Alprazolam combined with Morphine

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
International Normalised Ratio Increased 11/23/2004 9/12/2005 Physician United States
Primary
Concomitant
International Normalised Ratio Increased 11/23/2004 1/6/2006 Physician United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 5/24/2005 71 Female 12/6/2005 Pharmacist United States
Primary
Concomitant
Vomiting Hospitalization 1/1/2000 70 Female 146 lb 3/28/2006 Lawyer United States
Primary
Concomitant
Vomiting Hospitalization 1/1/2000 70 Female 146 lb 4/10/2006 Physician United States
Primary
Concomitant
Visual Field Defect Other Serious 1/1/2005 42 Female 203 lb 4/3/2006 Physician United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 42 Female 203 lb 4/21/2006 Physician United States
Primary
Concomitant
Oral Mucosal Exfoliation Other Serious 4/1/2006 53 Female 170 lb 5/19/2006 Other Health Professional United States
Primary
Secondary
Concomitant
Visual Field Defect Other Serious 1/1/2005 42 Female 203 lb 6/13/2006 Physician United States
Primary
Concomitant
Ventricular Hypertrophy Death 3/1/2005 43 Male 175 lb 6/20/2006 Other Health Professional United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 1/1/2006 1 Female 137 lb 6/27/2006 Consumer United States
Primary
Secondary
Urinary Tract Infection Hospitalization 6/15/2006 6/28/2006 Physician United States
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint Other Serious 1/1/2006 36 Male 210 lb 8/2/2006 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/1/2006 1 Female 143 lb 8/9/2006 Consumer United States
Primary
Secondary
Self-medication Other Serious 4/25/2006 28 Female 8/21/2006 Pharmacist United States
Primary
Secondary
Concomitant
Thrombosis Other Serious 5/1/2006 Female 8/14/2006 Consumer United States
Primary
Concomitant
Multiple Drug Overdose Intentional Death 43 Female 9/14/2006 Physician United States
Primary
Secondary
Haemoglobin Decreased Hospitalization 1/13/2006 Male 9/12/2006 Pharmacist United States
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 4/25/2006 Male 203 lb 4/26/2006 Pharmacist United States
Primary
Concomitant
Respiratory Arrest Death 43 Female 9/22/2006 Physician United States
Primary
Secondary
Renal Failure Hospitalization 5/21/2006 65 Male 216 lb 10/3/2006 Consumer United States
Primary
Secondary
Concomitant
Hypotension 5/2/2006 Male 10/23/2006 Pharmacist United States
Primary
Concomitant
Pain Required Intervention 1/1/2004 Female 10/19/2006 Lawyer United States
Primary
Concomitant
Respiratory Arrest Death 11/9/2006 United States
Primary
Secondary
Drug Level Increased Death 31 11/6/2006 Physician United States
Primary
Secondary
Unresponsive To Stimuli Death 42 Female 159 lb 11/16/2006
Primary
Secondary
Upper Gastrointestinal Haemorrhage Other Serious 5/21/2005 74 Male 11/15/2006 United States
Primary
Secondary
Concomitant
Vomiting Death 11/12/2002 24 Male 11/20/2006 United States
Primary
Secondary
Concomitant
Respiratory Arrest Death 1/1/2005 11/21/2006 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2005 43 Female 11/21/2006 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2005 31 11/21/2006 Physician United States
Primary
Secondary
Concomitant
Drug Abuser Death 1/1/2005 19 11/22/2006 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2005 19 Unknown 11/22/2006 Physician United States
Primary
Secondary
Intentional Overdose Other Serious 52 Male 1/4/2007 Consumer Ireland
Primary
Secondary
Haemorrhage Required Intervention 8/16/2006 78 Female 150 lb 10/2/2006 United States
Primary
Concomitant
Thrombocytopenia Other Serious 3/17/2006 73 Female 132 lb 1/17/2007 Consumer United States
