Amphotericin B combined with Fluconazole

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Venoocclusive Disease Life Threatening 11/23/2005 63 Female 121 lb 1/12/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hypercalcaemia 12/19/2005 65 Male 1/16/2006 United Kingdom
Primary
Concomitant
Weight Increased Other Serious 10/1/2005 59 Male 198 lb 1/24/2006 Pharmacist Spain
Primary
Concomitant
Therapy Non-responder Death 32 Male 1/19/2006 Physician United States
Primary
Secondary
Vomiting Hospitalization 32 Female 2/2/2006 Consumer Italy
Primary
Secondary
Concomitant
Pyrexia Other Serious 43 Male 2/2/2006 Consumer Italy
Primary
Secondary
Concomitant
Vomiting Hospitalization 32 Female 2/3/2006 Consumer Italy
Primary
Secondary
Concomitant
Pyrexia Other Serious 43 Male 2/3/2006 Consumer Italy
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 30 Male 1/4/2006 Physician United States
Primary
Concomitant
Venoocclusive Liver Disease Life Threatening 7/5/2001 34 Male 2/8/2006 United Kingdom
Primary
Concomitant
Tracheostomy Other Serious 65 Male 2/15/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Pyrexia Other Serious 1/1/1998 Male 154 lb 4/17/2006 Physician Germany
Primary
Secondary
Concomitant
Stomatitis Hospitalization 2/26/2006 51 Male 4/20/2006 Other Health Professional France
Primary
Concomitant
Febrile Neutropenia Other Serious 10 Male 6/9/2006 Other Health Professional Germany
Primary
Secondary
Concomitant
Torsade De Pointes Life Threatening 55 Female 6/16/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Pneumatosis Intestinalis Hospitalization 10 Male 6/15/2006 Germany
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 6/15/2006 6/28/2006 Physician United States
Primary
Secondary
Concomitant
White Blood Cell Count Increased Life Threatening 55 Female 7/7/2006 Other Health Professional Japan
Primary
Secondary
Concomitant
Vein Disorder Life Threatening 4/20/2006 53 Male 121 lb 7/20/2006 Physician France
Primary
Concomitant
Ventricular Tachycardia Life Threatening 8/7/2005 64 Male 7/28/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Febrile Neutropenia Other Serious 5/15/2006 83 Female 9/13/2006 United States
Primary
Secondary
Concomitant
Prescribed Overdose Hospitalization 27 Male 10/2/2006 Physician Germany
Primary
Secondary
Concomitant
Hypotension Other Serious 9/7/2006 0 Female 9/26/2006 Physician Panama
Primary
Concomitant
Sepsis Other Serious 9/7/2006 0 Female 10/6/2006 Panama
Primary
Secondary
Concomitant
Sepsis Other Serious 9/7/2006 0 Female 10/9/2006 Panama
Primary
Secondary
Concomitant
Transplant Rejection Hospitalization 8/1/2004 10 Female 10/19/2006 Germany
Primary
Concomitant
Immune Reconstitution Syndrome Death 65 Male 11/7/2006 Physician United States
Primary
Secondary
Concomitant
Pneumatosis Intestinalis Other Serious 10 Male 11/21/2006 United States
Primary
Secondary
Concomitant
Venoocclusive Disease Other Serious 10/14/2006 11 Female 60 lb 11/30/2006 Physician Canada
Primary
Concomitant
Red Blood Cell Count Decreased Life Threatening 1/1/2005 Male 110 lb 12/28/2006 Japan
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 10/14/2006 11 Female 60 lb 1/4/2007 Physician Canada
Primary
Concomitant
Transaminases Increased Other Serious 11/10/2005 5 Female 2/8/2007 Spain
Primary
Secondary
Concomitant
Conjunctivitis Hospitalization 1/5/2007 65 Male 2/12/2007 Germany
Primary
Secondary
Concomitant
Neutropenia Other Serious 5/15/2006 83 Female 2/26/2007 Japan
Primary
Secondary
Concomitant
Platelet Count Decreased Hospitalization 9/10/2005 Male 110 lb 3/16/2007 Japan
Primary
Concomitant
Neurotoxicity Other Serious 56 Female 3/22/2007 United States
Primary
Concomitant
Interacting
