Amphotericin B combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Malaise Hospitalization 10/15/2005 4 Female 1/5/2006 Other Health Professional France
Primary
Secondary
Concomitant
Visual Disturbance Hospitalization 10/15/2005 4 Female 2/14/2006 France
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 12/1/2004 74 Male 5/23/2006 Other Health Professional Czech Republic
Primary
Concomitant
Skin Lesion Other Serious 33 Female 6/12/2006 China
Primary
Secondary
Concomitant
Hospitalisation Other Serious 1/19/2006 Female 179 lb 11/20/2006 Other Health Professional United States
Primary
Concomitant
Venoocclusive Disease Other Serious 10/14/2006 11 Female 60 lb 11/30/2006 Physician Canada
Primary
Concomitant
Thrombocytopenia Other Serious 11/1/2005 Female 179 lb 12/12/2006 Other Health Professional United States
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 10/14/2006 11 Female 60 lb 1/4/2007 Physician Canada
Primary
Concomitant
Pyrexia Hospitalization 11/14/2005 Female 88 lb 1/19/2007 Physician United States
Primary
Secondary
Concomitant
Polyserositis Other Serious 10/15/2006 Female 104 lb 4/6/2007 Physician Switzerland
Primary
Secondary
Concomitant
Renal Tubular Disorder Death 7 Female 5/24/2007 Physician Italy
Primary
Secondary
Concomitant
Renal Tubular Disorder Other Serious 7 Female 5/30/2007 Physician Italy
Primary
Secondary
Concomitant
Pancreatitis Acute Other Serious 11/1/2004 9 Male 6/29/2007 Other Health Professional Taiwan, Province Of China
Primary
Secondary
Concomitant
Cerebellar Syndrome Death 5/21/2007 17 Male 7/24/2007 Other Health Professional France
Primary
Secondary
Concomitant
Renal Tubular Disorder Other Serious 7 Female 8/14/2007 Physician Italy
Primary
Secondary
Concomitant
Cerebellar Syndrome Death 5/21/2007 16 Male 8/21/2007 Other Health Professional France
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 8 Male 10/2/2007
Primary
Secondary
Concomitant
Tongue Disorder Other Serious 8 Male 10/17/2007 Other Health Professional United States
Primary
Concomitant
Stomatitis Other Serious 6 Male 12/23/2007 Japan
Primary
Concomitant
Stomatitis Other Serious 5/1/2007 6 Male 1/3/2008 Japan
Primary
Concomitant
Stomatitis Other Serious 36 Female 265 lb 1/8/2008
Primary
Secondary
Concomitant
Polyp Other Serious 8 Male 1/11/2008 United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 17 Male 1/18/2008 France
Primary
Secondary
Concomitant
Fungal Skin Infection Hospitalization 62 Male 2/28/2008
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 4/4/2008 Physician Germany
Primary
Concomitant
Pyrexia Other Serious 5/19/2008 Physician Germany
Primary
Concomitant
Pyrexia Other Serious 5/19/2008 Physician Germany
Primary
Concomitant
Pyrexia Other Serious 5/19/2008 Physician Germany
Primary
Concomitant
Pyrexia Other Serious 5/19/2008 Physician Germany
Primary
Concomitant
Virus Urine Test Positive Hospitalization 17 Male 6/5/2008
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Death 9 Female 7/3/2008
Primary
Secondary
Concomitant
Tuberculosis Other Serious 63 Female 7/31/2008
Primary
Secondary
Concomitant
Pancytopenia Life Threatening 1/31/2008 Male 8/6/2008 Physician Japan
Primary
Concomitant
Vomiting Hospitalization 13 Male 9/17/2008
Primary
Concomitant
Renal Impairment Other Serious 8/3/2007 24 Male 126 lb 10/20/2008 Consumer Japan
Primary
Secondary
Concomitant
Visual Acuity Reduced Other Serious 4/18/2008 Male 57 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Vision Blurred Hospitalization 12/14/2007 Male 52 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Visual Impairment Other Serious 4/21/2008 Male 36 lb 11/4/2008 Pharmacist Brazil
