Amitriptyline Hydrochloride combined with Simvastatin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Thrombotic Thrombocytopenic Purpura Other Serious 2/26/2006 35 Female 220 lb 3/15/2006 Physician Canada
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 2/26/2006 35 Female 220 lb 3/15/2006 Physician Canada
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 2/26/2006 35 Female 220 lb 3/16/2006 Physician Canada
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 2/26/2006 35 Female 220 lb 3/24/2006 Physician Canada
Primary
Secondary
Concomitant
Surgery Hospitalization 1/1/2002 67 Male 176 lb 4/25/2006 Lawyer United States
Primary
Concomitant
Surgery Hospitalization 1/1/2002 65 Male 176 lb 5/1/2006 Physician United States
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 3/1/2004 60 Male 181 lb 5/9/2006 Physician Canada
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 3/1/2004 60 Male 181 lb 5/12/2006 Physician Canada
Primary
Concomitant
Osteonecrosis Disability 69 Male 5/18/2006 Physician Australia
Primary
Concomitant
Pulmonary Oedema Other Serious 9/4/2003 57 Female 8/21/2006 United States
Primary
Concomitant
Vomiting Hospitalization 9/15/2005 32 Male 9/26/2006 Australia
Primary
Secondary
Concomitant
Synovitis Other Serious 9/4/2003 57 Female 11/17/2006 United States
Primary
Concomitant
Vertigo Hospitalization 4/20/2006 76 Male 11/28/2006 Other Health Professional France
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 8/6/2006 79 Male 143 lb 11/30/2006 Physician United States
Primary
Concomitant
Vomiting Other Serious 10/21/2006 85 Female 12/6/2006 Other Health Professional United Kingdom
Primary
Concomitant
Abnormal Dreams Other Serious 11/1/2005 70 Male 3/26/2007 Other Health Professional United Kingdom
Primary
Concomitant
Weight Increased Other Serious 42 Male 11/13/2006 Physician United States
Primary
Concomitant
Stent Occlusion Other Serious 3/23/2006 70 Male 12/13/2006 Physician United States
Primary
Secondary
Concomitant
Rash Generalised Other Serious 4/18/2007 Female 161 lb 6/18/2007 Consumer United Kingdom
Primary
Concomitant
Rash Generalised Other Serious 4/18/2007 Female 161 lb 6/22/2007 Consumer United Kingdom
Primary
Concomitant
Wound Dehiscence Hospitalization 3/8/2007 Female 143 lb 7/9/2007 Physician United Kingdom
Primary
Concomitant
Pancytopenia Life Threatening Female 7/16/2007 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/1/2007 73 Female 9/26/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Feeling Abnormal Other Serious 6/23/2007 77 Female 187 lb 10/19/2007 Physician United Kingdom
Primary
Concomitant
Sputum Discoloured Hospitalization 11/8/2006 Female 12/21/2007 Physician Belgium
Primary
Concomitant
Procedural Complication 2/25/2008 Female 190 lb 3/15/2008 Consumer United States
Primary
Concomitant
Rash Other Serious 4/4/2008 Female 8/11/2008 Physician United Kingdom
Primary
Concomitant
Wound Infection Staphylococcal Hospitalization 5/22/2008 48 Male 8/27/2008 Sweden
Primary
Concomitant
Wound Infection Staphylococcal Hospitalization 5/22/2008 48 Male 133 lb 9/9/2008 Sweden
Primary
Concomitant
Quadriparesis Hospitalization 7/10/2008 Female 10/2/2008 Other Health Professional France
Primary
Concomitant
Interacting
Death Death 9/14/2008 Male 400 lb 9/26/2008 Physician United States
Primary
Concomitant
Suicide Attempt Other Serious 9/27/2008 55 Female 10/2/2008 Physician Germany
Primary
Secondary
Thrombosis Hospitalization 8/29/2008 61 Female 141 lb 10/6/2008 United States
Primary
Concomitant
Phantom Pain Other Serious 1/1/2008 67 Female 146 lb 10/22/2008 Germany
Primary
Concomitant
Rhabdomyolysis Death 77 Female 12/4/2008 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Other Serious 7/1/2007 82 Female 11/26/2008 Physician United States
Primary
Concomitant
Sick Sinus Syndrome Hospitalization 8/30/2008 60 Male 108 lb 1/9/2009 Other Health Professional United Kingdom
Primary
Concomitant
Vertigo Hospitalization 11/1/2008 55 Female 112 lb 1/23/2009 Consumer United States