Conjunctivitis Hospitalization 1/5/2007 65 Male 3/13/2007 Germany
Primary
Secondary
Concomitant
Pneumonia Other Serious 5/15/2006 83 Female 3/19/2007 Japan
Primary
Secondary
Concomitant
Conjunctivitis Viral Hospitalization 1/5/2007 65 Male 3/26/2007 Germany
Primary
Secondary
Concomitant
Post Procedural Bile Leak Life Threatening 7/5/2004 51 Male 4/13/2007 Physician Norway
Primary
Secondary
Concomitant
Pneumonia Other Serious 5/15/2006 83 Female 4/13/2007 Japan
Primary
Secondary
Concomitant
Post Procedural Bile Leak Life Threatening 7/5/2004 51 Male 4/30/2007 Physician Norway
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 0 Male 4 lb 4/27/2007 United States
Primary
Secondary
Concomitant
Renal Cell Carcinoma Stage Unspecified Other Serious 5/31/2007 Pharmacist Canada
Primary
Secondary
Renal Cell Carcinoma Stage Unspecified Other Serious 5/31/2007 Pharmacist Canada
Primary
Secondary
Pneumonia Other Serious 5/15/2006 83 Female 6/21/2007 United States
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 9/19/2006 Male 7/5/2007 Physician Japan
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 9/19/2006 Male 8/2/2007 Physician Japan
Primary
Secondary
Concomitant
Vasculitis Hospitalization 3/1/2005 47 Female 7/30/2007 Physician Japan
Primary
Secondary
Concomitant
Drug Interaction Other Serious 4 Male 8/3/2007 Canada
Primary
Secondary
Concomitant
Leukoencephalopathy Hospitalization 12/5/2006 70 Female 9/6/2007 Physician Japan
Primary
Secondary
Concomitant
Vomiting Other Serious 4 Male 9/1/2007 Other Health Professional Canada
Primary
Secondary
Concomitant
Staphylococcal Infection Other Serious 12/4/2006 Male 9/18/2007 Physician United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 7/24/2007 51 Male 9/24/2007 United States
Primary
Secondary
Concomitant
Venous Occlusion Hospitalization 52 Female 9/28/2007 United States
Primary
Concomitant
Multi-organ Failure Hospitalization 63 Female 9/28/2007 United States
Primary
Concomitant
Multi-organ Failure Hospitalization 30 Male 9/28/2007 United States
Primary
Concomitant
Sepsis Death 5/1/2004 42 Female 10/8/2007 Other Health Professional Malaysia
Primary
Concomitant
Sepsis Death 5/1/2004 42 Female 10/12/2007 Other Health Professional Malaysia
Primary
Concomitant
Renal Impairment Hospitalization 84 Female 10/16/2007
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 36 Male 10/23/2007 Physician Italy
Primary
Secondary
Concomitant
Stomatitis Other Serious 7/24/2007 51 Male 11/2/2007 Japan
Primary
Secondary
Concomitant
Staphylococcal Bacteraemia Life Threatening 10/7/2007 14 Male 203 lb 11/8/2007 Physician United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 7/23/2007 Male 139 lb 11/7/2007 United States
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Other Serious 49 Male 11/21/2007 Other Health Professional France
Primary
Secondary
Staphylococcal Infection Other Serious 12/4/2006 Male 11/21/2007 Physician United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 49 Male 11/26/2007
Primary
Secondary
Concomitant
Respiratory Failure Life Threatening 9/17/2007 61 11/23/2007 Physician Netherlands
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/23/2007 Male 139 lb 11/28/2007 United States
Primary
Secondary
Concomitant
Stomatitis Other Serious 7/24/2007 51 Male 12/13/2007 United States
Primary
Secondary
Concomitant
Sepsis Hospitalization 49 Male 12/14/2007 Physician France
Primary
Secondary
Concomitant
Stomatitis Other Serious 36 Female 265 lb 1/8/2008
Primary
Secondary
Concomitant
Subcutaneous Abscess Other Serious 52 Male 1/16/2008
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Other Serious 40 Male 1/14/2008 Physician Portugal
Primary
Concomitant
Staphylococcal Infection Other Serious 12/4/2006 Male 1/28/2008 Physician United States
