitalization 2/9/2007 Male 160 lb 1/4/2008 United States
Primary
Concomitant
Lymphoma Other Serious 3/1/2007 Male 1/23/2008 Physician United States
Primary
Concomitant
Weight Decreased Hospitalization 5/4/2000 48 Female 154 lb 1/24/2008 Other Health Professional United States
Primary
Concomitant
Cataract Other Serious 51 Male 270 lb 1/5/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 5/4/2000 48 Female 154 lb 2/4/2008 Other Health Professional United States
Primary
Concomitant
Staphylococcal Infection Hospitalization 9/10/2007 66 Female 202 lb 2/5/2008 Physician United States
Primary
Secondary
Stevens-johnson Syndrome Other Serious 9/27/2004 67 Male 2/8/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Tooth Extraction Other Serious 12/1/2000 74 Female 2/12/2008 United States
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 9/27/2004 67 Male 2/15/2008 Other Health Professional Germany
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 5/4/2000 48 Female 154 lb 2/18/2008 Other Health Professional United States
Primary
Concomitant
Staphylococcal Infection Hospitalization 9/10/2007 66 Female 202 lb 2/20/2008 Physician United States
Primary
Secondary
Lung Cancer Metastatic Other Serious 7/25/2007 Male 144 lb 2/22/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 9/10/2007 66 Female 202 lb 2/27/2008 Physician United States
Primary
Secondary
Stevens-johnson Syndrome Hospitalization 9/20/2004 67 Male 2/22/2008 Physician Germany
Primary
Secondary
Concomitant
Surgery Hospitalization 9/27/2004 29 Male 2/26/2008 Germany
Primary
Secondary
Concomitant
Tooth Disorder Hospitalization 45 Female 154 lb 3/6/2008 Other Health Professional United Kingdom
Primary
Concomitant
Vomiting In Pregnancy Hospitalization 2/17/2006 Female 184 lb 3/14/2008 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis 1/1/2008 Male 178 lb 3/15/2008 Physician United States
Primary
Concomitant
Injection Site Irritation 2/11/2008 Female 185 lb 3/15/2008 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/18/2008 74 Female 112 lb 3/18/2008 Physician
Primary
Concomitant
Knee Arthroplasty Other Serious 1/7/2008 24 Female 3/19/2008 Brazil
Primary
Concomitant
Weight Decreased Hospitalization 5/4/2000 48 Female 154 lb 3/21/2008 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/18/2008 74 Female 3/20/2008 Other Health Professional United Kingdom
Primary
Concomitant
Respiratory Syncytial Virus Infection Other Serious 4/1/2007 Female 3/27/2008 Physician United States
Primary
Concomitant
Urticaria Other Serious 12/21/2006 Female 179 lb 3/28/2008 Physician United States
Primary
Concomitant
Gastric Ulcer Hospitalization 12/20/2007 65 Female 99 lb 4/4/2008 Other Health Professional Korea, Republic Of
Primary
Concomitant
Poor Peripheral Circulation Hospitalization 1/9/2008 Female 133 lb 4/8/2008 Physician United States
Primary
Concomitant
Myocardial Infarction Other Serious 5/8/2007 Female 185 lb 4/14/2008 Consumer Canada
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 1/1/2007 Female 143 lb 4/23/2008 Consumer United States
Primary
Concomitant
Raynaud's Phenomenon 2/1/2006 54 Female 4/3/2007 Physician United States
Primary
Concomitant
B-cell Lymphoma Stage Iii Other Serious 1/1/2008 Female 232 lb 4/28/2008 Other Health Professional United States
Primary
Concomitant
Poor Peripheral Circulation Hospitalization 1/9/2008 Female 133 lb 5/8/2008 Physician United States
Primary
Concomitant
B-cell Lymphoma Stage Iii Other Serious 1/1/2008 Female 232 lb 5/12/2008 Physician United States
Primary
Concomitant
Vision Blurred Other Serious 10/1/2007 Female 125 lb 6/12/2008 Canada
Primary
Concomitant
Overdose 3/7/2008 Female 142 lb 6/12/2008 United States
Primary
Concomitant
Pneumonia Hospitalization 3/1/2007 Female 124 lb 6/12/2008 United States
Primary
Concomitant
Rash 3/31/2008 Female 331 lb 6/12/2008 United States
Primary
Concomitant
Headache 3/1/2008 Female 116 lb 6/12/2008 United States
Primary
Concomitant
Injection Site Haemorrhage Hospitalization 5/9/2008 Male 195 lb 6/13/2008 Consumer United States
Primary
Concomitant
Metastatic Carcinoid Tumour Hospitalization 9/26/2007 Female 193 lb 6/19/2008 United States
Primary
Concomitant
Vision Blurred Other Serious 10/1/2007 Female 125 lb 6/20/2008 Canada
Primary
Concomitant
Blood Pressure Decreased Other Serious 82 Female 236 lb 6/25/2008 Consumer United States
Primary
Concomitant
Paranasal Sinus Hypersecretion 1/1/2007 57 Female 214 lb 6/30/2008 Physician United States
Primary
Concomitant
Gastric Ulcer Hospitalization 12/20/2007 65 Female 99 lb 7/2/2008 Other Health Professional Korea, Republic Of
Primary
Concomitant
Resorption Bone Increased Hospitalization 2/9/2007 Male 160 lb 7/9/2008 United States
Primary
Concomitant
Weight Decreased Hospitalization 5/4/2000 48 Female 154 lb 7/24/2008 Other Health Professional United States
Primary
Concomitant
Interstitial Lung Disease Life Threatening 5/27/2008 Male 190 lb 7/28/2008 United States
Primary
Concomitant
Skin Disorder Hospitalization 6/12/2008 Female 168 lb 9/3/2008 Other Health Professional United States
Primary
Concomitant
Malignant Neoplasm Progression Death 3/21/2008 71 Male 9/8/2008 Physician Japan
Primary
Concomitant
Resorption Bone Increased Hospitalization 2/9/2007 Male 160 lb 9/11/2008 United States
Primary
Concomitant
Sinus Congestion 6/1/2008 Female 140 lb 9/12/2008 United States
Primary
Concomitant
Weight Decreased Female 105 lb 9/12/2008 Consumer United States
Primary
Concomitant
Myalgia 5/1/2008 Female 9/12/2008 United States
Primary
Concomitant
Hypoaesthesia 7/15/2008 Female 209 lb 9/12/2008 United States
Primary
Concomitant
Tachycardia 1/1/2005 Female 146 lb 9/12/2008 United States
Primary
Concomitant
Rheumatoid Arthritis 6/1/2008 Female 145 lb 9/12/2008 Consumer United States
Primary
Concomitant
Visual Acuity Reduced Female 185 lb 9/12/2008 Consumer United States
Primary
Concomitant
Procedural Complication 8/17/2008 Female 165 lb 9/13/2008 Consumer United States
Primary
Concomitant

Drug Data