Amphotericin B combined with Itraconazole

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Venoocclusive Disease Life Threatening 11/23/2005 63 Female 121 lb 1/12/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Fungal Infection Life Threatening Female 3/8/2006 Physician France
Primary
Secondary
Concomitant
Respiratory Distress Other Serious 4/23/2005 50 Male 126 lb 4/25/2006 Pharmacist United States
Primary
Concomitant
Tracheal Haemorrhage Hospitalization 5/31/2006 69 Male 6/28/2006 Physician United States
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 5/15/2006 83 Female 9/13/2006 United States
Primary
Secondary
Concomitant
Pulmonary Toxicity Other Serious 53 Male 10/10/2006 Physician Netherlands
Primary
Secondary
Concomitant
Neutropenia Other Serious 5/15/2006 83 Female 2/26/2007 Japan
Primary
Secondary
Concomitant
Pneumonia Other Serious 5/15/2006 83 Female 3/19/2007 Japan
Primary
Secondary
Concomitant
Sepsis Life Threatening 4/27/2006 Female 99 lb 4/13/2007 Korea, Republic Of
Primary
Concomitant
Pneumonia Other Serious 5/15/2006 83 Female 4/13/2007 Japan
Primary
Secondary
Concomitant
Death Death 30 Female 5/25/2007 Physician Australia
Primary
Secondary
Pyrexia Life Threatening 4/29/2007 61 5/29/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Death Death 30 Female 6/4/2007 Physician Australia
Primary
Secondary
Pneumonia Other Serious 11/7/2006 30 Male 6/19/2007 Korea, Republic Of
Primary
Concomitant
Pneumonia Other Serious 5/15/2006 83 Female 6/21/2007 United States
Primary
Secondary
Concomitant
Pseudomembranous Colitis Other Serious 11/17/2006 45 Male 6/25/2007 Japan
Primary
Secondary
Concomitant
Death Hospitalization 15 Female 7/9/2007 Physician Turkey
Primary
Concomitant
Haemoptysis Hospitalization 35 Male 7/20/2007 Physician Japan
Primary
Secondary
Neurological Symptom Hospitalization 58 Male 8/9/2007 Other Health Professional France
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Neurological Symptom Hospitalization 58 Male 9/27/2007 Other Health Professional France
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Other Serious 1/1/1997 43 Male 9/18/2007 Italy
Primary
Secondary
Venous Occlusion Hospitalization 52 Female 9/28/2007 United States
Primary
Concomitant
Transplant Failure Hospitalization 44 Male 9/28/2007 United States
Primary
Concomitant
Transplant Failure Hospitalization 44 Male 9/28/2007 United States
Primary
Concomitant
Stomatitis Other Serious 2/23/2007 63 Male 10/22/2007 Physician Japan
Primary
Concomitant
Drug Resistance Other Serious 51 Male 107 lb 11/6/2007 United Kingdom
Primary
Secondary
Concomitant
Prothrombin Time Prolonged Hospitalization 10/1/2007 54 Female 171 lb 11/6/2007 Physician United States
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Hospitalization 10/1/2007 54 Female 171 lb 11/19/2007 Physician United States
Primary
Secondary
Concomitant
Treatment Noncompliance Hospitalization 22 Male 1/3/2008 Physician United States
Primary
Concomitant
Drug Interaction Other Serious 42 Male 1/18/2008 Other Health Professional United States
Primary
Concomitant
Interacting
Creatinine Renal Clearance Decreased Other Serious 53 Female 1/16/2008 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 2/20/2007 63 Male 3/31/2008 Physician Japan
Primary
Concomitant
Oxygen Saturation Decreased Other Serious 11/17/2006 29 Male 4/15/2008 Consumer Chile
Primary
Secondary
Renal Tubular Disorder Hospitalization 8 Male 37 lb 4/23/2008 Other Health Professional France
Primary
Secondary
Neuropathy Peripheral Disability 34 Female 194 lb 4/25/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neuropathy Peripheral Disability 34 Female 194 lb 4/30/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Neuropathy Peripheral Disability 34 Female 194 lb 5/23/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urinary Incontinence Hospitalization 45 Male 6/6/2008
