Alprazolam combined with Methotrexate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Pyrexia Other Serious 8/1/2005 Female 139 lb 1/19/2006 Belgium
Primary
Concomitant
International Normalised Ratio Increased Hospitalization 8/4/2005 48 Female 1/17/2005 Australia
Primary
Secondary
Concomitant
Tuberculosis Other Serious 8/1/2005 Female 139 lb 2/13/2006 Physician Belgium
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 8/22/2005 Male 2/17/2006 Physician United States
Primary
Secondary
Concomitant
Sudden Death Death Female 200 lb 2/24/2006 Physician United States
Primary
Concomitant
White Blood Cell Count Increased Hospitalization 8/22/2005 Male 3/2/2006 Physician United States
Primary
Secondary
Concomitant
Thrombotic Thrombocytopenic Purpura Hospitalization 5/9/2005 58 Female 150 lb 12/27/2005 Other Health Professional United States
Primary
Concomitant
Renal Failure Acute Hospitalization 8/22/2005 Male 3/27/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2000 70 Female 146 lb 3/28/2006 Lawyer United States
Primary
Concomitant
Hip Surgery Hospitalization 12/7/2005 51 Female 3/13/2006 Consumer Canada
Primary
Concomitant
Myocardial Infarction Other Serious 4/10/2003 77 Female 154 lb 4/4/2006 Lawyer United States
Primary
Concomitant
Vomiting Hospitalization 1/1/2000 70 Female 146 lb 4/10/2006 Physician United States
Primary
Concomitant
Vomiting Hospitalization 9/14/2001 Female 253 lb 4/26/2006 Physician United States
Primary
Secondary
Concomitant
Hepatitis Fulminant Hospitalization 8/8/2005 48 Female 5/10/2006 Physician Australia
Primary
Secondary
Concomitant
Squamous Cell Carcinoma Other Serious 9/1/2005 Female 5/12/2006 Physician United States
Primary
Concomitant
Hepatitis Fulminant Hospitalization 8/8/2005 48 Female 5/16/2006 Physician Australia
Primary
Secondary
Concomitant
Hepatitis Fulminant Hospitalization 8/8/2005 48 Female 5/17/2006 Physician Australia
Primary
Secondary
Concomitant
Hepatitis Fulminant Hospitalization 8/8/2005 48 Female 5/19/2006 Physician Australia
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 59 Female 157 lb 5/31/2006 United States
Primary
Secondary
Concomitant
Renal Failure Acute Death Female 6/12/2006 Physician United States
Primary
Concomitant
Vesical Fistula Other Serious 6/1/2006 Female 7/6/2006 Consumer United States
Primary
Concomitant
Urinary Retention Other Serious 12/1/2005 Female 160 lb 7/20/2006 Physician United States
Primary
Concomitant
Sepsis Other Serious 1/1/2006 67 Female 8/1/2006 Other Health Professional Peru
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 8/1/2002 Male 180 lb 8/7/2006 Physician United States
Primary
Concomitant
Urinary Tract Infection Other Serious 6/2/2005 Female 185 lb 8/23/2006 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Female 9/7/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Chronic Other Serious 10/2/2004 Female 9/26/2006 Physician United States
Primary
Concomitant
Respiratory Failure Other Serious 8/1/2002 Male 180 lb 9/27/2006 Physician United States
Primary
Concomitant
Ventricular Tachycardia Hospitalization 5/7/2006 Female 10/13/2006 Consumer United States
Primary
Concomitant
Sepsis Other Serious 1/1/2006 67 Female 10/19/2006 Other Health Professional Peru
Primary
Secondary
Concomitant
Sepsis Other Serious 1/1/2006 67 Female 11/7/2006 Other Health Professional Peru
Primary
Secondary
Concomitant
Hypokalaemia Hospitalization 10/31/2006 Female 11/22/2006 Consumer United States
Primary
Concomitant
Weight Decreased Hospitalization 1/1/2006 Female 12/5/2006 Physician United States
Primary
Secondary
Concomitant
Wound Treatment Other Serious 1/1/1997 59 Female 157 lb 1/23/2007 United States
Primary
