Allopurinol combined with Velcade

Reports:

Reaction Outcome Event Date Age Sex Weight Reported Reporter Country Treatment
Role Name
White Blood Cell Count Decreased Other Serious 1/14/2006 54 Male 214 lb 1/25/2006 Physician Netherlands
Primary
Secondary
Concomitant
Skin Toxicity Other Serious 1/13/2006 32 Female 183 lb 1/25/2006 Physician Netherlands
Primary
Secondary
Concomitant
Therapy Non-responder Hospitalization 11/29/2005 60 Male 212 lb 1/24/2006 Other Health Professional Australia
Primary
Concomitant
Po2 Decreased Other Serious 11/24/2005 54 Male 149 lb 1/25/2006 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 4/20/2004 53 Female 95 lb 1/31/2006 Physician Japan
Primary
Concomitant
Tremor Other Serious 11/6/2005 69 Male 154 lb 1/27/2006 Physician Italy
Primary
Concomitant
White Blood Cell Count Decreased Hospitalization 10/10/2005 64 Male 150 lb 2/2/2006 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/13/2006 32 Female 183 lb 2/1/2006 Physician Netherlands
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/14/2006 54 Male 214 lb 2/1/2006 Physician Netherlands
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/9/2006 75 Female 140 lb 2/3/2006 Other Health Professional United Kingdom
Primary
Concomitant
Tricuspid Valve Incompetence Other Serious 1/1/2005 48 Female 82 lb 2/8/2006 Physician Japan
Primary
Secondary
Concomitant
Therapy Non-responder Other Serious 1/13/2006 32 Female 183 lb 2/9/2006 Physician Netherlands
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/14/2006 54 Male 214 lb 2/10/2006 Physician Netherlands
Primary
Secondary
Concomitant
Pneumonitis Other Serious 11/24/2005 54 Male 149 lb 2/10/2006 Physician Japan
Primary
Concomitant
Tremor Other Serious 11/6/2005 69 Male 154 lb 2/10/2006 Physician Italy
Primary
Concomitant
Nausea Other Serious 11/24/2005 54 Male 149 lb 2/16/2006 Physician Japan
Primary
Concomitant
Nausea Other Serious 11/24/2005 54 Male 149 lb 2/22/2006 Physician Japan
Primary
Concomitant
Renal Failure Other Serious 3/10/2005 65 Female 154 lb 2/21/2006 Physician Italy
Primary
Concomitant
Thrombosis Mesenteric Vessel Required Intervention 4/22/2005 58 Female 2/24/2006 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/14/2006 54 Male 214 lb 2/23/2006 Physician Netherlands
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/13/2006 32 Female 190 lb 2/23/2006 Physician Netherlands
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/13/2006 32 Female 183 lb 3/1/2006 Physician Netherlands
Primary
Secondary
Concomitant
Sudden Cardiac Death Other Serious 1/14/2006 54 Male 214 lb 3/1/2006 Physician Netherlands
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 1/1/2004 76 Male 188 lb 3/2/2006 United States
Primary
Secondary
Concomitant
Sudden Cardiac Death Other Serious 1/14/2006 54 Male 214 lb 3/8/2006 Physician Netherlands
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/13/2006 32 Female 168 lb 3/8/2006 Physician Netherlands
Primary
Secondary
Concomitant
Thrombocytopenia Death 75 Female 3/17/2006 Other Health Professional United Kingdom
Primary
Concomitant
Thrombocytopenia Other Serious 1/9/2006 75 Female 140 lb 3/23/2006 Other Health Professional United Kingdom
Primary
Concomitant
Urine Output Decreased Life Threatening 3/27/2006 47 Female 134 lb 3/31/2006 Pharmacist United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 1/14/2006 54 Male 214 lb 3/21/2006 Physician Netherlands
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 1/13/2006 32 Female 168 lb 3/21/2006 Physician Netherlands
Primary
Secondary
Concomitant
Pulmonary Embolism Life Threatening 1/20/2006 Male 4/7/2006 Physician United States
Primary
Secondary
Concomitant
Vomiting Other Serious 10/7/2005 71 Male 3/31/2006 Pharmacist United Kingdom
Primary
Concomitant
Pulmonary Arterial Pressure Increased Hospitalization 10/25/2005 66 Male 163 lb 4/10/2006 Physician United Kingdom
Primary
Concomitant
Renal Impairment Hospitalization 12/27/2005 57 Male 123 lb 4/13/2006 Physician South Africa
Primary
Concomitant