Primary
Concomitant
Nausea Hospitalization 10/1/1999 70 Male 1/23/2009 Physician United States
Primary
Concomitant
Intra-abdominal Haematoma Other Serious 1/1/2007 58 Male 280 lb 2/19/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Liver Injury Hospitalization 63 Female 3/11/2009 Other Health Professional Germany
Primary
Secondary
Concomitant
Hyponatraemia Life Threatening 2/26/2009 49 Male 3/27/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
International Normalised Ratio Increased Hospitalization 4/7/2009 66 Male 4/29/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Septic Shock Hospitalization 9/14/2008 38 Male 400 lb 5/11/2009 Physician United States
Primary
Concomitant
Cerebellar Infarction Death 73 8/26/2009 Other Health Professional United Kingdom
Primary
Concomitant
Impaired Driving Ability Other Serious 8/31/2009 Female 150 lb 9/13/2009 Consumer United States
Primary
Concomitant
Rash Generalised Other Serious 9/1/2009 41 Female 132 lb 9/11/2009 Consumer United States
Primary
Concomitant
Rash Erythematous Other Serious 9/1/2009 41 Female 132 lb 9/11/2009 Consumer United States
Primary
Concomitant
Wound Infection Staphylococcal Required Intervention 8/1/2008 56 Male 200 lb 9/17/2009 Consumer United States
Primary
Concomitant
Vision Blurred Required Intervention 8/1/2008 56 Male 200 lb 9/23/2009 Physician United States
Primary
Concomitant
Paraesthesia Other Serious 10/20/2009 Consumer United Kingdom
Primary
Concomitant
Lip Neoplasm Other Serious 65 Female 10/20/2009 Consumer United States
Primary
Concomitant
Renal Impairment Other Serious 5/21/2009 59 Female 183 lb 10/29/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Myocardial Infarction Life Threatening 10/21/2009 69 Female 209 lb 11/9/2009 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Other Serious 2/13/2007 61 Male 214 lb 12/9/2009 Lawyer United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 9/7/2009 55 Female 12/1/2009 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pulmonary Embolism Other Serious 2/1/2008 46 Female 12/21/2009 Lawyer United States
Primary
Concomitant
Vomiting Life Threatening 11/19/2009 Female 12/29/2009 Consumer United States
Primary
Concomitant
Haematuria Life Threatening 9/1/2008 Female 265 lb 12/29/2009 Physician United Kingdom
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 73 Male 139 lb 2/3/2010 Other Health Professional United Kingdom
Primary
Concomitant
Renal Failure Other Serious 10/1/2007 61 Male 214 lb 3/3/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Loss Of Consciousness Other Serious 1/5/2010 Female 140 lb 3/4/2010 Consumer United States
Primary
Secondary
Concomitant
Renal Failure Acute Other Serious 12/1/2009 53 Female 5/3/2010 United Kingdom
Primary
Concomitant
Vasoconstriction Required Intervention 1/21/2008 77 Female 6/30/2010 United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/9/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 2/12/2010 69 Male 7/9/2010 Other Health Professional United Kingdom
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 7/12/2010 Physician Israel
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/12/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/7/2010 64 Male 130 lb 7/12/2010 Consumer United States
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/13/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization Female 7/13/2010 Other Health Professional Israel
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/6/2010 United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/8/2010 United Kingdom
Primary
Secondary
Concomitant
Somnolence Other Serious 1/1/2010 41 Female 7/16/2010 Other Health Professional Netherlands
Primary
Concomitant
Wheezing Other Serious 2/18/2008 66 Female 227 lb 7/16/2010 Physician United Kingdom
Primary
Concomitant
Visual Acuity Reduced Other Serious 1/1/2007 58 Male 183 lb 7/17/2010 Other Health Professional United States
Primary
Concomitant