Primary
Secondary
Concomitant
Death Death 6/9/2008 Other Health Professional Brazil
Primary
Secondary
Haemoptysis Life Threatening 23 Male 6/12/2008 Physician Czech Republic
Primary
Concomitant
Urinary Incontinence Hospitalization 45 Male 6/18/2008
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 6/24/2008 66 Male 7/24/2008 Physician China
Primary
Concomitant
Respiratory Failure Life Threatening 6/24/2008 66 Male 7/25/2008 Physician China
Primary
Concomitant
Respiratory Failure Life Threatening 6/24/2008 66 Male 7/28/2008 Physician China
Primary
Concomitant
Respiratory Failure Life Threatening 6/24/2008 66 Male 7/30/2008 Physician China
Primary
Secondary
Concomitant
Visual Acuity Reduced Hospitalization 24 Female 7/31/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Ineffective Hospitalization 49 Female 8/4/2008 Physician Korea, Republic Of
Primary
Concomitant
Drug Ineffective Hospitalization 49 Female 8/7/2008 Physician Korea, Republic Of
Primary
Concomitant
Cardiac Failure Hospitalization 5/13/2008 87 Male 332 lb 8/8/2008 Physician Japan
Primary
Secondary
Septic Embolus Hospitalization 24 Female 8/25/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Sepsis Hospitalization 24 Female 8/22/2008 United Kingdom
Primary
Secondary
Concomitant
Visual Acuity Reduced Hospitalization 24 Female 8/23/2008 United Kingdom
Primary
Secondary
Concomitant
Neutropenia Hospitalization 1/1/2003 41 Male 10/14/2008 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Supraventricular Tachycardia Hospitalization 1/1/2003 41 Male 121 lb 10/20/2008 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Pneumonia Cryptococcal Hospitalization 24 Male 10/21/2008 Other Health Professional Japan
Primary
Secondary
Drug Resistance Other Serious 55 Male 10/21/2008 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 55 Male 10/22/2008 Other Health Professional United States
Primary
Concomitant
Ventricular Dysfunction Hospitalization 1/1/2003 41 Male 10/24/2008 United Kingdom
Primary
Concomitant
Interacting
Pneumonia Cryptococcal Hospitalization 24 Male 10/30/2008 Other Health Professional Japan
Primary
Secondary
Pleurisy Other Serious 24 Male 11/3/2008 Japan
Primary
Concomitant
Pyrexia Other Serious 2/9/2007 Male 11/3/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 2/9/2007 Male 11/4/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Venous Thrombosis Other Serious 11 Male 11/17/2008 Germany
Primary
Secondary
Concomitant
Ventricular Dysfunction Hospitalization 1/1/2003 41 Male 11/28/2008 United Kingdom
Primary
Concomitant
Interacting
White Blood Cell Count Decreased Other Serious 9/3/2007 33 Female 12/1/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Meningitis Cryptococcal Other Serious 6/1/2008 53 Male 12/12/2008 United States
Primary
Secondary
Concomitant
Meningitis Cryptococcal Death 6/1/2008 53 Male 12/15/2008 Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 24 Male 12/18/2008
Primary
Secondary
Concomitant
Ventricular Dysfunction Hospitalization 1/1/2003 1/12/2009 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Subcutaneous Nodule Other Serious 49 Female 1/26/2009
Primary
Secondary
Concomitant
Culture Positive Other Serious 52 Female 2/16/2009 Germany
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/16/2009 46 Male 3/3/2009 Physician Japan
Primary
Secondary
Concomitant
Weight Increased Other Serious 1/16/2009 46 Male 2/27/2009 Physician Japan
Primary
Secondary
Concomitant
Ventricular Failure Hospitalization 1/1/2003 3/13/2009 United Kingdom
Primary
Concomitant
Interacting