Toxic Skin Eruption Other Serious 1/7/2006 64 Male 181 lb 4/18/2006 Physician France
Primary
Concomitant
Toxic Skin Eruption Required Intervention 12/29/2005 49 Female 123 lb 4/21/2006 Physician Spain
Primary
Concomitant
Peripheral Coldness 72 Female 138 lb 2/17/2006 Consumer United States
Primary
Secondary
Concomitant
Pneumonia Hospitalization 11/4/2005 72 Female 253 lb 2/17/2006 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Other Serious 1/26/2006 70 Male 5/12/2006 Pharmacist United Kingdom
Primary
Concomitant
Neutropenia Hospitalization 4/28/2006 58 Male 203 lb 5/16/2006 Physician Germany
Primary
Secondary
Concomitant
Troponin I Increased Hospitalization 3/14/2006 84 Male 112 lb 5/22/2006 Physician United Kingdom
Primary
Concomitant
Vena Cava Thrombosis Hospitalization 10/31/2005 51 Unknown 5/26/2006 Physician Germany
Primary
Secondary
Concomitant
Varicella Other Serious 5/20/2005 64 Male 5/26/2006 Physician Switzerland
Primary
Concomitant
Pancytopenia Other Serious 12/1/2002 53 Male 5/25/2006 Physician United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/20/2005 63 6/8/2006 Physician Switzerland
Primary
Secondary
Concomitant
Varicella Other Serious 5/20/2005 64 Male 6/8/2006 Physician Switzerland
Primary
Concomitant
Respiratory Failure Death 9/13/2005 63 6/8/2006 Physician Switzerland
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Hospitalization 5/10/2005 44 Female 101 lb 6/20/2006 Physician Argentina
Primary
Secondary
Concomitant
Respiratory Failure Other Serious 9/13/2005 63 6/29/2006 Physician Switzerland
Primary
Secondary
Concomitant
Leukopenia Other Serious 5/12/2006 62 Female 185 lb 6/29/2006 Physician Germany
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 6/20/2005 63 6/29/2006 Physician Switzerland
Primary
Secondary
Concomitant
Syncope 3/13/2006 85 Male 177 lb 5/24/2006 Physician United States
Primary
Concomitant
Urine Output Decreased Life Threatening 3/27/2006 47 Female 134 lb 5/24/2006 Pharmacist United States
Primary
Secondary
Concomitant
Thrombocytopenia Hospitalization 1/11/2005 70 Female 159 lb 5/24/2006 Consumer United States
Primary
Secondary
Concomitant
Rash Other Serious 4/13/2006 69 Male 5/24/2006 Other Health Professional United States
Primary
Concomitant
Troponin I Increased Hospitalization 3/14/2006 84 Male 112 lb 7/7/2006 Physician United Kingdom
Primary
Concomitant
Syncope Other Serious 11/24/2005 64 Male 159 lb 7/5/2006 Physician Poland
Primary
Secondary
Concomitant
Leukopenia Other Serious 5/12/2006 62 Female 185 lb 7/13/2006 Physician Germany
Primary
Secondary
Concomitant
Hepatitis Hospitalization 6/15/2006 63 7/31/2006 Physician Germany
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 5/26/2006 64 Female 181 lb 8/17/2006 Physician Germany
Primary
Concomitant
Urate Nephropathy Other Serious 60 Female 8/17/2006 Pharmacist United States
Primary
Concomitant
Troponin I Increased Hospitalization 3/14/2006 84 Male 112 lb 8/23/2006 Physician United Kingdom
Primary
Concomitant
Multiple Myeloma Death 8/7/2006 54 Male 9/7/2006 Physician New Zealand
Primary
Concomitant
Weight Decreased Hospitalization 4/28/2006 58 Male 203 lb 9/7/2006 Physician Germany
Primary
Secondary
Concomitant
Renal Failure Acute Life Threatening 5/26/2006 64 Female 181 lb 10/10/2006 Physician Germany
Primary
Concomitant
Therapy Non-responder Hospitalization 6/1/2006 76 Male 10/9/2006 Physician United States
Primary
Concomitant
Renal Failure Acute Life Threatening 5/26/2006 64 Female 181 lb 10/19/2006 Physician Germany
Primary
Concomitant
Urethral Haemorrhage Other Serious 10/30/2006 Male 181 lb 12/4/2006 Physician Czech Republic
Primary
Concomitant
Encephalitis Hospitalization 11/10/2006 52 11/22/2006 Physician Germany
Primary
Secondary
Concomitant
Lung Disorder Life Threatening 11/27/2006 64 Male 152 lb 12/5/2006 Physician France
Primary
Concomitant
Tachycardia Hospitalization 9/30/2006 50 Female 200 lb 12/6/2006 Physician United States
Primary
Secondary
Concomitant
Renal Failure Hospitalization 9/29/2006 82 Male 12/8/2006 Other Health Professional Greece
Primary
