Alprazolam combined with Topiramate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pharmaceutical Product Complaint Other Serious 1/14/2006 41 Female 150 lb 3/22/2006 Pharmacist United States
Primary
Concomitant
Nausea Other Serious 1/14/2006 41 Female 150 lb 4/4/2006 Pharmacist United States
Primary
Secondary
Concomitant
Stridor Disability 2/24/2006 45 Female 5/8/2006 United States
Primary
Concomitant
Speech Disorder Other Serious 3/24/2006 52 Male 292 lb 3/27/2006 Pharmacist United States
Primary
Concomitant
Cholelithiasis Hospitalization 5/28/2006 Female 159 lb 6/9/2006 Physician United States
Primary
Secondary
Concomitant
Drug Withdrawal Syndrome Hospitalization 9/14/2005 36 Male 247 lb 5/9/2006 Physician United States
Primary
Secondary
Concomitant
Leukopenia Required Intervention 9/16/2005 21 Female 1/17/2006 Consumer United States
Primary
Concomitant
Torsade De Pointes Hospitalization 1/1/2005 52 Female 8/22/2006 Pharmacist United States
Primary
Secondary
Concomitant
Cholelithiasis Hospitalization 5/29/2006 Female 159 lb 11/20/2006 Physician United States
Primary
Concomitant
Chest Discomfort Other Serious 3/19/2006 Female 12/13/2006 Consumer United States
Primary
Concomitant
Therapy Regimen Changed Other Serious 26 Female 7/3/2007 Other Health Professional United States
Primary
Secondary
Neuroleptic Malignant Syndrome Other Serious 26 Female 7/7/2007 Physician United States
Primary
Secondary
Neuroleptic Malignant Syndrome Other Serious 26 Female 8/7/2007 Physician United States
Primary
Secondary
Urticaria Other Serious 12/29/2006 Female 196 lb 10/5/2007 Other Health Professional Canada
Primary
Concomitant
Nausea 10/26/2007 Female 12/14/2007 United States
Primary
Concomitant
Death Death 12/8/2007 50 Female 178 lb 12/26/2007 United States
Primary
Concomitant
Nausea 9/26/2007 Female 135 lb 3/14/2008 United States
Primary
Concomitant
Overdose Life Threatening 26 Female 4/8/2008 United States
Primary
Secondary
Tremor Other Serious 1/1/2000 Female 165 lb 4/24/2008 United States
Primary
Concomitant
Interacting
Tremor Other Serious 1/1/2000 Female 165 lb 5/14/2008 United States
Primary
Concomitant
Interacting
Premature Labour Other Serious 10/31/2007 Female 157 lb 6/9/2008 United States
Primary
Concomitant
Pain In Extremity 6/16/2008 Female 168 lb 9/12/2008 United States
Primary
Concomitant
Somnolence Hospitalization 10/3/2008 64 Male 202 lb 10/6/2008 Pharmacist United States
Primary
Secondary
Tongue Haemorrhage 12/30/2007 Male 251 lb 11/20/2008 Physician Japan
Primary
Secondary
Concomitant
Blood Iron Increased 6/1/2008 Female 146 lb 12/12/2008 Other Health Professional United States
Primary
Concomitant
Alopecia 9/10/2008 Female 12/12/2008 Other Health Professional United States
Primary
Concomitant
Overdose Death 36 Female 12/29/2008 Pharmacist United States
Primary
Secondary
Death Death 6/10/2009 59 Female 157 lb 6/24/2009 Physician United States
Primary
Concomitant
Weight Increased Hospitalization 1/1/2007 Female 104 lb 8/6/2009 Physician United States
Primary
Concomitant
Pain In Extremity 6/16/2008 Female 168 lb 9/12/2009 United States
Primary
Concomitant
Vomiting Life Threatening 9/25/2009 Physician United States
Primary
Concomitant
Drug Ineffective Other Serious 15 Female 143 lb 9/29/2009
Primary
Secondary
Concomitant
Weight Increased Hospitalization 6/1/2009 48 Female 9/18/2009 Pharmacist United States
Primary
Secondary
Concomitant
Tinnitus Other Serious 3/1/2009 58 Female 155 lb 10/2/2009 Consumer United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 8/1/2009 51 Female 135 lb 10/12/2009 United States
Primary
Concomitant
Septic Shock Hospitalization 40 Female 10/19/2009 Physician United States
Primary
Concomitant
Weight Decreased Other Serious 2/1/2008 45 Female 256 lb 10/14/2009 United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 8/1/2009 51 Female 135 lb 11/9/2009 United States
