Alprazolam combined with Isosorbide Mononitrate

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
Wrong Technique In Drug Usage Process Other Serious 2/1/2004 Female 128 lb 1/24/2006 Physician United States
Primary
Concomitant
Wrong Technique In Drug Usage Process Other Serious 2/1/2004 Female 128 lb 2/10/2006 Physician United States
Primary
Concomitant
Subcutaneous Haematoma Hospitalization 6/15/2005 66 Male 198 lb 2/9/2006 Poland
Primary
Concomitant
Interacting
Wrong Technique In Drug Usage Process Other Serious 2/1/2004 Female 128 lb 3/3/2006 Physician United States
Primary
Concomitant
Skin Discolouration Hospitalization 2/1/2004 42 Female 140 lb 12/27/2005 Consumer United States
Primary
Concomitant
Oedema Due To Cardiac Disease Hospitalization 7/1/2005 60 Female 119 lb 3/10/2006 Physician Japan
Primary
Concomitant
Ventricular Hypertrophy Hospitalization 1/1/2001 64 Male 198 lb 3/30/2006 Physician United States
Primary
Concomitant
Ventricular Hypertrophy Hospitalization 6/1/2000 66 Female 157 lb 3/31/2006 Physician United States
Primary
Concomitant
Rhinitis Allergic Hospitalization 4/1/2003 49 Male 218 lb 5/5/2006 Physician United States
Primary
Concomitant
Myocardial Infarction Hospitalization 12/1/2000 65 Male 256 lb 5/15/2006 Lawyer United States
Primary
Concomitant
Myocardial Infarction Hospitalization 1/1/2005 65 Female 180 lb 11/1/2006 United States
Primary
Concomitant
Weight Decreased Hospitalization 87 Male 2/7/2007 Physician Spain
Primary
Secondary
Concomitant
Weight Decreased Hospitalization 87 Male 3/13/2007
Primary
Secondary
Concomitant
Hypocoagulable State Hospitalization 9/29/2006 63 Female 75 lb 3/15/2007 Physician Japan
Primary
Secondary
Concomitant
Weight Decreased Other Serious 9/1/2003 87 Male 5/9/2007 Physician United States
Primary
Concomitant
Myocardial Infarction Other Serious 10/8/2006 78 Female 9/7/2007 United States
Primary
Concomitant
Hypotension Life Threatening 7/18/2007 47 Female 126 lb 10/5/2007 Physician United States
Primary
Secondary
Concomitant
Pneumonia Other Serious 5/2/2007 Female 10/8/2007 United States
Primary
Concomitant
Ventricular Extrasystoles Life Threatening 7/18/2007 47 Female 126 lb 10/26/2007 Physician United States
Primary
Secondary
Concomitant
Nausea Life Threatening 7/18/2007 47 Female 11/6/2007 United States
Primary
Secondary
Concomitant
Weight Increased Hospitalization 11/1/2007 Female 170 lb 12/19/2007 Physician United States
Primary
Concomitant
Pulmonary Fibrosis Hospitalization 12/1/2007 Female 1/4/2008 United States
Primary
Concomitant
Hypotension Life Threatening 7/18/2007 47 Female 126 lb 2/6/2008 Physician United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 12/1/2006 57 Female 220 lb 11/29/2007 Consumer United States
Primary
Concomitant
Urinary Retention Other Serious 2/1/2008 Female 137 lb 4/30/2008 Consumer United States
Primary
Concomitant
Transient Ischaemic Attack Hospitalization 6/1/2006 53 Male 217 lb 6/18/2008 Other Health Professional United States
Primary
Concomitant
Stent Placement Hospitalization 79 Male 6/25/2008 Consumer United States
Primary
Concomitant
Renal Failure Other Serious 1/1/1998 Male 8/15/2008 United States
Primary
Secondary
Concomitant
Headache 7/7/2008 Female 8/27/2008 United States
Primary
Concomitant
Dehydration Hospitalization 8/20/2008 Female 199 lb 9/10/2008 Consumer United States
Primary
Secondary
Concomitant
Dehydration Hospitalization 8/20/2008 Female 199 lb 9/19/2008 Consumer United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/10/2008 Female 226 lb 9/22/2008 Physician Hungary
Primary
Secondary
Concomitant
Vomiting Hospitalization 9/10/2008 Female 9/25/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Viral Infection Hospitalization 9/10/2008 Female 226 lb 9/29/2008 Physician Hungary
Primary
Secondary
Concomitant
Viral Infection Hospitalization 9/10/2008 Female 10/3/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Respiratory Distress Hospitalization 10/12/2008 Female 10/31/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Viral Pharyngitis Hospitalization 10/12/2008 Female 11/7/2008 Physician United Kingdom
