Amitriptyline Hydrochloride combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Myocardial Infarction Hospitalization 12/7/2001 73 Female 154 lb 1/20/2006 Physician United Kingdom
Primary
Concomitant
Wheezing Other Serious 1/19/2001 69 Female 115 lb 2/24/2006 Physician United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 1/11/2001 69 Female 115 lb 3/2/2006 Physician United Kingdom
Primary
Concomitant
Urinary Tract Infection Other Serious 1/1/2000 64 Female 291 lb 4/17/2006 Physician United States
Primary
Concomitant
Pemphigus Hospitalization 9/28/2005 Female 88 lb 5/1/2006 Physician Austria
Primary
Concomitant
Urinary Tract Infection Hospitalization 1/11/2001 69 Female 115 lb 5/18/2006 Physician United Kingdom
Primary
Concomitant
Sleep Disorder Disability 4/6/2006 65 Female 97 lb 6/7/2006 Pharmacist United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 63 Male 273 lb 10/16/2006 Other Health Professional France
Primary
Secondary
Concomitant
Syncope Other Serious 2/1/2005 48 Male 1/27/2007 Other Health Professional Sweden
Primary
Concomitant
Thrombocytopenia Other Serious 12/12/2005 63 Male 273 lb 2/1/2007 Other Health Professional France
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 12/12/2005 63 Male 273 lb 3/30/2007 Other Health Professional France
Primary
Secondary
Concomitant
Sternal Fracture Disability 7/1/2006 61 Female 185 lb 4/12/2007 Physician United States
Primary
Concomitant
Rash Papular Hospitalization 1/1/2006 Female 5/18/2007 Physician Norway
Primary
Concomitant
Lower Respiratory Tract Infection Disability 1/22/2007 59 Female 187 lb 5/29/2007 Physician United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 3/23/2007 68 Female 128 lb 6/15/2007 Consumer Brazil
Primary
Concomitant
Syncope Other Serious 2/1/2005 Male 8/13/2007 Other Health Professional Sweden
Primary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2003 67 Female 11/2/2007 Physician United States
Primary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2003 67 Female 11/5/2007 Physician United States
Primary
Concomitant
Diplegia Hospitalization 10/1/2007 Female 11/8/2007 Canada
Primary
Concomitant
Diplegia Hospitalization 10/1/2007 Female 11/9/2007 Canada
Primary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2002 67 Female 11/14/2007 Physician United States
Primary
Concomitant
Myelitis Transverse Hospitalization 10/1/2007 Female 11/16/2007 Canada
Primary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2002 67 Female 11/21/2007 Physician United States
Primary
Concomitant
Tooth Loss Other Serious 8/1/2005 59 Female 11/28/2007 Other Health Professional United States
Primary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2002 67 Female 12/14/2007 Physician United States
Primary
Concomitant
Myelitis Transverse Hospitalization 10/1/2007 Female 12/14/2007 Canada
Primary
Concomitant
Musculoskeletal Pain Other Serious Female 154 lb 1/29/2008 Canada
Primary
Concomitant
Ventricular Extrasystoles Hospitalization 1/1/2000 54 Female 168 lb 2/12/2008 Physician United States
Primary
Concomitant
Vaginal Haemorrhage Other Serious 1/1/2002 67 Female 2/22/2008 Physician United States
Primary
Concomitant
Musculoskeletal Pain Other Serious Female 154 lb 2/25/2008 Canada
Primary
Concomitant
Tooth Loss Other Serious 8/1/2005 59 Female 3/13/2008 Other Health Professional United States
Primary
Concomitant
Throat Tightness 11/23/2007 Female 180 lb 3/14/2008 United States
Primary
Concomitant
Somnolence 12/5/2007 Female 175 lb 3/14/2008 United States
Primary
Concomitant
Sinus Headache 10/1/2007 Female 117 lb 3/15/2008 United States
Primary
Concomitant
Procedural Complication 2/25/2008 Female 190 lb 3/15/2008 Consumer United States
Primary
Concomitant
Wrist Fracture Other Serious 1/1/2002 67 Female 3/18/2008 Physician United States
Primary
Concomitant
Myelitis Transverse Hospitalization 10/1/2007 Female 182 lb 3/20/2008 Canada
Primary
Concomitant
Tooth Loss Other Serious 8/1/2005 59 Female 6/9/2008 Other Health Professional United States
Primary
Concomitant