Primary
Concomitant
Weight Increased Other Serious 16 Male 11/17/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Weight Increased Other Serious 16 Male 11/19/2009 Other Health Professional United States
Primary
Secondary
Weight Increased Other Serious 11/1/2008 36 Male 11/19/2009 Consumer United States
Primary
Concomitant
Weight Increased Hospitalization 16 Male 12/1/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Interacting
Weight Increased Other Serious 16 Male 11/24/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 16 Male 12/9/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Arrest Death 1/1/2008 31 Female 1/8/2010 Physician United States
Primary
Secondary
Drug Toxicity Other Serious 31 Female 1/25/2010 Physician United States
Primary
Secondary
Death Death 31 Female 1/20/2010 United States
Primary
Secondary
Respiratory Arrest Death 31 Female 1/25/2010 Physician United States
Primary
Secondary
Respiratory Arrest Death 31 Female 1/26/2010 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2008 31 Female 2/1/2010 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2008 31 Female 2/2/2010 Physician United States
Primary
Secondary
Treatment Noncompliance Other Serious 12/28/2009 39 Female 170 lb 2/4/2010 Consumer United States
Primary
Secondary
Concomitant
Drug Toxicity Death 37 Female 210 lb 2/27/2010 Consumer United States
Primary
Secondary
Concomitant
Respiratory Arrest Death 31 Female 3/5/2010 Other Health Professional United States
Primary
Secondary
Weight Increased Other Serious 36 Male 4/6/2010 Other Health Professional Austria
Primary
Secondary
Weight Increased Other Serious 1/1/2007 35 Female 5/7/2010 Consumer United States
Primary
Secondary
Concomitant
Priapism Other Serious 6/2/2010 21 Male 7/7/2010 Other Health Professional France
Primary
Secondary
Hypokalaemia Hospitalization 7/14/2010 30 Female 183 lb 8/10/2010 Other Health Professional United States
Primary
Concomitant
Hypokalaemia Hospitalization 7/14/2010 30 Female 183 lb 9/2/2010 Other Health Professional United States
Primary
Concomitant
Weight Increased Hospitalization 16 Male 9/29/2010 Physician United States
Primary
Secondary
Concomitant
Therapeutic Response Decreased Other Serious 1/1/2007 10/21/2010 Other Health Professional United States
Primary
Concomitant
Hypokalaemia Hospitalization 7/14/2010 30 Female 183 lb 11/4/2010 Other Health Professional United States
Primary
Concomitant
Suicide Attempt Life Threatening 7/18/2010 40 Female 11/5/2010 Other Health Professional Spain
Primary
Secondary
Gastrooesophageal Reflux Disease 63 Female 12/28/2010 Consumer United States
Primary
Concomitant
Fatigue Other Serious 10/1/2009 62 Female 241 lb 1/4/2011 Consumer United States
Primary
Concomitant
Nightmare 4/14/2010 59 Female 159 lb 1/28/2011 Consumer United States
Primary
Concomitant
Abdominal Discomfort 4/15/2010 59 Female 159 lb 1/29/2011 Physician United States
Primary
Secondary
Concomitant
Euphoric Mood Other Serious 1/22/2010 28 Female 188 lb 1/22/2011 Consumer United States
Primary
Concomitant
Overdose Other Serious 12/8/2010 Female 2/21/2011 Other Health Professional Spain
Primary
Concomitant
Physical Assault Other Serious 52 Female 3/18/2011 Physician United States
Primary
Secondary
Nausea Hospitalization 8/16/2009 27 Female 130 lb 3/23/2011 Consumer United States
Primary
Concomitant
Drug Interaction Hospitalization 16 Male 3/4/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 8/16/2009 27 Female 130 lb 3/23/2011 Pharmacist United States
Primary
Concomitant
Dysphagia 2/1/2011 88 Female 3/24/2011 Consumer United States
Primary
Concomitant
Dysphonia Other Serious 52 Female 4/4/2011 Other Health Professional United States
Primary
Secondary