Road Traffic Accident Life Threatening 35 Male 3/19/2009 Other Health Professional Korea, Republic Of
Primary
Secondary
Neutropenia Hospitalization 1/1/2003 41 Male 4/17/2009 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Sinusitis Aspergillus Other Serious 17 Male 4/22/2009 Other Health Professional Brazil
Primary
Secondary
Transplant Rejection Other Serious 1 Male 4/24/2009 Other Health Professional United States
Primary
Secondary
Neutropenia Hospitalization 1/1/2003 41 Male 4/24/2009 Other Health Professional United Kingdom
Primary
Concomitant
Interacting
Sepsis Other Serious 24 Female 4/24/2009 Other Health Professional United Kingdom
Primary
Secondary
Immune Reconstitution Syndrome Other Serious 33 Male 5/8/2009
Primary
Secondary
Concomitant
Fungal Endocarditis Death 19 5/8/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Fungal Endocarditis Death 19 5/18/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Fungal Endocarditis Death 19 6/2/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Shock Haemorrhagic Other Serious 1/1/2009 54 Male 6/19/2009 Physician Japan
Primary
Secondary
Concomitant
Respiratory Distress Life Threatening 15 Female 7/14/2009 Other Health Professional Turkey
Primary
Secondary
Pulmonary Function Test Decreased Other Serious 48 Male 7/15/2009 Other Health Professional Denmark
Primary
Secondary
Visual Impairment Other Serious 67 Female 7/16/2009 Other Health Professional United States
Primary
Concomitant
Aspergillosis Hospitalization 65 Female 7/16/2009 Other Health Professional Japan
Primary
Concomitant
Pyrexia Required Intervention 16 Female 7/16/2009 Other Health Professional Turkey
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 81 Male 7/24/2009 Other Health Professional United States
Primary
Secondary
Meningitis Cryptococcal Other Serious 5/1/2007 Male 7/29/2009 United States
Primary
Secondary
Concomitant
Meningitis Cryptococcal Other Serious 5/1/2007 Male 9/11/2009 United States
Primary
Secondary
Concomitant
Fungal Infection Death 9/28/2009 Physician Canada
Primary
Concomitant
Cytomegalovirus Infection Other Serious 55 Male 10/26/2009 Other Health Professional Germany
Primary
Secondary
Cytomegalovirus Infection Other Serious 58 Female 10/26/2009 Other Health Professional Germany
Primary
Secondary
Cytomegalovirus Infection Other Serious 41 Male 10/26/2009 Other Health Professional Germany
Primary
Secondary
Aspergillosis Death 60 Male 10/26/2009 Other Health Professional Germany
Primary
Secondary
Aspergillosis Death 41 Male 10/26/2009 Other Health Professional Germany
Primary
Secondary
Cytomegalovirus Infection Other Serious 44 Male 10/26/2009 Other Health Professional Germany
Primary
Secondary
Aspergillosis Death 61 Male 10/26/2009 Other Health Professional Germany
Primary
Secondary
Cytomegalovirus Infection Other Serious 47 Male 10/26/2009 Other Health Professional Germany
Primary
Secondary
Aspergillosis Death 60 Male 10/26/2009 Other Health Professional Germany
Primary
Secondary
Aspergillosis Death 63 Male 10/26/2009 Other Health Professional Germany
Primary
Secondary
Cytomegalovirus Infection Other Serious 61 Male 10/26/2009 Other Health Professional Germany
Primary
Secondary
Cytomegalovirus Infection Other Serious 61 Female 10/26/2009 Other Health Professional Germany
Primary
Secondary
Aspergillosis Death 57 Male 10/27/2009 Other Health Professional Germany
Primary
Secondary
Weight Decreased Life Threatening 7/5/2005 Male 143 lb 1/26/2010 Physician United Kingdom
Primary
Secondary
Septic Embolus Other Serious 24 Female 1/27/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sepsis Other Serious 24 Female 1/29/2010 Other Health Professional United Kingdom
Primary
Secondary
