Alteplase combined with Heparin

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Liver Function Test Abnormal 11/1/2004 61 9/12/2005 Pharmacist United States
Primary
Concomitant
Pulmonary Haemorrhage Death 10/7/2004 50 9/12/2005 Physician United States
Primary
Concomitant
Renal Infarct Other Serious 4/4/2006 68 Male 4/17/2008 Physician Japan
Primary
Concomitant
Cerebral Haemorrhage Death 4/23/2008
Primary
Secondary
Cerebral Haemorrhage Death 4/24/2008 Sweden
Primary
Secondary
Haematuria Other Serious 5/7/2008 69 Female 5/13/2008 Pharmacist United States
Primary
Concomitant
Tracheal Obstruction Hospitalization 59 Male 9/2/2009 Other Health Professional Germany
Primary
Secondary
Vena Cava Thrombosis Hospitalization 11 Female 150 lb 9/14/2009 Other Health Professional United States
Primary
Secondary
Concomitant
No Therapeutic Response Required Intervention 1/17/2009 74 Female 9/28/2009 Pharmacist United States
Primary
Secondary
Concomitant
Wound Infection Hospitalization 29 Female 276 lb 9/29/2009 United States
Primary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 1/11/2010 Pharmacist United States
Primary
Concomitant
Throat Irritation Other Serious 1/1/2005 Female 153 lb 1/21/2010 Pharmacist United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 Female 153 lb 1/30/2010 Pharmacist United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 Female 153 lb 2/8/2010 Pharmacist United States
Primary
Concomitant
Wound Drainage Other Serious 2/1/2002 2/24/2010 United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 2/1/2002 3/5/2010 United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 2/1/2002 3/18/2010 Physician United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 2/1/2002 3/31/2010 Physician United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 2/1/2002 4/13/2010 Physician United States
Primary
Secondary
Concomitant
Haemorrhagic Stroke Death 5/26/2010 Physician Poland
Primary
Concomitant
Haemorrhage Death 5/28/2010 Sweden
Primary
Secondary
Vision Blurred Other Serious 1/1/2005 64 Female 153 lb 6/11/2010 United States
Primary
Concomitant
Wound Drainage Other Serious 2/1/2002 63 Male 140 lb 6/11/2010 Physician United States
Primary
Secondary
Concomitant
Wound Drainage Other Serious 2/1/2002 63 Male 140 lb 6/23/2010 Physician United States
Primary
Secondary
Concomitant
Pyrexia Other Serious 12/1/2010 58 Female 251 lb 12/22/2010 Pharmacist United States
Primary
Concomitant
Pyrexia Other Serious 12/1/2010 58 Female 251 lb 3/9/2011 Pharmacist United States
Primary
Secondary
Concomitant
Hypovolaemia Life Threatening 78 Male 6/10/2011 Other Health Professional Greece
Primary
Concomitant
Palpitations Hospitalization 1/1/2007 53 Female 220 lb 6/15/2011 United States
Primary
Secondary
Concomitant
Haemorrhage Other Serious 0 Female 7 lb 6/17/2011 Other Health Professional Saudi Arabia
Primary
Concomitant
Haemorrhage Other Serious 1 Female 8 lb 6/17/2011 Pharmacist Saudi Arabia
Primary
Concomitant
Pain Hospitalization 9/20/2009 27 Female 200 lb 8/5/2011 Consumer United States
Primary
Concomitant
Vertigo Other Serious 1/1/2007 53 Female 220 lb 8/8/2011 United States
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death 76 Female 10/21/2011 Physician Japan
Primary
Secondary
Metastatic Neoplasm Death 3/31/2011 55 Female 10/28/2011 United States
Primary
Secondary
Concomitant
Nausea Death 8/20/2011 63 Male 226 lb 11/14/2011 Consumer United States
Primary
Concomitant
Arteriosclerosis Other Serious 2/1/2002 63 Male 140 lb 11/16/2011 Physician United States
Primary
Secondary
Concomitant
Radiculopathy Other Serious 2/1/2002 63 Male 140 lb 11/17/2011 Physician United States
Primary
Secondary
Concomitant
Haemorrhagic Stroke Hospitalization 3/31/2011 55 Female 11/21/2011 United States
