Amlodipine Besylate combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Aortic Aneurysm Rupture Death 11/21/2003 Male 1/4/2006 France
Primary
Concomitant
Somnolence Hospitalization 6/28/2005 62 Male 141 lb 1/24/2006 Physician United Kingdom
Primary
Secondary
Concomitant
Hypersensitivity Required Intervention 11/14/2005 79 Male 208 lb 11/16/2005 Pharmacist United States
Primary
Concomitant
Tachycardia Other Serious 1/1/2004 64 Male 203 lb 2/10/2006 Physician Switzerland
Primary
Secondary
Concomitant
Pruritus Generalised 9/13/2005 66 Female 222 lb 1/5/2006 Consumer United States
Primary
Concomitant
Speech Disorder Other Serious 10/1/2005 83 Male 174 lb 1/20/2006 Physician United States
Primary
Concomitant
Myositis Hospitalization 56 Male 3/2/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Catheter Site Haemorrhage Hospitalization 10/11/2004 65 Male 217 lb 12/21/2005 United States
Primary
Secondary
Concomitant
Pulmonary Alveolar Haemorrhage Hospitalization 8/29/2004 75 Female 170 lb 12/29/2005 Other Health Professional United States
Primary
Concomitant
Rectal Haemorrhage Hospitalization 7/1/2004 80 Male 190 lb 12/21/2005 Physician United States
Primary
Concomitant
Gastric Ulcer Hospitalization 11/9/2005 49 Female 3/10/2006 Physician Japan
Primary
Concomitant
Osteoporosis Hospitalization 1/1/2002 64 Female 220 lb 3/29/2006 Physician Germany
Primary
Concomitant
Stress Ulcer Hospitalization 11/8/2005 49 Female 4/18/2006 Physician Japan
Primary
Concomitant
Somnolence 1/1/2006 70 Female 158 lb 4/3/2006 Consumer United States
Primary
Concomitant
Insomnia 4/1/2005 71 Male 150 lb 4/3/2006 Consumer United States
Primary
Concomitant
Initial Insomnia 1/22/2006 70 Female 116 lb 4/3/2006 Consumer United States
Primary
Concomitant
Pneumonitis 2/24/2006 79 Male 163 lb 4/3/2006 Pharmacist United States
Primary
Concomitant
Dysgeusia 11/20/2005 66 Male 270 lb 4/3/2006 Consumer United States
Primary
Concomitant
Renal Failure Hospitalization 10/14/2005 65 Male 5/30/2006 China
Primary
Concomitant
Vomiting Life Threatening 4/1/2006 71 Female 130 lb 7/7/2006 Physician Germany
Primary
Secondary
Concomitant
Renal Failure Acute Hospitalization 2/8/2006 Female 7/7/2006 Physician France
Primary
Concomitant
International Normalised Ratio Decreased Other Serious 4/4/2006 71 Male 7/4/2006 Belgium
Primary
Concomitant
Myalgia Life Threatening 4/23/2006 71 Female 130 lb 7/18/2006 Physician Germany
Primary
Secondary
Concomitant
Pyrexia Life Threatening 4/23/2006 71 Female 130 lb 7/20/2006 Physician Germany
Primary
Secondary
Concomitant
International Normalised Ratio Decreased Other Serious 4/4/2006 71 Male 7/13/2006 Belgium
Primary
Concomitant
Pharyngolaryngeal Pain Other Serious 6/15/2006 79 Male 320 lb 8/11/2006 Other Health Professional United Kingdom
Primary
Concomitant
Transient Ischaemic Attack Other Serious 12/20/2005 Male 187 lb 8/10/2006 Other Health Professional United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 8/10/2006 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Other Serious 6/19/2006 60 Female 10/4/2006 Other Health Professional United States
Primary
Concomitant
Urinary Tract Infection Life Threatening 6/18/2006 60 Female 10/5/2006 Other Health Professional United States
Primary
Concomitant
Vertigo Hospitalization 4/20/2006 76 Male 11/28/2006 Other Health Professional France
Primary
Secondary
Concomitant
Psychotic Disorder Hospitalization 10/1/2006 74 Male 12/1/2006 Other Health Professional United Kingdom
Primary
Concomitant
Myalgia Other Serious 7/12/2006 58 Male 198 lb 8/15/2006 Other Health Professional United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 2/15/2006 69 Male 12/4/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Psychotic Disorder Hospitalization 10/1/2006 74 Male 12/8/2006 United States
Primary
Concomitant
Hallucination 5/1/2006 76 Female 10/11/2006 Consumer United States
