Amlodipine Besylate combined with Spironolactone

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Speech Disorder Other Serious 1/1/1999 52 Female 1/5/2006 Physician Japan
Primary
Concomitant
Visual Disturbance Other Serious 12/26/2005 52 Female 1/23/2006 Physician Japan
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Death 7/18/2005 Female 102 lb 1/23/2006 United States
Primary
Concomitant
Speech Disorder Other Serious 12/26/2005 52 Female 1/25/2006 Physician Japan
Primary
Concomitant
Speech Disorder Other Serious 12/26/2005 52 Female 2/7/2006 Physician Japan
Primary
Concomitant
Muscular Weakness Life Threatening 11/10/2005 85 Female 110 lb 2/23/2006 Other Health Professional Japan
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 68 Male 3/2/2006 Physician Japan
Primary
Concomitant
Ventricular Tachycardia Other Serious 4/12/2006 56 Male 132 lb 4/28/2006 Japan
Primary
Concomitant
Psoriasis Hospitalization 2/14/2006 Male 5/5/2006 Physician Belgium
Primary
Concomitant
Drug Interaction Other Serious 6/24/2005 68 Female 187 lb 5/9/2006 Consumer United States
Primary
Secondary
Concomitant
Gallbladder Cancer Hospitalization 3/14/2006 Male 7/14/2006 Physician Japan
Primary
Concomitant
Myocarditis Hospitalization 7/1/2002 Male 8/25/2006 Physician Japan
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 68 Male 9/28/2006 Physician Japan
Primary
Concomitant
Hyperlipidaemia Other Serious 7/1/2002 Male 11/1/2006 Physician Japan
Primary
Secondary
Concomitant
Wound Infection Other Serious 3/1/2006 60 Female 105 lb 10/30/2006 Physician United States
Primary
Concomitant
Sepsis Death 11/1/2006 85 Male 2/5/2007 Physician Japan
Primary
Concomitant
White Blood Cells Urine Positive Other Serious 7/17/2006 Male 5/18/2007 Physician Belgium
Primary
Concomitant
Pneumonia Hospitalization 11/25/2006 42 Female 148 lb 5/24/2007 Other Health Professional Japan
Primary
Concomitant
Renal Failure Other Serious 58 Male 6/22/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Peritonitis Life Threatening 10/7/2006 72 Female 78 lb 7/20/2007 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 8/8/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Hospitalization 58 Male 8/16/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Large Intestine Perforation Life Threatening 10/7/2006 72 Female 78 lb 8/13/2007 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Hospitalization 58 Male 8/17/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Transfusion Reaction Other Serious 54 Male 8/28/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Peritonitis Life Threatening 10/7/2006 72 Female 78 lb 8/23/2007 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Hospitalization 58 Male 8/30/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 10/10/2006 Male 9/4/2007 Germany
Primary
Concomitant
Renal Failure Hospitalization 58 Male 9/10/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 9/11/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 9/12/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Therapeutic Response Decreased Hospitalization 58 Male 9/7/2007 United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 9/13/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 9/21/2007 United Kingdom
Primary
Secondary
Concomitant
Cardiovascular Disorder Hospitalization 10/15/2007 66 Female 11/21/2007 Physician Russian Federation
Primary
Concomitant
Renal Failure Life Threatening 1/16/2008 84 Female 2/19/2008 Other Health Professional France
Primary
Secondary
Concomitant
Lipodystrophy Acquired Hospitalization 1/8/2008 Male 172 lb 5/2/2008 Physician Brazil
Primary
Secondary
Concomitant
Weight Increased Hospitalization 1/1/2008 65 Male 5/27/2008 Consumer United States
Primary
Concomitant