Primary
Secondary
Concomitant
Hepatitis Cholestatic Hospitalization 6/4/2007 0 Female 2/4/2008 Other Health Professional Spain
Primary
Concomitant
Immune Reconstitution Syndrome Hospitalization 1/1/2006 49 Male 1/30/2008 Other Health Professional France
Primary
Secondary
Sepsis Death 1/25/2006 Female 143 lb 3/10/2008 Germany
Primary
Secondary
Concomitant
Swollen Tongue Death 11/4/2004 Female 3/14/2008 Germany
Primary
Secondary
Concomitant
Visual Disturbance Other Serious 1/24/2008 Male 121 lb 3/31/2008 Physician Australia
Primary
Concomitant
Venoocclusive Disease Hospitalization 2 Male 3/31/2008
Primary
Secondary
Concomitant
Myocarditis Other Serious 12/1/2007 Female 1 lb 4/10/2008 Other Health Professional Sweden
Primary
Concomitant
Death Death 52 Male 4/2/2008 Germany
Primary
Concomitant
Sinus Bradycardia Required Intervention 12/19/2000 52 Male 170 lb 4/2/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Swollen Tongue Death 11/4/2004 Female 4/18/2008 Germany
Primary
Secondary
Concomitant
Ventricular Fibrillation Death 68 Female 4/21/2008 Australia
Primary
Concomitant
Ventricular Fibrillation Other Serious 68 Female 5/8/2008 Australia
Primary
Secondary
Concomitant
Ventricular Fibrillation Death 68 Female 6/2/2008
Primary
Secondary
Concomitant
Death Death 6/9/2008 Other Health Professional Brazil
Primary
Secondary
Drug Level Increased Other Serious 19 Female 7/11/2008 Other Health Professional United States
Primary
Secondary
Myocarditis Other Serious 12/1/2007 Female 1 lb 7/17/2008 Other Health Professional Sweden
Primary
Concomitant
Respiratory Failure Life Threatening 6/24/2008 66 Male 7/24/2008 Physician China
Primary
Concomitant
Respiratory Failure Life Threatening 6/24/2008 66 Male 7/25/2008 Physician China
Primary
Concomitant
Respiratory Failure Life Threatening 6/24/2008 66 Male 7/28/2008 Physician China
Primary
Concomitant
Withdrawal Syndrome Hospitalization 16 Female 106 lb 7/28/2008 Poland
Primary
Concomitant
Withdrawal Syndrome Hospitalization 16 Female 106 lb 7/30/2008 Poland
Primary
Concomitant
Respiratory Failure Life Threatening 6/24/2008 66 Male 7/30/2008 Physician China
Primary
Secondary
Concomitant
Withdrawal Syndrome Hospitalization 16 Female 106 lb 8/1/2008 Poland
Primary
Concomitant
Drug Ineffective Hospitalization 49 Female 8/4/2008 Physician Korea, Republic Of
Primary
Concomitant
Drug Ineffective Hospitalization 49 Female 8/7/2008 Physician Korea, Republic Of
Primary
Concomitant
Staphylococcal Sepsis Other Serious 12/4/2006 Male 8/11/2008 Physician United States
Primary
Secondary
Concomitant
Withdrawal Syndrome Hospitalization 16 Female 106 lb 8/22/2008 Poland
Primary
Concomitant
Pyrexia Hospitalization 8/21/2008 Female 118 lb 8/22/2008 United States
Primary
Secondary
Concomitant
Sudden Death Other Serious 8/6/2008 Female 118 lb 8/26/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Wound Dehiscence Hospitalization 49 Male 9/9/2008 Other Health Professional United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 8/21/2008 Female 118 lb 9/8/2008 United States
Primary
Secondary
Concomitant
Pneumonitis Other Serious 8/6/2008 Female 118 lb 9/19/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Staphylococcal Sepsis Other Serious 12/4/2006 Male 10/13/2008 Physician United States
Primary
Secondary
Concomitant
Drug Resistance Other Serious 55 Male 10/15/2008 Other Health Professional United States
Primary
Concomitant
Pneumonia Cryptococcal Hospitalization 24 Male 10/21/2008 Other Health Professional Japan
Primary
Secondary
Drug Resistance Other Serious 55 Male 10/21/2008 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 55 Male 10/22/2008 Other Health Professional United States