Primary
Concomitant
Thrombocytopenia Other Serious 62 Male 1/8/2007 Consumer United Kingdom
Primary
Secondary
Sensation Of Heaviness Other Serious Female 1/9/2007 Consumer Brazil
Primary
Secondary
Concomitant
Sensation Of Heaviness Other Serious Female 1/12/2007 Consumer Brazil
Primary
Secondary
Concomitant
Sensation Of Heaviness Other Serious Female 1/23/2007 Consumer Brazil
Primary
Secondary
Concomitant
Encephalopathy Hospitalization 3/15/2006 80 Male 1/27/2007 Other Health Professional France
Primary
Concomitant
Renal Failure Hospitalization 12/29/2006 66 Male 173 lb 1/26/2007 Physician United Kingdom
Primary
Secondary
Somnolence Other Serious 12/14/2005 65 Female 190 lb 2/12/2007 Physician Poland
Primary
Concomitant
Somnolence Other Serious 5/1/2005 65 Female 190 lb 2/19/2007 Physician Poland
Primary
Concomitant
Somnolence Other Serious 5/1/2005 65 Female 190 lb 2/21/2007 Physician Poland
Primary
Concomitant
Femur Fracture Other Serious 10/15/2005 Female 3/2/2007 Other Health Professional Sweden
Primary
Concomitant
Dysgeusia 11/1/2006 85 Female 140 lb 1/12/2007 Consumer United States
Primary
Concomitant
Middle Insomnia 10/1/2006 85 Male 172 lb 1/12/2007 Consumer United States
Primary
Concomitant
Insomnia 9/28/2006 55 Male 245 lb 1/12/2007 Consumer United States
Primary
Concomitant
Haemoglobin Decreased Hospitalization 3/1/2007 78 Female 4/21/2007 United States
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 3/1/2007 72 Male 4/25/2007 Other Health Professional France
Primary
Concomitant
Delirium Other Serious 3/13/2007 70 Male 169 lb 3/28/2007 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased Other Serious 2/15/2006 69 Male 4/30/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 3/20/2007 67 Male 5/1/2007 Japan
Primary
Secondary
Somnolence Other Serious 5/1/2005 65 Female 190 lb 5/14/2007 Physician Poland
Primary
Concomitant
Syncope Other Serious 1/1/2005 65 Female 190 lb 5/16/2007 Physician Poland
Primary
Concomitant
Rhabdomyolysis Other Serious 3/20/2007 67 Male 5/21/2007 Japan
Primary
Secondary
Middle Insomnia 1/1/2007 69 Male 142 lb 4/12/2007 Consumer United States
Primary
Concomitant
Rhabdomyolysis Other Serious 3/20/2007 67 Male 6/20/2007 Japan
Primary
Secondary
Urticaria Required Intervention 7/15/2007 55 Male 175 lb 7/18/2007 Pharmacist United States
Primary
Concomitant
Vertigo Hospitalization 3/12/2006 56 Female 136 lb 8/1/2007 Lawyer United States
Primary
Concomitant
Insomnia 4/1/2007 64 Male 240 lb 7/10/2007 Consumer United States
Primary
Concomitant
Somnolence 1/1/2005 68 Male 230 lb 7/10/2007 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 58 Male 8/16/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Hospitalization 58 Male 8/17/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Renal Failure Hospitalization 58 Male 8/30/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 8/1/2005 60 Male 216 lb 9/4/2007 Consumer Brazil
Primary
Concomitant
Renal Failure Other Serious 58 Male 8/22/2007 United Kingdom
Primary
Secondary
Femur Fracture Hospitalization 6/13/2007 65 Female 9/10/2007 Physician Singapore
Primary
Concomitant
Renal Failure Hospitalization 58 Male 9/10/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Therapeutic Response Decreased Hospitalization 58 Male 9/7/2007 United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 9/13/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Other Serious 58 Male 9/21/2007 United Kingdom
Primary
Secondary
Concomitant
Pyrexia Other Serious 10/13/2007 79 Female 130 lb 10/24/2007 United States
Primary
Concomitant
Tetany Disability 8/1/2007 60 Male 11/12/2007 Other Health Professional United Kingdom
Primary
Concomitant
Oedema Hospitalization 3/15/2006 80 Male 11/26/2007 Other Health Professional France
Primary
Concomitant
Hepatic Encephalopathy Life Threatening 11/18/2007 62 Male 11/28/2007 Physician United States