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Disability 3/31/2011 55 Female 12/2/2011 United States
Primary
Secondary
Concomitant
Gait Disturbance Other Serious Female 123 lb 12/15/2011 Lawyer United States
Primary
Secondary
Concomitant
Neutropenia Death 12/20/2011 58 Female 229 lb 1/6/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Neutropenic Infection Death 12/20/2011 58 Female 229 lb 1/12/2012 Physician United States
Primary
Secondary
Concomitant
Dyspnoea Hospitalization Female 123 lb 1/17/2012 Physician United States
Primary
Secondary
Concomitant
Hypoaesthesia Other Serious 2/1/2002 63 Male 140 lb 1/17/2012 United States
Primary
Secondary
Concomitant
Back Pain Other Serious 2/1/2002 63 Male 140 lb 1/25/2012 Physician United States
Primary
Secondary
Concomitant
Compartment Syndrome Other Serious 2/8/2012 Physician Norway
Primary
Secondary
Shock Death 2/20/2012 Korea, Republic Of
Primary
Secondary
Concomitant
Brain Oedema Other Serious 2/20/2012 Korea, Republic Of
Primary
Secondary
Concomitant
Puncture Site Infection Other Serious 2/28/2012 Other Health Professional Norway
Primary
Concomitant
Haemorrhagic Transformation Stroke Hospitalization Male 3/5/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Cerebellar Infarction Other Serious 3/6/2012 France
Primary
Concomitant
Sepsis Hospitalization 2/15/2012 63 Male 209 lb 3/8/2012 Consumer United States
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death 76 Female 4/5/2012 Physician Japan
Primary
Secondary
Cerebral Haemorrhage Death 76 Female 5/24/2012 Physician Japan
Primary
Secondary
Cerebral Haemorrhage Death 1/1/2010 Female 5/29/2012 Other Health Professional Finland
Primary
Concomitant
Lactic Acidosis Death 52 Female 5/29/2012 Other Health Professional United States
Primary
Secondary
Hemiparesis Death Male 6/4/2012 United States
Primary
Secondary
Concomitant
Intestinal Ischaemia Death 0 Female 6/6/2012 Germany
Primary
Secondary
Haemodynamic Instability Hospitalization 7/5/2009 76 Female 6/19/2012 Spain
Primary
Concomitant
Cardiogenic Shock Death 75 Female 7/2/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Haemorrhage Intracranial Hospitalization 6/1/2012 Male 15 lb 7/26/2012 Other Health Professional United Kingdom
Primary
Concomitant
Subdural Haemorrhage Other Serious Male 8/1/2012 Other Health Professional United States
Primary
Secondary
Aphasia Hospitalization 67 Male 8/3/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Aphasia Death 67 Male 8/3/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Cerebral Haemorrhage Death 1/1/2010 Female 8/22/2012 Other Health Professional Finland
Primary
Secondary
Mouth Haemorrhage Hospitalization 6/23/2012 9 Female 122 lb 8/13/2012 Pharmacist United States
Primary
Concomitant
Stevens-johnson Syndrome Other Serious 11/15/2010 60 Female 10/4/2012 Lawyer Us
Primary
Concomitant
Neutropenic Sepsis Life Threatening 12/20/2011 58 Female 208 lb 10/26/2012 Physician Us
Primary
Secondary
Concomitant
Thrombotic Microangiopathy Other Serious 4/2012 Male 231 lb 11/5/2012 Physician Gb
Primary
Concomitant
Hepatic Enzyme Increased Other Serious 7/16/2012 67 Male 9/20/2012 Consumer Us
Primary
Secondary
Concomitant
Haemorrhage Other Serious 5 Male 1/8/2013 Other Health Professional Country Not Specified
Primary
Secondary
Hyperpyrexia Other Serious 9/10/2012 82 Male 212 lb 9/26/2012 Other Health Professional Cz
Primary
Concomitant
Gastrointestinal Haemorrhage Life Threatening 84 Female 10/8/2012 Other Health Professional Country Not Specified
Primary
Secondary
Thrombosis In Device Other Serious 37 Male 9/29/2012 Other Health Professional Country Not Specified
Primary
Secondary
Septic Shock Life Threatening 10/7/2012 81 Male 172 lb 2/20/2013 Other Health Professional Us
Primary
Concomitant