Primary
Concomitant
Drug Toxicity Other Serious 4 Female 11/21/2008
Primary
Secondary
Concomitant
Skin Nodule Other Serious 1/1/2006 36 Female 12/1/2008 Other Health Professional Germany
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 9/3/2007 33 Female 12/1/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/22/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/23/2008
Primary
Secondary
Concomitant
Stomatitis Other Serious 12/23/2008
Primary
Secondary
Concomitant
Visual Impairment Hospitalization 11/27/2008 Male 110 lb 12/26/2008 United States
Primary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 12/21/2008 4 Male 44 lb 1/7/2009 Physician Germany
Primary
Secondary
Concomitant
Puncture Site Infection Hospitalization 12/21/2008 4 Male 44 lb 1/22/2009 Physician Germany
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 12/21/2008 4 Male 44 lb 2/2/2009 Physician Germany
Primary
Secondary
Concomitant
Visual Impairment Hospitalization 11/27/2008 Male 110 lb 2/19/2009 Japan
Primary
Concomitant
Culture Positive Other Serious 52 Female 2/16/2009 Germany
Primary
Secondary
Concomitant
Pyrexia Other Serious 5 Male 3/13/2009 Other Health Professional Turkey
Primary
Secondary
Concomitant
Generalised Erythema Death 82 Female 84 lb 4/17/2009 Japan
Primary
Secondary
Concomitant
Systemic Mycosis Hospitalization 7/1/2006 50 Female 5/29/2009 Other Health Professional Italy
Primary
Secondary
Concomitant
Visual Impairment Hospitalization 11/27/2008 Male 110 lb 6/22/2009 Japan
Primary
Concomitant
Transaminases Increased Hospitalization 12/21/2008 4 Male 44 lb 6/26/2009 Physician Germany
Primary
Secondary
Concomitant
Visceral Leishmaniasis Hospitalization 55 Female 7/15/2009
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 60 Female 7/15/2009
Primary
Secondary
Concomitant
Pyrexia Required Intervention 16 Female 7/16/2009 Other Health Professional Turkey
Primary
Secondary
Concomitant
Renal Function Test Abnormal Hospitalization 6/9/2009 Male 150 lb 8/4/2009 Pharmacist Netherlands
Primary
Concomitant
Interacting
Pneumonia Other Serious 8/1/1997 31 Male 8/12/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Febrile Bone Marrow Aplasia Life Threatening 7/28/2009 Male 8/28/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Febrile Bone Marrow Aplasia Life Threatening 7/28/2009 Male 9/3/2009 Physician France
Primary
Secondary
Concomitant
Pancytopenia Life Threatening 1/31/2008 Male 9/10/2009 Japan
Primary
Concomitant
Sepsis Hospitalization 4/1/2006 63 Female 351 lb 9/4/2009 Germany
Primary
Concomitant
Visual Impairment Life Threatening 7/28/2009 Male 10/14/2009 Physician France
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 7/28/2009 Male 10/29/2009 Physician France
Primary
Secondary
Concomitant
Hemiplegia Other Serious 8/11/2009 16 Male 11/6/2009 Other Health Professional France
Primary
Secondary
Concomitant
Systemic Mycosis Hospitalization 7/1/2006 50 Female 11/24/2009 Other Health Professional Italy
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 7/28/2009 Male 12/1/2009 Physician France
Primary
Secondary
Concomitant
Stenotrophomonas Infection Other Serious 10/5/2006 35 Female 1/25/2010
Primary
Secondary
Concomitant
Tachypnoea Hospitalization 11/12/2009 Female 15 lb 1/12/2010 United States
Primary
Secondary
Concomitant
Renal Impairment Other Serious 8/3/2007 Male 126 lb 2/24/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Death 46 Male 3/17/2010 Physician United States
Primary
Secondary
Renal Impairment Life Threatening 1/31/2008 Male 3/19/2010 Japan