Pyrexia Other Serious 5/21/2008 Female 132 lb 6/11/2008 Canada
Primary
Concomitant
Weight Increased Other Serious Female 6/11/2008 Physician Australia
Primary
Concomitant
Underdose 2/1/2008 Male 198 lb 6/12/2008 Consumer United States
Primary
Concomitant
Bronchitis 2/1/2008 Female 160 lb 6/13/2008 United States
Primary
Concomitant
Vertigo Positional Other Serious 1/1/1997 54 Female 168 lb 6/18/2008 Physician United States
Primary
Concomitant
Tooth Loss Other Serious 8/1/2005 59 Female 6/26/2008 Other Health Professional United States
Primary
Concomitant
Vertigo Positional Other Serious 1/1/1997 54 Female 168 lb 7/1/2008 Physician United States
Primary
Concomitant
Vomiting Hospitalization 6/1/2008 Female 7/8/2008 Brazil
Primary
Concomitant
Vertigo Positional Other Serious 1/1/1997 54 Female 168 lb 8/13/2008 Physician United States
Primary
Concomitant
Tooth Loss Other Serious 2/1/2005 59 Female 269 lb 9/8/2008 Other Health Professional United States
Primary
Concomitant
Drug Ineffective 9/1/2007 Female 170 lb 9/12/2008 Consumer United States
Primary
Concomitant
Sinusitis Other Serious 4/1/2002 Male 9/15/2008 Consumer France
Primary
Secondary
Concomitant
Wrist Fracture Other Serious 1/17/2006 72 Female 147 lb 9/10/2008 Consumer United States
Primary
Concomitant
Homicidal Ideation Other Serious 9/26/2007 59 Female 9/29/2008 Other Health Professional Australia
Primary
Concomitant
Pyrexia Other Serious 5/21/2008 Female 132 lb 9/30/2008 Canada
Primary
Concomitant
Vertigo Positional Other Serious 1/1/1997 54 Female 168 lb 11/20/2008 Physician United States
Primary
Concomitant
Sinusitis Other Serious 4/1/2002 12/17/2008 Other Health Professional France
Primary
Secondary
Concomitant
Wrist Fracture Other Serious 1/1/2002 66 Female 12/22/2008 Physician United States
Primary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 12/3/2008 United States
Primary
Secondary
Concomitant
Xerosis Other Serious 1/1/2000 11 Male 77 lb 12/3/2008 United States
Primary
Secondary
Concomitant
Supraventricular Tachycardia Hospitalization 3/16/2009 57 Male 4/15/2009 Other Health Professional United Kingdom
Primary
Concomitant
Sinusitis Other Serious 4/1/2002 Male 5/28/2009 Other Health Professional France
Primary
Secondary
Concomitant
Tooth Fracture Other Serious 9/28/2005 68 Female 123 lb 4/20/2009 Physician United States
Primary
Secondary
Concomitant
Vertigo Positional Other Serious 1/1/1997 46 Female 168 lb 6/29/2009 Physician United States
Primary
Concomitant
Lethargy Other Serious 6/12/2009 53 Male 220 lb 7/16/2009 Other Health Professional United Kingdom
Primary
Concomitant
Vertigo Positional Other Serious 1/1/1997 46 Female 168 lb 7/29/2009 Physician United States
Primary
Concomitant
Respiratory Tract Infection Bacterial Hospitalization 1/1/2004 Female 130 lb 10/2/2009 Other Health Professional
Primary
Secondary
Concomitant
Vertigo Positional Other Serious 1/1/1997 46 Female 168 lb 10/15/2009 Physician United States
Primary
Concomitant
Deafness Neurosensory Hospitalization 4/1/2004 Female 128 lb 10/20/2009 Germany
Primary
Concomitant
Transaminases Increased Hospitalization 8/1/2009 74 Female 125 lb 11/6/2009 Physician Switzerland
Primary
Secondary
Concomitant
Osteonecrosis Disability 12/1/2007 57 Female 11/25/2009 United States
Primary
Concomitant
Mouth Haemorrhage Life Threatening 12/31/2009 40 Female 1/15/2010 Physician Germany
Primary
Secondary
Concomitant
Hyponatraemia Other Serious 11/4/2009 Female 152 lb 2/5/2010 Physician Austria
Primary
Concomitant
Therapy Cessation Other Serious 1/1/2009 Female 152 lb 3/17/2010 Physician Austria
Primary
Concomitant
Cholecystitis Acute Other Serious 10/15/2009 66 Female 4/2/2010 United Kingdom
Primary
Concomitant
Thrombophlebitis Superficial Hospitalization 11/28/2009 59 Female 335 lb 7/9/2010 Other Health Professional United States
Primary
Concomitant
Optic Neuritis Other Serious 6/28/2010 40 Female 132 lb 7/9/2010 Physician Argentina
Primary
Secondary
Concomitant
Subdural Haematoma Hospitalization 6/18/2010 69 Female 218 lb 7/9/2010 Physician Canada