Uterine Cervix Stenosis Other Serious 11/1/2007 60 Female 6/4/2008 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Other Serious 58 Male 6/13/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 6/16/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Transfusion Reaction Hospitalization 54 Male 6/18/2008 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 1/1/2004 58 Male 6/27/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 6/24/2008 United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 10/10/2006 Male 7/11/2008 Germany
Primary
Concomitant
Lipohypertrophy Hospitalization 3/10/2008 Male 172 lb 7/21/2008 Physician Brazil
Primary
Secondary
Concomitant
Social Avoidant Behaviour Other Serious 7/1/2008 61 235 lb 8/22/2008 United States
Primary
Concomitant
Restlessness Other Serious 7/1/2008 61 Male 235 lb 9/12/2008 Consumer United States
Primary
Concomitant
Social Avoidant Behaviour Other Serious 7/1/2008 61 Male 235 lb 10/10/2008 Consumer United States
Primary
Concomitant
Memory Impairment Required Intervention 3/1/2008 52 Female 158 lb 10/16/2008 Consumer United States
Primary
Concomitant
Pulmonary Haemorrhage Hospitalization 9/10/2007 32 Female 123 lb 10/31/2008 Physician Japan
Primary
Secondary
Concomitant
Memory Impairment Other Serious 3/1/2008 52 Female 185 lb 11/5/2008 Other Health Professional United States
Primary
Concomitant
Stevens-johnson Syndrome Hospitalization 9/12/2008 66 Female 12/5/2008 Other Health Professional France
Primary
Secondary
Concomitant
Weight Decreased Other Serious 3/15/2006 7 Male 40 lb 12/11/2008 Physician Japan
Primary
Concomitant
Nasopharyngitis Hospitalization 12/21/1999 79 Female 12/22/2008 Other Health Professional Japan
Primary
Secondary
Concomitant
Hyperkalaemia Hospitalization 12/21/1999 79 Female 1/9/2009 Other Health Professional Japan
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 1/16/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Interacting
Hyperkalaemia Hospitalization 2/29/2008 57 Female 1/16/2009 Consumer Germany
Primary
Secondary
Concomitant
Sensory Loss Other Serious 58 Male 1/21/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 1/19/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 1/19/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Nasopharyngitis Hospitalization 12/21/1999 79 Female 1/23/2009 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Hospitalization 58 Male 1/23/2009
Primary
Secondary
Concomitant
Varicose Vein Hospitalization 1/7/2009 52 Male 338 lb 2/16/2009 United States
Primary
Concomitant
Weight Decreased Other Serious 3/15/2006 7 Male 40 lb 2/20/2009 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 7/1/2008 78 Female 176 lb 3/16/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Sputum Culture Positive 6/1/2007 82 Male 3/13/2009 Japan
Primary
Secondary
Concomitant
Type Iii Immune Complex Mediated Reaction Other Serious 51 Female 3/19/2009 Physician United States
Primary
Concomitant
Tubulointerstitial Nephritis Hospitalization 51 Female 3/30/2009 Consumer United States
Primary
Secondary
Concomitant
Myoclonus Other Serious 79 Male 5/6/2009 Physician United States
Primary
Concomitant
Renal Failure Hospitalization 58 Male 7/31/2009 United Kingdom
Primary
Secondary
Concomitant
Dyspnoea Hospitalization Female 161 lb 8/19/2009 Physician United States
Primary
Concomitant
Weight Increased Other Serious 7/22/2008 69 Male 8/27/2009 Physician United States
Primary
Secondary
Concomitant
Hydrocele Other Serious 1/1/2008 Male 241 lb 9/3/2009 Consumer United States
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 9/1/2009 Male 240 lb 9/30/2009 Consumer United States
Primary
Concomitant
Nervous System Disorder Other Serious 7/22/2008 69 Male 10/6/2009 Physician United States
Primary
Secondary
Concomitant
Pulmonary Hypertension Hospitalization Female 10/9/2009 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 9/7/2008 53 Male 243 lb 10/9/2009 United States
