Alprazolam combined with Morphine Sulfate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Skin Lesion Hospitalization 11/29/2005 63 Male 157 lb 1/5/2006 Physician Australia
Primary
Concomitant
Toxic Epidermal Necrolysis Death 4/19/2005 48 Female 132 lb 2/8/2006
Primary
Secondary
Concomitant
Toxic Epidermal Necrolysis Life Threatening 4/6/2005 48 Female 2/8/2006 France
Primary
Secondary
Vomiting Hospitalization 1/19/2006 69 Female 359 lb 2/24/2006 Physician Slovakia (Slovak Republic)
Primary
Concomitant
Vomiting Hospitalization 1/19/2006 69 Female 359 lb 2/28/2006 Physician Slovakia (Slovak Republic)
Primary
Concomitant
Vomiting Hospitalization 1/19/2006 69 Female 359 lb 3/13/2006 Physician Slovakia (Slovak Republic)
Primary
Concomitant
Vomiting Hospitalization 1/1/2000 70 Female 146 lb 3/28/2006 Lawyer United States
Primary
Concomitant
Vomiting Hospitalization 1/1/2000 70 Female 146 lb 4/10/2006 Physician United States
Primary
Concomitant
Pneumonia Hospitalization 2/5/2006 57 Male 122 lb 4/6/2006 Pharmacist United States
Primary
Secondary
Sepsis Other Serious 1/10/2006 38 Male 176 lb 4/5/2006 Physician United States
Primary
Concomitant
Renal Failure Life Threatening 3/16/2006 56 88 lb 4/7/2006 Physician Korea, Republic Of
Primary
Concomitant
Vomiting Hospitalization 1/19/2006 69 Female 359 lb 4/10/2006 Physician Slovakia (Slovak Republic)
Primary
Concomitant
Renal Failure Life Threatening 3/16/2006 56 Female 88 lb 4/18/2006 Physician Korea, Republic Of
Primary
Concomitant
Disease Progression Death 11/21/2005 Male 5/17/2006 Physician United States
Primary
Concomitant
Polysubstance Abuse Other Serious 8/30/2003 38 Male 178 lb 5/12/2006 United States
Primary
Secondary
Vision Blurred Death 9/3/2005 Male 5/19/2006 Physician Japan
Primary
Concomitant
Respiratory Arrest Death 43 Unknown 5/23/2006 Physician United States
Primary
Secondary
Dry Mouth Other Serious 6/21/2006 56 Male 277 lb 6/28/2006 Pharmacist United States
Primary
Concomitant
Vein Disorder Life Threatening 4/20/2006 53 Male 121 lb 7/20/2006 Physician France
Primary
Concomitant
Death Death 4/22/2005 40 Male 5/9/2005 Pharmacist United States
Primary
Concomitant
Somnolence Other Serious 11/1/2005 75 Female 8/8/2006 Physician Japan
Primary
Secondary
Concomitant
Somnolence Other Serious 10/24/2005 74 Female 8/15/2006 Physician Japan
Primary
Secondary
Concomitant
Substance Abuse Death 11/4/2003 47 Female 150 lb 7/17/2006 Other Health Professional United States
Primary
Secondary
Accidental Overdose Death 3/9/2001 44 Male 176 lb 7/17/2006 Consumer United States
Primary
Secondary
Somnolence Other Serious 10/24/2005 74 Female 8/25/2006 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Bacterial Hospitalization 3/1/2006 76 Female 9/25/2006 Consumer United States
Primary
Concomitant
Swelling Required Intervention 8/13/2006 64 Male 242 lb 9/20/2006 Pharmacist United States
Primary
Concomitant
Intentional Drug Misuse Death 19 11/21/2006 Physician United States
Primary
Secondary
Drug Abuser Death 19 11/21/2006 Physician United States
Primary
Secondary
Red Blood Cell Morphology Abnormal Other Serious 10/3/2006 65 Female 11/8/2006 Physician United States
Primary
Concomitant
Surgery Other Serious 10/3/2006 65 Female 11/17/2006 Consumer United States
Primary
Concomitant
Drug Abuser Death 19 NotSpecified 11/20/2006 Physician United States
Primary
Secondary
Weight Decreased Hospitalization 3/21/2006 73 Male 12/13/2006 Consumer United Kingdom
Primary
Secondary
Concomitant
Substance Abuse Other Serious 8/20/2006 20 Male 161 lb 12/18/2006 United States
Primary
Secondary
Skin Exfoliation Other Serious 1/11/2007 74 Female 1/23/2007 Pharmacist United States
Primary
Concomitant
Wheelchair User Other Serious 7/8/2006 52 Male 1/29/2007 United States
Primary
Secondary
Cardio-respiratory Arrest Death 1/1/2005 31 Unknown 2/8/2007 Physician United States