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 2/12/2010 69 Male 7/9/2010 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Other Serious Female 7/13/2010 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
White Blood Cell Count Increased Hospitalization 2/1/2009 72 Male 197 lb 7/7/2010 Other Health Professional United States
Primary
Concomitant
Scotoma Other Serious 6/28/2010 40 Female 132 lb 7/15/2010 Physician Argentina
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 1/1/2007 57 Female 163 lb 7/16/2010 Consumer Brazil
Primary
Concomitant
Urinary Tract Infection Pseudomonal Hospitalization 6/1/2010 11 Female 122 lb 7/19/2010 Physician United States
Primary
Concomitant
Tooth Abscess Hospitalization 7/6/2010 38 Male 153 lb 7/12/2010 Other Health Professional New Zealand
Primary
Concomitant
Tooth Fracture Other Serious 9/28/2005 68 Female 123 lb 4/13/2010 Physician United States
Primary
Secondary
Concomitant
Tooth Fracture Other Serious 9/28/2005 68 Female 123 lb 4/13/2010 Physician United States
Primary
Secondary
Concomitant
Tooth Abscess Hospitalization 7/6/2010 38 Male 153 lb 7/15/2010 Physician New Zealand
Primary
Concomitant
Tooth Abscess Hospitalization 7/6/2010 38 Male 153 lb 7/20/2010 Physician New Zealand
Primary
Concomitant
Melaena Other Serious 7/1/2010 Female 165 lb 7/23/2010 Consumer United States
Primary
Concomitant
Rhabdomyolysis Other Serious 2/9/2009 57 Female 154 lb 7/23/2010 Physician United States
Primary
Concomitant
Urinary Tract Infection Pseudomonal Hospitalization 6/1/2010 13 Female 122 lb 7/27/2010 Physician United States
Primary
Concomitant
Colon Adenoma Hospitalization 4/8/2010 59 Female 165 lb 7/28/2010 Physician Brazil
Primary
Concomitant
Breast Cancer Other Serious 7/1/2010 60 Female 8/2/2010 Other Health Professional United Kingdom
Primary
Concomitant
Rheumatoid Arthritis Other Serious Female 8/2/2010 Pharmacist United Kingdom
Primary
Secondary
Concomitant
Rheumatoid Arthritis Other Serious Female 8/2/2010 Consumer United Kingdom
Primary
Secondary
Concomitant
Malaise Hospitalization 6/26/2010 58 Female 8/4/2010 Physician France
Primary
Concomitant
Liver Disorder Other Serious Female 148 lb 8/6/2010 Consumer Brazil
Primary
Concomitant
Wound Infection Hospitalization 7/6/2010 38 Male 153 lb 8/2/2010 Other Health Professional New Zealand
Primary
Concomitant
Weight Decreased Other Serious 4/1/2008 56 Female 154 lb 8/12/2010 Physician United States
Primary
Concomitant
Vomiting Other Serious 6/5/2005 53 Male 174 lb 8/18/2010 Physician United States
Primary
Concomitant
Urinary Tract Infection Hospitalization Female 8/23/2010 Consumer Brazil
Primary
Concomitant
Tremor Other Serious 7/1/2010 53 Female 148 lb 9/2/2010 Consumer Brazil
Primary
Concomitant
Vomiting Other Serious 1/1/2004 61 Female 258 lb 9/4/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Tooth Disorder Hospitalization 1/1/2007 57 Female 9/8/2010 Other Health Professional United States
Primary
Concomitant
Tooth Disorder Hospitalization 1/1/2007 57 Female 9/30/2010 Other Health Professional United States
Primary
Concomitant
Tooth Infection Other Serious 1/1/2007 57 Female 10/14/2010 Other Health Professional United States
Primary
Concomitant
Weight Increased Other Serious 7/31/2004 57 Female 181 lb 11/15/2010 Other Health Professional United States
Primary
Concomitant
Nausea Hospitalization 5/1/2009 12/13/2010 Physician United States
Primary
Secondary
Concomitant
Multiple Allergies Other Serious 2/22/2010 48 Female 161 lb 12/15/2010 Other Health Professional United States
Primary
Concomitant
Tooth Fracture Other Serious 9/28/2005 68 Female 123 lb 10/28/2010 Physician United States
Primary
Secondary
Concomitant
Intracranial Aneurysm Hospitalization 1/1/2010 62 Female 132 lb 2/9/2011 Physician Brazil
Primary
Concomitant
Fibrocystic Breast Disease Other Serious 1/1/1997 46 Female 168 lb 2/10/2011 Physician United States
Primary
Concomitant
Headache Hospitalization 1/1/2010 62 Female 132 lb 2/11/2011 Consumer Brazil
Primary
Concomitant
Cough Hospitalization 1/1/1997 46 Female 168 lb 3/3/2011 Physician United States