Suicidal Ideation Life Threatening 7/18/2010 40 Female 4/7/2011 Physician Spain
Primary
Secondary
Suicidal Ideation Hospitalization 7/18/2010 40 Female 4/19/2011 Physician Spain
Primary
Secondary
Cholecystectomy Other Serious 1/1/2007 26 Female 216 lb 5/18/2011 Lawyer United States
Primary
Secondary
Concomitant
Diabetes Mellitus Other Serious Female 5/20/2011 Consumer United States
Primary
Concomitant
Hypertension Other Serious 3/1/2011 31 Female 135 lb 6/9/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Multiple Sclerosis Other Serious 6/24/2011 United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 63 Female 7/4/2011 Consumer United States
Primary
Concomitant
Platelet Disorder Other Serious 7/30/2010 24 Female 7/8/2011 United States
Primary
Secondary
Concomitant
Emotional Disorder Other Serious 5/1/2011 54 Male 284 lb 7/12/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Gastric Perforation Other Serious 54 Male 284 lb 7/22/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Biliary Dyskinesia Other Serious 1/1/2007 26 Female 216 lb 8/19/2011 Physician United States
Primary
Secondary
Concomitant
Product Adhesion Issue 6/1/2011 48 Female 186 lb 8/23/2011 Consumer United States
Primary
Concomitant
Necrosis Hospitalization 6/16/2011 51 Female 181 lb 9/7/2011 Consumer Brazil
Primary
Concomitant
Hypothyroidism Hospitalization 12/1/2010 46 Female 160 lb 8/31/2011 Consumer United States
Primary
Concomitant
Electrolyte Imbalance Hospitalization 63 Female 9/8/2011 Physician United States
Primary
Concomitant
Bradykinesia Hospitalization 46 Male 9/12/2011 Physician Japan
Primary
Secondary
Deep Vein Thrombosis Other Serious 9/7/2011 39 Female 216 lb 9/16/2011 Other Health Professional United States
Primary
Concomitant
Impaired Fasting Glucose Other Serious 6/23/2006 50 Female 9/22/2011 Other Health Professional United States
Primary
Concomitant
Somnolence 9/22/2011 Consumer United States
Primary
Concomitant
Vitamin D Deficiency Hospitalization 4/1/2011 24 Female 9/22/2011 United States
Primary
Secondary
Concomitant
Neuroleptic Malignant Syndrome Other Serious 46 Male 10/17/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Neuroleptic Malignant Syndrome Other Serious 46 Male 10/21/2011 Other Health Professional Japan
Primary
Secondary
Concomitant
Weight Decreased Female 10/24/2011 Consumer United States
Primary
Concomitant
Weight Increased 9/1/2011 39 Female 149 lb 10/24/2011 Consumer United States
Primary
Concomitant
Condition Aggravated Other Serious 1/1/2008 36 Female 218 lb 10/20/2011 Pharmacist United States
Primary
Secondary
Concomitant
Fatigue 6/7/2011 55 Female 9/8/2011 Consumer United States
Primary
Concomitant
Diarrhoea 8/11/2011 55 Female 10/26/2011 Consumer United States
Primary
Concomitant
Death Death 53 Female 12/26/2011 Physician United States
Primary
Secondary
Drug Dose Omission Other Serious 2/17/2010 33 Female 180 lb 12/15/2011 Consumer United States
Primary
Secondary
Concomitant
Metabolic Acidosis Hospitalization 2/17/2010 33 Female 180 lb 12/15/2011 Consumer United States
Primary
Secondary
Concomitant
Cardiac Arrest Death 1/1/2010 53 Female 12/23/2011 Physician United States
Primary
Secondary
Death Death 1/1/2010 49 Female 12/22/2011 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2010 53 Female 12/29/2011 Physician United States
Primary
Secondary
Toxicity To Various Agents Death 53 Female 1/4/2012 Physician United States
Primary
Secondary
Toxicity To Various Agents Death 49 Female 1/4/2012 Other Health Professional United States
Primary
Secondary
Death Death 49 Female 1/5/2012 Physician United States
Primary
Secondary
Amnesia Hospitalization 2/17/2010 33 Female 180 lb 12/21/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Death 49 Female 1/6/2012 Physician United States
Primary
Secondary