Interacting
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/18/2010 Other Health Professional Germany
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/19/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 7/20/2010 Physician Israel
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Death 70 Female 7/13/2010 Israel
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/21/2010 Other Health Professional Israel
Primary
Secondary
Concomitant
Pyrexia Hospitalization 6/1/2010 67 Female 7/21/2010 Other Health Professional United States
Primary
Concomitant
Toxic Epidermal Necrolysis Hospitalization 70 Female 7/21/2010 Other Health Professional Japan
Primary
Secondary
Concomitant
Mood Altered 52 Female 164 lb 7/21/2010 Other Health Professional United States
Primary
Concomitant
Visual Acuity Reduced Other Serious 4/1/2008 42 Male 321 lb 7/21/2010 Other Health Professional United States
Primary
Concomitant
Paralysis Hospitalization 56 Female 7/19/2010 United Kingdom
Primary
Secondary
Concomitant
Skin Ulcer Other Serious 9/1/2006 79 Male 152 lb 7/23/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 2/9/2009 57 Female 154 lb 7/23/2010 Physician United States
Primary
Concomitant
Gastrointestinal Infection Hospitalization 3/5/2010 74 Male 200 lb 7/28/2010 Other Health Professional United States
Primary
Concomitant
Wound Hospitalization Male 7/29/2010 Physician United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 4/1/2010 64 Male 7/30/2010 Other Health Professional United States
Primary
Concomitant
Deep Vein Thrombosis Other Serious 7/20/2010 52 Male 7/30/2010 Physician New Zealand
Primary
Secondary
Concomitant
Suicidal Behaviour Other Serious 6/1/2008 60 Male 271 lb 5/18/2010 Other Health Professional United States
Primary
Concomitant
Pulmonary Embolism Hospitalization 11/29/2006 25 Female 229 lb 8/2/2010 Lawyer United States
Primary
Secondary
Concomitant
Dizziness 7/10/2008 68 Female 121 lb 8/3/2010 Other Health Professional United States
Primary
Concomitant
Tremor Hospitalization 6/1/2010 62 Male 170 lb 8/4/2010 Consumer United States
Primary
Concomitant
Arterial Thrombosis Limb Other Serious 6/4/2010 83 Male 151 lb 8/4/2010 Physician United States
Primary
Concomitant
Pain In Extremity Other Serious 7/20/2010 52 Male 252 lb 8/6/2010 Physician New Zealand
Primary
Secondary
Concomitant
Sepsis Other Serious 5/16/2010 70 Female 200 lb 8/5/2010 Physician United States
Primary
Secondary
Concomitant
Urinary Tract Infection Hospitalization 4/1/2010 64 Male 8/11/2010 Other Health Professional United States
Primary
Concomitant
Paraesthesia Other Serious 1/1/2010 41 Female 8/11/2010 Other Health Professional Netherlands
Primary
Concomitant
Weight Decreased Other Serious 4/1/2008 56 Female 154 lb 8/12/2010 Physician United States
Primary
Concomitant
Vomiting Other Serious 1/1/2007 54 Male 381 lb 8/17/2010 Lawyer United States
Primary
Concomitant
Wheezing Other Serious 2/18/2008 66 Female 227 lb 8/17/2010 Physician United Kingdom
Primary
Concomitant
Nervousness 83 Female 8/18/2010 Consumer United States
Primary
Concomitant
Tibia Fracture Hospitalization 55 Female 233 lb 8/19/2010 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 60 Male 241 lb 8/19/2010 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Other Serious 1/16/2008 64 Female 154 lb 8/19/2010 Other Health Professional United States
Primary
Concomitant
Angina Unstable Hospitalization 8/7/2010 52 Male 252 lb 8/19/2010 Physician New Zealand
Primary
Secondary
Concomitant
Tremor Hospitalization 6/1/2010 62 Male 170 lb 8/20/2010 Consumer United States
Primary
Concomitant
Skin Ulcer Other Serious 9/1/2006 79 Male 152 lb 8/20/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Pyrexia Other Serious Female 9/1/2010 United States
Primary
Concomitant
Crepitations Other Serious Female 9/1/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 1/1/2008 46 Female 306 lb 9/30/2010 Lawyer United States
Primary
Concomitant