Primary
Secondary
Weight Increased Other Serious 12/11/2006 Male 3/5/2007 Consumer France
Primary
Secondary
Concomitant
Weight Decreased Other Serious 2/8/2006 73 Male 3/15/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Weight Decreased Other Serious 2/8/2006 73 Male 3/19/2007 Consumer United Kingdom
Primary
Secondary
Concomitant
Renal Failure Hospitalization 3/16/2006 Female 88 lb 5/9/2007 Korea, Republic Of
Primary
Concomitant
Substance Abuse Other Serious 1/30/2006 42 Male 183 lb 5/24/2007 Physician United States
Primary
Secondary
Urinary Tract Infection Other Serious 2/1/2007 77 Female 7/6/2007 Consumer United States
Primary
Concomitant
Urticaria Other Serious 1/1/2007 Female 189 lb 8/16/2007 Consumer United States
Primary
Secondary
Concomitant
Panic Attack Other Serious 7/2/2007 Male 175 lb 8/24/2007 United States
Primary
Concomitant
Multiple Drug Overdose Death 7/20/2003 54 Male 6/7/2007 Physician United States
Primary
Secondary
Renal Failure Hospitalization 3/16/2006 Female 88 lb 8/29/2007 Korea, Republic Of
Primary
Concomitant
Dyspnoea Hospitalization 7/10/2007 51 Female 10/12/2007 Other Health Professional United States
Primary
Secondary
Concomitant
Lung Neoplasm Malignant Hospitalization 1/1/2006 51 Female 10/19/2007 United States
Primary
Concomitant
Trismus Other Serious 1/1/1998 42 Male 10/20/2007 United States
Primary
Secondary
Concomitant
General Physical Health Deterioration Hospitalization 9/19/2007 Female 128 lb 11/19/2007 France
Primary
Concomitant
Vomiting Other Serious 4/1/2007 Female 12/28/2007 Consumer United Kingdom
Primary
Secondary
Restless Legs Syndrome Other Serious 35 Female 192 lb 1/2/2008 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 4/1/2007 Female 1/4/2008 Consumer United Kingdom
Primary
Secondary
Vomiting Life Threatening 10/15/2007 Female 1/24/2008 Physician United States
Primary
Secondary
Vomiting Life Threatening 10/15/2007 Female 2/4/2008 Physician United States
Primary
Secondary
Vomiting Other Serious 4/1/2007 Female 2/4/2008 Consumer United Kingdom
Primary
Secondary
Lung Neoplasm Malignant Hospitalization 1/1/2006 51 Female 2/7/2008 United States
Primary
Concomitant
Cardio-respiratory Arrest Death 1/1/2006 46 Female 2/13/2008 Physician United States
Primary
Secondary
Death Death 1/1/2006 59 Female 2/13/2008 Physician United States
Primary
Secondary
Pulmonary Congestion Death 1/1/2006 46 Female 2/20/2008 Physician United States
Primary
Secondary
Sinus Operation 12/15/2007 Female 200 lb 3/14/2008 Consumer United States
Primary
Concomitant
Trismus Other Serious 1/1/1998 42 Male 165 lb 3/19/2008 United States
Primary
Secondary
Concomitant
Syncope Hospitalization 4/17/2008 45 Male 236 lb 5/8/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Tinnitus Hospitalization 4/16/2008 45 Male 236 lb 5/15/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Diabetes Mellitus Other Serious 10/7/2004 Female 5/15/2008 United States
Primary
Secondary
Concomitant
Vena Cava Injury Death 2/8/2008 Female 180 lb 6/10/2008 Pharmacist United States
Primary
Secondary
Concomitant
Drug Toxicity Death 66 Female 6/23/2008 Canada
Primary
Secondary
Ventricular Septal Defect Life Threatening 10/17/2002 Female 4 lb 6/24/2008 Consumer United States
Primary
Concomitant
Ventricular Septal Defect Life Threatening 10/17/2002 Female 2 lb 6/24/2008 Physician United States
Primary
Concomitant
Tinnitus Hospitalization 4/16/2008 45 Male 236 lb 6/30/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Ventricular Septal Defect Life Threatening 10/17/2002 Female 2 lb 7/1/2008 Physician United States
Primary
Concomitant
Pyrexia Death 4/3/2008 37 Male 7/8/2008 United States
Primary
Concomitant