Sinus Disorder Other Serious 9/4/2012 7 Male 44 lb 5/3/2013 Consumer Us
Primary
Secondary
Concomitant
Aspartate Aminotransferase Increased Other Serious 7/16/2012 67 Male 11/13/2012 Consumer Us
Primary
Secondary
Concomitant
Shock Other Serious 65 Male 12/3/2012 Physician Country Not Specified
Primary
Secondary
Vaginal Haemorrhage Life Threatening 40 Female 190 lb 12/11/2012 Physician Country Not Specified
Primary
Secondary
Concomitant
Brain Oedema Hospitalization 87 Female 1/11/2013 Other Health Professional Country Not Specified
Primary
Secondary
Death Death NotSpecified 1/22/2013 Other Health Professional Country Not Specified
Primary
Concomitant
Death Death NotSpecified 1/18/2013 Other Health Professional Country Not Specified
Primary
Concomitant
Cardiac Death Death NotSpecified 1/10/2013 Physician Country Not Specified
Primary
Concomitant
Rhabdomyolysis Life Threatening Male 154 lb 1/2/2013 Physician Gb
Primary
Secondary
Concomitant
Compartment Syndrome Hospitalization Male 1/2/2013 Other Health Professional De
Primary
Concomitant
Embolism Arterial Hospitalization NotSpecified 1/14/2013 Physician Country Not Specified
Primary
Concomitant
Pneumonia Death Male 1/11/2013 Other Health Professional Country Not Specified
Primary
Secondary
Postinfarction Angina Hospitalization Male 1/2/2013 Physician De
Primary
Concomitant
Myocardial Infarction Death 69 Male 1/2/2013 Physician Be
Primary
Concomitant
Spinal Epidural Haematoma Death 69 Male 1/2/2013 Other Health Professional Country Not Specified
Primary
Secondary
Concomitant
Death Death NotSpecified 1/18/2013 Other Health Professional Country Not Specified
Primary
Concomitant
Cardiac Death Death NotSpecified 1/10/2013 Physician Country Not Specified
Primary
Concomitant
Death Death NotSpecified 1/18/2013 Other Health Professional Country Not Specified
Primary
Concomitant
Haemorrhagic Stroke Death 11/8/2010 53 Male 1/2/2013 Physician Tn
Primary
Concomitant
Pulseless Electrical Activity Life Threatening 5/30/1994 55 Male 1/2/2013 Physician De
Primary
Concomitant
Postinfarction Angina Other Serious 56 Male 1/4/2013 Physician De
Primary
Concomitant
Peripheral Artery Thrombosis Hospitalization Male 1/4/2013 Physician De
Primary
Concomitant
Shock Death Male 1/11/2013 Physician Country Not Specified
Primary
Secondary
Lethargy Other Serious 67 Female 1/25/2013 Physician Country Not Specified
Primary
Concomitant
Peripheral Arterial Occlusive Disease Disability Female 159 lb 1/3/2013 Physician De
Primary
Concomitant
Shock Death Male 1/11/2013 Physician Country Not Specified
Primary
Secondary
Haemoglobin Decreased Hospitalization Male 1/7/2013 Physician De
Primary
Secondary
Concomitant
Coronary Artery Stenosis Hospitalization 6/25/1994 65 Male 1/7/2013 Physician De
Primary
Concomitant
Shock Death Male 1/7/2013 Physician Country Not Specified
Primary
Secondary
Ventricular Extrasystoles Hospitalization 3/24/1994 76 Male 1/7/2013 Physician De
Primary
Secondary
Concomitant
Cardiac Valve Prosthesis User Other Serious 10/24/1989 68 Male 2/12/2013 Other Health Professional Country Not Specified
Primary
Concomitant
Death Death 81 Male 2/19/2013 Other Health Professional Country Not Specified
Primary
Secondary
Sepsis Life Threatening 75 Female 2/1/2013 Other Health Professional Country Not Specified
Primary
Secondary
Concomitant
Vomiting Hospitalization 7/25/2012 71 Female 5/14/2013 Physician Ca
Primary
Secondary
Concomitant
Upper Gastrointestinal Haemorrhage Other Serious 72 Male 2/14/2013 Other Health Professional Country Not Specified
Primary
Secondary
Haematoma Other Serious 42 Female 2/27/2013 Other Health Professional Country Not Specified
Primary
Secondary
Death Other Serious 67 Female 2/8/2013 Other Health Professional Country Not Specified
Primary
Secondary