Respiratory Failure Other Serious 12/1/2007 71 Male 192 lb 10/15/2010 Lawyer United States
Primary
Concomitant
Hypoglycaemia Other Serious 4/28/2010 76 Female 10/25/2010 Other Health Professional United Kingdom
Primary
Concomitant
Restlessness Other Serious 8/16/2010 76 Female 11/17/2010 Physician Germany
Primary
Concomitant
Psoriasis 10/1/2009 12/14/2010 Physician United States
Primary
Secondary
Concomitant
Tongue Dry Hospitalization 10/9/2008 65 Female 141 lb 11/26/2010 Germany
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 10/12/2010 75 Female 12/28/2010 Other Health Professional France
Primary
Secondary
Concomitant
Skin Exfoliation Other Serious 11/16/2010 71 Female 143 lb 12/28/2010 Other Health Professional United Kingdom
Primary
Concomitant
Somnolence Disability 1/24/2011 77 Female 187 lb 2/4/2011 Other Health Professional United Kingdom
Primary
Concomitant
Hyperthyroidism Hospitalization 1/20/2011 75 Male 2/11/2011 Other Health Professional United Kingdom
Primary
Concomitant
Somnolence Disability 1/24/2011 77 Female 187 lb 2/16/2011 Other Health Professional United Kingdom
Primary
Concomitant
Cardiomyopathy Death 12/1/2007 71 Male 192 lb 3/7/2011 Other Health Professional United States
Primary
Concomitant
Asthenopia Other Serious 1/21/2011 72 Female 155 lb 3/10/2011 Other Health Professional United Kingdom
Primary
Concomitant
Confusional State Hospitalization 10/21/2010 50 Male 3/18/2011 Consumer United Kingdom
Primary
Concomitant
Anxiety Other Serious 10/21/2010 50 Male 3/21/2011 Consumer United Kingdom
Primary
Concomitant
Rapid Correction Of Hyponatraemia Life Threatening 12/9/2010 76 Male 3/9/2011 Other Health Professional United Kingdom
Primary
Concomitant
Pleuritic Pain Hospitalization 3/14/2011 74 Male 243 lb 3/17/2011 Other Health Professional United States
Primary
Concomitant
Lip Swelling Other Serious 5/6/2011 93 Female 110 lb 5/24/2011 Other Health Professional
Primary
Secondary
Concomitant
Blood Albumin Decreased Hospitalization 12/20/2005 43 Male 6/7/2011 Physician Australia
Primary
Concomitant
Salivary Gland Enlargement Other Serious 5/18/2011 89 Female 6/14/2011 Other Health Professional United Kingdom
Primary
Concomitant
Liver Injury Hospitalization 9/5/2008 63 Female 190 lb 6/16/2011 Other Health Professional Germany
Primary
Secondary
Concomitant
Tremor Hospitalization 6/1/2010 62 Male 170 lb 6/16/2011 Physician United States
Primary
Concomitant
Anaemia Other Serious 1/1/2007 76 Female 166 lb 6/16/2011 United States
Primary
Concomitant
Pneumonia Aspiration Life Threatening 5/9/2011 82 Female 165 lb 6/17/2011 Other Health Professional Australia
Primary
Secondary
Concomitant
Angioedema Hospitalization 5/18/2011 89 Female 6/22/2011 Other Health Professional United Kingdom
Primary
Concomitant
Joint Effusion Other Serious 1/1/2003 61 Female 121 lb 7/7/2011 Physician United States
Primary
Concomitant
Fatigue Hospitalization 1/1/2003 61 Female 121 lb 7/21/2011 Physician United States
Primary
Secondary
Concomitant
Anaemia Hospitalization 1/1/2003 61 Female 121 lb 7/22/2011 Physician United States
Primary
Secondary
Concomitant
Myalgia Other Serious 6/28/2011 43 Female 312 lb 7/18/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Osteonecrosis Of Jaw Hospitalization 80 Female 8/3/2011 Other Health Professional United Kingdom
Primary
Concomitant
Cholestasis Hospitalization 7/7/2011 68 Female 7/29/2011 United Kingdom
Primary
Concomitant
Hemiparesis Life Threatening 7/18/2011 80 Female 146 lb 8/25/2011 Other Health Professional United Kingdom
Primary
Concomitant
Apraxia Death 58 Female 8/22/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant
Gastroenteritis Disability 1/1/2003 61 Female 121 lb 8/31/2011 Physician United States
Primary
Secondary
Concomitant
Restlessness Other Serious 8/1/2011 74 Female 154 lb 9/13/2011 Other Health Professional United Kingdom
Primary
Concomitant
Nervous System Disorder Other Serious 58 Female 9/8/2011 Other Health Professional Denmark
Primary
Secondary
Concomitant

Drug Data