Primary
Concomitant
Interacting
Renal Failure Other Serious 40 Female 4/26/2010
Primary
Secondary
Concomitant
Pyrexia Other Serious 5 Male 5/28/2010 Other Health Professional Turkey
Primary
Secondary
Concomitant
Vaginal Lesion Hospitalization 4/14/2010 3 Female 43 lb 6/17/2010 United States
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 1/1/2009 61 Female 6/15/2010 Physician Germany
Primary
Secondary
Concomitant
Vomiting Hospitalization 4/4/2010 3 Female 43 lb 6/21/2010 United States
Primary
Secondary
Concomitant
Vomiting Life Threatening 6/18/2010 70 Male 115 lb 7/6/2010 Consumer United States
Primary
Secondary
Concomitant
Blood Potassium Decreased Other Serious 6/15/2006 63 Female 8/5/2010 Physician Japan
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 1/1/2009 59 Female 132 lb 8/23/2010 Consumer United States
Primary
Secondary
Concomitant
Urinary Incontinence Other Serious 6/1/2009 59 Female 132 lb 9/1/2010 Physician Germany
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 8/30/2010 Physician Italy
Primary
Concomitant
Unevaluable Event Other Serious Male 8/30/2010 Physician Italy
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 4/13/2009 4 Female 31 lb 9/9/2010 Physician Japan
Primary
Concomitant
Hepatitis B Surface Antigen Positive Required Intervention 57 Female 9/17/2010 Other Health Professional Turkey
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Other Serious 9/24/2010 Physician Iran (Islamic Republic Of)
Primary
Concomitant
Mucosal Inflammation Other Serious 9 Female 9/30/2010 Physician Italy
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 4/10/2009 4 Female 31 lb 10/8/2010 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 4/10/2009 4 Female 31 lb 10/11/2010 Physician Japan
Primary
Secondary
Concomitant
Pulmonary Embolism Hospitalization 11/4/2009 17 Male 10/14/2010 Other Health Professional France
Primary
Secondary
Concomitant
Neutropenic Sepsis Life Threatening 6/18/2010 70 Male 115 lb 10/27/2010 Consumer United States
Primary
Secondary
Concomitant
Thyroid Disorder Other Serious 7/17/2009 28 Male 110 lb 11/23/2010 Physician Japan
Primary
Concomitant
Pancytopenia Hospitalization 10/28/2009 7 Male 49 lb 12/7/2010 Physician Japan
Primary
Secondary
Concomitant
Reversible Posterior Leukoencephalopathy Syndrome Life Threatening 2/19/2010 7 Male 51 lb 12/13/2010 Physician Japan
Primary
Concomitant
Enterococcal Sepsis Death 11 Female 12/17/2010 Physician Italy
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 4/13/2009 4 Female 31 lb 12/20/2010 Physician Japan
Primary
Concomitant
Pancytopenia Death 11 Female 12/21/2010 United States
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Life Threatening 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Subclavian Vein Thrombosis Life Threatening 7 Female 12/22/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Graft Versus Host Disease Other Serious 11/26/2010 35 Male 110 lb 1/4/2011 Physician Japan
Primary
Concomitant
Therapeutic Response Decreased Other Serious 7/1/2009 48 Female 115 lb 1/6/2011 Physician Japan
Primary
Concomitant
Haemorrhage Death 4/13/2009 4 Female 31 lb 1/7/2011 Physician Japan
Primary
Concomitant
Blood Pressure Increased Other Serious 8/9/2009 48 Female 115 lb 1/10/2011 Physician Japan
Primary
Secondary
Concomitant
Adult T-cell Lymphoma/leukaemia Death Female 126 lb 1/13/2011 Physician Japan
Primary
Secondary
Concomitant
Fungal Sepsis Death 1/1/2007 63 Female 1/18/2011 Other Health Professional Japan
Primary
Concomitant
Renal Impairment Other Serious 2/1/2009 35 Female 1/21/2011 Other Health Professional Tunisia