Primary
Concomitant
Pulmonary Hypertension Hospitalization Female 10/20/2009 Physician United States
Primary
Concomitant
Wheezing Hospitalization 9/7/2008 53 Male 243 lb 10/27/2009 United States
Primary
Concomitant
Death Death 10/21/2009 Male 157 lb 12/8/2009 Other Health Professional United States
Primary
Concomitant
Peritonitis Hospitalization 4/29/2009 85 Female 11/3/2009 Other Health Professional United States
Primary
Concomitant
Pancreatitis Hospitalization 9/1/2009 69 Male 240 lb 11/17/2009 Consumer United States
Primary
Concomitant
Malignant Neoplasm Progression Other Serious 2/2/2009 80 Female 108 lb 12/15/2009 Other Health Professional Japan
Primary
Concomitant
Primary Hyperaldosteronism Hospitalization 58 Male 1/4/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Acute Generalised Exanthematous Pustulosis Hospitalization 52 Female 1/8/2010 Physician Poland
Primary
Secondary
Sepsis Death Male 157 lb 1/21/2010 Physician United States
Primary
Concomitant
Acute Generalised Exanthematous Pustulosis Hospitalization 52 Female 1/22/2010 Physician Poland
Primary
Secondary
Primary Hyperaldosteronism Other Serious 58 Male 1/25/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Sepsis Death Male 157 lb 1/26/2010 Physician United States
Primary
Concomitant
Acute Generalised Exanthematous Pustulosis Hospitalization 52 Female 2/8/2010 Physician Poland
Primary
Secondary
Primary Hyperaldosteronism Other Serious 6/17/2009 58 Male 3/3/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Primary Hyperaldosteronism Other Serious 6/17/2009 58 Male 3/5/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 11/19/2009 Female 106 lb 3/18/2010 Physician Japan
Primary
Secondary
Concomitant
Staphylococcal Bacteraemia Other Serious 1/1/2008 69 Male 3/19/2010 Physician United States
Primary
Secondary
Concomitant
Interstitial Lung Disease Life Threatening 11/19/2009 Female 106 lb 3/23/2010 Physician Japan
Primary
Secondary
Concomitant
Nausea Hospitalization 8/7/2007 Female 175 lb 3/25/2010 Japan
Primary
Concomitant
Primary Hyperaldosteronism Other Serious 6/17/2009 58 Male 3/31/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Acute Generalised Exanthematous Pustulosis Hospitalization 1/1/2009 52 Female 4/16/2010 Other Health Professional Poland
Primary
Secondary
Staphylococcal Bacteraemia Other Serious 1/1/2008 69 Male 4/19/2010 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 52 Female 4/13/2010 Physician Poland
Primary
Secondary
Weight Increased Other Serious 8/24/2008 69 Male 3/19/2010 Physician United States
Primary
Secondary
Concomitant
Vision Blurred Other Serious 8/24/2008 69 Male 4/19/2010 Physician United States
Primary
Secondary
Concomitant
Acute Generalised Exanthematous Pustulosis Hospitalization 1/1/2009 52 Female 5/6/2010 Other Health Professional Poland
Primary
Secondary
Malignant Neoplasm Progression Other Serious 2/2/2009 80 Female 108 lb 5/11/2010 Other Health Professional Japan
Primary
Concomitant
Thrombocytopenia Hospitalization 52 Female 5/17/2010 Poland
Primary
Secondary
Thrombocytopenia Hospitalization 52 Female 5/20/2010 Poland
Primary
Secondary
Hyperkalaemia Life Threatening 12/1/2008 79 Female 152 lb 6/14/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Myocardial Ischaemia Death Female 6/30/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Myocardial Ischaemia Death Female 6/30/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Myocardial Ischaemia Death Female 6/25/2010 Other Health Professional United Kingdom
Primary
Concomitant
Tubulointerstitial Nephritis Other Serious Male 143 lb 7/1/2010 Physician Japan
Primary
Concomitant
Therapeutic Response Decreased Hospitalization 88 Male 6/29/2010 Physician Japan
Primary
Concomitant
Myocardial Ischaemia Death Female 7/5/2010 United Kingdom
Primary
Secondary
Concomitant