Primary
Concomitant
Hepatic Encephalopathy Life Threatening 11/18/2007 62 Male 12/3/2007 Physician United States
Primary
Concomitant
Hepatic Encephalopathy Life Threatening 11/18/2007 62 Male 12/5/2007 Physician United States
Primary
Concomitant
Hepatic Encephalopathy Life Threatening 11/18/2007 62 Male 12/7/2007 Physician United States
Primary
Concomitant
Pyrexia Other Serious 10/13/2007 79 Female 130 lb 12/3/2007 Consumer United States
Primary
Concomitant
Kidney Infection Other Serious 10/13/2007 79 Female 130 lb 12/3/2007 Consumer United States
Primary
Concomitant
Hepatic Encephalopathy Life Threatening 11/18/2007 62 Male 12/11/2007 Physician United States
Primary
Concomitant
Syncope Other Serious 8/1/2004 65 Female 190 lb 1/9/2008 Physician Poland
Primary
Concomitant
Surgery Hospitalization 3/1/2006 59 Male 108 lb 1/24/2008 Physician Japan
Primary
Concomitant
Tachycardia Other Serious 12/17/2007 74 Male 1/24/2008 Italy
Primary
Secondary
Concomitant
Surgery Hospitalization 3/1/2006 59 Male 108 lb 2/6/2008 Physician Japan
Primary
Concomitant
Oesophageal Pain Other Serious 1/29/2008 Male 250 lb 2/5/2008 Pharmacist United States
Primary
Concomitant
General Physical Health Deterioration Hospitalization 10/15/2007 Female 132 lb 2/7/2008 Physician United Kingdom
Primary
Concomitant
Palpitations 1/24/2008 61 Male 249 lb 2/17/2008 United States
Primary
Concomitant
Myalgia Required Intervention 2/18/2008 83 Male 169 lb 2/25/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Palpitations 1/24/2008 61 Male 249 lb 2/27/2008 Consumer United States
Primary
Concomitant
Tooth Disorder Other Serious 2/1/2008 61 Male 180 lb 3/6/2008 Consumer United States
Primary
Concomitant
Scrotal Oedema Other Serious 1/21/2008 77 Male 3/28/2008 United Kingdom
Primary
Concomitant
Peripheral Ischaemia Hospitalization 2/12/2008 79 Female 139 lb 3/28/2008
Primary
Concomitant
Pulmonary Hypertension Death 3/1/2008 Female 4/10/2008 Pharmacist United States
Primary
Concomitant
Myocardial Infarction Hospitalization 2/1/2008 Female 4/11/2008 Consumer United Kingdom
Primary
Concomitant
Fatigue Other Serious 82 Female 124 lb 4/11/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Pulmonary Hilar Enlargement Other Serious 3/26/2004 Male 258 lb 4/10/2008 Physician United States
Primary
Concomitant
Pulmonary Hypertension Death 3/1/2008 Female 4/18/2008 Physician United States
Primary
Concomitant
General Physical Health Deterioration Hospitalization 10/15/2007 Female 132 lb 4/29/2008 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Increased 5/2/2007 75 Female 101 lb 4/21/2008 Physician Japan
Primary
Secondary
Concomitant
Visual Disturbance Other Serious 4/28/2008 Female 130 lb 5/6/2008 Consumer Brazil
Primary
Concomitant
Weight Increased Hospitalization 1/1/2008 65 Male 5/27/2008 Consumer United States
Primary
Concomitant
Uterine Cervix Stenosis Other Serious 11/1/2007 60 Female 6/4/2008 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Other Serious 58 Male 6/16/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Sinus Bradycardia Hospitalization 1/27/2007 85 Female 6/13/2008 Other Health Professional France
Primary
Concomitant
Heart Rate Increased Other Serious 5/28/2008 79 Male 6/12/2008 Consumer United States
Primary
Concomitant
Flatulence Other Serious 3/28/2008 69 Male 201 lb 6/19/2008 Other Health Professional United Kingdom
Primary
Concomitant
Oedema Peripheral Other Serious 3/5/2008 70 Female 190 lb 6/20/2008 Physician United States
Primary
Secondary
Concomitant
Haemoglobin Decreased Other Serious 3/1/2007 6/25/2008 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Hospitalization 1/1/2004 58 Male 6/27/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Hepatic Function Abnormal Other Serious 3/1/2007 6/30/2008 Other Health Professional United Kingdom
Primary