Primary
Concomitant
Pain Other Serious 1/1/2004 Female 1/22/2007 Lawyer United States
Primary
Concomitant
Intentional Overdose Death 11/12/2002 Male 1/22/2007 Consumer United States
Primary
Secondary
Concomitant
Completed Suicide Death Unknown 1/25/2007 Physician United States
Primary
Secondary
Completed Suicide Death 43 Unknown 1/25/2007 Physician United States
Primary
Secondary
Cardio-respiratory Arrest Death 31 Unknown 1/25/2007 Physician United States
Primary
Secondary
Drug Abuser Death 19 Unknown 1/25/2007 Physician United States
Primary
Secondary
Platelet Count Decreased Hospitalization 10/9/2006 75 Female 2/1/2007 Physician United States
Primary
Secondary
Concomitant
Syncope Other Serious 12/18/2002 Female 3/8/2007 Consumer United States
Primary
Concomitant
Thrombocytopenia Life Threatening 9/16/2006 Male 90 lb 3/14/2007 Spain
Primary
Concomitant
Interacting
Syncope Other Serious 12/18/2002 Female 3/20/2007 Lawyer United States
Primary
Concomitant
Tendon Injury Other Serious 1/1/2005 Male 219 lb 3/27/2007 Consumer United States
Primary
Secondary
Concomitant
Intentional Overdose Death 11/12/2002 Male 3/27/2007 Lawyer United States
Primary
Secondary
Concomitant
Myoclonus Hospitalization 2/15/2006 57 Male 260 lb 8/17/2006 United States
Primary
Concomitant
Prothrombin Time Prolonged Hospitalization 3/1/2007 54 Female 3/26/2007 Physician Peru
Primary
Secondary
Concomitant
Somnolence Life Threatening 12/12/2006 57 Female 4/6/2007 Germany
Primary
Secondary
Concomitant
Sepsis Life Threatening 5/8/2007 57 Male 5/17/2007 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 3/1/2007 54 Female 6/25/2007 Physician Peru
Primary
Secondary
Concomitant
Vomiting Hospitalization 10/21/2007 Male 166 lb 10/31/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Orthostatic Hypotension Hospitalization 11/20/2007 68 Male 11/29/2007 Physician United States
Primary
Secondary
Concomitant
Orthostatic Hypotension Hospitalization 11/20/2007 68 Male 12/10/2007 Physician United States
Primary
Secondary
Concomitant
Completed Suicide Death 1/1/2006 59 Female 1/18/2008 United States
Primary
Secondary
Respiratory Arrest Death 1/1/2006 46 Female 1/18/2008 United States
Primary
Secondary
Death Death 1/1/2006 39 Male 1/18/2008 United States
Primary
Secondary
Vision Blurred Other Serious 11/17/2007 Female 1/18/2008 Consumer United States
Primary
Secondary
Dehydration Hospitalization 10/8/2007 60 Female 95 lb 1/22/2008 Physician Portugal
Primary
Secondary
Concomitant
Poisoning Death 59 Female 1/22/2008 Physician United States
Primary
Secondary
Respiratory Arrest Death 46 Female 1/22/2008 Physician United States
Primary
Secondary
Poisoning Death 39 Male 1/22/2008 Physician United States
Primary
Secondary
Poisoning Death 59 Female 2/1/2008 Physician United States
Primary
Secondary
Nausea Death 1/6/2008 61 Male 165 lb 2/8/2008 United States
Primary
Concomitant
Suicide Attempt Other Serious 9/18/2003 46 Male 1/11/2008 United States
Primary
Concomitant
Vision Blurred Other Serious 11/17/2007 Female 2/15/2008 Consumer United States
Primary
Secondary
Nausea Death 1/6/2008 61 Male 165 lb 2/27/2008 Other Health Professional United States
Primary
Concomitant
Vision Blurred Other Serious 11/17/2007 Female 3/3/2008 Consumer United States
Primary
Secondary
Back Pain 54 Male 320 lb 11/16/2007 Consumer United States
Primary
Concomitant
Death Death 3/19/2008 Physician United States
Primary
Secondary
Cerebral Haematoma Death 3/18/2008 55 Female 249 lb 3/19/2008 Pharmacist United States
Primary
Concomitant
Stomach Discomfort Other Serious 12/1/2006 Male 3/26/2008 Lawyer United States
Primary
Concomitant