Spinal Osteoarthritis Other Serious 3/21/2001 47 Female 245 lb 7/21/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Weight Increased Other Serious 3/21/2001 47 Female 245 lb 7/31/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Femur Fracture Hospitalization 2/5/2006 57 Female 8/6/2008 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Pharmaceutical Product Complaint Death 4/10/2008 67 Female 8/22/2008 Lawyer United States
Primary
Concomitant
Weight Increased Other Serious 3/21/2001 47 Female 245 lb 10/2/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Product Quality Issue Death 4/10/2008 67 Female 8/22/2008 Lawyer United States
Primary
Concomitant
Vomiting Other Serious 1/1/2008 Female 11/21/2008 Consumer United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/1991 Male 188 lb 11/21/2008 United States
Primary
Secondary
Concomitant
Vomiting Other Serious 1/1/2008 Female 11/25/2008 Consumer United States
Primary
Concomitant
Sputum Discoloured Hospitalization 1/1/2004 170 lb 11/25/2008 United States
Primary
Concomitant
Myocardial Infarction Hospitalization 10/31/2004 63 Female 200 lb 12/2/2008 Physician United States
Primary
Concomitant
Stent Placement Hospitalization 67 Male 12/2/2008 Consumer United States
Primary
Secondary
Concomitant
Product Quality Issue Death 57 Male 140 lb 12/8/2008 Consumer United States
Primary
Concomitant
Visual Impairment 4/1/2008 Female 250 lb 12/12/2008 United States
Primary
Concomitant
Weight Increased 9/8/2008 Female 243 lb 12/12/2008 United States
Primary
Concomitant
Stent Placement Hospitalization 10/26/2008 67 Male 12/22/2008 Consumer United States
Primary
Secondary
Concomitant
Respiratory Arrest Death 1/1/2007 44 Female 12/24/2008 Physician United States
Primary
Secondary
Respiratory Arrest Death 1/1/2007 59 Female 12/24/2008 Physician United States
Primary
Secondary
Completed Suicide Death 1/1/2007 49 Female 12/29/2008 Physician United States
Primary
Secondary
Product Quality Issue Hospitalization 7/1/2008 72 Female 170 lb 12/22/2008 Consumer United States
Primary
Concomitant
Drug Toxicity Hospitalization 4/16/2008 Male 12/29/2008 Consumer United States
Primary
Secondary
Concomitant
Myocardial Infarction Hospitalization 10/31/2004 63 Female 200 lb 1/7/2009 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 10/31/2004 63 Female 200 lb 1/9/2009 Physician United States
Primary
Concomitant
Tooth Extraction Other Serious Female 1/14/2009 United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Death 1/24/2006 38 Male 190 lb 1/16/2009 Physician United States
Primary
Secondary
Death Death 1/6/2009 41 Female 1/23/2009 Other Health Professional France
Primary
Secondary
Multiple Drug Overdose Death 1/24/2006 Male 190 lb 1/26/2009 Consumer
Primary
Secondary
Death Death 1/6/2009 1/30/2009 Physician France
Primary
Secondary
Ventricular Septal Defect Life Threatening 10/17/2002 Female 2 lb 2/24/2009 Other Health Professional United States
Primary
Concomitant
Tooth Extraction Other Serious Female 3/2/2009 Pharmacist United States
Primary
Secondary
Concomitant
Skin Turgor Decreased Other Serious Female 143 lb 3/9/2009 Lawyer United States
Primary
Secondary
Concomitant
Poisoning Deliberate Death 49 Female 3/5/2009 Physician United States
Primary
Secondary
Tooth Extraction Other Serious 2/1/2003 Female 4/11/2009 Pharmacist United States
Primary
Secondary
Concomitant
Swelling 2/1/2008 57 Female 4/29/2009 Consumer United States
Primary
Concomitant
Sputum Discoloured Hospitalization 1/1/2004 170 lb 5/4/2009 United States
Primary
Concomitant
Somnolence Hospitalization 8/16/2007 64 Female 128 lb 5/1/2009 Lawyer United States
Primary
Concomitant
Gun Shot Wound Death 2/21/2009 5/20/2009 Other Health Professional United States
Primary
Concomitant
Type 2 Diabetes Mellitus Other Serious 1/1/1991 Male 188 lb 5/20/2009 Consumer United States
Primary
Secondary
Concomitant
Gun Shot Wound Death 2/21/2009 Male 5/29/2009 Other Health Professional United States