Concomitant
Tubulointerstitial Nephritis Hospitalization 10/8/2007 Female 254 lb 7/2/2008 Other Health Professional United Kingdom
Primary
Concomitant
Syncope Other Serious 8/1/2004 65 Female 190 lb 7/7/2008 Physician Poland
Primary
Concomitant
Oedema Peripheral Other Serious 3/5/2008 70 Female 190 lb 7/14/2008 Physician United States
Primary
Secondary
Concomitant
Orthostatic Hypotension Hospitalization 73 Female 181 lb 7/16/2008 United States
Primary
Secondary
Concomitant
Rhabdomyolysis Life Threatening 7/10/2008 85 Female 7/28/2008 Physician China
Primary
Concomitant
Macular Degeneration Other Serious 1/1/2008 Male 7/25/2008 Consumer United States
Primary
Concomitant
Macular Degeneration Other Serious 1/1/2008 Male 8/1/2008 Physician United States
Primary
Concomitant
Pyrexia Hospitalization 8/6/2008 Female 268 lb 8/12/2008 Consumer United States
Primary
Concomitant
Nausea 4/6/2008 69 Female 270 lb 7/7/2008 Consumer United States
Primary
Concomitant
Wheezing Hospitalization 7/22/2008 65 Female 8/26/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Social Avoidant Behaviour Other Serious 7/1/2008 61 235 lb 8/22/2008 United States
Primary
Concomitant
Blood Glucose Abnormal 7/9/2008 63 Female 8/15/2008 United States
Primary
Concomitant
Flushing 4/17/2008 Male 224 lb 8/27/2008 Consumer United States
Primary
Concomitant
Macular Degeneration Other Serious 8/1/2008 82 Female 8/28/2008 Consumer United States
Primary
Concomitant
Interacting
Wheezing Hospitalization 7/22/2008 65 Female 9/8/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Female 9/12/2008 Consumer United States
Primary
Concomitant
Radiation Pneumonitis Other Serious 7/1/2008 67 Male 215 lb 9/10/2008 Physician United States
Primary
Secondary
Concomitant
Tremor Life Threatening 6/1/2008 Male 198 lb 9/9/2008 Consumer United States
Primary
Concomitant
Radiation Pneumonitis Hospitalization 8/9/2008 Male 215 lb 9/17/2008 Physician United States
Primary
Secondary
Concomitant
Restlessness Other Serious 7/1/2008 61 Male 235 lb 9/12/2008 Consumer United States
Primary
Concomitant
Oedema Hospitalization 3/15/2006 80 Male 9/23/2008 Other Health Professional France
Primary
Concomitant
Pneumonia Pneumococcal Other Serious 5/1/2008 69 Male 9/19/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Wheezing Hospitalization 7/22/2008 65 Female 10/14/2008 Other Health Professional United Kingdom
Primary
Concomitant
Nasal Congestion 8/27/2008 61 Male 10/14/2008 Consumer United States
Primary
Concomitant
Social Avoidant Behaviour Other Serious 7/1/2008 61 Male 235 lb 10/10/2008 Consumer United States
Primary
Concomitant
Rash Erythematous Other Serious 8/30/2008 66 Male 10/10/2008 Other Health Professional United Kingdom
Primary
Concomitant
Radiation Pneumonitis Other Serious 8/9/2008 Male 215 lb 10/20/2008 Physician United States
Primary
Secondary
Concomitant
Swelling Other Serious 8/30/2008 66 Male 10/14/2008 United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 7/1/2008 67 Male 215 lb 10/15/2008 Physician United States
Primary
Secondary
Concomitant
Nephrolithiasis Hospitalization 10/7/2008 85 Female 10/14/2008 Other Health Professional United States
Primary
Concomitant
Vasculitis Death 74 Male 11/25/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Death 74 Male 11/28/2008 United Kingdom
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Other Serious 11/1/2008 61 Male 12/9/2008 Physician France
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 7/1/2008 76 Male 12/5/2008 United Kingdom
Primary
Secondary
Weight Decreased Other Serious 12/12/2008 Consumer United Kingdom
Primary
Secondary
Concomitant
Radiation Pneumonitis Other Serious 8/9/2008 Male 215 lb 12/23/2008 Physician United States
Primary
Secondary
Concomitant
Weight Decreased Death 74 Male 12/19/2008 Consumer United Kingdom
Primary
Secondary
Concomitant

Drug Data