Primary
Secondary
Concomitant
Pulmonary Fibrosis Hospitalization 8/1/2007 Female 11/14/2008 United States
Primary
Concomitant
Product Quality Issue Hospitalization 5/7/2008 71 Female 106 lb 12/22/2008 Consumer United States
Primary
Concomitant
Product Quality Issue Death 5/1/2008 75 Male 195 lb 12/30/2008 Consumer United States
Primary
Concomitant
Troponin Increased Other Serious 1/1/2003 78 Male 140 lb 1/8/2009 United States
Primary
Concomitant
Syncope Death 9/18/2008 75 Male 1/9/2009 Consumer United States
Primary
Concomitant
Renal Failure Other Serious 1/1/1998 78 Male 137 lb 1/14/2009 Consumer United States
Primary
Secondary
Concomitant
Pancreatitis Hospitalization 1/19/2009 Female 258 lb 2/4/2009 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Hospitalization 1/21/2009 Male 174 lb 2/11/2009 Physician Argentina
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 1/31/2009 44 Female 117 lb 2/17/2009 Consumer Brazil
Primary
Secondary
Concomitant
Road Traffic Accident Hospitalization 5/10/2008 Female 176 lb 3/25/2009 Other Health Professional United States
Primary
Secondary
Concomitant
Troponin Increased Other Serious 1/1/2003 78 Male 140 lb 4/14/2009 United States
Primary
Concomitant
Febrile Neutropenia Hospitalization 10/10/2008 Female 7/6/2009 Physician United States
Primary
Secondary
Concomitant
Toxic Skin Eruption Other Serious 6/1/2009 Male 8/12/2009 Portugal
Primary
Concomitant
Toxic Skin Eruption Other Serious 6/1/2009 Male 8/28/2009 Portugal
Primary
Concomitant
Urinary Retention Other Serious 5/30/2009 Male 9/19/2009 Consumer
Primary
Concomitant
Thrombotic Thrombocytopenic Purpura Other Serious 9/8/2009 66 Female 229 lb 10/1/2009 Pharmacist United States
Primary
Secondary
Concomitant
Visual Impairment Other Serious 65 Male 11/17/2009 United States
Primary
Concomitant
Peritonitis Bacterial Other Serious 3/5/2009 76 Male 168 lb 11/3/2009 Other Health Professional United States
Primary
Concomitant
Haemorrhage Hospitalization 10/20/2009 72 Male 12/1/2009 Consumer Brazil
Primary
Concomitant
Sepsis Life Threatening 11/21/2009 Male 161 lb 12/16/2009 Physician India
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/21/2009 Male 161 lb 12/23/2009 Physician India
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/21/2009 Male 161 lb 12/28/2009 Physician India
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/21/2009 Male 161 lb 12/29/2009 Physician India
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/21/2009 Male 161 lb 1/6/2010 Physician India
Primary
Secondary
Concomitant
Ventricular Tachycardia Other Serious 65 Male 1/12/2010 United States
Primary
Concomitant
Ventricular Tachycardia Death 6/27/2008 87 Female 115 lb 1/26/2010 Lawyer United States
Primary
Concomitant
Thrombosis Other Serious 12/1/2007 Male 3/4/2010 Lawyer United States
Primary
Concomitant
Vomiting Life Threatening 12/14/2007 69 Male 3/4/2010 Lawyer United States
Primary
Secondary
Concomitant
Respiratory Arrest Death 9/25/2006 85 Female 115 lb 3/3/2010 Lawyer United States
Primary
Concomitant
Weight Decreased Other Serious 11/21/2009 74 Male 161 lb 4/1/2010 Physician India
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/21/2009 74 Male 161 lb 4/12/2010 Physician India
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/21/2009 74 Male 161 lb 5/20/2010 Physician India
Primary
Secondary
Concomitant
Thrombosis Other Serious 12/1/2007 54 Male 163 lb 6/3/2010 Other Health Professional United States
Primary
Concomitant
Vomiting Other Serious 1/2/2007 69 Male 187 lb 6/7/2010 Lawyer United States
Primary
Secondary
Concomitant
Myocardial Infarction Other Serious 1/31/2009 44 Female 117 lb 6/10/2010 Consumer Brazil
Primary
Secondary
Concomitant
Paraesthesia Other Serious 1/1/2008 54 Female 179 lb 6/16/2010 Lawyer United States
Primary
Concomitant
Vomiting Other Serious 2/1/2008 61 Male 6/22/2010 Lawyer United States
Primary
Concomitant