Primary
Concomitant
Myocardial Infarction Hospitalization 10/31/2004 63 Female 200 lb 5/29/2009 Physician United States
Primary
Concomitant
Subileus Hospitalization 6/24/2008 Female 6/24/2009 Physician France
Primary
Secondary
Concomitant
Subileus Hospitalization 6/24/2008 Female 7/6/2009 Physician France
Primary
Secondary
Concomitant
Off Label Use Other Serious 1/1/2007 7/9/2009 Other Health Professional United States
Primary
Concomitant
Weight Increased Hospitalization 6/25/2002 49 Male 192 lb 7/14/2009 United States
Primary
Concomitant
Stomatitis Other Serious 1/1/2004 Female 7/20/2009 Lawyer United States
Primary
Secondary
Concomitant
Multiple Drug Overdose Accidental Other Serious 7/28/2007 53 Male 6/8/2009 Physician United States
Primary
Secondary
Renal Failure Chronic Other Serious 2/1/2006 7/29/2009 Other Health Professional United States
Primary
Concomitant
Urticaria Hospitalization 5/14/2009 Female 8/4/2009 Other Health Professional France
Primary
Secondary
Concomitant
Ureteric Cancer Death 71 Male 7/22/2009 United States
Primary
Concomitant
Thrombocytopenia Hospitalization 12/26/2008 Male 231 lb 8/11/2009 United States
Primary
Concomitant
Urinary Tract Infection Other Serious 6/10/2009 Female 219 lb 8/12/2009 Physician United States
Primary
Concomitant
Ureteric Cancer Death 71 Male 8/4/2009 United States
Primary
Concomitant
Unresponsive To Stimuli Hospitalization 70 Male 8/28/2009
Primary
Secondary
Concomitant
Vomiting Hospitalization 62 Female 8/25/2009 Lawyer United States
Primary
Concomitant
Unresponsive To Stimuli Other Serious 70 Male 9/10/2009 United States
Primary
Secondary
Concomitant
Femur Fracture Hospitalization 2/5/2006 57 Female 9/11/2009 Other Health Professional Switzerland
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 70 Male 9/3/2009 Physician United States
Primary
Secondary
Sputum Discoloured 7/14/2009 Female 140 lb 9/19/2009 United States
Primary
Concomitant
Sinusitis Death 3/22/2008 38 Male 197 lb 9/15/2009 Lawyer United States
Primary
Secondary
Concomitant
Type 2 Diabetes Mellitus Other Serious 6/1/2004 41 Male 315 lb 9/23/2009 United States
Primary
Concomitant
Vomiting Hospitalization 56 Female 9/17/2009 United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 9/24/2009 United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 70 Male 10/3/2009 Physician United States
Primary
Secondary
Concomitant
Unresponsive To Stimuli Hospitalization 70 Male 10/2/2009 Physician United States
Primary
Secondary
Concomitant
Ventricular Septal Defect Life Threatening 10/17/2002 Female 4 lb 10/13/2009 Consumer United States
Primary
Concomitant
Ventricular Septal Defect Life Threatening 10/17/2002 Female 2 lb 10/13/2009 Other Health Professional United States
Primary
Concomitant
Visual Impairment Other Serious 4/4/2009 Male 10/19/2009 Physician United States
Primary
Concomitant
Upper Limb Fracture Hospitalization 66 Female 10/17/2009 United States
Primary
Concomitant
Wheezing Hospitalization 66 Male 10/17/2009 United States
Primary
Concomitant
Atrial Fibrillation Other Serious 70 Male 10/23/2009 Physician United States
Primary
Secondary
Atrial Fibrillation Other Serious 70 Male 11/3/2009 Physician United States
Primary
Secondary
Wound Dehiscence Hospitalization 66 Female 10/26/2009 United States
Primary
Concomitant
Atrial Fibrillation Other Serious 70 Male 11/5/2009 Physician United States
Primary
Secondary
Ventricular Septal Defect Life Threatening 10/17/2002 Female 4 lb 11/11/2009 Consumer United States
Primary
Concomitant
Ventricular Septal Defect Life Threatening 10/17/2002 Female 2 lb 11/11/2009 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 53 Female 11/4/2009 United States
Primary
Concomitant
Wound Dehiscence Hospitalization 66 Female 11/4/2009 United States
Primary
Concomitant

Drug Data