Primary
Concomitant
Gastrointestinal Pain Hospitalization 6/11/2010 53 Female 132 lb 3/4/2011 Consumer Brazil
Primary
Concomitant
Ill-defined Disorder Other Serious 6/11/2010 53 Female 132 lb 3/8/2011 Consumer Brazil
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Other Serious 1/1/2005 57 Female 181 lb 3/10/2011 Other Health Professional United States
Primary
Concomitant
Chronic Obstructive Pulmonary Disease Other Serious 1/1/2005 57 Female 181 lb 3/14/2011 Other Health Professional United States
Primary
Concomitant
Cough Other Serious 1/1/1997 46 Female 168 lb 5/13/2011 Physician United States
Primary
Concomitant
Dyspnoea Hospitalization 5/3/2011 82 Female 6/10/2011 Other Health Professional United Kingdom
Primary
Concomitant
Dysphonia Other Serious 9/15/2009 58 Female 198 lb 6/15/2011 Consumer United Kingdom
Primary
Secondary
Concomitant
Rectal Haemorrhage Other Serious 10/1/2010 45 Female 6/15/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rectal Haemorrhage Other Serious 10/1/2010 45 6/16/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Rectal Haemorrhage Other Serious 10/1/2010 45 6/17/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Renal Failure Acute Disability 66 Male 6/20/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Paranoia Other Serious 1/1/2011 64 Female 187 lb 8/26/2011 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Drug Ineffective Other Serious 6/11/2010 53 Female 132 lb 8/31/2011 Consumer Brazil
Primary
Concomitant
Inappropriate Antidiuretic Hormone Secretion Hospitalization 17 Female 154 lb 4/2/2012 Pharmacist Canada
Primary
Concomitant
Hypersensitivity Other Serious 48 Female 159 lb 4/9/2012 Consumer Brazil
Primary
Concomitant
Angioedema Other Serious 2/22/2012 Female 4/9/2012 Physician Mexico
Primary
Concomitant
Pneumonia Hospitalization 3/8/2012 83 Female 110 lb 4/13/2012 Physician United States
Primary
Concomitant
Klebsiella Infection Hospitalization 2/1/2012 78 Female 7/25/2012 Other Health Professional United Kingdom
Primary
Concomitant
Glycosylated Haemoglobin Increased Other Serious 6/8/2012 42 Male 264 lb 7/30/2012 Consumer United States
Primary
Concomitant
Polyarthritis Hospitalization 3/10/2012 58 Male 137 lb 7/30/2012 Physician Germany
Primary
Concomitant
Constipation 6/1/2012 78 Female 119 lb 8/24/2012 Consumer United States
Primary
Concomitant
Nasopharyngitis Other Serious 7/29/2012 64 Female 153 lb 8/24/2012 Other Health Professional Canada
Primary
Concomitant
Vasculitic Rash Other Serious 66 Male 8/16/2012 Other Health Professional Gb
Primary
Secondary
Concomitant
Varicose Vein Other Serious 2002 Female 144 lb 3/12/2013 Consumer Us
Primary
Secondary
Concomitant
Multiple Sclerosis Other Serious 3/2012 55 Female 10/8/2012 Physician Gr
Primary
Concomitant
Still's Disease Adult Onset Hospitalization 5/2013 57 Female 181 lb 6/21/2013 Physician Country Not Specified
Primary
Concomitant
Intestinal Adenocarcinoma Other Serious 7/17/2008 63 Female 144 lb 6/6/2013 Consumer Us
Primary
Concomitant
Weight Increased Female 6/16/2013 Consumer Us
Primary
Secondary
Concomitant
Vestibular Neuronitis Hospitalization 2/28/2013 76 Female 8/20/2013 Other Health Professional Au
Primary
Secondary
Concomitant
Non-hodgkin's Lymphoma Other Serious 2/4/2000 59 Female 8/27/2013 Physician Us
Primary
Secondary
Concomitant
Pulmonary Fibrosis Other Serious Female 8/28/2013 Consumer Ca
Primary
Concomitant
Alveolitis Other Serious 8/9/2013 87 Male 207 lb 8/29/2013 Physician Gb
Primary
Concomitant
Drug Level Increased Hospitalization 8/24/2013 14 Female 95 lb 9/12/2013 Physician Cl
Primary
Secondary
Concomitant
Treatment Failure Other Serious 10/29/2012 67 Female 9/19/2013 Other Health Professional Gb
Primary
Secondary
Concomitant
Treatment Failure Other Serious 10/29/2012 67 Female 9/25/2013 Pharmacist Gb
Primary
Secondary
Concomitant
Treatment Failure Other Serious 10/29/2012 67 Female 9/26/2013 Consumer Gb
Primary
Secondary
Concomitant
Treatment Failure Hospitalization 10/29/2012 67 Female 9/27/2013 Gb
Primary
Secondary
Concomitant

Drug Data