Thrombosis Other Serious 12/1/2007 54 Male 163 lb 7/21/2010 Other Health Professional United States
Primary
Concomitant
Vomiting Hospitalization 11/1/2008 8/3/2010 Other Health Professional Algeria
Primary
Secondary
Concomitant
Paraesthesia Other Serious 7/1/2008 54 Female 179 lb 8/12/2010 Physician United States
Primary
Concomitant
Vomiting Other Serious 2/1/2008 61 Male 187 lb 8/19/2010 Other Health Professional United States
Primary
Concomitant
Sepsis Life Threatening 11/21/2009 74 Male 161 lb 8/26/2010 Physician India
Primary
Secondary
Concomitant
Weight Decreased Life Threatening 11/21/2009 74 Male 161 lb 8/27/2010 Physician India
Primary
Secondary
Concomitant
Sepsis Life Threatening 11/21/2009 74 Male 161 lb 9/2/2010 Physician India
Primary
Secondary
Concomitant
Anxiety 9/28/2010 65 Male 160 lb 10/7/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 12/14/2007 69 Male 187 lb 10/11/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Condition Aggravated Other Serious 45 Female 10/12/2010 Physician
Primary
Secondary
Concomitant
Upper-airway Cough Syndrome Female 10/13/2010 Consumer United States
Primary
Concomitant
Mental Disorder Other Serious 45 Female 10/13/2010 Physician United States
Primary
Secondary
Thrombosis Other Serious 12/1/2007 54 Male 163 lb 10/25/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Serotonin Syndrome Hospitalization 59 Male 10/26/2010 Physician Norway
Primary
Concomitant
Serotonin Syndrome Death 59 Male 10/28/2010 Other Health Professional Norway
Primary
Secondary
Concomitant
Mental Disorder Other Serious 45 Female 10/29/2010 Physician United States
Primary
Secondary
Mental Disorder Other Serious 45 Female 10/29/2010 Physician United States
Primary
Secondary
Thrombosis Other Serious 12/1/2007 54 Male 163 lb 11/2/2010 Lawyer United States
Primary
Secondary
Concomitant
Mental Disorder Hospitalization 45 Female 11/3/2010 Physician United States
Primary
Secondary
Vertigo Other Serious 9/28/2010 65 Male 160 lb 11/3/2010 Consumer United States
Primary
Concomitant
Vomiting Other Serious 2/1/2008 61 Male 187 lb 11/18/2010 Other Health Professional United States
Primary
Concomitant
Mental Disorder Other Serious 45 Female 11/24/2010 Physician United States
Primary
Secondary
Mental Disorder Hospitalization 45 Female 11/8/2010 United States
Primary
Secondary
Mental Disorder Hospitalization 45 Female 12/1/2010 Other Health Professional United States
Primary
Secondary
Unresponsive To Stimuli Other Serious 2/21/2008 69 Female 150 lb 12/1/2010 Other Health Professional United States
Primary
Secondary
Concomitant
Vomiting Hospitalization 12/14/2007 69 Male 187 lb 1/31/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Sinus Tachycardia Other Serious 2/21/2008 69 Female 150 lb 1/31/2011 Pharmacist United States
Primary
Secondary
Concomitant
Septic Shock Death 1/21/2011 83 Female 2/2/2011 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Headache Other Serious 7/1/2008 54 Female 179 lb 2/3/2011 Physician United States
Primary
Concomitant
Hypotension Death 1/21/2011 83 Female 2/9/2011 Physician Korea, Republic Of
Primary
Secondary
Concomitant
Chest Pain Death 9/22/2007 58 Male 3/10/2011 Lawyer United States
Primary
Concomitant
Depressed Level Of Consciousness Life Threatening 59 Male 3/10/2011 Other Health Professional Norway
Primary
Secondary
Concomitant
Arrhythmia Other Serious 7/1/2010 55 Male 3/29/2011 Physician United States
Primary
Concomitant
Loss Of Consciousness Other Serious 86 Male 3/30/2011 Consumer United States
Primary
Concomitant
Dizziness Other Serious 9/22/2007 58 Male 265 lb 3/31/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Arrhythmia Other Serious 12/1/2007 54 Male 163 lb 4/18/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Dizziness Hospitalization 61 Male 3/31/2011 Consumer United States
Primary
Concomitant
Metabolic Acidosis Hospitalization 59 Male 4/14/2011 Norway
Primary
Secondary
Concomitant
Guillain-barre Syndrome Hospitalization 2/26/2008 55 Male 197 lb 5/23/2011 Other Health Professional United States
Primary