Primary
Concomitant
Tachycardia Hospitalization 74 Male 10/22/2008
Primary
Secondary
Concomitant
Ventricular Fibrillation Death 68 Female 10/13/2008 Australia
Primary
Concomitant
Pneumonia Cryptococcal Hospitalization 24 Male 10/30/2008 Other Health Professional Japan
Primary
Secondary
Somnolence Other Serious 12/11/2006 14 Male 10/30/2008 Japan
Primary
Secondary
Concomitant
Pleurisy Other Serious 24 Male 11/3/2008 Japan
Primary
Concomitant
Vision Blurred Hospitalization 12/14/2007 Male 52 lb 11/4/2008 Other Health Professional Brazil
Primary
Concomitant
Coccidioidomycosis Other Serious 55 Male 11/4/2008 United States
Primary
Secondary
Sepsis Other Serious 73 Male 11/25/2008
Primary
Secondary
Tinnitus Other Serious 33 Male 11/25/2008
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 5/14/2007 Female 123 lb 11/24/2008 Physician Poland
Primary
Secondary
Concomitant
Sepsis Other Serious 41 Male 11/17/2008 Taiwan, Province Of China
Primary
Secondary
Concomitant
Systemic Candida Other Serious 46 Male 12/1/2008
Primary
Secondary
Concomitant
Systemic Candida Other Serious 2 Male 12/2/2008
Primary
Secondary
Upper Gastrointestinal Haemorrhage Hospitalization 0 Male 11/25/2008 Physician Taiwan, Province Of China
Primary
Secondary
Concomitant
Meningitis Cryptococcal Other Serious 6/1/2008 53 Male 12/12/2008 United States
Primary
Secondary
Concomitant
Meningitis Cryptococcal Death 6/1/2008 53 Male 12/15/2008 Japan
Primary
Secondary
Concomitant
Pyrexia Hospitalization 24 Male 12/18/2008
Primary
Secondary
Concomitant
Thrombophlebitis Other Serious 26 Female 12/29/2008 Other Health Professional France
Primary
Secondary
Thrombophlebitis Hospitalization 46 Male 12/29/2008 Other Health Professional France
Primary
Secondary
Hallucinations, Mixed Other Serious 12/7/2008 Female 93 lb 1/5/2009 Physician Thailand
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 12/21/2008 4 Male 44 lb 1/7/2009 Physician Germany
Primary
Secondary
Concomitant
Hallucinations, Mixed Other Serious 12/7/2008 1/21/2009 Physician Thailand
Primary
Secondary
Concomitant
Hepatitis Cholestatic Hospitalization 11/26/2008 Male 1/22/2009 Physician
Primary
Secondary
Concomitant
Hepatitis Cholestatic Hospitalization 11/26/2008 Male 1/26/2009 Physician
Primary
Secondary
Concomitant
Puncture Site Infection Hospitalization 12/21/2008 4 Male 44 lb 1/22/2009 Physician Germany
Primary
Secondary
Concomitant
Hepatitis Cholestatic Hospitalization 11/26/2008 Male 2/2/2009 Physician
Primary
Secondary
Concomitant
Transaminases Increased Hospitalization 12/21/2008 4 Male 44 lb 2/2/2009 Physician Germany
Primary
Secondary
Concomitant
Pneumonia Cryptococcal Hospitalization 11/22/2008 Male 220 lb 2/9/2009 United States
Primary
Secondary
Concomitant
Bronchospasm Life Threatening 2/18/2009 2/25/2009 Physician Russian Federation
Primary
Concomitant
Immune Reconstitution Syndrome Other Serious 24 Male 3/4/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Bronchospasm Life Threatening 2/18/2009 3/4/2009 Physician Russian Federation
Primary
Concomitant
Immune Reconstitution Syndrome Other Serious 24 Unknown 3/3/2009 Germany
Primary
Secondary
Concomitant
Epilepsy Other Serious 6/2/2005 1 Male 22 lb 3/6/2009 Italy
Primary
Concomitant
Splenomegaly Other Serious 24 163 lb 3/17/2009 Consumer Germany
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/3/2009 44 Female 110 lb 3/26/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Other Serious 24 Male 163 lb 4/10/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Immune Reconstitution Syndrome Other Serious 24 Male 163 lb 4/15/2009
Primary
Secondary
Concomitant
Unevaluable Event Death 82 Female 4/3/2009 Japan
Primary
Secondary
Concomitant

Drug Data