Secondary
Concomitant
Uterine Leiomyoma Other Serious 2/6/2006 Female 2/2/2007 Physician United States
Primary
Concomitant
Sleep Apnoea Syndrome Hospitalization 8/17/2006 Female 3/9/2007 Physician United States
Primary
Concomitant
Wound Treatment Other Serious 1/1/1997 59 Female 157 lb 3/17/2007 Physician United States
Primary
Secondary
Concomitant
Vision Blurred 1/1/2005 66 Female 200 lb 1/23/2007 Pharmacist United States
Primary
Concomitant
Metastatic Malignant Melanoma Other Serious 1/1/2006 Female 137 lb 4/17/2007 Physician United States
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 12/1/2003 Female 5/18/2007 Consumer United States
Primary
Concomitant
Wound Infection Staphylococcal Other Serious 12/1/2003 Female 7/10/2007 Physician United States
Primary
Concomitant
Neoplasm Skin Other Serious 7/7/2007 Female 235 lb 7/23/2007 Consumer United States
Primary
Concomitant
Rheumatoid Arthritis Hospitalization 8/22/2007 Female 165 lb 9/21/2007 Canada
Primary
Concomitant
Vomiting Hospitalization 4/21/2007 Female 9/28/2007 Other Health Professional Japan
Primary
Concomitant
Skin Lesion Hospitalization 8/22/2007 Female 165 lb 10/4/2007 Canada
Primary
Concomitant
Urticaria Other Serious 12/29/2006 Female 196 lb 10/5/2007 Other Health Professional Canada
Primary
Concomitant
Tuberculosis Hospitalization 3/26/2007 Male 157 lb 10/8/2007 Physician United States
Primary
Concomitant
Vision Blurred Other Serious 1/1/2005 Female 132 lb 10/12/2007 United States
Primary
Secondary
Concomitant
Tuberculosis Hospitalization 3/26/2007 Male 157 lb 10/25/2007 Physician United States
Primary
Concomitant
Urinary Incontinence Hospitalization 1/1/2007 Female 160 lb 11/1/2007 Physician United States
Primary
Secondary
Concomitant
Tumour Invasion Other Serious 5/1/2007 Female 11/16/2007 Belgium
Primary
Concomitant
Rheumatoid Arthritis Other Serious 6/1/2004 Female 168 lb 12/3/2007 Consumer United States
Primary
Concomitant
Syncope Other Serious 1/1/2004 Female 103 lb 12/13/2007 United States
Primary
Secondary
Concomitant
Injection Site Rash Female 150 lb 12/14/2007 United States
Primary
Concomitant
Overdose Hospitalization 10/16/2007 Female 180 lb 12/14/2007 Consumer United States
Primary
Secondary
Concomitant
Pharyngolaryngeal Pain 10/6/2007 Female 141 lb 12/15/2007 Physician United States
Primary
Concomitant
Pulmonary Fibrosis Hospitalization 12/1/2007 Female 1/4/2008 United States
Primary
Concomitant
Drug Toxicity Death 52 Male 1/11/2008 Physician United States
Primary
Secondary
Respiratory Arrest Death 52 Male 1/21/2008 United States
Primary
Secondary
Respiratory Arrest Death 52 Male 1/22/2008 Physician United States
Primary
Secondary
Respiratory Arrest Death 52 Male 1/22/2008 Physician United States
Primary
Secondary
Tooth Extraction Other Serious 12/1/2000 74 Female 2/12/2008 United States
Primary
Concomitant
Cardio-respiratory Arrest Death 1/1/2006 52 Male 2/13/2008 Physician United States
Primary
Secondary
Varicose Vein Other Serious 5/1/2007 Male 134 lb 2/27/2008 Brazil
Primary
Concomitant
Sudden Death Hospitalization 11/1/2007 74 Male 123 lb 3/4/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Dry Skin 10/1/2003 Female 169 lb 3/14/2008 United States
Primary
Concomitant
Inappropriate Schedule Of Drug Administration 8/23/2006 Female 3/14/2008 Consumer United States
Primary
Concomitant
Drug Ineffective 10/1/2007 Female 165 lb 3/14/2008 United States
Primary
Concomitant
Accidental Exposure 1/24/2008 Female 115 lb 3/15/2008 Consumer United States
Primary
Concomitant
Joint Swelling 2/4/2008 Female 183 lb 3/15/2008 Consumer United States
Primary
Concomitant
Mental Impairment 2/16/2008 3/15/2008 United States
Primary
Concomitant