Secondary
Concomitant
Renal Failure Hospitalization 9/29/2006 82 Male 176 lb 12/11/2006 Pharmacist Greece
Primary
Secondary
Concomitant
Encephalitis Viral Hospitalization 11/10/2006 52 12/15/2006 Physician Germany
Primary
Secondary
Concomitant
Weight Increased Other Serious 10/30/2006 62 Female 151 lb 12/18/2006 Physician United States
Primary
Secondary
Concomitant
Splenic Haemorrhage Death 12/19/2006 76 Male 181 lb 12/22/2006 Other Health Professional United Kingdom
Primary
Secondary
Concomitant
Toxic Skin Eruption Other Serious 1/7/2006 64 Male 181 lb 1/2/2007 Physician France
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 12/13/2006 60 Male 1/10/2007 Physician Japan
Primary
Secondary
Concomitant
Splenic Haemorrhage Hospitalization 12/19/2006 76 Male 181 lb 1/15/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Troponin I Increased Life Threatening 1/14/2007 76 Female 150 lb 1/17/2007 Physician Australia
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 1/17/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Hospitalization 12/1/2006 67 Male 1/17/2007 Physician United States
Primary
Secondary
Concomitant
Spontaneous Haematoma Hospitalization 9/10/2006 75 Male 143 lb 1/24/2007 Spain
Primary
Concomitant
Tachycardia Death 1/12/2007 72 Male 1/25/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 1/25/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 2/5/2007 Physician Japan
Primary
Secondary
Concomitant
Volume Blood Decreased Death 12/22/2006 64 Female 2/5/2007 Physician France
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 12/13/2006 60 Male 2/5/2007 Physician Japan
Primary
Secondary
Concomitant
Supraventricular Tachycardia Hospitalization 1/26/2007 54 Female 146 lb 2/5/2007 Physician Ireland
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 10/3/2006 74 Male 127 lb 2/5/2007 Physician France
Primary
Concomitant
Pulmonary Embolism Other Serious 11/30/2006 73 Male 194 lb 2/6/2007 United Kingdom
Primary
Concomitant
Tumour Lysis Syndrome Life Threatening 10/26/2006 73 Male 2/7/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Tumour Lysis Syndrome Hospitalization 1/25/2007 53 Male 2/7/2007 Physician Japan
Primary
Concomitant
Ventricular Hypokinesia Other Serious 11/18/2006 79 Female 130 lb 2/9/2007 Physician United Kingdom
Primary
Concomitant
Supraventricular Tachycardia Hospitalization 1/26/2007 54 Female 146 lb 2/15/2007 Physician Ireland
Primary
Secondary
Concomitant
Toxic Skin Eruption Hospitalization 10/3/2006 74 Male 127 lb 2/16/2007 Physician France
Primary
Concomitant
Tumour Lysis Syndrome Hospitalization 1/25/2007 53 Male 2/16/2007 Physician Japan
Primary
Concomitant
Troponin I Increased Life Threatening 1/14/2007 76 Female 150 lb 2/15/2007 Physician Australia
Primary
Secondary
Concomitant
Urinary Retention Hospitalization 1/12/2007 71 Female 2/19/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 2/12/2007 Physician Japan
Primary
Secondary
Concomitant
Restlessness Hospitalization 11/10/2006 52 Unknown 2/15/2007 Physician Germany
Primary
Secondary
Concomitant
Ventricular Dysfunction Other Serious 11/18/2006 79 Female 130 lb 2/23/2007 Physician United Kingdom
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 1/17/2007 53 Male 2/23/2007 Physician Japan
Primary
Secondary
Concomitant
Sepsis Other Serious 10/10/2005 64 Male 150 lb 2/27/2007 Physician Japan
Primary
Concomitant
Troponin I Increased Life Threatening 1/14/2007 76 Female 150 lb 3/2/2007 Physician Australia
Primary
Secondary
Concomitant
Sudden Death Death 2/9/2007 81 Female 2/28/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Pulmonary Infarction Life Threatening 1/18/2007 61 Female 3/1/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Life Threatening 1/17/2007 53 Male 3/2/2007 Physician Japan
Primary
Secondary
Concomitant
Supraventricular Tachycardia Hospitalization 1/26/2007 54 Female 146 lb 3/2/2007 Physician Ireland
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 2/28/2007 Physician Japan
Primary
Secondary
Concomitant