Completed Suicide Death 3/27/2008 Physician United States
Primary
Secondary
Visual Disturbance Other Serious 11/17/2007 Female 4/2/2008 Consumer United States
Primary
Secondary
Concomitant
Ocular Discomfort Other Serious 4/8/2007 38 Female 220 lb 4/1/2008 United States
Primary
Concomitant
Therapy Cessation Hospitalization 62 Female 110 lb 4/15/2008 Physician France
Primary
Concomitant
Stomach Discomfort Other Serious 12/1/2006 Male 5/1/2008 Lawyer United States
Primary
Concomitant
Vomiting Hospitalization 8/1/2006 50 Male 5/5/2008
Primary
Secondary
Concomitant
Overdose Death 1/1/2007 34 Male 4/17/2008 Physician Sweden
Primary
Concomitant
Stomach Discomfort Other Serious 12/1/2006 Male 5/14/2008 Lawyer United States
Primary
Concomitant
Tinnitus Hospitalization 4/16/2008 45 Male 236 lb 6/9/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Respiratory Arrest Other Serious 27 6/9/2008 Other Health Professional United States
Primary
Secondary
Substance Abuse Other Serious 44 Male 6/11/2008 Physician Canada
Primary
Secondary
Vena Cava Injury Death 2/8/2008 Female 180 lb 6/10/2008 Pharmacist United States
Primary
Secondary
Concomitant
High Density Lipoprotein Decreased Other Serious 50 Male 6/17/2008 United States
Primary
Concomitant
Unresponsive To Stimuli Other Serious 4/25/2007 Female 7/7/2008 Consumer United States
Primary
Secondary
Rhabdomyolysis Other Serious 10/23/2007 50 Female 7/3/2008 Canada
Primary
Secondary
Concomitant
Weight Increased Hospitalization 5/1/2008 Female 121 lb 7/10/2008 United States
Primary
Secondary
Concomitant
Hypercapnia 3/24/2008 62 Male 106 lb 4/29/2008 Pharmacist United States
Primary
Secondary
Rhabdomyolysis Other Serious 10/23/2007 50 Female 7/21/2008 Canada
Primary
Concomitant
Nausea 3/25/2008 Female 7/25/2008 Pharmacist United States
Primary
Concomitant
Weight Increased Hospitalization 5/1/2008 Female 121 lb 7/28/2008 United States
Primary
Secondary
Concomitant
Malaise Hospitalization 6/25/2008 Female 8/6/2008 Other Health Professional France
Primary
Secondary
Concomitant
Stomach Discomfort Other Serious 12/1/2006 Male 8/7/2008 Lawyer United States
Primary
Concomitant
Stomach Discomfort Other Serious 12/1/2006 Male 8/19/2008 Lawyer United States
Primary
Concomitant
Respiratory Depression Death 1/1/2006 39 Male 8/18/2008 Physician United States
Primary
Secondary
Unresponsive To Stimuli Other Serious 4/25/2007 Female 8/28/2008 Consumer United States
Primary
Secondary
Pain Other Serious Male 9/3/2008 United States
Primary
Secondary
Concomitant
Dehydration Hospitalization 8/20/2008 Female 199 lb 9/10/2008 Consumer United States
Primary
Secondary
Concomitant
Stomach Discomfort Other Serious 12/1/2006 Male 9/10/2008 Lawyer United States
Primary
Concomitant
Blood Glucose Increased 6/6/2008 Male 180 lb 9/12/2008 United States
Primary
Concomitant
Contusion 6/23/2008 Male 175 lb 9/12/2008 Consumer United States
Primary
Concomitant
Urinary Hesitation 1/1/2008 Female 9/12/2008 United States
Primary
Concomitant
Dehydration Hospitalization 8/20/2008 Female 199 lb 9/19/2008 Consumer United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 1/1/2005 19 Male 9/19/2008 Physician United States
Primary
Secondary
Pulmonary Congestion Death 1/1/2005 17 Female 9/19/2008 Physician United States
Primary
Secondary
Therapeutic Agent Toxicity Death 1/1/2005 Male 9/17/2008 Physician United States
Primary
Secondary
White Blood Cell Count Increased Hospitalization 1/1/2005 31 Female 9/19/2008 Physician United States
Primary
Secondary
Cardio-respiratory Arrest Other Serious 1/1/2005 19 Male 9/14/2008 Physician United States
Primary
Secondary