Splenomegaly Hospitalization 1/1/2010 67 Female 294 lb 7/13/2010 Physician United States
Primary
Concomitant
Tubulointerstitial Nephritis Other Serious Male 143 lb 7/23/2010 Physician Japan
Primary
Concomitant
Heart Rate Irregular Male 237 lb 7/29/2010 Physician United States
Primary
Secondary
Blood Pressure Increased Other Serious Male 260 lb 7/31/2010 Consumer United States
Primary
Concomitant
Regurgitation Other Serious 10/12/2009 69 Female 204 lb 6/3/2010 United States
Primary
Concomitant
Tubulointerstitial Nephritis Other Serious Male 143 lb 8/17/2010 Physician Japan
Primary
Concomitant
Tubulointerstitial Nephritis Other Serious Male 143 lb 9/10/2010 Physician Japan
Primary
Concomitant
Rhabdomyolysis Life Threatening 8/26/2009 71 Male 128 lb 9/23/2010 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 2/2/2009 80 Female 108 lb 9/30/2010 Physician Japan
Primary
Concomitant
Tubulointerstitial Nephritis Other Serious 4/27/2010 37 Male 143 lb 10/6/2010 Physician Japan
Primary
Concomitant
Gastric Cancer Hospitalization 10/29/2010 76 Male 148 lb 11/10/2010 Physician Japan
Primary
Secondary
Concomitant
Tubulointerstitial Nephritis Other Serious 4/27/2010 37 Male 143 lb 11/16/2010 Physician Japan
Primary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 10/1/2010 76 Male 148 lb 11/17/2010 Physician Japan
Primary
Secondary
Concomitant
Breast Cancer Female Life Threatening 4/8/2010 12/6/2010 Physician Japan
Primary
Concomitant
Large Intestine Carcinoma Hospitalization 10/1/2010 76 Male 148 lb 12/22/2010 Physician Japan
Primary
Secondary
Concomitant
Nephrogenic Systemic Fibrosis Other Serious 1/1/2000 48 Female 121 lb 12/22/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Large Intestine Carcinoma Hospitalization 10/1/2010 Male 148 lb 1/4/2011 Physician Japan
Primary
Secondary
Concomitant
Gastrointestinal Haemorrhage Hospitalization 10/1/2010 Male 148 lb 1/26/2011 Physician Japan
Primary
Secondary
Concomitant
Renal Impairment Other Serious 1/1/2007 78 Female 106 lb 1/27/2011 Consumer Argentina
Primary
Concomitant
Myalgia Other Serious 1/1/2010 74 Male 247 lb 1/28/2011 Physician United States
Primary
Concomitant
Irritability Hospitalization Male 2/7/2011 Consumer Brazil
Primary
Concomitant
Pulmonary Fibrosis Other Serious 1/1/2000 48 Female 121 lb 2/9/2011 Physician United States
Primary
Secondary
Concomitant
Road Traffic Accident Death 2/20/2008 52 Male 228 lb 1/28/2011 Lawyer United States
Primary
Concomitant
Malaise Death 2/20/2008 52 Male 228 lb 3/4/2011 Consumer United States
Primary
Concomitant
Malaise Death 2/20/2008 52 Male 228 lb 3/15/2011 Lawyer United States
Primary
Concomitant
Portal Hypertension Hospitalization 9/20/2010 59 Male 231 lb 3/15/2011 Physician Germany
Primary
Secondary
Concomitant
Malaise Female 3/29/2011 Consumer United States
Primary
Concomitant
Pulmonary Arterial Hypertension Death 3/8/2011 76 Female 3/29/2011 Other Health Professional United States
Primary
Concomitant
Respiratory Arrest Death 2/20/2008 52 Male 228 lb 3/23/2011 Lawyer United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 71 Female 4/5/2011 Physician United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 9/20/2010 59 Male 231 lb 3/24/2011 Physician Germany
Primary
Secondary
Concomitant
Muscle Tightness Other Serious 1/1/2000 49 Female 121 lb 4/11/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Pericardial Effusion Death 3/15/2006 7 Male 40 lb 4/12/2011 Physician Japan
Primary
Secondary
Concomitant
Ventricular Fibrillation Hospitalization 1/1/2008 87 Female 4/20/2011 Other Health Professional France
Primary
Secondary
Concomitant
Muscle Haemorrhage Death 1/12/2008 87 Female 4/20/2011 Other Health Professional France
Primary
Secondary
Concomitant
Haematemesis Hospitalization 3/1/2011 46 Male 276 lb 4/21/2011 Physician United States
Primary
Concomitant

Drug Data