Acute Sinusitis 2/1/2008 Female 189 lb 3/15/2008 Consumer United States
Primary
Concomitant
Tooth Abscess Other Serious 8/24/2007 56 Female 3/17/2008 Physician Canada
Primary
Concomitant
Psoriasis Hospitalization 12/1/2007 Female 139 lb 3/24/2008 United States
Primary
Concomitant
Completed Suicide Death 3/27/2008 Physician United States
Primary
Secondary
Walking Aid User Other Serious 1/1/2007 Female 160 lb 3/21/2008 Consumer United States
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 12/27/2007 58 Male 3/28/2008 Physician France
Primary
Secondary
Concomitant
Unevaluable Event Hospitalization 6/27/2007 Female 326 lb 3/31/2008 Other Health Professional United States
Primary
Concomitant
Rash Macular Other Serious 1/1/2007 42 Female 148 lb 4/1/2008 Consumer Mexico
Primary
Concomitant
Aspergillosis Death 1/20/2008 Male 4/2/2008 Physician France
Primary
Secondary
Concomitant
Pupils Unequal Hospitalization 24 Female 4/4/2008
Primary
Concomitant
Pupils Unequal Other Serious 24 Female 4/10/2008 Germany
Primary
Concomitant
Injection Site Bruising Other Serious 12/1/2007 Female 120 lb 4/18/2008 United States
Primary
Concomitant
Suicidal Ideation Other Serious 4/1/2008 Female 120 lb 5/7/2008 United States
Primary
Concomitant
Wheezing Hospitalization 6/1/2005 Female 168 lb 5/21/2008 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 159 lb 5/23/2008 Physician United States
Primary
Secondary
Concomitant
Sleep Disorder Hospitalization 1/1/2000 Male 220 lb 6/3/2008 Consumer United States
Primary
Secondary
Concomitant
Swelling Other Serious 61 Female 6/3/2008 Consumer Turkey
Primary
Concomitant
Intervertebral Disc Protrusion Hospitalization Male 6/5/2008 Belgium
Primary
Concomitant
Overdose Hospitalization 10/16/2007 Female 180 lb 6/12/2008 Consumer United States
Primary
Secondary
Concomitant
Mental Impairment 2/16/2008 6/12/2008 United States
Primary
Concomitant
Injection Site Pain 12/1/2007 Female 240 lb 6/12/2008 United States
Primary
Concomitant
Accidental Exposure 3/26/2008 Male 162 lb 6/12/2008 Consumer United States
Primary
Concomitant
Oedema Peripheral 4/28/2008 Female 6/13/2008 United States
Primary
Concomitant
Urinary Tract Infection Hospitalization 8/1/2007 Female 170 lb 6/13/2008 Physician United States
Primary
Concomitant
Vomiting Hospitalization 1/1/2007 Female 159 lb 6/16/2008 Physician United States
Primary
Secondary
Concomitant
Respiratory Arrest Other Serious 52 Male 6/19/2008 Physician United States
Primary
Secondary
Pyrexia Other Serious 1/20/2008 Female 110 lb 6/27/2008 Spain
Primary
Concomitant
Pyrexia Other Serious 1/20/2008 Female 110 lb 7/31/2008 Spain
Primary
Concomitant
Pyrexia Other Serious 1/20/2008 Female 110 lb 8/1/2008 Spain
Primary
Concomitant
Post Herpetic Neuralgia Hospitalization 8/2/2008 57 Female 137 lb 8/4/2008 Other Health Professional United States
Primary
Concomitant
Oedema Peripheral Other Serious Female 150 lb 8/18/2008 Consumer United States
Primary
Concomitant
Paraesthesia 7/1/2008 Female 8/29/2008 United States
Primary
Concomitant
Thrombocytopenia Hospitalization 1/1/2007 63 Male 9/5/2008 Consumer Japan
Primary
Secondary
Concomitant
Underdose 1/1/2007 Female 180 lb 9/12/2008 Physician United States
Primary
Concomitant
Psoriasis 10/2/2006 Female 115 lb 9/12/2008 Consumer United States
Primary
Concomitant
Suicidal Ideation 1/1/2008 Female 9/12/2008
Primary
Concomitant
Injection Site Nodule 6/27/2008 Male 206 lb 9/12/2008 United States
Primary
Concomitant
Accidental Exposure 6/26/2008 Male 300 lb 9/12/2008
Primary
Concomitant
Injection Site Pain 7/3/2008 Female 9/12/2008 United States
Primary
Concomitant
Myalgia 5/1/2008 Female 9/12/2008 United States
Primary
Concomitant