White Blood Cell Count Decreased Other Serious 9/30/2003 67 Female 298 lb 2/21/2007 Physician United States
Primary
Secondary
Concomitant
Sedation Hospitalization 10/25/2008 60 Male 11/10/2008 Other Health Professional United States
Primary
Secondary
Dehydration Hospitalization 10/24/2008 Female 11/14/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Drug Toxicity Death Male 11/25/2008 Consumer
Primary
Secondary
Lymphangitis Other Serious 10/24/2008 Female 12/8/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Tooth Disorder Other Serious 1/1/2001 Female 147 lb 12/9/2008 United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Other Serious 12/8/2008 United States
Primary
Secondary
Lung Neoplasm Malignant Death 10/1/2008 12/11/2008 Consumer Peru
Primary
Concomitant
Urinary Retention Hospitalization 11/7/2008 49 Female 120 lb 12/15/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 11/7/2008 49 Female 120 lb 12/18/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 11/7/2008 49 Female 120 lb 12/22/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Drug Toxicity Death Male 12/22/2008 Consumer United States
Primary
Secondary
Concomitant
Drug Toxicity Death 49 Female 12/23/2008 Physician United States
Primary
Secondary
Drug Toxicity Death 59 Female 12/30/2008 United States
Primary
Secondary
Respiratory Arrest Death 1/1/2007 59 Female 1/6/2009 Physician United States
Primary
Secondary
Intentional Drug Misuse Death 1/1/2007 49 Female 1/6/2009 United States
Primary
Secondary
Respiratory Arrest Death 1/1/2007 16 Female 1/6/2009 United States
Primary
Secondary
Intentional Drug Misuse Death 1/1/2007 37 Male 1/6/2009 Other Health Professional United States
Primary
Secondary
Intentional Drug Misuse Death 1/1/2007 44 Female 1/6/2009 Other Health Professional United States
Primary
Secondary
Cardio-respiratory Arrest Death 59 Female 1/15/2009 United States
Primary
Secondary
Upper Limb Fracture Other Serious 1/1/2003 64 Female 150 lb 1/21/2009 Other Health Professional United States
Primary
Concomitant
Intentional Drug Misuse Death 49 Female 1/15/2009 Physician United States
Primary
Secondary
Respiratory Arrest Death 59 Female 1/15/2009 Physician United States
Primary
Secondary
Respiratory Arrest Other Serious 16 Female 1/23/2009 Physician United States
Primary
Secondary
Respiratory Arrest Death 44 Female 1/23/2009 Physician United States
Primary
Secondary
Respiratory Arrest Death 37 Male 1/23/2009 Physician United States
Primary
Secondary
Respiratory Arrest Death 59 Female 1/23/2009 Physician United States
Primary
Secondary
Splenomegaly Other Serious 12/1/2006 Male 1/29/2009 Lawyer United States
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/13/2009 73 Male 99 lb 2/3/2009 Physician Japan
Primary
Concomitant
Cataract Other Serious Female 134 lb 2/3/2009 Consumer United States
Primary
Concomitant
Poisoning Deliberate Death 49 Female 1/26/2009 Physician United States
Primary
Secondary
Neoplasm Progression Death Male 122 lb 2/4/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Pneumonia Cryptococcal Hospitalization 11/22/2008 Male 220 lb 2/9/2009 United States
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/13/2009 73 Male 99 lb 2/11/2009 Physician Japan
Primary
Concomitant
Wrong Technique In Drug Usage Process Death 33 Female 2/12/2009 United States
Primary
Secondary
Drug Abuse Death 16 Female 2/20/2009 Physician United States
Primary
Secondary
Respiratory Arrest Death 59 Female 2/13/2009 Physician United States
Primary
Secondary
Maculopathy Other Serious Female 134 lb 2/27/2009 Physician United States
Primary
Concomitant
Intentional Drug Misuse Death 37 Male 2/26/2009 Physician United States
Primary
Secondary

Drug Data