Swelling Face Life Threatening 7/1/2008 67 Male 143 lb 2/1/2010 Consumer United Kingdom
Primary
Secondary
Sepsis Death 24 Female 2/8/2010 United Kingdom
Primary
Secondary
Weight Decreased Life Threatening 7/9/2008 67 Male 1/29/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 4/20/2009 25 Male 126 lb 2/9/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Meningeal Disorder Hospitalization 33 Female 2/26/2010 Physician Spain
Primary
Concomitant
Interacting
Tremor Other Serious 67 Male 3/24/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tremor Other Serious 67 Male 4/1/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Tremor Other Serious 67 Male 4/26/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Ineffective Death 20 Male 5/12/2010 Other Health Professional Mexico
Primary
Secondary
Drug Interaction Death 25 Male 5/12/2010 Other Health Professional Mayotte
Primary
Secondary
Drug Ineffective Death 32 Male 5/12/2010 Other Health Professional Mexico
Primary
Secondary
Drug Ineffective Death 29 Male 5/12/2010 Other Health Professional Mayotte
Primary
Secondary
Drug Ineffective Death 28 Male 5/12/2010 Other Health Professional Mayotte
Primary
Secondary
Drug Ineffective Death 30 Male 5/12/2010 Other Health Professional Mayotte
Primary
Secondary
Drug Ineffective Death 40 Male 5/12/2010 Other Health Professional Mexico
Primary
Secondary
Drug Ineffective Death 25 Male 5/12/2010 Other Health Professional Mexico
Primary
Secondary
Drug Ineffective Death 16 Female 5/12/2010 Physician Japan
Primary
Secondary
Drug Ineffective Death 17 Male 5/12/2010 Physician Japan
Primary
Secondary
Hypopyon Hospitalization 48 Female 5/17/2010 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Drug Ineffective Death 67 Female 6/8/2010 Other Health Professional China
Primary
Secondary
General Physical Health Deterioration Other Serious 14 Male 6/9/2010 Other Health Professional Brazil
Primary
Concomitant
Drug Ineffective Death 40 Female 6/9/2010 Other Health Professional China
Primary
Secondary
Drug Ineffective Death 40 Male 6/9/2010 Other Health Professional China
Primary
Secondary
Weight Decreased Hospitalization 5/1/2007 14 Male 7/15/2010 Other Health Professional Brazil
Primary
Secondary
Pyrexia Hospitalization 12 Male 7/15/2010 Other Health Professional Brazil
Primary
Secondary
Paradoxical Drug Reaction Other Serious 14 Male 7/19/2010 Other Health Professional Brazil
Primary
Secondary
Paradoxical Drug Reaction Other Serious 12 Male 7/19/2010 Other Health Professional Brazil
Primary
Secondary
Respiratory Failure Death 74 Male 7/30/2010 Other Health Professional Italy
Primary
Concomitant
Nodal Rhythm Other Serious 48 Male 8/2/2010 Physician United States
Primary
Interacting
Respiratory Failure Death 74 Male 8/5/2010 Other Health Professional Italy
Primary
Concomitant
Paradoxical Drug Reaction Other Serious 1/1/2007 14 Male 8/5/2010 Other Health Professional Brazil
Primary
Secondary
Paradoxical Drug Reaction Hospitalization 4/1/2007 12 Male 8/5/2010 Other Health Professional Brazil
Primary
Secondary
Visual Acuity Reduced Other Serious 74 Male 8/19/2010 Physician United States
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 7/7/2010 64 Male 117 lb 9/3/2010 Physician Japan
Primary
Concomitant
Multi-organ Failure Hospitalization 6/24/2009 15 Male 126 lb 9/23/2010 Physician Japan
Primary
Concomitant
Weight Decreased Hospitalization 5/1/2007 14 Male 9/22/2010 Brazil
Primary
Secondary
Thrombotic Microangiopathy Death 9/21/2009 62 Female 126 lb 11/3/2010 Physician Japan
Primary
Concomitant
Multi-organ Failure Hospitalization 6/24/2009 15 Male 126 lb 11/23/2010 Physician Japan
Primary
Concomitant
Drug Ineffective Death Female 12/21/2010 Other Health Professional China
Primary
Secondary
Concomitant

Drug Data