Injection Site Swelling 6/30/2008 Female 160 lb 9/12/2008 Consumer United States
Primary
Concomitant
Injection Site Haemorrhage 7/14/2008 163 lb 9/12/2008 Consumer United States
Primary
Concomitant
Injection Site Pain 7/16/2008 Female 220 lb 9/12/2008 United States
Primary
Concomitant
Tremor 5/1/2008 Female 210 lb 9/12/2008 Consumer United States
Primary
Concomitant
Psoriasis 1/1/2008 Female 176 lb 9/13/2008 Physician United States
Primary
Concomitant
Renal Failure Other Serious 4/13/2003 Female 9/16/2008 Physician United States
Primary
Secondary
Concomitant
Staphylococcal Infection Hospitalization 7/1/2008 Female 326 lb 9/25/2008 Consumer United States
Primary
Concomitant
Thrombocytopenia Hospitalization 1/1/2007 63 Male 9/26/2008 Consumer Japan
Primary
Secondary
Concomitant
Urinary Tract Infection Other Serious 1/20/2008 Female 110 lb 9/29/2008 Spain
Primary
Concomitant
Renal Failure Other Serious 4/13/2003 Female 10/3/2008 Physician United States
Primary
Secondary
Concomitant
Sepsis Other Serious 1/20/2008 Female 110 lb 10/24/2008 Spain
Primary
Concomitant
Renal Failure Other Serious 4/1/2003 Female 10/31/2008 Other Health Professional United States
Primary
Secondary
Concomitant
Transient Ischaemic Attack Other Serious 11/1/2007 Female 11/3/2008 Physician United States
Primary
Concomitant
Pulmonary Fibrosis Hospitalization 8/1/2007 Female 11/14/2008 United States
Primary
Concomitant
Conduct Disorder Hospitalization 11/24/2008 54 Female 139 lb 12/3/2008 Physician Peru
Primary
Concomitant
Joint Stiffness 1/1/2007 Male 252 lb 12/8/2008 Physician United States
Primary
Concomitant
Weight Increased 1/1/2007 Female 190 lb 12/12/2008 Physician United States
Primary
Concomitant
Tremor 5/1/2008 Female 210 lb 12/12/2008 Consumer United States
Primary
Concomitant
Accidental Exposure 6/26/2008 Male 300 lb 12/12/2008
Primary
Concomitant
Irritability 8/28/2008 Female 220 lb 12/12/2008 United States
Primary
Concomitant
Visual Impairment 4/1/2008 Female 250 lb 12/12/2008 United States
Primary
Concomitant
Procedural Complication 8/30/2008 Male 300 lb 12/12/2008 Consumer United States
Primary
Concomitant
Pain In Extremity 3/1/2008 Female 178 lb 12/12/2008 Consumer United States
Primary
Concomitant
Vomiting 9/24/2008 Female 117 lb 12/12/2008 Consumer United States
Primary
Concomitant
Tongue Disorder 9/26/2008 Male 12/12/2008 United States
Primary
Concomitant
Pain 9/27/2008 Female 12/12/2008 Physician United States
Primary
Concomitant
Pain Female 132 lb 12/12/2008 Consumer United States
Primary
Concomitant
Injection Site Irritation 11/18/2008 Male 178 lb 12/12/2008 Other Health Professional United States
Primary
Concomitant
Weight Increased 8/1/2008 Female 12/12/2008 Other Health Professional United States
Primary
Concomitant
Acute Myocardial Infarction Death 12/15/2008 Female 115 lb 1/13/2009 Japan
Primary
Concomitant
Renal Failure Death 1/1/2009 Female 1/22/2009 Physician United States
Primary
Concomitant
Rhabdomyolysis Other Serious 5/1/2008 1/23/2009 France
Primary
Concomitant
Interacting
Skin Toxicity Death 10/29/2008 Female 3/10/2009 Pharmacist France
Primary
Concomitant
Vaginal Infection Other Serious Female 135 lb 3/14/2009 Physician United States
Primary
Concomitant
Crohn's Disease Hospitalization 11/8/2008 Female 106 lb 3/14/2009 United States
Primary
Concomitant
Paraesthesia 10/20/2008 Female 275 lb 3/14/2009 Consumer United States
Primary
Concomitant
Urticaria 11/27/2008 58 Female 3/14/2009 Other Health Professional
Primary
Concomitant
Acute Myocardial Infarction Death 12/15/2008 Female 115 lb 3/16/2009 Japan
Primary
Concomitant
Eye Disorder 75 Female 3/18/2009 Consumer United States
Primary
Concomitant

Drug Data