Respiratory Arrest Death 49 Female 1/11/2012 Physician United States
Primary
Secondary
Completed Suicide Death 53 Female 1/12/2012 Physician United States
Primary
Secondary
Cardiac Infection Other Serious 1/1/2010 Male 1/17/2012 Consumer United States
Primary
Secondary
Concomitant
Respiratory Arrest Death 1/1/2010 49 Female 1/11/2012 Physician United States
Primary
Secondary
Completed Suicide Death 1/1/2010 53 Female 1/11/2012 Physician United States
Primary
Secondary
Arrhythmia Death 12/8/2007 50 Female 178 lb 1/13/2012 Other Health Professional United States
Primary
Concomitant
Toxicity To Various Agents Death 1/1/2010 53 Female 1/9/2012 Physician United States
Primary
Secondary
Intentional Drug Misuse Death 1/1/2010 49 Female 1/13/2012 Physician United States
Primary
Secondary
Cardio-respiratory Arrest Death 53 Female 1/17/2012 Other Health Professional Denmark
Primary
Secondary
Poisoning Death 6/9/2009 59 Female 157 lb 1/20/2012 Physician United States
Primary
Secondary
Concomitant
Intentional Drug Misuse Death 1/1/2010 49 Female 1/13/2012 Physician United States
Primary
Secondary
Dysarthria Hospitalization 10/1/2003 55 Male 185 lb 1/30/2012 Lawyer United States
Primary
Concomitant
Abortion Spontaneous Other Serious 2/17/2010 33 Female 200 lb 1/24/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Paranoia Hospitalization 9/1/2007 30 Male 2/9/2012 Lawyer United States
Primary
Concomitant
Pyrexia Other Serious 1/1/2009 Female 2/9/2012 Consumer Brazil
Primary
Secondary
Concomitant
Expired Drug Administered Other Serious 1/1/2009 Female 2/9/2012 Consumer Brazil
Primary
Secondary
Concomitant
Cardio-respiratory Arrest Death 49 Female 2/15/2012 Physician United States
Primary
Secondary
Cardio-respiratory Arrest Life Threatening 53 Female 2/15/2012 Physician United States
Primary
Concomitant
Cholecystectomy Hospitalization 3/1/2011 35 Female 3/16/2012 Lawyer United States
Primary
Secondary
Concomitant
Respiratory Arrest Death 49 Female 2/8/2012 Physician United States
Primary
Secondary
Intentional Overdose Hospitalization 9/7/2011 47 Female 3/23/2012 Physician Spain
Primary
Secondary
Coma Hospitalization 9/7/2011 47 Female 3/28/2012 Physician Spain
Primary
Secondary
Concomitant
Cardiac Arrest Death 53 Female 4/3/2012 Other Health Professional United States
Primary
Secondary
Intentional Overdose Death 49 Female 4/4/2012 Other Health Professional United States
Primary
Secondary
Inappropriate Schedule Of Drug Administration 8/1/2011 43 Female 2/24/2012 Physician United States
Primary
Concomitant
Pulmonary Embolism Other Serious 9/7/2011 39 Female 216 lb 4/18/2012 Other Health Professional United States
Primary
Concomitant
Pregnancy Hospitalization 2/17/2010 33 Female 200 lb 4/17/2012 Other Health Professional United States
Primary
Secondary
Concomitant
Sinusitis Other Serious 1/1/2012 58 Female 4/27/2012 Physician United States
Primary
Concomitant
Bipolar Disorder Other Serious 43 Female 5/17/2012 Consumer Brazil
Primary
Concomitant
Anxiety Hospitalization 10/20/2009 42 Female 154 lb 5/31/2012 Other Health Professional United States
Primary
Concomitant
Tongue Pruritus 5/29/2012 46 Female 220 lb 6/5/2012 Consumer United States
Primary
Concomitant
Splenic Necrosis Life Threatening 27 Female 7/10/2012 Other Health Professional Netherlands
Primary
Concomitant
Dizziness Life Threatening 4/1/2011 51 Female 7/13/2012 Consumer Brazil
Primary
Secondary
Concomitant
Hyponatraemia Life Threatening 27 Female 7/27/2012 Physician Netherlands
Primary
Concomitant
Hallucination Other Serious 7/1/2012 56 Female 141 lb 8/2/2012 Consumer Brazil
Primary
Concomitant
Ileus Hospitalization 27 Female 7/20/2012 Physician Netherlands
Primary
Concomitant
Pruritus Generalised 2/24/2012 68 Male 195 lb 8/3/2012 Consumer United States
Primary
Concomitant

Drug Data