Primary
Concomitant
Interacting
Staphylococcal Infection Hospitalization 9/10/2009 18 Male 137 lb 1/24/2011 Physician Japan
Primary
Concomitant
Sepsis Other Serious 9/10/2009 18 Male 137 lb 2/15/2011 Physician Japan
Primary
Concomitant
Hypotension Life Threatening 1/22/2011 2/22/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neutropenic Sepsis Death 6/18/2010 70 Male 115 lb 2/25/2011 Consumer United States
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 2/17/2009 35 Female 3/7/2011 Other Health Professional Tunisia
Primary
Secondary
Acanthamoeba Infection Other Serious 2 Male 3/1/2011 Other Health Professional Austria
Primary
Secondary
Concomitant
Acute Graft Versus Host Disease In Skin Other Serious 29 Male 3/18/2011 Physician Japan
Primary
Concomitant
Hypophosphataemia Other Serious 9 Female 3/7/2011 Other Health Professional France
Primary
Secondary
Concomitant
Cardiac Disorder Disability 1/19/2010 2 Female 22 lb 3/24/2011 Physician Japan
Primary
Secondary
Concomitant
Diffuse Large B-cell Lymphoma Other Serious 55 Male 3/18/2011 Physician Japan
Primary
Concomitant
Abdominal Pain Other Serious 6/25/2007 9 Female 3/15/2011 Other Health Professional France
Primary
Secondary
Concomitant
Engraftment Syndrome Other Serious 4/6/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Enteritis Other Serious 4/6/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Renal Impairment Hospitalization 35 Female 3/31/2011 Physician Tunisia
Primary
Concomitant
Enteritis Other Serious 4/20/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Epstein-barr Virus Infection Other Serious 4/20/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Cytomegalovirus Gastroenteritis Death 55 Male 4/20/2011 Physician Japan
Primary
Concomitant
Drug Ineffective Other Serious 63 Female 4/21/2011 Physician Japan
Primary
Secondary
Concomitant
Drug Ineffective Death 63 Female 4/21/2011 Physician Japan
Primary
Secondary
Concomitant
Bronchopulmonary Aspergillosis Hospitalization 8/6/2006 63 Female 4/25/2011 Physician Japan
Primary
Secondary
Concomitant
Abscess Bacterial Death 11/25/2009 61 Male 141 lb 4/25/2011 Physician Japan
Primary
Secondary
Concomitant
Pyrexia Death 54 Male 4/29/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pleural Effusion Hospitalization 11/8/2010 2 Male 31 lb 5/4/2011 Physician Japan
Primary
Concomitant
Anaphylactic Reaction Hospitalization 4/3/2010 16 Female 95 lb 5/4/2011 Physician Japan
Primary
Secondary
Concomitant
Venoocclusive Liver Disease Hospitalization 7/25/2010 12 Female 80 lb 5/13/2011 Physician Japan
Primary
Secondary
Concomitant
Off Label Use Death 54 Male 5/12/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Aspergillosis Other Serious 49 Male 5/23/2011 Physician Japan
Primary
Concomitant
General Physical Health Deterioration Life Threatening 6/18/2010 70 Male 116 lb 5/20/2011 Physician Germany
Primary
Secondary
Concomitant
Drug Ineffective Death 17 Male 6/7/2011 Other Health Professional Portugal
Primary
Secondary
Pulmonary Mycosis Other Serious 3/2/2010 63 Male 130 lb 6/7/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Haemorrhage Other Serious 1/1/2007 63 Female 6/30/2011 Other Health Professional Japan
Primary
Concomitant
Abscess Bacterial Hospitalization 11/25/2009 61 Male 141 lb 7/18/2011 Physician Japan
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Hospitalization 7/25/2010 12 Female 80 lb 7/19/2011 Physician Japan
Primary
Secondary
Concomitant
Cytomegalovirus Infection Other Serious 6/18/2010 39 Female 110 lb 7/22/2011 Physician Japan
Primary
Secondary
Concomitant

Drug Data