Haemorrhagic Infarction Death 88 Male 2/8/2013 Other Health Professional Country Not Specified
Primary
Secondary
Thrombosis Other Serious Female 3/7/2013 Other Health Professional Ca
Primary
Concomitant
Pulmonary Embolism Life Threatening 74 Male 3/25/2013 Other Health Professional Country Not Specified
Primary
Secondary
Death Death 59 Male 5/21/2013 Other Health Professional Pl
Primary
Secondary
Death Death 53 Male 5/21/2013 Other Health Professional Country Not Specified
Primary
Secondary
Death Death 66 Male 5/21/2013 Other Health Professional Country Not Specified
Primary
Secondary
Death Death 61 Male 5/21/2013 Other Health Professional Country Not Specified
Primary
Secondary
Death Death 59 Male 5/21/2013 Other Health Professional Country Not Specified
Primary
Secondary
Death Death 26 Female 5/13/2013 Physician Country Not Specified
Primary
Concomitant
Shock Death NotSpecified 4/9/2013 Other Health Professional Country Not Specified
Primary
Concomitant
Cerebrovascular Accident Other Serious NotSpecified 6/11/2013 Other Health Professional Cn
Primary
Secondary
Concomitant
Intraocular Pressure Increased Other Serious NotSpecified 5/6/2013 Physician De
Primary
Concomitant
Sudden Death Death Male 132 lb 4/10/2013 Physician Cn
Primary
Concomitant
Epistaxis Hospitalization 46 Male 6/11/2013 Other Health Professional At
Primary
Secondary
Concomitant
Multi-organ Failure Death NotSpecified 6/11/2013 Other Health Professional Cn
Primary
Concomitant
Septic Shock Death 4/15/2003 71 Female 165 lb 4/11/2013 Other Health Professional Cn
Primary
Concomitant
Rash Other Serious NotSpecified 5/24/2013 Physician De
Primary
Concomitant
Visual Acuity Reduced Other Serious 70 Female 5/21/2013 Other Health Professional Country Not Specified
Primary
Secondary
Compartment Syndrome Hospitalization 79 Male 5/10/2013 Other Health Professional Country Not Specified
Primary
Secondary
Ventricular Fibrillation Death NotSpecified 4/18/2013 Other Health Professional Country Not Specified
Primary
Concomitant
Death Other Serious NotSpecified 6/24/2013 Physician Se
Primary
Secondary
Ischaemic Stroke Other Serious NotSpecified 5/14/2013 Other Health Professional Country Not Specified
Primary
Secondary
Haematocrit Decreased Hospitalization 84 Male 5/10/2013 Other Health Professional Country Not Specified
Primary
Secondary
Cerebral Vasoconstriction Death NotSpecified 6/20/2013 Physician Jp
Primary
Concomitant
Overdose Other Serious 49 Male 6/18/2013 Physician It
Primary
Secondary
Muscle Haemorrhage Other Serious 71 NotSpecified 5/2/2013 Physician Country Not Specified
Primary
Secondary
Gastrointestinal Ulcer Other Serious NotSpecified 5/6/2013 Other Health Professional De
Primary
Secondary
Deep Vein Thrombosis Other Serious 41 Male 5/18/2013 Other Health Professional Country Not Specified
Primary
Secondary
Cardiac Arrest Death NotSpecified 5/6/2013 Physician De
Primary
Concomitant
Drug Ineffective Death 76 Female 6/15/2013 Physician Fr
Primary
Secondary
Femoral Artery Aneurysm Hospitalization 82 Male 5/10/2013 Other Health Professional Country Not Specified
Primary
Secondary
Death Death 74 Male 4/11/2013 Other Health Professional Country Not Specified
Primary
Secondary
Death Death NotSpecified 5/6/2013 Physician Country Not Specified
Primary
Secondary
Upper Gastrointestinal Haemorrhage Death NotSpecified 6/18/2013 Physician It
Primary
Secondary
Deep Vein Thrombosis Other Serious 21 Female 5/18/2013 Other Health Professional Country Not Specified
Primary
Secondary
Deep Vein Thrombosis Other Serious 30 Female 5/18/2013 Other Health Professional Country Not Specified
Primary
Secondary
Peripheral Embolism Other Serious NotSpecified 6/18/2013 Physician Gr
Primary
Secondary
Weight Increased Other Serious 2007 55 Female 220 lb 5/10/2013 Us
Primary
Secondary
Concomitant

Drug Data