Concomitant
Serotonin Syndrome Hospitalization 59 Male 7/1/2011 Physician Norway
Primary
Secondary
Concomitant
Toxicity To Various Agents Death 59 Male 7/1/2011 Physician Norway
Primary
Secondary
Concomitant
Anxiety Other Serious 5/9/2006 57 Female 229 lb 7/19/2011 Other Health Professional United States
Primary
Concomitant
Disseminated Intravascular Coagulation Death 59 Male 7/19/2011 Physician Norway
Primary
Secondary
Agitation Death 59 Male 7/18/2011 Other Health Professional Norway
Primary
Secondary
Concomitant
Diabetic Vascular Disorder Other Serious 6/2/2004 68 Female 287 lb 7/12/2011 Physician United States
Primary
Concomitant
Thrombocytopenia Death 12/1/2007 54 Male 163 lb 7/22/2011 Lawyer United States
Primary
Secondary
Concomitant
Cardiac Output Decreased Other Serious 12/1/2007 54 Male 163 lb 7/22/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Prothrombin Level Decreased 73 Female 7/25/2011 Consumer United States
Primary
Concomitant
Fatigue Hospitalization 59 Male 7/15/2011 Physician Norway
Primary
Secondary
Concomitant
Cerebellar Atrophy Life Threatening 59 Male 7/21/2011 Physician Norway
Primary
Secondary
Concomitant
Multi-organ Failure Death 59 Male 7/28/2011 Physician Norway
Primary
Secondary
Drug Interaction Hospitalization 59 Male 7/25/2011 Physician Norway
Primary
Secondary
Concomitant
Cerebellar Atrophy Life Threatening 59 Male 7/26/2011 Physician Norway
Primary
Secondary
Metabolic Acidosis Death 59 Male 8/8/2011 Other Health Professional Norway
Primary
Secondary
Concomitant
Toxicity To Various Agents Hospitalization 2/1/2008 59 Male 8/15/2011 Physician Norway
Primary
Secondary
Concomitant
Depressed Level Of Consciousness Life Threatening 59 Male 8/17/2011 Other Health Professional Norway
Primary
Concomitant
Disseminated Intravascular Coagulation Life Threatening 59 Male 8/16/2011 Other Health Professional Norway
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 9/8/2007 64 Female 207 lb 9/21/2011 Physician United States
Primary
Secondary
Concomitant
Multiple Drug Overdose Hospitalization 2/1/2008 59 Male 9/29/2011 Physician Norway
Primary
Secondary
Concomitant
Rhabdomyolysis Other Serious 9/8/2007 64 Female 207 lb 10/4/2011 Physician United States
Primary
Secondary
Concomitant
Depressed Level Of Consciousness Life Threatening 59 Male 10/3/2011 Physician Norway
Primary
Secondary
Concomitant
Hepatic Enzyme Increased Hospitalization 59 Male 10/19/2011 Other Health Professional Norway
Primary
Concomitant
Anaemia Life Threatening 69 Male 187 lb 10/31/2011 Other Health Professional United States
Primary
Secondary
Concomitant
Diabetes Mellitus Death 12/1/2010 71 Female 301 lb 11/8/2011 Consumer United States
Primary
Concomitant
Cholelithiasis Death 12/1/2007 54 Male 163 lb 11/16/2011 Lawyer United States
Primary
Secondary
Concomitant
Death Death 11/11/2011 72 Male 265 lb 11/11/2011 Consumer United States
Primary
Secondary
Concomitant
Neoplasm Malignant Death 11/11/2011 72 Male 265 lb 11/11/2011 United States
Primary
Secondary
Concomitant
Death Death 11/11/2011 72 Male 265 lb 11/24/2011 United States
Primary
Secondary
Concomitant
Off Label Use Death 11/11/2011 Male 265 lb 11/28/2011 Physician United States
Primary
Secondary
Concomitant
Death Death 11/11/2011 72 Male 265 lb 12/2/2011 Physician United States
Primary
Secondary
Concomitant
Cardiac Arrest Hospitalization 11/11/2011 72 Male 225 lb 12/6/2011 Physician United States
Primary
Secondary
Concomitant
Cardiac Arrest Death 11/11/2011 72 Male 225 lb 12/8/2011 Physician United States
Primary
Secondary
Concomitant
Blood Thyroid Stimulating Hormone Increased Other Serious 81 Male 1/4/2012 Other Health Professional Israel
Primary
Concomitant
Interacting
Anxiety Other Serious Male 157 lb 1/9/2012 Other Health Professional United States
Primary
Concomitant
Nervousness Hospitalization 2/3/2012 75 Female 2/14/2012 Consumer Brazil
Primary
Concomitant
Product Substitution Issue Hospitalization 1/13/2012 86 Female 123 lb 2/9/2012 Consumer United States
Primary
Concomitant

Drug Data