Pneumonia Aspiration Other Serious 12/25/2006 71 Female 3/5/2007 Physician Japan
Primary
Concomitant
Urinary Retention Hospitalization 1/12/2007 71 Female 3/5/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/13/2006 60 Male 3/7/2007 Physician Japan
Primary
Secondary
Concomitant
Renal Failure Hospitalization 9/29/2006 82 Male 176 lb 3/14/2007 Physician Greece
Primary
Secondary
Concomitant
Renal Failure Hospitalization 9/29/2006 82 Male 3/13/2007 Pharmacist Greece
Primary
Secondary
Concomitant
Tachycardia Death 1/12/2007 72 Male 3/14/2007 Physician Japan
Primary
Concomitant
Urinary Retention Hospitalization 1/12/2007 71 Female 3/16/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/13/2006 60 Male 3/20/2007 Physician Japan
Primary
Secondary
Concomitant
Myocardial Infarction Death 2/24/2007 61 Female 148 lb 3/22/2007 United Kingdom
Primary
Concomitant
Renal Impairment Life Threatening 3/19/2007 65 Female 3/26/2007 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Life Threatening 10/26/2006 73 Male 3/29/2007 Physician United Kingdom
Primary
Secondary
Concomitant
Vomiting Life Threatening 2/12/2007 73 Female 143 lb 3/29/2007 Physician Italy
Primary
Secondary
Concomitant
Multiple Myeloma Hospitalization 3/29/2007 Female 4/9/2007 Pharmacist United States
Primary
Concomitant
Renal Impairment Life Threatening 3/19/2007 65 Female 4/4/2007 Physician Japan
Primary
Concomitant
Ventricular Extrasystoles Life Threatening 1/17/2007 53 Male 4/5/2007 Physician Japan
Primary
Secondary
Concomitant
Renal Cyst Other Serious 3/1/2007 75 Female 4/20/2007 Physician United States
Primary
Secondary
Concomitant
Constipation Hospitalization 4/18/2007 56 Female 121 lb 4/30/2007 Physician Italy
Primary
Concomitant
Troponin I Increased Other Serious 2/25/2007 61 Female 148 lb 5/3/2007 Pharmacist United Kingdom
Primary
Concomitant
Neuropathy Peripheral 5/2/2007 Female 5/11/2007 Pharmacist United States
Primary
Concomitant
Thrombocytopenia Other Serious 2/2/2007 Female 119 lb 5/18/2007 Physician Japan
Primary
Secondary
Concomitant
Blood Alkaline Phosphatase Increased Other Serious 69 Male 181 lb 5/11/2007 Pharmacist United Kingdom
Primary
Concomitant
Pulmonary Infarction Life Threatening 1/18/2007 61 Female 5/17/2007 Physician Japan
Primary
Secondary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 5/18/2007 Physician Japan
Primary
Concomitant
Tumour Lysis Syndrome Other Serious 12/13/2006 60 Male 5/18/2007 Physician Japan
Primary
Secondary
Concomitant
Toxic Induced Encephalopathy Other Serious 4/15/2007 78 Male 128 lb 5/18/2007 Physician Switzerland
Primary
Concomitant
Constipation Hospitalization 4/18/2007 56 Female 121 lb 5/25/2007 Physician Italy
Primary
Concomitant
Pulmonary Mass Other Serious 12/4/2006 71 Male 5/24/2007 Physician Japan
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 2/1/2007 63 Male 5/25/2007 Physician Japan
Primary
Concomitant
Respiratory Failure Life Threatening 1/18/2007 61 Female 6/1/2007 Physician Japan
Primary
Secondary
Concomitant
Gamma-glutamyltransferase Increased Hospitalization 58 Male 6/1/2007 Physician Germany
Primary
Secondary
Concomitant
Sepsis Hospitalization 4/2/2007 63 Male 6/11/2007 Physician Japan
Primary
Concomitant
Troponin I Increased Other Serious 2/25/2007 61 Female 148 lb 6/8/2007 Pharmacist United Kingdom
Primary
Concomitant
Respiratory Failure Life Threatening 1/18/2007 61 Female 6/14/2007 Physician Japan
Primary
Secondary
Concomitant
Rash Other Serious 4/2/2007 71 Male 6/15/2007 Physician Japan
Primary
Concomitant
Stomatitis Other Serious 2/23/2007 63 Male 6/15/2007 Physician Japan
Primary
Concomitant
Constipation Hospitalization 4/18/2007 56 Female 121 lb 6/15/2007 Physician Italy
Primary
Concomitant
Septic Shock Other Serious 2/25/2007 61 Female 148 lb 6/21/2007 Pharmacist United Kingdom
Primary
Concomitant
Thrombocytopenia Hospitalization 6/4/2007 69 Female 160 lb 6/25/2007 Other Health Professional United States
Primary
Concomitant
White Blood Cell Count Decreased Other Serious 12/4/2006 71 Male 6/28/2007 Physician Japan
Primary
Concomitant

Drug Data